Details for: RDX

Gene ID: 5962

Symbol: RDX

Ensembl ID: ENSG00000137710

Description: radixin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 548.5864
    Cell Significance Index: -85.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 369.2192
    Cell Significance Index: -93.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 263.6986
    Cell Significance Index: -108.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.5597
    Cell Significance Index: -99.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 188.0829
    Cell Significance Index: -76.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 179.2431
    Cell Significance Index: -92.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 80.4405
    Cell Significance Index: -76.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.7538
    Cell Significance Index: -97.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.9216
    Cell Significance Index: -93.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.9870
    Cell Significance Index: -98.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.5626
    Cell Significance Index: -69.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.0090
    Cell Significance Index: -45.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.2035
    Cell Significance Index: 166.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.4165
    Cell Significance Index: 230.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.3065
    Cell Significance Index: 241.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.1116
    Cell Significance Index: 479.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.1722
    Cell Significance Index: 43.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0541
    Cell Significance Index: 81.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.9004
    Cell Significance Index: 178.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8658
    Cell Significance Index: 256.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6506
    Cell Significance Index: 327.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.6312
    Cell Significance Index: 39.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.6085
    Cell Significance Index: 206.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4769
    Cell Significance Index: 51.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4554
    Cell Significance Index: 178.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2994
    Cell Significance Index: 466.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1592
    Cell Significance Index: 633.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1034
    Cell Significance Index: 31.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0859
    Cell Significance Index: 83.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0467
    Cell Significance Index: 209.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7955
    Cell Significance Index: 143.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.7645
    Cell Significance Index: 1039.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6261
    Cell Significance Index: 276.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5425
    Cell Significance Index: 88.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5081
    Cell Significance Index: 23.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4917
    Cell Significance Index: 340.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4702
    Cell Significance Index: 46.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4303
    Cell Significance Index: 15.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3671
    Cell Significance Index: 62.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3353
    Cell Significance Index: 9.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3290
    Cell Significance Index: 619.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3047
    Cell Significance Index: 39.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2910
    Cell Significance Index: 55.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2171
    Cell Significance Index: 334.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1585
    Cell Significance Index: 100.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1415
    Cell Significance Index: 64.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1194
    Cell Significance Index: 5.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1153
    Cell Significance Index: 5.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1150
    Cell Significance Index: 212.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0276
    Cell Significance Index: 3.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0099
    Cell Significance Index: 0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -18.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0514
    Cell Significance Index: -0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0537
    Cell Significance Index: -40.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0558
    Cell Significance Index: -34.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0739
    Cell Significance Index: -0.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0856
    Cell Significance Index: -2.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0997
    Cell Significance Index: -56.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1114
    Cell Significance Index: -2.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1215
    Cell Significance Index: -4.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1252
    Cell Significance Index: -12.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1736
    Cell Significance Index: -12.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2167
    Cell Significance Index: -45.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2204
    Cell Significance Index: -11.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2268
    Cell Significance Index: -14.3000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2406
    Cell Significance Index: -3.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2548
    Cell Significance Index: -37.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2728
    Cell Significance Index: -78.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3545
    Cell Significance Index: -7.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3967
    Cell Significance Index: -17.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4033
    Cell Significance Index: -20.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4287
    Cell Significance Index: -49.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4649
    Cell Significance Index: -53.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4888
    Cell Significance Index: -31.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4958
    Cell Significance Index: -5.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5350
    Cell Significance Index: -39.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5828
    Cell Significance Index: -39.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6250
    Cell Significance Index: -13.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6355
    Cell Significance Index: -43.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7403
    Cell Significance Index: -10.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7408
    Cell Significance Index: -77.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7433
    Cell Significance Index: -13.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7698
    Cell Significance Index: -90.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7998
    Cell Significance Index: -21.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8477
    Cell Significance Index: -67.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8504
    Cell Significance Index: -14.3300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8940
    Cell Significance Index: -12.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9422
    Cell Significance Index: -27.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9630
    Cell Significance Index: -59.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.3228
    Cell Significance Index: -66.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4720
    Cell Significance Index: -25.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.5287
    Cell Significance Index: -29.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.6002
    Cell Significance Index: -36.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.7000
    Cell Significance Index: -54.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.7310
    Cell Significance Index: -26.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.7390
    Cell Significance Index: -42.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.7976
    Cell Significance Index: -37.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.9683
    Cell Significance Index: -41.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Radixin is a cytoskeletal protein that belongs to the ERM protein family, which consists of ezrin, radixin, and moesin. These proteins share a common structural motif, characterized by an ERM domain, a tail domain, and a rod domain. Radixin possesses a high degree of sequence homology with other ERM proteins, including ezrin and moesin. Its expression is widespread, with significant levels found in endothelial cells, cardiac neurons, lung endothelial cells, and other cell types. **Pathways and Functions** Radixin plays a multifaceted role in regulating various cellular processes, including: 1. **Cell shape and structure**: Radixin interacts with actin filaments and other cytoskeletal components to maintain cell shape and structure. 2. **Cell adhesion**: Radixin binds to cadherins and other cell adhesion molecules, regulating cell-cell adhesion and maintaining the integrity of adherens junctions. 3. **Actin cytoskeleton organization**: Radixin regulates actin filament bundle assembly, capping, and dynamics, ensuring proper cytoskeletal organization. 4. **Cell migration and movement**: Radixin facilitates cell migration by regulating the actin cytoskeleton and adherens junctions. 5. **Endocytosis and exocytosis**: Radixin regulates the trafficking of proteins and lipids within the cell, influencing endocytosis and exocytosis processes. 6. **Apoptosis and cell survival**: Radixin has been implicated in regulating apoptosis and cell survival, with potential roles in maintaining endothelial barrier function. **Clinical Significance** Radixin's dysregulation has been implicated in various diseases and disorders, including: 1. **Neurological disorders**: Radixin has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation may contribute to neuronal damage and dysfunction. 2. **Cardiovascular diseases**: Radixin's role in endothelial cell function and vascular integrity has been implicated in cardiovascular diseases, including atherosclerosis and hypertension. 3. **Cancer**: Radixin's involvement in cell migration, invasion, and metastasis has been explored in the context of various cancers, suggesting potential therapeutic targets. 4. **Endothelial barrier dysfunction**: Radixin's regulation of the endothelial barrier has been implicated in diseases such as sepsis, acute kidney injury, and multiple organ dysfunction syndrome. In conclusion, Radixin is a multifunctional protein that plays a crucial role in maintaining cellular structure, function, and integrity. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into its mechanisms and potential therapeutic applications.

