Details for: RARG

Gene ID: 5916

Symbol: RARG

Ensembl ID: ENSG00000172819

Description: retinoic acid receptor gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.2982
    Cell Significance Index: -12.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.2818
    Cell Significance Index: -12.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.7873
    Cell Significance Index: -10.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.5997
    Cell Significance Index: -10.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.1220
    Cell Significance Index: -12.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5542
    Cell Significance Index: -12.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.3701
    Cell Significance Index: 45.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1956
    Cell Significance Index: -12.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2069
    Cell Significance Index: -4.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8923
    Cell Significance Index: 98.3000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.8585
    Cell Significance Index: 4.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6583
    Cell Significance Index: 34.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3884
    Cell Significance Index: 38.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0540
    Cell Significance Index: 16.9100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9814
    Cell Significance Index: 13.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.9284
    Cell Significance Index: 14.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8182
    Cell Significance Index: 7.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7551
    Cell Significance Index: 143.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7007
    Cell Significance Index: 309.7800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.6593
    Cell Significance Index: 3.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6180
    Cell Significance Index: 72.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6152
    Cell Significance Index: 75.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5967
    Cell Significance Index: 42.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5386
    Cell Significance Index: 14.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5361
    Cell Significance Index: 53.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5212
    Cell Significance Index: 93.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5063
    Cell Significance Index: 64.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4796
    Cell Significance Index: 24.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4775
    Cell Significance Index: 10.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3705
    Cell Significance Index: 18.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3641
    Cell Significance Index: 328.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2885
    Cell Significance Index: 39.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2701
    Cell Significance Index: 43.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2634
    Cell Significance Index: 28.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2528
    Cell Significance Index: 11.4600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2400
    Cell Significance Index: 2.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2345
    Cell Significance Index: 14.0800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2318
    Cell Significance Index: 2.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2162
    Cell Significance Index: 4.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2141
    Cell Significance Index: 10.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1385
    Cell Significance Index: 3.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1314
    Cell Significance Index: 47.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1165
    Cell Significance Index: 23.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1103
    Cell Significance Index: 7.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1079
    Cell Significance Index: 5.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1039
    Cell Significance Index: 3.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0952
    Cell Significance Index: 12.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0944
    Cell Significance Index: 1.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0569
    Cell Significance Index: 31.0700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0502
    Cell Significance Index: 0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0352
    Cell Significance Index: 65.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0317
    Cell Significance Index: 21.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0265
    Cell Significance Index: 49.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0248
    Cell Significance Index: 38.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0166
    Cell Significance Index: 10.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0063
    Cell Significance Index: 0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0045
    Cell Significance Index: 2.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0011
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0021
    Cell Significance Index: -0.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0111
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0237
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0245
    Cell Significance Index: -15.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0306
    Cell Significance Index: -1.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0356
    Cell Significance Index: -10.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0384
    Cell Significance Index: -4.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0481
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0631
    Cell Significance Index: -10.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0638
    Cell Significance Index: -13.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0667
    Cell Significance Index: -4.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0689
    Cell Significance Index: -7.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0711
    Cell Significance Index: -5.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0787
    Cell Significance Index: -2.5200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0914
    Cell Significance Index: -1.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1002
    Cell Significance Index: -1.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1007
    Cell Significance Index: -11.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1014
    Cell Significance Index: -10.5600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1170
    Cell Significance Index: -1.0100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1190
    Cell Significance Index: -1.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1354
    Cell Significance Index: -1.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1380
    Cell Significance Index: -8.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1400
    Cell Significance Index: -11.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1499
    Cell Significance Index: -10.0800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1511
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1559
    Cell Significance Index: -4.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1754
    Cell Significance Index: -4.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1820
    Cell Significance Index: -3.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1895
    Cell Significance Index: -11.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1956
    Cell Significance Index: -8.6500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1973
    Cell Significance Index: -1.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2140
    Cell Significance Index: -3.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2212
    Cell Significance Index: -12.4100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2254
    Cell Significance Index: -3.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2268
    Cell Significance Index: -8.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RARG is a nuclear receptor that belongs to the retinoic acid receptor family. It is characterized by its ability to bind to specific DNA sequences, known as retinoic acid response elements (RAREs), and regulate gene expression. RARG is highly expressed in epithelial cells, neuronal cells, and stem cells, and is involved in the regulation of cell proliferation, differentiation, and apoptosis. Some of the key characteristics of RARG include: * High expression levels in epithelial cells, neuronal cells, and stem cells * Ability to bind to specific DNA sequences (RAREs) * Regulation of gene expression by binding to RAREs * Involvement in cell proliferation, differentiation, and apoptosis * Activation by retinoic acid, a derivative of vitamin A **Pathways and Functions** RARG is involved in various biological pathways, including: * **Activation of anterior hox genes in hindbrain development**: RARG plays a crucial role in the development of the hindbrain during embryogenesis by regulating the expression of anterior hox genes. * **Activation of hox genes during differentiation**: RARG regulates the expression of hox genes during cellular differentiation, leading to the formation of specific cell types. * **Anterior/posterior pattern specification**: RARG is involved in the specification of anterior/posterior patterns during embryogenesis, which is critical for the development of the embryo. * **Apoptotic process**: RARG regulates the expression of genes involved in apoptosis, leading to the programmed death of cells. * **Canonical Wnt signaling pathway**: RARG interacts with the Wnt signaling pathway to regulate cell proliferation and differentiation. * **Cell differentiation**: RARG regulates the expression of genes involved in cell differentiation, leading to the formation of specific cell types. * **Stem cell proliferation**: RARG regulates the expression of genes involved in stem cell proliferation, leading to the maintenance of stem cells. **Clinical Significance** Alterations in RARG expression have been implicated in several diseases, including: * **Cancer**: RARG is often overexpressed in various types of cancer, including breast cancer, prostate cancer, and lung cancer. * **Developmental disorders**: RARG is involved in the development of the embryo, and alterations in RARG expression have been implicated in developmental disorders, such as heart defects and neural tube defects. * **Neurological disorders**: RARG is involved in the development of the nervous system, and alterations in RARG expression have been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RARG is a critical transcription factor that plays a central role in various biological processes, including development, differentiation, and cell growth. Its dysregulation has been implicated in several diseases, highlighting the importance of RARG in human health and disease.

