RAB5A | ENSG00000144566 | NCBI 5868

Details for: RAB5A

Gene ID: 5868

Symbol: RAB5A

Ensembl ID: ENSG00000144566

Description: RAB5A, member RAS oncogene family

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Disease
(R-HSA-1643685)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Hemostasis
(R-HSA-109582)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Phospholipid metabolism
(R-HSA-1483257)
Pi metabolism
(R-HSA-1483255)
Post-translational protein modification
(R-HSA-597592)
Prevention of phagosomal-lysosomal fusion
(R-HSA-9636383)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab geranylgeranylation
(R-HSA-8873719)
Rab regulation of trafficking
(R-HSA-9007101)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Response of mtb to phagocytosis
(R-HSA-9637690)
Suppression of phagosomal maturation
(R-HSA-9637687)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
Tbc/rabgaps
(R-HSA-8854214)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Actin cytoskeleton
(GO:0015629)
Amyloid-beta clearance by transcytosis
(GO:0150093)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Canonical wnt signaling pathway
(GO:0060070)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Cytoplasm
(GO:0005737)
Cytoplasmic side of early endosome membrane
(GO:0098559)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Early endosome to late endosome transport
(GO:0045022)
Early phagosome
(GO:0032009)
Endocytosis
(GO:0006897)
Endomembrane system
(GO:0012505)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Extracellular exosome
(GO:0070062)
Gdp binding
(GO:0019003)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular protein transport
(GO:0006886)
Melanosome
(GO:0042470)
Membrane raft
(GO:0045121)
Modulation by host of viral process
(GO:0044788)
Neuronal cell body
(GO:0043025)
Nucleoplasm
(GO:0005654)
Phagocytic vesicle
(GO:0045335)
Phagocytic vesicle membrane
(GO:0030670)
Phagocytosis
(GO:0006909)
Plasma membrane
(GO:0005886)
Positive regulation of exocytosis
(GO:0045921)
Postsynaptic early endosome
(GO:0098842)
Protein binding
(GO:0005515)
Receptor internalization
(GO:0031623)
Regulation of autophagosome assembly
(GO:2000785)
Regulation of endosome size
(GO:0051036)
Regulation of filopodium assembly
(GO:0051489)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Ruffle
(GO:0001726)
Somatodendritic compartment
(GO:0036477)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle membrane
(GO:0030672)
Synaptic vesicle recycling
(GO:0036465)
Terminal bouton
(GO:0043195)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 343.0514
Cell Significance Index: -53.3600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 212.3060
Cell Significance Index: -53.8500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 136.1824
Cell Significance Index: -56.1000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 122.9659
Cell Significance Index: -58.0600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 105.3102
Cell Significance Index: -54.1700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 86.8787
Cell Significance Index: -58.3000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 45.0381
Cell Significance Index: -55.5300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.2727
Cell Significance Index: -48.9500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.6197
Cell Significance Index: -57.6900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.4046
Cell Significance Index: -24.9600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 5.3355
Cell Significance Index: 621.7900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.4773
Cell Significance Index: 33.8000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.9732
Cell Significance Index: 567.7600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.6699
Cell Significance Index: 44.5900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5287
Cell Significance Index: 41.6100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3517
Cell Significance Index: 271.1500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.1858
Cell Significance Index: 20.9600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1314
Cell Significance Index: 184.0100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0974
Cell Significance Index: 990.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0582
Cell Significance Index: 210.0100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9583
Cell Significance Index: 117.8400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9475
Cell Significance Index: 170.8100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8397
Cell Significance Index: 39.1500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8224
Cell Significance Index: 23.7000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.7712
Cell Significance Index: 57.4800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.6842
Cell Significance Index: 88.4000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6742
Cell Significance Index: 31.6900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6444
Cell Significance Index: 13.9600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6208
Cell Significance Index: 32.2500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5555
Cell Significance Index: 199.2500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5485
Cell Significance Index: 299.5500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4956
Cell Significance Index: 68.0600
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.4303
Cell Significance Index: 11.3200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4263
Cell Significance Index: 188.4600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3853
Cell Significance Index: 29.5700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2985
Cell Significance Index: 206.4800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2631
Cell Significance Index: 26.0300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2149
Cell Significance Index: 6.1600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2013
Cell Significance Index: 25.8100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2012
Cell Significance Index: 11.2900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1445
Cell Significance Index: 10.2200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1039
Cell Significance Index: 17.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0978
Cell Significance Index: 11.5300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0853
Cell Significance Index: 160.6400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0568
Cell Significance Index: 36.1000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0425
Cell Significance Index: 65.4500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0373
Cell Significance Index: 2.3500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0332
Cell Significance Index: 61.1800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0229
Cell Significance Index: 10.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0189
Cell Significance Index: 3.5900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0170
Cell Significance Index: 1.0500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0140
Cell Significance Index: 19.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0031