Genular Protein ID: 3892085966

Symbol: RADI_HUMAN

Name: Radixin

UniProtKB Accession Codes:

P35241 A7YIJ8 A7YIK0 A7YIK3 B7Z9U6 F5H1A7 Q86Y61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 7 ExpressionAtlas 1 GO 48 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8486357

Title: Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes.

PubMed ID: 8486357

DOI: 10.1006/geno.1993.1159

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17226784

Title: Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus.

PubMed ID: 17226784

DOI: 10.1002/humu.20469

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430655

Title: NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins.

PubMed ID: 9430655

DOI: 10.1074/jbc.273.3.1273

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 583
  • Mass: 68564
  • Checksum: 889687E1D675FFE7
  • Sequence:
    • MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK 
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE 
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR 
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF 
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI 
EVQQMKAQAR EEKHQKQLER AQLENEKKKR EIAEKEKERI EREKEELMER LKQIEEQTIK 
AQKELEEQTR KALELDQERK RAKEEAERLE KERRAAEEAK SAIAKQAADQ MKNQEQLAAE 
LAEFTAKIAL LEEAKKKKEE EATEWQHKAF AAQEDLEKTK EELKTVMSAP PPPPPPPVIP 
PTENEHDEHD ENNAEASAEL SNEGVMNHRS EEERVTETQK NERVKKQLQA LSSELAQARD 
ETKKTQNDVL HAENVKAGRD KYKTLRQIRQ GNTKQRIDEF EAM

Genular Protein ID: 2068966893

Symbol: Q6PKD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PKD3

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 3 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 339
  • Mass: 40397
  • Checksum: 13E7CBCD38B37F0A
  • Sequence:
    • MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTVGLR EVWFFGLQYV DSKGYSTWLK 
LNKKVTQQDV KKENPLQFKF RAKFFPEDVS EELIQEITQR LFFLQVKEAI LNDEIYCPPE 
TAVLLASYAV QAKYGDYNKE IHKPGYLAND RLLPQRVLEQ HKLTKEQWEE RIQNWHEEHR 
GMLREDSMME YLKIAQDLEM YGVNYFEIKN KKGTELWLGV DALGLNIYEH DDKLTPKIGF 
PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LALCMGNHEL YMRRRKPDTI 
EVQQMKAQAR EEKHQKQLER AQLEKKKKKK KKKKKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.