Details for: PTPRO

Gene ID: 5800

Symbol: PTPRO

Ensembl ID: ENSG00000151490

Description: protein tyrosine phosphatase receptor type O

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 234.5941
    Cell Significance Index: -36.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 144.8293
    Cell Significance Index: -36.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.5955
    Cell Significance Index: -36.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.4856
    Cell Significance Index: 131.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.5326
    Cell Significance Index: -9.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.4219
    Cell Significance Index: 271.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.3289
    Cell Significance Index: 291.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.0589
    Cell Significance Index: 88.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 4.0397
    Cell Significance Index: 50.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.9047
    Cell Significance Index: 172.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.7082
    Cell Significance Index: 140.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.7033
    Cell Significance Index: 207.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.7008
    Cell Significance Index: 105.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.5760
    Cell Significance Index: 923.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5734
    Cell Significance Index: 516.2300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.2979
    Cell Significance Index: 29.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1642
    Cell Significance Index: 1496.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9801
    Cell Significance Index: 15.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3361
    Cell Significance Index: 254.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2946
    Cell Significance Index: 128.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0284
    Cell Significance Index: 9.4700
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.8384
    Cell Significance Index: 9.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6669
    Cell Significance Index: 602.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6257
    Cell Significance Index: 101.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5023
    Cell Significance Index: 54.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3111
    Cell Significance Index: 14.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3055
    Cell Significance Index: 18.3400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2887
    Cell Significance Index: 2.2200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.1188
    Cell Significance Index: 1.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0838
    Cell Significance Index: 2.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0597
    Cell Significance Index: 1.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0327
    Cell Significance Index: 0.5600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0250
    Cell Significance Index: 0.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0233
    Cell Significance Index: 1.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0139
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0081
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0085
    Cell Significance Index: -15.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0122
    Cell Significance Index: -2.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -23.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0162
    Cell Significance Index: -22.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0228
    Cell Significance Index: -0.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0269
    Cell Significance Index: -0.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0295
    Cell Significance Index: -18.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0340
    Cell Significance Index: -24.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0391
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0420
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0430
    Cell Significance Index: -31.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0462
    Cell Significance Index: -2.8300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0494
    Cell Significance Index: -0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0499
    Cell Significance Index: -37.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0522
    Cell Significance Index: -23.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0620
    Cell Significance Index: -38.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0640
    Cell Significance Index: -34.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0709
    Cell Significance Index: -40.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0746
    Cell Significance Index: -14.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0767
    Cell Significance Index: -1.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0954
    Cell Significance Index: -27.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1075
    Cell Significance Index: -1.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1153
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1158
    Cell Significance Index: -16.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1868
    Cell Significance Index: -39.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1892
    Cell Significance Index: -19.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2011
    Cell Significance Index: -34.3500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2129
    Cell Significance Index: -2.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2149
    Cell Significance Index: -4.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2232
    Cell Significance Index: -4.6300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2281
    Cell Significance Index: -2.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2435
    Cell Significance Index: -15.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2543
    Cell Significance Index: -2.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2600
    Cell Significance Index: -33.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2615
    Cell Significance Index: -5.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2629
    Cell Significance Index: -31.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2637
    Cell Significance Index: -1.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2681
    Cell Significance Index: -36.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2918
    Cell Significance Index: -34.0100
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.3033
    Cell Significance Index: -3.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3155
    Cell Significance Index: -24.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3338
    Cell Significance Index: -38.2400
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3377
    Cell Significance Index: -2.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3447
    Cell Significance Index: -17.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3492
    Cell Significance Index: -9.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3554
    Cell Significance Index: -37.0100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.3694
    Cell Significance Index: -3.8600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3713
    Cell Significance Index: -4.4400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3956
    Cell Significance Index: -4.6200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4331
    Cell Significance Index: -5.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4352
    Cell Significance Index: -33.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4378
    Cell Significance Index: -4.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4524
    Cell Significance Index: -33.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4633
    Cell Significance Index: -10.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4815
    Cell Significance Index: -10.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4838
    Cell Significance Index: -31.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4843
    Cell Significance Index: -5.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4880
    Cell Significance Index: -25.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4987
    Cell Significance Index: -17.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4991
    Cell Significance Index: -26.0000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.5272
    Cell Significance Index: -3.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6360
    Cell Significance Index: -22.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6415
    Cell Significance Index: -20.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PTPRO gene is a member of the RPTP family, which is characterized by the presence of a protein tyrosine phosphatase (PTP) domain and a transmembrane domain. The PTPRO protein is a receptor-type PTP, meaning it has a ligand-binding domain that interacts with its ligand to activate its PTP activity. The PTPRO protein is highly expressed in various tissues, including the nervous system, kidney, and lung. **Pathways and Functions:** The PTPRO gene is involved in several signaling pathways, including: 1. **Apical plasma membrane signaling:** PTPRO is expressed in epithelial cells, where it regulates cell adhesion and migration through signaling pathways that involve the Wnt and Notch families. 2. **Neuron projection development:** PTPRO is expressed in neurons and plays a role in regulating axon guidance and dendritic spine formation. 3. **Glomerulus development:** PTPRO is involved in regulating the development of the glomerulus in the kidney, where it modulates the activity of the Wnt/β-catenin pathway. 4. **Negative regulation of canonical Wnt signaling pathway:** PTPRO acts as a negative regulator of the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. The PTPRO protein has several functions, including: 1. **Peptidyl-tyrosine dephosphorylation:** PTPRO is a PTP that dephosphorylates tyrosine residues on its substrates, which can lead to the inactivation of signaling pathways. 2. **Protein binding:** PTPRO binds to various proteins, including the Wnt family receptors and the adaptor protein, NTRK3. 3. **Regulation of glomerular filtration:** PTPRO regulates the activity of the Wnt/β-catenin pathway in the kidney, which is involved in glomerular filtration. **Clinical Significance:** Dysregulation of the PTPRO gene has been implicated in several diseases, including: 1. **Nephrotic syndrome:** Mutations in the PTPRO gene have been associated with nephrotic syndrome, a kidney disease characterized by excessive proteinuria. 2. **Neurodevelopmental disorders:** Alterations in PTPRO expression have been linked to neurodevelopmental disorders, such as autism and schizophrenia. 3. **Cancer:** The PTPRO gene has been implicated in cancer development and progression, where it may act as a tumor suppressor or oncogene. In conclusion, the PTPRO gene is a multifaceted regulator of cellular signaling and development, with implications for various diseases. Further research is needed to fully understand the functions of the PTPRO gene and its role in human disease.