Cell Significance Index: -0.1700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0208
Cell Significance Index: -15.2300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0298
Cell Significance Index: -22.0500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0318
Cell Significance Index: -0.8900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0322
Cell Significance Index: -24.3800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0407
Cell Significance Index: -5.9100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0423
Cell Significance Index: -23.8500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0460
Cell Significance Index: -2.9700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0497
Cell Significance Index: -31.0100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0540
Cell Significance Index: -1.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0740
Cell Significance Index: -7.5600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0828
Cell Significance Index: -2.9100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1201
Cell Significance Index: -2.0100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1208
Cell Significance Index: -0.7300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1305
Cell Significance Index: -4.5400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1335
Cell Significance Index: -28.1200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2013
Cell Significance Index: -13.5400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2217
Cell Significance Index: -25.4000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2385
Cell Significance Index: -5.0800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2867
Cell Significance Index: -2.6400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.3178
Cell Significance Index: -34.5700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3385
Cell Significance Index: -2.7600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3512
Cell Significance Index: -40.0900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3757
Cell Significance Index: -16.6200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4139
Cell Significance Index: -10.6400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4178
Cell Significance Index: -12.2700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4291
Cell Significance Index: -5.1200
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4417
Cell Significance Index: -8.6200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4603
Cell Significance Index: -20.8700
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.4649
Cell Significance Index: -4.9400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4863
Cell Significance Index: -50.6400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5185
Cell Significance Index: -19.6400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5485
Cell Significance Index: -9.2400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5527
Cell Significance Index: -14.8100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5577
Cell Significance Index: -44.1700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6010
Cell Significance Index: -19.2500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7364
Cell Significance Index: -12.6200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7777
Cell Significance Index: -19.4400
Cell Name: peg cell (CL4033014)
Fold Change: -0.8198
Cell Significance Index: -18.9400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.9125
Cell Significance Index: -19.5100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9180
Cell Significance Index: -56.2800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.9344
Cell Significance Index: -17.2700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.9727
Cell Significance Index: -27.7600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0073
Cell Significance Index: -26.9500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.0545
Cell Significance Index: -15.5700
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.1367
Cell Significance Index: -27.2600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.1477
Cell Significance Index: -42.1300
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.1477
Cell Significance Index: -25.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RAB5A is a small GTPase that belongs to the RAS superfamily, which is characterized by its small size, high GTPase activity, and ability to bind GDP and GTP. RAB5A is specifically activated by guanine nucleotide exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). It regulates the activity of various proteins involved in membrane trafficking, including clathrin, dynamin, and Rab GTPases. RAB5A is also involved in the regulation of actin cytoskeleton dynamics, which is essential for cell motility, shape changes, and intracellular transport. **Pathways and Functions** RAB5A is involved in various cellular pathways, including: 1. **Actin Cytoskeleton**: RAB5A regulates the dynamics of the actin cytoskeleton, which is essential for cell motility, shape changes, and intracellular transport. 2. **Endocytosis**: RAB5A is involved in the regulation of endocytosis, including clathrin-mediated endocytosis and caveolae-mediated endocytosis. 3. **Exocytosis**: RAB5A regulates the activity of proteins involved in exocytosis, including synaptic vesicle exocytosis and melanosome formation. 4. **Phagocytosis**: RAB5A is involved in the regulation of phagocytosis, including the formation and maturation of phagosomes. 5. **Autophagy**: RAB5A regulates the activity of autophagy-related proteins, including LC3 and Atg proteins. **Clinical Significance** Abnormal expression or activity of RAB5A has been implicated in various diseases, including: 1. **Cancer**: RAB5A is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with tumor progression and metastasis. 2. **Neurological Disorders**: RAB5A is involved in the regulation of synaptic plasticity and is implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Infectious Diseases**: RAB5A is involved in the regulation of phagocytosis and is implicated in the pathogenesis of infectious diseases, including tuberculosis and respiratory syncytial virus infection. 4. **Autoimmune Diseases**: RAB5A is involved in the regulation of immune cell functions and is implicated in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. In conclusion, RAB5A is a critical regulator of cellular processes, including membrane trafficking, endocytosis, and exocytosis. Its abnormal expression or activity has been implicated in various diseases, highlighting the importance of RAB5A in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms of RAB5A and its role in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ras-related protein Rab-5A

Genular Protein ID: 2986456458

Symbol: RAB5A_HUMAN

Name: Ras-related protein Rab-5A

UniProtKB Accession Codes:

P20339 B4DJA5 Q6FI44

Database IDs:

Citations:

PubMed ID: 2501306

Title: The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

PubMed ID: 2501306

DOI: 10.1016/s0021-9258(18)63872-4

PubMed ID: 7991565

Title: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.

