Details for: PEX19

Gene ID: 5824

Symbol: PEX19

Ensembl ID: ENSG00000162735

Description: peroxisomal biogenesis factor 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.7593
    Cell Significance Index: -13.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.1993
    Cell Significance Index: -13.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.7624
    Cell Significance Index: -15.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.7831
    Cell Significance Index: -15.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.0118
    Cell Significance Index: -14.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9611
    Cell Significance Index: -13.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0469
    Cell Significance Index: -12.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8874
    Cell Significance Index: -15.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5989
    Cell Significance Index: 186.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3434
    Cell Significance Index: 218.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1886
    Cell Significance Index: 1073.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1205
    Cell Significance Index: 67.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0115
    Cell Significance Index: 52.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9895
    Cell Significance Index: 107.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9750
    Cell Significance Index: 8.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8164
    Cell Significance Index: 21.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5941
    Cell Significance Index: 16.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5916
    Cell Significance Index: 106.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5247
    Cell Significance Index: 51.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5035
    Cell Significance Index: 4.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4630
    Cell Significance Index: 56.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4118
    Cell Significance Index: 8.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4111
    Cell Significance Index: 118.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3962
    Cell Significance Index: 27.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3844
    Cell Significance Index: 24.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3689
    Cell Significance Index: 12.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3626
    Cell Significance Index: 19.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3488
    Cell Significance Index: 47.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3280
    Cell Significance Index: 42.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3055
    Cell Significance Index: 61.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2989
    Cell Significance Index: 21.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2893
    Cell Significance Index: 3.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2639
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2266
    Cell Significance Index: 123.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2207
    Cell Significance Index: 6.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2118
    Cell Significance Index: 93.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2095
    Cell Significance Index: 9.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2049
    Cell Significance Index: 4.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1856
    Cell Significance Index: 13.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1787
    Cell Significance Index: 4.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1757
    Cell Significance Index: 2.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1655
    Cell Significance Index: 7.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1654
    Cell Significance Index: 4.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1489
    Cell Significance Index: 53.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1419
    Cell Significance Index: 27.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1004
    Cell Significance Index: 11.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0908
    Cell Significance Index: 0.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0904
    Cell Significance Index: 11.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0845
    Cell Significance Index: 5.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0836
    Cell Significance Index: 0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0736
    Cell Significance Index: 3.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0681
    Cell Significance Index: 7.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0637
    Cell Significance Index: 10.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0394
    Cell Significance Index: 0.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0072
    Cell Significance Index: 5.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0058
    Cell Significance Index: 4.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0015
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0030
    Cell Significance Index: -1.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0041
    Cell Significance Index: -0.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0066
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0091
    Cell Significance Index: -16.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0106
    Cell Significance Index: -16.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0158
    Cell Significance Index: -8.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0164
    Cell Significance Index: -1.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0222
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0304
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0323
    Cell Significance Index: -6.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0340
    Cell Significance Index: -15.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0386
    Cell Significance Index: -1.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0399
    Cell Significance Index: -0.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0415
    Cell Significance Index: -8.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0432
    Cell Significance Index: -0.5900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0625
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0656
    Cell Significance Index: -1.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0693
    Cell Significance Index: -5.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0823
    Cell Significance Index: -5.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0881
    Cell Significance Index: -2.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1018
    Cell Significance Index: -14.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1041
    Cell Significance Index: -5.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1095
    Cell Significance Index: -8.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1141
    Cell Significance Index: -3.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1428
    Cell Significance Index: -3.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1498
    Cell Significance Index: -15.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1543
    Cell Significance Index: -9.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1569
    Cell Significance Index: -5.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1585
    Cell Significance Index: -7.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1963
    Cell Significance Index: -7.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2359
    Cell Significance Index: -15.8600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2457
    Cell Significance Index: -1.5200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2673
    Cell Significance Index: -4.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2792
    Cell Significance Index: -5.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3103
    Cell Significance Index: -11.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3175
    Cell Significance Index: -5.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3183
    Cell Significance Index: -11.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3422
    Cell Significance Index: -10.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3480
    Cell Significance Index: -10.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PEX19 is a small, non-coding protein (33 kDa) that is highly conserved across species. It is part of the PEX family of proteins, which are essential for the biogenesis and function of peroxisomes. PEX19 is specifically involved in the targeting of peroxisomal membrane proteins to the peroxisome, a process that requires precise regulation to ensure proper peroxisome assembly and function. PEX19 interacts with other proteins, such as PEX1 and PEX6, to facilitate the targeting of peroxisomal membrane proteins. **Pathways and Functions** PEX19 is involved in several key pathways, including: 1. **Peroxisome biogenesis**: PEX19 plays a critical role in the assembly and targeting of peroxisomal membrane proteins, ensuring the proper formation and function of peroxisomes. 2. **Lipid metabolism**: Peroxisomes are essential for the oxidation of fatty acids, and PEX19 helps to regulate this process by ensuring the proper targeting of peroxisomal membrane proteins. 3. **Detoxification**: Peroxisomes are involved in the detoxification of various substances, including xenobiotics and reactive oxygen species. PEX19 helps to regulate this process by ensuring the proper targeting of peroxisomal membrane proteins. 4. **Cellular homeostasis**: PEX19 is involved in maintaining cellular homeostasis by regulating the levels of reactive oxygen species and maintaining the balance of lipid metabolism. **Clinical Significance** Dysregulation of PEX19 has been implicated in various diseases, including: 1. **Zellweger spectrum disorders**: PEX19 mutations have been associated with Zellweger spectrum disorders, a group of rare, genetic disorders characterized by peroxisomal biogenesis defects. 2. **Peroxisomal disorders**: PEX19 mutations have also been linked to peroxisomal disorders, such as adrenoleukodystrophy and Refsum disease. 3. **Neurological disorders**: PEX19 has been implicated in the pathogenesis of certain neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: PEX19 has been shown to play a role in cancer development and progression, particularly in the context of peroxisome-related metabolic dysregulation. In conclusion, PEX19 is a critical gene involved in the biogenesis and function of peroxisomes, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which PEX19 regulates peroxisome biogenesis and function, and to explore the therapeutic potential of targeting PEX19 in the treatment of peroxisomal disorders and other diseases.

