Details for: KDM5A

Gene ID: 5927

Symbol: KDM5A

Ensembl ID: ENSG00000073614

Description: lysine demethylase 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 411.9059
    Cell Significance Index: -64.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 244.9502
    Cell Significance Index: -62.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.5252
    Cell Significance Index: -69.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 137.8560
    Cell Significance Index: -56.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 124.5565
    Cell Significance Index: -64.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.9923
    Cell Significance Index: -56.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.7465
    Cell Significance Index: -67.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.1409
    Cell Significance Index: -64.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.9498
    Cell Significance Index: -61.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.4643
    Cell Significance Index: -68.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2381
    Cell Significance Index: -33.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4346
    Cell Significance Index: 395.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7821
    Cell Significance Index: 353.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5699
    Cell Significance Index: 120.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5360
    Cell Significance Index: 86.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4963
    Cell Significance Index: 269.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4628
    Cell Significance Index: 159.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3753
    Cell Significance Index: 169.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1594
    Cell Significance Index: 60.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1586
    Cell Significance Index: 415.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0377
    Cell Significance Index: 66.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8661
    Cell Significance Index: 118.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7768
    Cell Significance Index: 701.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7326
    Cell Significance Index: 400.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7243
    Cell Significance Index: 44.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6236
    Cell Significance Index: 12.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5972
    Cell Significance Index: 15.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5724
    Cell Significance Index: 25.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5453
    Cell Significance Index: 14.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5304
    Cell Significance Index: 234.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4821
    Cell Significance Index: 18.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4220
    Cell Significance Index: 291.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4205
    Cell Significance Index: 84.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4119
    Cell Significance Index: 48.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3914
    Cell Significance Index: 26.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3276
    Cell Significance Index: 14.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2009
    Cell Significance Index: 5.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1838
    Cell Significance Index: 8.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1571
    Cell Significance Index: 10.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1504
    Cell Significance Index: 283.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1413
    Cell Significance Index: 13.9800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1205
    Cell Significance Index: 15.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1029
    Cell Significance Index: 2.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1011
    Cell Significance Index: 186.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0986
    Cell Significance Index: 151.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0884
    Cell Significance Index: 56.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0605
    Cell Significance Index: 2.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0369
    Cell Significance Index: 16.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0048
    Cell Significance Index: 6.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0187
    Cell Significance Index: -3.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0291
    Cell Significance Index: -1.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0689
    Cell Significance Index: -52.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0721
    Cell Significance Index: -53.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1064
    Cell Significance Index: -3.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1150
    Cell Significance Index: -1.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1178
    Cell Significance Index: -66.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1195
    Cell Significance Index: -12.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1255
    Cell Significance Index: -78.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1274
    Cell Significance Index: -9.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1513
    Cell Significance Index: -25.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2083
    Cell Significance Index: -59.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2112
    Cell Significance Index: -27.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2195
    Cell Significance Index: -31.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2299
    Cell Significance Index: -26.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2374
    Cell Significance Index: -8.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2834
    Cell Significance Index: -17.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3570
    Cell Significance Index: -75.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3740
    Cell Significance Index: -8.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3981
    Cell Significance Index: -11.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4248
    Cell Significance Index: -31.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4474
    Cell Significance Index: -51.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5596
    Cell Significance Index: -58.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5608
    Cell Significance Index: -16.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5717
    Cell Significance Index: -7.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5877
    Cell Significance Index: -16.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6051
    Cell Significance Index: -31.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6160
    Cell Significance Index: -10.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6293
    Cell Significance Index: -20.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6486
    Cell Significance Index: -9.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7081
    Cell Significance Index: -56.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7282
    Cell Significance Index: -8.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7555
    Cell Significance Index: -20.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7964
    Cell Significance Index: -18.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8047
    Cell Significance Index: -7.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8327
    Cell Significance Index: -15.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8554
    Cell Significance Index: -24.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8964
    Cell Significance Index: -54.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9166
    Cell Significance Index: -24.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9485
    Cell Significance Index: -23.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0741
    Cell Significance Index: -27.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1268
    Cell Significance Index: -30.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1321
    Cell Significance Index: -6.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1571
    Cell Significance Index: -58.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2897
    Cell Significance Index: -27.9400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.4170
    Cell Significance Index: -20.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4317
    Cell Significance Index: -46.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.4446
    Cell Significance Index: -24.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4519
    Cell Significance Index: -46.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.5087
    Cell Significance Index: -21.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KDM5A is a 1,500-amino acid protein that belongs to the JARID family of demethylases. It contains a Jumonji C domain, which is responsible for its histone demethylase activity. KDM5A is expressed in a wide range of cell types, including vascular leptomeningeal cells, immune cells, and neurons. It is also known to interact with various transcription factors and coactivators, which regulate its activity and substrate specificity. **Pathways and Functions:** KDM5A is involved in several key pathways, including: 1. **Chromatin remodeling:** KDM5A removes methyl groups from histones, leading to chromatin relaxation and the activation of gene expression. 2. **Circadian regulation:** KDM5A has been shown to regulate the expression of circadian genes, which are essential for maintaining the body's internal clock. 3. **Developmental biology:** KDM5A plays a crucial role in embryonic development, particularly in the regulation of gene expression during the maternal-to-zygotic transition (mzt). 4. **Immune responses:** KDM5A is involved in the regulation of immune responses, particularly in the activation of T cells and the production of cytokines. **Clinical Significance:** Alterations in KDM5A expression and function have been implicated in various disease states, including: 1. **Neurological disorders:** KDM5A has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by the loss of neurons and the dysregulation of gene expression. 2. **Cancer:** KDM5A has been shown to be involved in the regulation of cancer cell proliferation and survival, making it a potential target for cancer therapy. 3. **Autoimmune diseases:** KDM5A has been implicated in the regulation of immune responses, particularly in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. In conclusion, KDM5A is a complex enzyme that plays a crucial role in regulating gene expression through the removal of methyl groups from histones. Its dysregulation has been implicated in various disease states, highlighting the need for further research into the mechanisms of KDM5A and its potential therapeutic applications. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of KDM5A in regulating gene expression and its role in disease states. 2. KDM5A could be a potential target for the development of novel therapeutics for neurological and autoimmune diseases. 3. The study of KDM5A's interaction with transcription factors and coactivators could provide insights into the regulation of gene expression and the dysregulation of disease states. By exploring the complex role of KDM5A in regulating gene expression, we can gain a deeper understanding of its involvement in various disease states and identify new therapeutic targets for the treatment of these conditions.

