Details for: NECTIN2

Gene ID: 5819

Symbol: NECTIN2

Ensembl ID: ENSG00000130202

Description: nectin cell adhesion molecule 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.2845
    Cell Significance Index: -38.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.1977
    Cell Significance Index: -44.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 66.9948
    Cell Significance Index: -44.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.5554
    Cell Significance Index: -38.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0913
    Cell Significance Index: -15.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.2558
    Cell Significance Index: 32.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.0880
    Cell Significance Index: 32.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.0407
    Cell Significance Index: 55.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.9912
    Cell Significance Index: 70.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.4342
    Cell Significance Index: 255.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8135
    Cell Significance Index: 76.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.3522
    Cell Significance Index: 61.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9176
    Cell Significance Index: 247.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8423
    Cell Significance Index: 95.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8393
    Cell Significance Index: 27.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8279
    Cell Significance Index: 39.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7332
    Cell Significance Index: 19.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6157
    Cell Significance Index: 73.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.3771
    Cell Significance Index: 9.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3739
    Cell Significance Index: 149.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3352
    Cell Significance Index: 264.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2559
    Cell Significance Index: 36.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1149
    Cell Significance Index: 66.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1052
    Cell Significance Index: 38.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0669
    Cell Significance Index: 582.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7349
    Cell Significance Index: 10.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6887
    Cell Significance Index: 94.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6797
    Cell Significance Index: 67.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5925
    Cell Significance Index: 27.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5268
    Cell Significance Index: 29.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4748
    Cell Significance Index: 428.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4695
    Cell Significance Index: 21.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4371
    Cell Significance Index: 193.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4193
    Cell Significance Index: 12.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3792
    Cell Significance Index: 48.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3554
    Cell Significance Index: 43.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2992
    Cell Significance Index: 53.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2921
    Cell Significance Index: 2.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2814
    Cell Significance Index: 1.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2672
    Cell Significance Index: 9.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2470
    Cell Significance Index: 47.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2181
    Cell Significance Index: 78.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1773
    Cell Significance Index: 1.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1229
    Cell Significance Index: 2.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1028
    Cell Significance Index: 2.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0841
    Cell Significance Index: 2.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0687
    Cell Significance Index: 0.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0620
    Cell Significance Index: 4.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0584
    Cell Significance Index: 89.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0583
    Cell Significance Index: 107.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0502
    Cell Significance Index: 34.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0472
    Cell Significance Index: 0.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0412
    Cell Significance Index: 77.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0280
    Cell Significance Index: 4.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0245
    Cell Significance Index: 1.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0036
    Cell Significance Index: -0.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0163
    Cell Significance Index: -7.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.2900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0254
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0274
    Cell Significance Index: -20.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0311
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0342
    Cell Significance Index: -25.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0455
    Cell Significance Index: -5.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0569
    Cell Significance Index: -8.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0724
    Cell Significance Index: -40.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0840
    Cell Significance Index: -52.4500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0957
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0999
    Cell Significance Index: -20.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1234
    Cell Significance Index: -35.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1379
    Cell Significance Index: -7.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1602
    Cell Significance Index: -8.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2081
    Cell Significance Index: -10.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2253
    Cell Significance Index: -47.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2455
    Cell Significance Index: -28.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3469
    Cell Significance Index: -36.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3733
    Cell Significance Index: -23.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3748
    Cell Significance Index: -12.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3773
    Cell Significance Index: -23.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3884
    Cell Significance Index: -45.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3971
    Cell Significance Index: -5.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4434
    Cell Significance Index: -13.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5173
    Cell Significance Index: -40.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5788
    Cell Significance Index: -37.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6055
    Cell Significance Index: -8.6200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.6168
    Cell Significance Index: -3.0000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6212
    Cell Significance Index: -4.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6515
    Cell Significance Index: -43.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6569
    Cell Significance Index: -40.2800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6709
    Cell Significance Index: -8.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6954
    Cell Significance Index: -28.4900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.7320
    Cell Significance Index: -4.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7374
    Cell Significance Index: -19.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7808
    Cell Significance Index: -10.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9029
    Cell Significance Index: -23.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9300
    Cell Significance Index: -34.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9531
    Cell Significance Index: -42.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Nectin2 is a type of cell adhesion molecule that belongs to the immunoglobulin superfamily. It is a transmembrane protein that consists of a cytoplasmic tail, a transmembrane domain, and an extracellular domain. The extracellular domain of Nectin2 contains four immunoglobulin-like domains that interact with other nectin family members to form heterodimers. Nectin2 is also known to interact with other proteins, including integrins, cadherins, and selectins, to regulate various cellular processes. Its expression is tightly regulated during development and in response to environmental stimuli. **Pathways and Functions** Nectin2 is involved in various cellular processes, including: 1. **Cell-cell communication**: Nectin2 forms heterodimers with other nectin family members to facilitate cell-cell communication and adhesion. 2. **Adhesion of symbiont to host**: Nectin2 is involved in the adhesion of symbionts to host cells, which is critical for the establishment of symbiotic relationships. 3. **Apical junction complex**: Nectin2 is a component of the apical junction complex, which regulates cell-cell adhesion and signaling. 4. **Adhesion of immune cells**: Nectin2 is expressed on the surface of immune cells, including thymocytes, and is involved in their adhesion and migration. 5. **Coreceptor-mediated virion attachment**: Nectin2 is a coreceptor for viruses, such as HIV, which are involved in the entry of viruses into host cells. 6. **Immune system regulation**: Nectin2 is involved in the regulation of immune responses, including adaptive and innate immunity. **Clinical Significance** Nectin2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: Nectin2 has been associated with autoimmune disorders, such as rheumatoid arthritis and lupus, which are characterized by immune system dysregulation. 2. **Cancer**: Nectin2 has been implicated in cancer, including breast and lung cancer, where it is involved in cell adhesion and signaling. 3. **Infectious diseases**: Nectin2 has been associated with infectious diseases, such as HIV and herpes simplex virus, which are characterized by viral entry into host cells. 4. **Neurological disorders**: Nectin2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, which are characterized by immune system dysregulation. In conclusion, Nectin2 is a critical cell adhesion molecule that plays a significant role in various biological processes, including cell-cell communication, adhesion, and signaling. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, infectious diseases, and neurological disorders. Further research is needed to fully understand the role of Nectin2 in human health and disease.