Genular Protein ID: 4196106739

Symbol: PTPRO_HUMAN

Name: Receptor-type tyrosine-protein phosphatase O

UniProtKB Accession Codes:

Q16827 A0AV39 Q13101 Q8IYG3 Q9UBF0 Q9UBT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 14 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 6 Rhea 3 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7753550

Title: Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents.

PubMed ID: 7753550

PubMed ID: 7665166

Title: Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13.

PubMed ID: 7665166

DOI: 10.1006/geno.1995.1021

PubMed ID: 10498613

Title: PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.

PubMed ID: 10498613

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21722858

Title: Disruption of PTPRO causes childhood-onset nephrotic syndrome.

PubMed ID: 21722858

DOI: 10.1016/j.ajhg.2011.05.026

PubMed ID: 19167335

Title: Large-scale structural analysis of the classical human protein tyrosine phosphatome.

PubMed ID: 19167335

DOI: 10.1016/j.cell.2008.11.038

PubMed ID: 18058037

Title: Structural genomics of protein phosphatases.

PubMed ID: 18058037

DOI: 10.1007/s10969-007-9036-1

Sequence Information:

  • Length: 1216
  • Mass: 138344
  • Checksum: C902B48D1A73BFE1
  • Sequence:
    • MGHLPTGIHG ARRLLPLLWL FVLFKNATAF HVTVQDDNNI VVSLEASDVI SPASVYVVKI 
TGESKNYFFE FEEFNSTLPP PVIFKASYHG LYYIITLVVV NGNVVTKPSR SITVLTKPLP 
VTSVSIYDYK PSPETGVLFE IHYPEKYNVF TRVNISYWEG KDFRTMLYKD FFKGKTVFNH 
WLPGMCYSNI TFQLVSEATF NKSTLVEYSG VSHEPKQHRT APYPPQNISV RIVNLNKNNW 
EEQSGNFPEE SFMRSQDTIG KEKLFHFTEE TPEIPSGNIS SGWPDFNSSD YETTSQPYWW 
DSASAAPESE DEFVSVLPME YENNSTLSET EKSTSGSFSF FPVQMILTWL PPKPPTAFDG 
FHIHIEREEN FTEYLMVDEE AHEFVAELKE PGKYKLSVTT FSSSGSCETR KSQSAKSLSF 
YISPSGEWIE ELTEKPQHVS VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR 
LEKQYCTQVN SSKPIIENLV PGAQYQVVIY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP 
LGPTAVVLSW TRPYLGVFRK YVVEMFYFNP ATMTSEWTTY YEIAATVSLT ASVRIANLLP 
AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS WTYGDDTTDL 
SHSRMLHWMV VAEGKKKIKK SVTRNVMTAI LSLPPGDIYN LSVTACTERG SNTSMLRLVK 
LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD FFEVFCQQVG SSQKTKLQEP VAVSSHVVTI 
SSLLPATAYN CSVTSFSHDS PSVPTFIAVS TMVTEMNPNV VVISVLAILS TLLIGLLLVT 
LIILRKKHLQ MARECGAGTF VNFASLERDG KLPYNWRRSI FAFLTLLPSC LWTDYLLAFY 
INPWSKNGLK KRKLTNPVQL DDFDAYIKDM AKDSDYKFSL QFEELKLIGL DIPHFAADLP 
LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA DYINANYIPG YNSPQEYIAT QGPLPETRND 
FWKMVLQQKS QIIVMLTQCN EKRRVKCDHY WPFTEEPIAY GDITVEMISE EEQDDWACRH 
FRINYADEMQ DVMHFNYTAW PDHGVPTANA AESILQFVHM VRQQATKSKG PMIIHCSAGV 
GRTGTFIALD RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ CVQLMWMKKK 
QQFCISDVIY ENVSKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.