RFC1 | ENSG00000035928 | NCBI 5981

Details for: RFC1

Associated with

Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromosome maintenance
(R-HSA-73886)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna replication
(R-HSA-69306)
Dna strand elongation
(R-HSA-69190)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Extension of telomeres
(R-HSA-180786)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-HSA-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Lagging strand synthesis
(R-HSA-69186)
Leading strand synthesis
(R-HSA-69109)
Nucleotide excision repair
(R-HSA-5696398)
Pcna-dependent long patch base excision repair
(R-HSA-5651801)
Polymerase switching
(R-HSA-69091)
Polymerase switching on the c-strand of the telomere
(R-HSA-174411)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-HSA-110373)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Telomere maintenance
(R-HSA-157579)
Termination of translesion dna synthesis
(R-HSA-5656169)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Translesion synthesis by polh
(R-HSA-110320)
Translesion synthesis by poli
(R-HSA-5656121)
Translesion synthesis by polk
(R-HSA-5655862)
Translesion synthesis by rev1
(R-HSA-110312)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated dna replication
(GO:0006261)
Dna binding
(GO:0003677)
Dna clamp loader activity
(GO:0003689)
Dna clamp unloader activity
(GO:0061860)
Dna clamp unloading
(GO:0090618)
Dna repair
(GO:0006281)
Dna replication factor c complex
(GO:0005663)
Double-stranded dna binding
(GO:0003690)
Elg1 rfc-like complex
(GO:0031391)
Enzyme activator activity
(GO:0008047)
Extracellular exosome
(GO:0070062)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Sequence-specific dna binding
(GO:0043565)
Telomere maintenance via telomerase
(GO:0007004)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

