Details for: PEX19
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 86.7593
Cell Significance Index: -13.5000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 52.1993
Cell Significance Index: -13.2400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 33.7624
Cell Significance Index: -15.9400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 29.7831
Cell Significance Index: -15.3200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.0118
Cell Significance Index: -14.8100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.9611
Cell Significance Index: -13.2900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.0469
Cell Significance Index: -12.4300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.8874
Cell Significance Index: -15.3400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.5989
Cell Significance Index: 186.3300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3434
Cell Significance Index: 218.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1886
Cell Significance Index: 1073.1900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1205
Cell Significance Index: 67.2700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0115
Cell Significance Index: 52.5500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9895
Cell Significance Index: 107.6300 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.9750
Cell Significance Index: 8.1900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.8164
Cell Significance Index: 21.8800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5941
Cell Significance Index: 16.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5916
Cell Significance Index: 106.6600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5247
Cell Significance Index: 51.9000 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.5035
Cell Significance Index: 4.0200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4630
Cell Significance Index: 56.9300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.4118
Cell Significance Index: 8.6200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.4111
Cell Significance Index: 118.3000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3962
Cell Significance Index: 27.4000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3844
Cell Significance Index: 24.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3689
Cell Significance Index: 12.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3626
Cell Significance Index: 19.0400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3488
Cell Significance Index: 47.9000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3280
Cell Significance Index: 42.0500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3055
Cell Significance Index: 61.2900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2989
Cell Significance Index: 21.1400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.2893
Cell Significance Index: 3.1500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2639
Cell Significance Index: 2.4300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2266
Cell Significance Index: 123.7700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2207
Cell Significance Index: 6.4800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2118
Cell Significance Index: 93.6400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2095
Cell Significance Index: 9.7700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2049
Cell Significance Index: 4.4400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1856
Cell Significance Index: 13.8300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1787
Cell Significance Index: 4.7000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1757
Cell Significance Index: 2.2500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1655
Cell Significance Index: 7.5000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1654
Cell Significance Index: 4.7700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1489
Cell Significance Index: 53.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1419
Cell Significance Index: 27.0100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1004
Cell Significance Index: 11.8400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0908
Cell Significance Index: 0.9400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0904
Cell Significance Index: 11.6800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0845
Cell Significance Index: 5.4500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0836
Cell Significance Index: 0.9500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0736
Cell Significance Index: 3.4600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0681
Cell Significance Index: 7.8100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0637
Cell Significance Index: 10.8800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0394
Cell Significance Index: 0.9100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0072
Cell Significance Index: 5.0000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0058
Cell Significance Index: 4.2500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0056
Cell Significance Index: 0.1500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0015
Cell Significance Index: -1.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0020
Cell Significance Index: -1.5100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0030
Cell Significance Index: -1.8800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0041
Cell Significance Index: -0.2100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0066
Cell Significance Index: -0.1100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0072
Cell Significance Index: -13.6000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0091
Cell Significance Index: -16.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0106
Cell Significance Index: -16.3700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0127
Cell Significance Index: -17.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0158
Cell Significance Index: -8.8900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0164
Cell Significance Index: -1.6800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0222
Cell Significance Index: -14.1000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0304
Cell Significance Index: -3.4700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0323
Cell Significance Index: -6.8000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0340
Cell Significance Index: -15.4400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0386
Cell Significance Index: -1.2400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0399
Cell Significance Index: -0.8500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0415
Cell Significance Index: -8.2300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0432
Cell Significance Index: -0.5900 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0625
Cell Significance Index: -0.5100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0656
Cell Significance Index: -1.3600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0693
Cell Significance Index: -5.3200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0823
Cell Significance Index: -5.0600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0881
Cell Significance Index: -2.2500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1018
Cell Significance Index: -14.8000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1041
Cell Significance Index: -5.8400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1095
Cell Significance Index: -8.6700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1141
Cell Significance Index: -3.2700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1428
Cell Significance Index: -3.9900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1498
Cell Significance Index: -15.6000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1543
Cell Significance Index: -9.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1569
Cell Significance Index: -5.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1585
Cell Significance Index: -7.0100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1963
Cell Significance Index: -7.4400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2359
Cell Significance Index: -15.8600 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.2457
Cell Significance Index: -1.5200 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.2673
Cell Significance Index: -4.2400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2792
Cell Significance Index: -5.1600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3103
Cell Significance Index: -11.3900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3175
Cell Significance Index: -5.6100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3183
Cell Significance Index: -11.1500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3422
Cell Significance Index: -10.9000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3480
Cell Significance Index: -10.2500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3513206536
Symbol: PEX19_HUMAN
Name: 33 kDa housekeeping protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8076834
Title: Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1.
PubMed ID: 8076834
PubMed ID: 9339377
Title: Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.
PubMed ID: 9339377
PubMed ID: 10051604
Title: Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.
PubMed ID: 10051604
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10777694
Title: Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.
PubMed ID: 10777694
PubMed ID: 10704444
Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.
PubMed ID: 10704444
PubMed ID: 11259404
Title: Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.
PubMed ID: 11259404
PubMed ID: 11390669
Title: Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.
PubMed ID: 11390669
PubMed ID: 11883941
Title: Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.
PubMed ID: 11883941
PubMed ID: 15007061
Title: PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.
PubMed ID: 15007061
PubMed ID: 14709540
Title: PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.
PubMed ID: 14709540
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20683989
Title: A mutation in PEX19 causes a severe clinical phenotype in a patient with peroxisomal biogenesis disorder.
PubMed ID: 20683989
DOI: 10.1002/ajmg.a.33560
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27181750
Title: Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response.
PubMed ID: 27181750
DOI: 10.1038/srep26028
PubMed ID: 19197237
Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
PubMed ID: 19197237
DOI: 10.1038/emboj.2009.7
PubMed ID: 21102411
Title: Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
PubMed ID: 21102411
PubMed ID: 20554521
Title: Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.
PubMed ID: 20554521
PubMed ID: 33798445
Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.
PubMed ID: 33798445
Sequence Information:
- Length: 299
- Mass: 32807
- Checksum: 399AF6B79F219100
- Sequence:
MAAAEEGCSV GAEADRELEE LLESALDDFD KAKPSPAPPS TTTAPDASGP QKRSPGDTAK DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDMT SQQEFTSCLK ETLSGLAKNA TDLQNSSMSE EELTKAMEGL GMDEGDGEGN ILPIMQSIMQ NLLSKDVLYP SLKEITEKYP EWLQSHRESL PPEQFEKYQE QHSVMCKICE QFEAETPTDS ETTQKARFEM VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ASGEQCLIM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.