Genular Protein ID: 440112201

Symbol: KDM5A_HUMAN

Name: Lysine-specific demethylase 5A

UniProtKB Accession Codes:

P29375 A8MV76 Q4LE72 Q86XZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugCentral 1 EC 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 46 PDBsum 46 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8414517

Title: Characterization of the retinoblastoma binding proteins RBP1 and RBP2.

PubMed ID: 8414517

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1857421

Title: Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product.

PubMed ID: 1857421

DOI: 10.1038/352251a0

PubMed ID: 7935440

Title: Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.

PubMed ID: 7935440

DOI: 10.1128/mcb.14.11.7256-7264.1994

PubMed ID: 9129143

Title: T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2.

PubMed ID: 9129143

DOI: 10.1038/sj.onc.1200988

PubMed ID: 11358960

Title: Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription.

PubMed ID: 11358960

DOI: 10.1074/jbc.m100313200

PubMed ID: 15949438

Title: Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.

PubMed ID: 15949438

DOI: 10.1016/j.molcel.2005.05.012

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17320163

Title: The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

PubMed ID: 17320163

DOI: 10.1016/j.cell.2007.02.013

PubMed ID: 17320161

Title: RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

PubMed ID: 17320161

DOI: 10.1016/j.cell.2007.02.003

PubMed ID: 17320160

Title: The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

PubMed ID: 17320160

DOI: 10.1016/j.cell.2007.02.017

PubMed ID: 17311883

Title: The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.

PubMed ID: 17311883

DOI: 10.1101/gad.1523007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21960634

Title: Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

PubMed ID: 21960634

DOI: 10.1126/science.1206022

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18270511

Title: The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif.

PubMed ID: 18270511

DOI: 10.1038/nsmb.1400

PubMed ID: 19430464

Title: Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.

PubMed ID: 19430464

DOI: 10.1038/nature08036

PubMed ID: 27499454

Title: Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

PubMed ID: 27499454

DOI: 10.1016/j.bmcl.2016.07.070

PubMed ID: 27427228

Title: Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.

PubMed ID: 27427228

DOI: 10.1016/j.chembiol.2016.06.006

PubMed ID: 26645689

Title: Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

PubMed ID: 26645689

DOI: 10.1074/jbc.m115.698449

PubMed ID: 27214401

Title: An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

PubMed ID: 27214401

DOI: 10.1038/nchembio.2085

PubMed ID: 16419055

Title: Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.

PubMed ID: 16419055

DOI: 10.1002/gcc.20308

PubMed ID: 23531517

Title: NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.

