Details for: RASA2

Gene ID: 5922

Symbol: RASA2

Ensembl ID: ENSG00000155903

Description: RAS p21 protein activator 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 317.3996
    Cell Significance Index: -49.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 190.1587
    Cell Significance Index: -48.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 123.1953
    Cell Significance Index: -50.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.4843
    Cell Significance Index: -51.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 108.6504
    Cell Significance Index: -44.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.6129
    Cell Significance Index: -50.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.4209
    Cell Significance Index: -44.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.6422
    Cell Significance Index: -50.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9181
    Cell Significance Index: -48.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.5729
    Cell Significance Index: -44.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7849
    Cell Significance Index: -50.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.7444
    Cell Significance Index: -23.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6699
    Cell Significance Index: 535.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2844
    Cell Significance Index: 128.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8999
    Cell Significance Index: 116.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.7863
    Cell Significance Index: 42.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7543
    Cell Significance Index: 117.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.6603
    Cell Significance Index: 35.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5216
    Cell Significance Index: 545.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3208
    Cell Significance Index: 913.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3055
    Cell Significance Index: 259.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2391
    Cell Significance Index: 1118.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1984
    Cell Significance Index: 23.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0748
    Cell Significance Index: 28.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0583
    Cell Significance Index: 46.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0085
    Cell Significance Index: 38.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9321
    Cell Significance Index: 20.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9314
    Cell Significance Index: 26.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8702
    Cell Significance Index: 40.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8593
    Cell Significance Index: 65.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7225
    Cell Significance Index: 20.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7089
    Cell Significance Index: 19.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7039
    Cell Significance Index: 76.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6022
    Cell Significance Index: 97.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5940
    Cell Significance Index: 17.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5853
    Cell Significance Index: 14.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4474
    Cell Significance Index: 26.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4089
    Cell Significance Index: 10.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3320
    Cell Significance Index: 15.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3231
    Cell Significance Index: 39.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2778
    Cell Significance Index: 27.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2684
    Cell Significance Index: 3.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2644
    Cell Significance Index: 144.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2628
    Cell Significance Index: 47.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2492
    Cell Significance Index: 4.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2145
    Cell Significance Index: 403.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2037
    Cell Significance Index: 14.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1929
    Cell Significance Index: 2.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1785
    Cell Significance Index: 33.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1726
    Cell Significance Index: 109.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1689
    Cell Significance Index: 21.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1552
    Cell Significance Index: 238.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1417
    Cell Significance Index: 62.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1274
    Cell Significance Index: 15.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1171
    Cell Significance Index: 215.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0802
    Cell Significance Index: 109.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0708
    Cell Significance Index: 4.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0612
    Cell Significance Index: 0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0520
    Cell Significance Index: 23.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0408
    Cell Significance Index: 5.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0246
    Cell Significance Index: 1.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0429
    Cell Significance Index: -6.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0559
    Cell Significance Index: -41.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0584
    Cell Significance Index: -43.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0628
    Cell Significance Index: -47.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0662
    Cell Significance Index: -3.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0844
    Cell Significance Index: -47.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0895
    Cell Significance Index: -55.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1263
    Cell Significance Index: -5.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1316
    Cell Significance Index: -16.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1372
    Cell Significance Index: -23.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1391
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1511
    Cell Significance Index: -43.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1812
    Cell Significance Index: -2.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2161
    Cell Significance Index: -22.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2230
    Cell Significance Index: -6.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2570
    Cell Significance Index: -19.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2597
    Cell Significance Index: -54.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2698
    Cell Significance Index: -30.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2946
    Cell Significance Index: -34.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3135
    Cell Significance Index: -32.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4447
    Cell Significance Index: -31.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4686
    Cell Significance Index: -9.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4861
    Cell Significance Index: -25.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5314
    Cell Significance Index: -7.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5452
    Cell Significance Index: -10.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6009
    Cell Significance Index: -47.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6193
    Cell Significance Index: -19.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6683
    Cell Significance Index: -21.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6990
    Cell Significance Index: -20.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7028
    Cell Significance Index: -43.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7396
    Cell Significance Index: -38.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7464
    Cell Significance Index: -16.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7670
    Cell Significance Index: -15.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8159
    Cell Significance Index: -16.3800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8313
    Cell Significance Index: -8.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8401
    Cell Significance Index: -17.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.9260
    Cell Significance Index: -8.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9464
    Cell Significance Index: -8.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RASA2 is a member of the Ras GTPase-activating protein family and is characterized by its ability to accelerate the GTPase activity of Ras proteins, thereby regulating their activity. This gene is specifically expressed in various cell types, including Purkinje cells, GABAergic cortical interneurons, corneal epithelial cells, and neurons. RASA2's expression is also observed in endothelial cells, vascular leptomeningeal cells, and L2/3-6 intratelencephalic projecting glutamatergic neurons, underscoring its widespread involvement in neural and vascular systems. **Pathways and Functions:** RASA2's primary function is to regulate Ras signaling pathways, which are crucial for various cellular processes, including cell growth, differentiation, and survival. Specifically, RASA2 modulates the activity of Ras proteins by accelerating their GTPase activity, thereby inhibiting their constitutive activity and preventing the formation of aberrant signaling complexes. This regulation is essential for maintaining proper cellular homeostasis and preventing the development of cancer. In addition to its role in Ras signaling, RASA2 has been implicated in other cellular processes, including: 1. **Regulation of MAPK signaling cascades**: RASA2 interacts with MAPK kinases, such as MAPK1 and MAPK3, to modulate their activity and regulate downstream signaling pathways. 2. **Negative regulation of Ras protein signal transduction**: RASA2's ability to accelerate GTPase activity of Ras proteins prevents the formation of aberrant signaling complexes, thereby inhibiting the activation of downstream signaling pathways. 3. **Regulation of Ras by GAPs**: RASA2 interacts with other GAPs, such as RAP1GAP and RHOGAP, to regulate the activity of Ras proteins and maintain proper cellular homeostasis. **Clinical Significance:** Dysregulation of RASA2 has been implicated in various diseases, including: 1. **Cancer**: Alterations in RASA2 expression have been observed in several types of cancer, suggesting its potential role as a tumor suppressor gene. 2. **Neurological disorders**: RASA2's involvement in neural signaling pathways has led to its association with neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Vascular diseases**: RASA2's expression in endothelial cells and vascular leptomeningeal cells has led to its potential role in vascular diseases, such as atherosclerosis and stroke. In conclusion, RASA2 is a complex gene that plays a critical role in regulating Ras signaling pathways and maintaining proper cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its functions and clinical significance.