retinal cone cell CL0000573

CSI 14.8

rCSI 23.82%

PRS 25.67
helper T cell CL0000912

CSI 13.39

rCSI 18.94%

PRS 42.84
activated CD4-positive, alpha-beta T cell CL0000896

CSI 13.28

rCSI 12.28%

PRS 52.86
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 12.23

rCSI 17.34%

PRS 30.68
CD4-positive helper T cell CL0000492

CSI 12.01

rCSI 9.08%

PRS 43.83
dendritic cell, human CL0001056

CSI 10.53

rCSI 16.18%

PRS 38.67
common dendritic progenitor CL0001029

CSI 8.85

rCSI 11.11%

PRS 41.42
small intestine goblet cell CL1000495

CSI 7.05

rCSI 15.44%

PRS 42.24
lung pericyte CL0009089

CSI 6.78

rCSI 17.91%

PRS 38.83
CD14-positive monocyte CL0001054

CSI 6.34

rCSI 7.89%

PRS 43.66
large pre-B-II cell CL0000957

CSI 6.02

rCSI 17.19%

PRS 48.4
epithelial cell of lower respiratory tract CL0002632

CSI 5.75

rCSI 4.46%

PRS 32.46
astrocyte of the cerebral cortex CL0002605

CSI 5.71

rCSI 12.81%

PRS 21.35
naive T cell CL0000898

CSI 5.66

rCSI 3.94%

PRS 44.35
CD1c-positive myeloid dendritic cell CL0002399

CSI 5.62

rCSI 6.78%

PRS 39.23
bronchus fibroblast of lung CL2000093

CSI 5.59

rCSI 4.54%

PRS 33.81
lymphoid lineage restricted progenitor cell CL0000838

CSI 5.44

rCSI 21.17%

PRS 51.72
unswitched memory B cell CL0000970

CSI 5.34

rCSI 4.49%

PRS 48.73
promyelocyte CL0000836

CSI 5.27

rCSI 7.59%

PRS 42.64
myeloid lineage restricted progenitor cell CL0000839

CSI 5.17

rCSI 26.68%

PRS 56.37
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 5.12

rCSI 30.16%

PRS 21.89
T-helper 17 cell CL0000899

CSI 5.11

rCSI 4.06%

PRS 53.58
fallopian tube secretory epithelial cell CL4030006

CSI 5.09

rCSI 4.9%

PRS 33.7
lamp5 GABAergic cortical interneuron CL4023011

CSI 4.79

rCSI 8.04%

PRS 20.81
CD8-positive, alpha-beta memory T cell CL0000909

CSI 4.79

rCSI 5%

PRS 66.88
podocyte CL0000653

CSI 4.78

rCSI 21.26%

PRS 31.63
Schwann cell CL0002573

CSI 4.75

rCSI 13.5%

PRS 34.49
transit amplifying cell of small intestine CL0009012

CSI 4.53

rCSI 19.89%

PRS 53.02
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 4.52

rCSI 10.3%

PRS 32.48
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 4.43

rCSI 22.22%

PRS 42.22
Bergmann glial cell CL0000644

CSI 4.42

rCSI 6.05%

PRS 31.48
interneuron CL0000099

CSI 4.36

rCSI 8.75%

PRS 24.94
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 4.13

rCSI 14.85%

PRS 19.79
adventitial cell CL0002503

CSI 3.87

rCSI 9.25%

PRS 44.73
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.67

rCSI 2.16%

PRS 45.39
pancreatic acinar cell CL0002064

CSI 3.66

rCSI 4.87%

PRS 36.33
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.65

rCSI 6.45%

PRS 20.14
common myeloid progenitor CL0000049

CSI 3.64

rCSI 2.94%

PRS 33.15
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 3.62

rCSI 4.92%

PRS 61.69
sncg GABAergic cortical interneuron CL4023015

CSI 3.56

rCSI 5.73%

PRS 22.56
effector CD4-positive, alpha-beta T cell CL0001044

CSI 3.56

rCSI 10.21%

PRS 48.04
forebrain radial glial cell CL0013000

CSI 3.49

rCSI 11.18%

PRS 41.64
squamous epithelial cell CL0000076

CSI 3.41

rCSI 8.1%

PRS 38.62
stromal cell of ovary CL0002132

CSI 3.41

rCSI 9.36%

PRS 48.92
hematopoietic precursor cell CL0008001

CSI 3.32

rCSI 3.42%

PRS 49.27
cerebellar granule cell CL0001031

CSI 3.24

rCSI 4.77%

PRS 30.57