Genular Protein ID: 3513206536

Symbol: PEX19_HUMAN

Name: 33 kDa housekeeping protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8076834

Title: Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1.

PubMed ID: 8076834

DOI: 10.1016/0378-1119(94)90308-5

PubMed ID: 9339377

Title: Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein.

PubMed ID: 9339377

DOI: 10.1006/geno.1997.4914

PubMed ID: 10051604

Title: Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.

PubMed ID: 10051604

DOI: 10.1073/pnas.96.5.2116

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10777694

Title: Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.

PubMed ID: 10777694

DOI: 10.1006/bbrc.2000.2572

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 11259404

Title: Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.

PubMed ID: 11259404

DOI: 10.1074/jbc.c100011200

PubMed ID: 11390669

Title: Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.

PubMed ID: 11390669

DOI: 10.1128/mcb.21.13.4413-4424.2001

PubMed ID: 11883941

Title: Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.

PubMed ID: 11883941

DOI: 10.1006/bbrc.2002.6568

PubMed ID: 15007061

Title: PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins.

PubMed ID: 15007061

DOI: 10.1083/jcb.200311131

PubMed ID: 14709540

Title: PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.

PubMed ID: 14709540

DOI: 10.1083/jcb.200304111

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20683989

Title: A mutation in PEX19 causes a severe clinical phenotype in a patient with peroxisomal biogenesis disorder.

PubMed ID: 20683989

DOI: 10.1002/ajmg.a.33560

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27181750

Title: Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response.

PubMed ID: 27181750

DOI: 10.1038/srep26028

PubMed ID: 19197237

Title: Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.

PubMed ID: 19197237

DOI: 10.1038/emboj.2009.7

PubMed ID: 21102411

Title: Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.

PubMed ID: 21102411

DOI: 10.1038/emboj.2010.293

PubMed ID: 20554521

Title: Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19.

PubMed ID: 20554521

DOI: 10.1074/jbc.m110.138503

PubMed ID: 33798445

Title: Progressive myoclonus epilepsies-Residual unsolved cases have marked genetic heterogeneity including dolichol-dependent protein glycosylation pathway genes.

PubMed ID: 33798445

DOI: 10.1016/j.ajhg.2021.03.013

Sequence Information:

  • Length: 299
  • Mass: 32807
  • Checksum: 399AF6B79F219100
  • Sequence:
  • MAAAEEGCSV GAEADRELEE LLESALDDFD KAKPSPAPPS TTTAPDASGP QKRSPGDTAK 
    DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDMT 
    SQQEFTSCLK ETLSGLAKNA TDLQNSSMSE EELTKAMEGL GMDEGDGEGN ILPIMQSIMQ 
    NLLSKDVLYP SLKEITEKYP EWLQSHRESL PPEQFEKYQE QHSVMCKICE QFEAETPTDS 
    ETTQKARFEM VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ASGEQCLIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.