Genular Protein ID: 3527835060

Symbol: RARG_HUMAN

Name: Retinoic acid receptor gamma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2546152

Title: A third human retinoic acid receptor, hRAR-gamma.

PubMed ID: 2546152

DOI: 10.1073/pnas.86.14.5310

PubMed ID: 2172793

Title: A functional retinoic acid receptor encoded by the gene on human chromosome 12.

PubMed ID: 2172793

DOI: 10.1210/mend-4-6-837

PubMed ID: 1849262

Title: Genomic organization of the retinoic acid receptor gamma gene.

PubMed ID: 1849262

DOI: 10.1093/nar/19.3.573

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2157210

Title: Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

PubMed ID: 2157210

DOI: 10.1073/pnas.87.7.2700

PubMed ID: 1320193

Title: RAR-gamma-2 expression is regulated through a retinoic acid response element embedded in Sp1 sites.

PubMed ID: 1320193

DOI: 10.1128/mcb.12.7.2976-2985.1992

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 7501014

Title: Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.

PubMed ID: 7501014

DOI: 10.1038/378681a0

PubMed ID: 9501913

Title: Conformational adaptation of agonists to the human nuclear receptor RAR gamma.

PubMed ID: 9501913

DOI: 10.1038/nsb0398-199

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

Sequence Information:

  • Length: 454
  • Mass: 50342
  • Checksum: 1EE27B22772D4AFD
  • Sequence:
  • MATNKERLFA AGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS 
    LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK 
    NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY 
    ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK 
    IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 
    NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA 
    LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE 
    MFEDDSSQPG PHPNASSEDE VPGGQGKGGL KSPA

Genular Protein ID: 978391113

Symbol: B7Z4B4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 333
  • Mass: 37539
  • Checksum: 5974D8CE3C55D05F
  • Sequence:
  • MVYTCHRDKN CIINKVTRNR CQYCRLQKCF EVGMSKEAVR NDRNKKKKEV KEEGSPDSYE 
    LSPQLEELIT KVSKAHQETF PSLCQLGKYT TNSSADHRVQ LDLGLWDKFS ELATKCIIKI 
    VEFAKRLPGF TGLSIADQIT LLKAACLDIL MLRICTRYTP EQDTMTFSDG LTLNRTQMRN 
    AGFGPLTDLV FAFAGQLLPL EMDDTETGLL SAICLICGDR MDLEEPEKVD KLQEPLLEAL 
    RLYARRRRPS QPYMFPRMLM KITDLRGIST KGAERAITLK MEIPGPMPPL IREMLENPEM 
    FEDDSSQPGP HPNASSEDEV PGGQGKGGLK SPA

Genular Protein ID: 180951686

Symbol: F1D8P1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 443
  • Mass: 49308
  • Checksum: 4D709194F5111E86
  • Sequence:
  • MYDCMETFAP GPRRLYGAAG PGAGLLRRAT GGSCFAGLES FAWPQPASLQ SVETQSTSSE 
    EMVPSSPSPP PPPRVYKPCF VCNDKSSGYH YGVSSCEGCK GFFRRSIQKN MVYTCHRDKN 
    CIINKVTRNR CQYCRLQKCF EVGMSKEAVR NDRNKKKKEV KEEGSPDSYE LSPQLEELIT 
    KVSKAHQETF PSLCQLGKYT TNSSADHRVQ LDLGLWDKFS ELATKCIIKI VEFAKRLPGF 
    TGLSIADQIT LLKAACLDIL MLRICTRYTP EQDTMTFSDG LTLNRTQMHN AGFGPLTDLV 
    FAFAGQLLPL EMDDTETGLL SAICLICGDR MDLEEPEKVD KLQEPLLEAL RLYARRRRPS 
    QPYMFPRMLM KITDLRGIST KGAERAITLK MEIPGPMPPL IREMLENPEM FEDDSSQPGP 
    HPNASSEDEV PGGQGKGGLK SPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.