PubMed ID: 7991565

DOI: 10.1073/pnas.91.25.11963

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10491193

Title: Direct interaction of EEA1 with Rab5b.

PubMed ID: 10491193

DOI: 10.1046/j.1432-1327.1999.00743.x

PubMed ID: 10818110

Title: A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.

PubMed ID: 10818110

DOI: 10.1074/jbc.m909600199

PubMed ID: 11062261

Title: Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.

PubMed ID: 11062261

DOI: 10.1083/jcb.151.3.601

PubMed ID: 11703925

Title: Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

PubMed ID: 11703925

DOI: 10.1016/s1534-5807(01)00008-9

PubMed ID: 15388334

Title: ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.

PubMed ID: 15388334

DOI: 10.1016/j.febslet.2004.07.092

PubMed ID: 14617813

Title: Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.

PubMed ID: 14617813

DOI: 10.1091/mbc.e03-05-0343

PubMed ID: 14978216

Title: Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.

PubMed ID: 14978216

DOI: 10.1091/mbc.e03-07-0493

PubMed ID: 16034420

Title: Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.

PubMed ID: 16034420

DOI: 10.1038/nature03798

PubMed ID: 16410077

Title: Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis.

PubMed ID: 16410077

DOI: 10.1016/j.bbrc.2005.12.099

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22431521

Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

PubMed ID: 22431521

DOI: 10.1128/mcb.06726-11

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 23382462

Title: RabGEFs are a major determinant for specific Rab membrane targeting.

PubMed ID: 23382462

DOI: 10.1083/jcb.201209113

PubMed ID: 23815289

Title: Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy.

PubMed ID: 23815289

DOI: 10.3109/09687688.2013.818725

PubMed ID: 25869668

Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

PubMed ID: 25869668

DOI: 10.1083/jcb.201409064

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 32974215

Title: The Salmonella effector SseK3 targets small Rab GTPases.

PubMed ID: 32974215

DOI: 10.3389/fcimb.2020.00419

PubMed ID: 36604604

Title: ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity.

PubMed ID: 36604604

DOI: 10.1038/s41380-022-01940-w

PubMed ID: 12433916

Title: High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop.

PubMed ID: 12433916

DOI: 10.1074/jbc.m211042200

PubMed ID: 14684892

Title: Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution.

PubMed ID: 14684892

DOI: 10.1107/s0907444903021632

PubMed ID: 15378032

Title: Structural basis of Rab5-Rabaptin5 interaction in endocytosis.

PubMed ID: 15378032

DOI: 10.1038/nsmb832

PubMed ID: 20534488

Title: Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of early endosomal autoantigen 1 (EEA1).

PubMed ID: 20534488

DOI: 10.1073/pnas.1000843107

PubMed ID: 37267906

Title: Structural basis of mRNA binding by the human FERRY Rab5 effector complex.

PubMed ID: 37267906

DOI: 10.1016/j.molcel.2023.05.009

Sequence Information:

Length: 215
Mass: 23659
Checksum: EC03DDF96BBEF821
Sequence:

MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ 
TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR 
QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK 
LPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RAB5A

Associated with

Cells (max top 100)

Other Information

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. PubMed ID: 2501306

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. PubMed ID: 7991565

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Direct interaction of EEA1 with Rab5b. PubMed ID: 10491193

A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. PubMed ID: 10818110

Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. PubMed ID: 11062261

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. PubMed ID: 11703925

ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. PubMed ID: 15388334

Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. PubMed ID: 14617813

Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. PubMed ID: 14978216

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. PubMed ID: 16034420

Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. PubMed ID: 16410077

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. PubMed ID: 22431521

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. PubMed ID: 22660413

RabGEFs are a major determinant for specific Rab membrane targeting. PubMed ID: 23382462

Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy. PubMed ID: 23815289

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. PubMed ID: 25869668

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462

The Salmonella effector SseK3 targets small Rab GTPases. PubMed ID: 32974215

ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity. PubMed ID: 36604604

High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. PubMed ID: 12433916

Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. PubMed ID: 14684892

Structural basis of Rab5-Rabaptin5 interaction in endocytosis. PubMed ID: 15378032

Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of early endosomal autoantigen 1 (EEA1). PubMed ID: 20534488

Structural basis of mRNA binding by the human FERRY Rab5 effector complex. PubMed ID: 37267906