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 3.22

rCSI 6.42%

PRS 50.44
mesenchymal cell CL0008019

CSI 3.18

rCSI 8.09%

PRS 31
precursor B cell CL0000817

CSI 3.16

rCSI 2.76%

PRS 42.02
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.15

rCSI 2.52%

PRS 53.34
tracheobronchial serous cell CL0019001

CSI 3.07

rCSI 13.28%

PRS 50.45
class switched memory B cell CL0000972

CSI 3.06

rCSI 2.28%

PRS 50.59
perivascular cell CL4033054

CSI 3.01

rCSI 4.12%

PRS 36.81
goblet cell CL0000160

CSI 3

rCSI 2.83%

PRS 34.01
microcirculation associated smooth muscle cell CL0008035

CSI 2.93

rCSI 8.49%

PRS 35.76
IgG plasma cell CL0000985

CSI 2.93

rCSI 3.51%

PRS 51.35
neuroendocrine cell CL0000165

CSI 2.91

rCSI 11.25%

PRS 53.42
fibroblast of cardiac tissue CL0002548

CSI 2.86

rCSI 13.71%

PRS 30.78
neural crest cell CL0011012

CSI 2.83

rCSI 2.24%

PRS 23.18
placental villous trophoblast CL2000060

CSI 2.68

rCSI 4.13%

PRS 31.15
pro-B cell CL0000826

CSI 2.67

rCSI 2.21%

PRS 33.5
hematopoietic stem cell CL0000037

CSI 2.66

rCSI 1.77%

PRS 37.21
regular ventricular cardiac myocyte CL0002131

CSI 2.62

rCSI 16.37%

PRS 27.13
Mueller cell CL0000636

CSI 2.58

rCSI 5.89%

PRS 28.33
myoepithelial cell CL0000185

CSI 2.57

rCSI 6.5%

PRS 39.96
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 2.55

rCSI 7.96%

PRS 23.53
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.54

rCSI 1.82%

PRS 43.95
double negative thymocyte CL0002489

CSI 2.53

rCSI 1.76%

PRS 39.6
immature B cell CL0000816

CSI 2.52

rCSI 1.87%

PRS 45.14
exhausted T cell CL0011025

CSI 2.49

rCSI 42.12%

PRS 70.76
lung neuroendocrine cell CL1000223

CSI 2.48

rCSI 3.66%

PRS 37.05
early lymphoid progenitor CL0000936

CSI 2.42

rCSI 2.12%

PRS 37.36
IgA plasma cell CL0000987

CSI 2.4

rCSI 2.46%

PRS 51.6
peripheral nervous system neuron CL2000032

CSI 2.39

rCSI 3.25%

PRS 28.35
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.39

rCSI 1.82%

PRS 42.48
regular atrial cardiac myocyte CL0002129

CSI 2.36

rCSI 7.6%

PRS 33.53
midzonal region hepatocyte CL0019028

CSI 2.32

rCSI 5.44%

PRS 43.16
neuroblast (sensu Vertebrata) CL0000031

CSI 2.3

rCSI 2.95%

PRS 31.46
cardiac neuron CL0010022

CSI 2.3

rCSI 7.35%

PRS 29.95
plasmablast CL0000980

CSI 2.29

rCSI 1.81%

PRS 38.62
myofibroblast cell CL0000186

CSI 2.29

rCSI 3.17%

PRS 39.81
CD14-low, CD16-positive monocyte CL0002396

CSI 2.27

rCSI 1.75%

PRS 31.35
granulocyte CL0000094

CSI 2.26

rCSI 3.45%

PRS 41.22
radial glial cell CL0000681

CSI 2.23

rCSI 3.1%

PRS 33.05
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 2.2

rCSI 10.09%

PRS 56.37
mononuclear phagocyte CL0000113

CSI 2.19

rCSI 4.81%

PRS 36.59
alpha-beta T cell CL0000789

CSI 2.16

rCSI 2.54%

PRS 45.82
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.15

rCSI 1.45%

PRS 41
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 2.14

rCSI 1.43%

PRS 61.02
mucus secreting cell CL0000319

CSI 2.12

rCSI 3.37%

PRS 41.79
mature T cell CL0002419

CSI 2.12

rCSI 1.65%

PRS 47.43
renal alpha-intercalated cell CL0005011

CSI 2.12

rCSI 2.84%

PRS 40.33
plasmacytoid dendritic cell, human CL0001058

CSI 2.12

rCSI 1.48%

PRS 34.52
Kupffer cell CL0000091

CSI 2.12

rCSI 4.84%

PRS 32.43
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 2.11

rCSI 1.58%