PubMed ID: 23531517

DOI: 10.1038/leu.2013.87

PubMed ID: 33350388

Title: KDM5A mutations identified in autism spectrum disorder using forward genetics.

PubMed ID: 33350388

DOI: 10.7554/elife.56883

Sequence Information:

  • Length: 1690
  • Mass: 192095
  • Checksum: FCF6DC22DEF001DF
  • Sequence:
    • MAGVGPGGYA AEFVPPPECP VFEPSWEEFT DPLSFIGRIR PLAEKTGICK IRPPKDWQPP 
FACEVKSFRF TPRVQRLNEL EAMTRVRLDF LDQLAKFWEL QGSTLKIPVV ERKILDLYAL 
SKIVASKGGF EMVTKEKKWS KVGSRLGYLP GKGTGSLLKS HYERILYPYE LFQSGVSLMG 
VQMPNLDLKE KVEPEVLSTD TQTSPEPGTR MNILPKRTRR VKTQSESGDV SRNTELKKLQ 
IFGAGPKVVG LAMGTKDKED EVTRRRKVTN RSDAFNMQMR QRKGTLSVNF VDLYVCMFCG 
RGNNEDKLLL CDGCDDSYHT FCLIPPLPDV PKGDWRCPKC VAEECSKPRE AFGFEQAVRE 
YTLQSFGEMA DNFKSDYFNM PVHMVPTELV EKEFWRLVSS IEEDVIVEYG ADISSKDFGS 
GFPVKDGRRK ILPEEEEYAL SGWNLNNMPV LEQSVLAHIN VDISGMKVPW LYVGMCFSSF 
CWHIEDHWSY SINYLHWGEP KTWYGVPSHA AEQLEEVMRE LAPELFESQP DLLHQLVTIM 
NPNVLMEHGV PVYRTNQCAG EFVVTFPRAY HSGFNQGYNF AEAVNFCTAD WLPIGRQCVN 
HYRRLRRHCV FSHEELIFKM AADPECLDVG LAAMVCKELT LMTEEETRLR ESVVQMGVLM 
SEEEVFELVP DDERQCSACR TTCFLSALTC SCNPERLVCL YHPTDLCPCP MQKKCLRYRY 
PLEDLPSLLY GVKVRAQSYD TWVSRVTEAL SANFNHKKDL IELRVMLEDA EDRKYPENDL 
FRKLRDAVKE AETCASVAQL LLSKKQKHRQ SPDSGRTRTK LTVEELKAFV QQLFSLPCVI 
SQARQVKNLL DDVEEFHERA QEAMMDETPD SSKLQMLIDM GSSLYVELPE LPRLKQELQQ 
ARWLDEVRLT LSDPQQVTLD VMKKLIDSGV GLAPHHAVEK AMAELQELLT VSERWEEKAK 
VCLQARPRHS VASLESIVNE AKNIPAFLPN VLSLKEALQK AREWTAKVEA IQSGSNYAYL 
EQLESLSAKG RPIPVRLEAL PQVESQVAAA RAWRERTGRT FLKKNSSHTL LQVLSPRTDI 
GVYGSGKNRR KKVKELIEKE KEKDLDLEPL SDLEEGLEET RDTAMVVAVF KEREQKEIEA 
MHSLRAANLA KMTMVDRIEE VKFCICRKTA SGFMLQCELC KDWFHNSCVP LPKSSSQKKG 
SSWQAKEVKF LCPLCMRSRR PRLETILSLL VSLQKLPVRL PEGEALQCLT ERAMSWQDRA 
RQALATDELS SALAKLSVLS QRMVEQAARE KTEKIISAEL QKAAANPDLQ GHLPSFQQSA 
FNRVVSSVSS SPRQTMDYDD EETDSDEDIR ETYGYDMKDT ASVKSSSSLE PNLFCDEEIP 
IKSEEVVTHM WTAPSFCAEH AYSSASKSCS QGSSTPRKQP RKSPLVPRSL EPPVLELSPG 
AKAQLEELMM VGDLLEVSLD ETQHIWRILQ ATHPPSEDRF LHIMEDDSME EKPLKVKGKD 
SSEKKRKRKL EKVEQLFGEG KQKSKELKKM DKPRKKKLKL GADKSKELNK LAKKLAKEEE 
RKKKKEKAAA AKVELVKEST EKKREKKVLD IPSKYDWSGA EESDDENAVC AAQNCQRPCK 
DKVDWVQCDG GCDEWFHQVC VGVSPEMAEN EDYICINCAK KQGPVSPGPA PPPSFIMSYK 
LPMEDLKETS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.