Genular Protein ID: 3130796184

Symbol: RASA2_HUMAN

Name: Ras GTPase-activating protein 2

UniProtKB Accession Codes:

Q15283 A8K7K1 G3V0F9 O00695 Q15284 Q92594 Q99577 Q9UEQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8917095

Title: Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization.

PubMed ID: 8917095

DOI: 10.1016/0378-1119(96)00144-8

PubMed ID: 8812506

Title: cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras.

PubMed ID: 8812506

DOI: 10.1006/geno.1996.0412

PubMed ID: 9382842

Title: Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting.

PubMed ID: 9382842

DOI: 10.1016/s0960-9822(06)00423-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 850
  • Mass: 96614
  • Checksum: 1F357940CA106E5E
  • Sequence:
    • MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL LPYLGPHKMR 
DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ YLSFYVYDKN VLQRDLRIGK 
VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ GKVHLELKLN ELITENGTVC QQLVVHIKAC 
HGLPLINGQS CDPYATVSLV GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ 
FQVEEEDIEK LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS 
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL SEICRDKNDA 
VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS LATRCLDEMM KIVGGHYLKV 
TLKPILDEIC DSSKSCEIDP IKLKEGDNVE NNKENLRYYV DKLFNTIVKS SMSCPTVMCD 
IFYSLRQMAT QRFPNDPHVQ YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL 
ISKTIQTLGS WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT 
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGSKDAI YTIPVKNILA 
VEKLEESSFN KKNMFQVIHT EKPLYVQANN CVEANEWIDV LCRVSRCNQN RLSFYHPSVY 
LNGNWLCCQE TGENTLGCKP CTAGVPADIQ IDIDEDRETE RIYSLFTLSL LKLQKMEEAC 
GTIAVYQGPQ KEPDDYSNFV IEDSVTTFKT IQQIKSIIEK LDEPHEKYRK KRSSSAKYGS 
KENPIVGKAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.