PRS 68.1
interstitial cell of Cajal CL0002088

CSI 2.1

rCSI 2.68%

PRS 37.53
keratinocyte CL0000312

CSI 2.07

rCSI 1.74%

PRS 37.78
intrahepatic cholangiocyte CL0002538

CSI 2.07

rCSI 4.97%

PRS 50.45
enteroendocrine cell CL0000164

CSI 2.06

rCSI 2.81%

PRS 35.58
melanocyte CL0000148

CSI 2.04

rCSI 1.51%

PRS 28.31

mesenchymal stem cell CL0000134

CSI 0.1

rCSI 1.1%

PRS 50.4%
respiratory goblet cell CL0002370

CSI 0.1

rCSI 1.5%

PRS 54.1%
hair follicular keratinocyte CL2000092

CSI 0.2

rCSI 2.9%

PRS 73.5%
peptic cell CL0000155

CSI 0.2

rCSI 1.8%

PRS 62.8%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.2%

PRS 45.1%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 4.4%

PRS 29.1%
ON parasol ganglion cell CL4033052

CSI 0.2

rCSI 3.4%

PRS 27.5%
pre-conventional dendritic cell CL0002010

CSI 0.3

rCSI 3.6%

PRS 68.8%
ON midget ganglion cell CL4033046

CSI 0.3

rCSI 5.7%

PRS 27.9%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.6%

PRS 44.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.3

rCSI 1.2%

PRS 21.6%
eosinophil CL0000771

CSI 0.3

rCSI 2.2%

PRS 65.6%
Cajal-Retzius cell CL0000695

CSI 0.4

rCSI 2.9%

PRS 52.4%
pancreatic stellate cell CL0002410

CSI 0.4

rCSI 2.3%

PRS 44.5%
myeloid dendritic cell CL0000782

CSI 0.4

rCSI 0.6%

PRS 47.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.4

rCSI 1.0%

PRS 20.2%
L6b glutamatergic cortical neuron CL4023038

CSI 0.4

rCSI 1.3%

PRS 21.8%
luminal epithelial cell of mammary gland CL0002326

CSI 0.4

rCSI 0.8%

PRS 47.9%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 2.3%

PRS 58.5%
mammary gland epithelial cell CL0002327

CSI 0.5

rCSI 1.6%

PRS 49.4%
amacrine cell CL0000561

CSI 0.5

rCSI 1.3%

PRS 26.4%
IgM plasma cell CL0000986

CSI 0.5

rCSI 2.0%

PRS 79.9%
indirect pathway medium spiny neuron CL4023029

CSI 0.5

rCSI 11.2%

PRS 21.0%
neural progenitor cell CL0011020

CSI 0.5

rCSI 2.2%

PRS 28.6%
brush cell CL0002204

CSI 0.5

rCSI 1.0%

PRS 61.5%
endothelial cell of placenta CL0009092

CSI 0.5

rCSI 2.5%

PRS 42.9%
type B pancreatic cell CL0000169

CSI 0.5

rCSI 1.2%

PRS 30.5%
pancreatic PP cell CL0002275

CSI 0.5

rCSI 2.1%

PRS 49.1%
pancreatic epsilon cell CL0005019

CSI 0.6

rCSI 2.7%

PRS 58.1%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.6

rCSI 1.6%

PRS 41.4%
foveolar cell of stomach CL0002179

CSI 0.6

rCSI 1.3%

PRS 47.6%
central nervous system neuron CL2000029

CSI 0.6

rCSI 4.7%

PRS 23.1%
intermediate monocyte CL0002393

CSI 0.7

rCSI 1.0%

PRS 34.0%
vasa recta ascending limb cell CL1001131

CSI 0.7

rCSI 3.0%

PRS 66.7%
thymocyte CL0000893

CSI 0.7

rCSI 2.4%

PRS 72.0%
mature alpha-beta T cell CL0000791

CSI 0.7

rCSI 2.5%

PRS 50.9%
hepatocyte CL0000182

CSI 0.7

rCSI 1.2%

PRS 31.2%
kidney connecting tubule epithelial cell CL1000768

CSI 0.7

rCSI 1.8%

PRS 25.7%
colon goblet cell CL0009039

CSI 0.7

rCSI 1.7%

PRS 45.1%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.7%

PRS 49.0%
innate lymphoid cell CL0001065

CSI 0.7

rCSI 1.5%

PRS 42.3%
cardiac muscle cell CL0000746

CSI 0.7

rCSI 1.1%

PRS 26.2%
endocardial cell CL0002350

CSI 0.8

rCSI 3.6%

PRS 36.5%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.8

rCSI 0.9%

PRS 34.0%
choroid plexus epithelial cell CL0000706

CSI 0.8

rCSI 1.3%

PRS 25.9%
direct pathway medium spiny neuron CL4023026