Genular Protein ID: 4042416888

Symbol: NECT2_HUMAN

Name: Nectin-2

UniProtKB Accession Codes:

Q92692 A8K5L5 O75455 Q6IBI6 Q96J29

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7622062

Title: The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene.

PubMed ID: 7622062

DOI: 10.1016/0378-1119(95)00180-e

PubMed ID: 9657005

Title: A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.

PubMed ID: 9657005

DOI: 10.1006/viro.1998.9218

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10520737

Title: Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1.

PubMed ID: 10520737

DOI: 10.3109/10425179809086433

PubMed ID: 11602758

Title: Structural features of nectin-2 (HveB) required for herpes simplex virus entry.

PubMed ID: 11602758

DOI: 10.1128/jvi.75.22.11185-11195.2001

PubMed ID: 15607800

Title: PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.

PubMed ID: 15607800

DOI: 10.1016/j.molimm.2004.07.028

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19011627

Title: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

PubMed ID: 19011627

DOI: 10.1038/ni.1674

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26755705

Title: Identification of CD112R as a novel checkpoint for human T cells.

PubMed ID: 26755705

DOI: 10.1084/jem.20150785

PubMed ID: 22927415

Title: Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.

PubMed ID: 22927415

DOI: 10.1073/pnas.1212912109

Sequence Information:

  • Length: 538
  • Mass: 57742
  • Checksum: 3AE4F83E92F6F624
  • Sequence:
    • MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV ELPCHLLPPV 
PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS ERLSFVSAKQ STGQDTEAEL 
QDATLALHGL TVEDEGNYTC EFATFPKGSV RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV 
ALCISKEGRP PARISWLSSL DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV 
EHESFEEPAL IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS 
GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP NTAGAGATGG 
IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL EGPPSYKPPT PKAKLEAQEM 
PSQLFTLGAS EHSPLKTPYF DAGASCTEQE MPRYHELPTL EERSGPLHPG ATSLGSPIPV 
PPGPPAVEDV SLDLEDEEGE EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.