CSI 0.8

rCSI 19.2%

PRS 20.2%
pancreatic ductal cell CL0002079

CSI 0.8

rCSI 1.6%

PRS 34.1%
nasal mucosa goblet cell CL0002480

CSI 0.8

rCSI 0.9%

PRS 43.5%
intestinal epithelial cell CL0002563

CSI 0.8

rCSI 0.9%

PRS 33.2%
retinal ganglion cell CL0000740

CSI 0.9

rCSI 1.9%

PRS 24.0%
respiratory basal cell CL0002633

CSI 0.9

rCSI 0.9%

PRS 38.1%
glycinergic amacrine cell CL4030028

CSI 0.9

rCSI 2.2%

PRS 33.2%
basophil CL0000767

CSI 0.9

rCSI 1.8%

PRS 55.3%
erythroblast CL0000765

CSI 0.9

rCSI 2.3%

PRS 46.1%
mucous neck cell CL0000651

CSI 0.9

rCSI 1.3%

PRS 46.7%
promonocyte CL0000559

CSI 0.9

rCSI 1.5%

PRS 41.9%
pulmonary alveolar type 1 cell CL0002062

CSI 0.9

rCSI 5.4%

PRS 37.1%
memory T cell CL0000813

CSI 1.0

rCSI 1.8%

PRS 63.0%
T-helper 1 cell CL0000545

CSI 1.0

rCSI 1.7%

PRS 61.9%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.0

rCSI 1.2%

PRS 51.9%
paneth cell of epithelium of small intestine CL1000343

CSI 1.0

rCSI 2.8%

PRS 47.5%
retinal blood vessel endothelial cell CL0002585

CSI 1.0

rCSI 1.7%

PRS 35.8%
retinal pigment epithelial cell CL0002586

CSI 1.0

rCSI 2.1%

PRS 33.2%
acinar cell CL0000622

CSI 1.1

rCSI 1.5%

PRS 42.2%
OFF-bipolar cell CL0000750

CSI 1.1

rCSI 1.4%

PRS 44.2%
primitive red blood cell CL0002355

CSI 1.1

rCSI 5.7%

PRS 48.2%
intestinal tuft cell CL0019032

CSI 1.1

rCSI 1.7%

PRS 37.1%
mature B cell CL0000785

CSI 1.1

rCSI 1.0%

PRS 40.7%
alveolar adventitial fibroblast CL4028006

CSI 1.1

rCSI 1.8%

PRS 33.5%
small pre-B-II cell CL0000954

CSI 1.1

rCSI 1.1%

PRS 57.2%
corneal epithelial cell CL0000575

CSI 1.1

rCSI 3.2%

PRS 51.0%
transit amplifying cell of colon CL0009011

CSI 1.1

rCSI 1.3%

PRS 36.5%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.1

rCSI 2.9%

PRS 30.2%
duct epithelial cell CL0000068

CSI 1.1

rCSI 1.7%

PRS 35.0%
periportal region hepatocyte CL0019026

CSI 1.2

rCSI 4.5%

PRS 42.5%
lung ciliated cell CL1000271

CSI 1.2

rCSI 1.3%

PRS 24.9%
transit amplifying cell CL0009010

CSI 1.2

rCSI 1.8%

PRS 49.1%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.2

rCSI 3.0%

PRS 65.8%
glandular epithelial cell CL0000150

CSI 1.2

rCSI 3.1%

PRS 55.9%
paneth cell CL0000510

CSI 1.2

rCSI 1.8%

PRS 48.6%
basal cell CL0000646

CSI 1.2

rCSI 1.6%

PRS 34.8%
vascular associated smooth muscle cell CL0000359

CSI 1.2

rCSI 3.9%

PRS 37.0%
enteroendocrine cell of small intestine CL0009006

CSI 1.2

rCSI 2.7%

PRS 46.8%
erythrocyte CL0000232

CSI 1.2

rCSI 2.8%

PRS 39.5%
stromal cell CL0000499

CSI 1.2

rCSI 3.5%

PRS 36.4%
VIP GABAergic cortical interneuron CL4023016

CSI 1.2

rCSI 1.5%

PRS 20.7%
pulmonary alveolar type 2 cell CL0002063

CSI 1.2

rCSI 1.9%

PRS 43.7%
rod bipolar cell CL0000751

CSI 1.2

rCSI 2.2%

PRS 27.7%
cerebral cortex GABAergic interneuron CL0010011

CSI 1.2

rCSI 3.7%

PRS 37.6%
granulocyte monocyte progenitor cell CL0000557

CSI 1.3

rCSI 1.1%

PRS 36.3%
kidney epithelial cell CL0002518

CSI 1.3

rCSI 2.4%

PRS 57.1%
keratocyte CL0002363

CSI 1.3

rCSI 3.1%

PRS 44.1%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.3

rCSI 1.7%

PRS 44.8%
natural T-regulatory cell CL0000903

CSI 1.3

rCSI 2.5%

PRS 69.0%
lung macrophage CL1001603

CSI 1.3

rCSI 2.9%

PRS 38.2%
inhibitory interneuron CL0000498

CSI 1.3

rCSI 3.0%

PRS 27.2%
alveolar type 1 fibroblast cell CL4028004

CSI 1.4

rCSI 1.5%

PRS 36.5%
myeloid leukocyte CL0000766

CSI 1.4

rCSI 1.3%

PRS 34.0%
pulmonary artery endothelial cell CL1001568

CSI 1.4

rCSI 1.9%

PRS 45.4%
Hofbauer cell CL3000001

CSI 1.4

rCSI 2.6%

PRS 41.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RFC1](/details-gene/5981) encodes the large subunit of Replication Factor C (RFC), a heteropentameric protein complex essential for eukaryotic DNA metabolism. The RFC complex functions as a "clamp loader," utilizing ATP hydrolysis to load the Proliferating Cell Nuclear Antigen (PCNA) sliding clamp onto DNA. This action is a prerequisite for processive DNA synthesis by DNA polymerases during replication and repair. Its clinical association is noted in OMIM ([102579](https://omim.org/entry/102579)). Reflecting its fundamental role, [RFC1](/details-gene/5981) shows significant expression in a diverse range of cell types. **Overall**, it is a key marker in immune cells such as [helper T cells](/details-cell/CL0000912) and [dendritic cells](/details-cell/CL0001056), as well as in specialized, long-lived cells like [retinal cone cells](/details-cell/CL0000573) and certain epithelial cells, highlighting its critical function in both cellular proliferation and genomic maintenance. ## Cellular Roles and Expression Landscape The expression profile of [RFC1](/details-gene/5981) underscores its indispensable role in cellular processes requiring high genomic fidelity. **Overall**, the gene exhibits high significance in multiple lineages of the adaptive and innate immune systems, including [helper T cells](/details-cell/CL0000912), [activated CD4-positive, alpha-beta T cells](/details-cell/CL0000896), and various dendritic cell populations such as [common dendritic progenitors](/details-cell/CL0001029). This pattern is consistent with the extensive DNA replication required for clonal expansion during an immune response and the ongoing DNA repair needed to maintain lymphocyte integrity. Beyond the immune system, [RFC1](/details-gene/5981) is notably significant in cell types with distinct biological demands. Its highest overall significance is observed in [retinal cone cells](/details-cell/CL0000573), which are terminally differentiated and do not proliferate. This suggests that in such post-mitotic cells, the primary role of [RFC1](/details-gene/5981) is likely centered on DNA repair and genome maintenance rather than replication. Similarly, high significance in [kidney loop of Henle thin descending limb epithelial cells](/details-cell/CL1001111) and [astrocytes of the cerebral cortex](/details-cell/CL0002605) may point to a crucial function in preserving genomic stability in tissues with specific metabolic stresses or long lifespans. Its presence in high-turnover tissues, such as in [small intestine goblet cells](/details-cell/CL1000495), further supports its canonical role in DNA replication. ## Pathways and Molecular Function [RFC1](/details-gene/5981) is functionally integral to a vast network of pathways governing genome dynamics. As the primary subunit of the RFC complex, its core molecular function is [DNA clamp loader activity](/details-go/GO0003689), which is essential for loading PCNA onto DNA [Link](https://doi.org/10.1074/jbc.272.3.1769). This activity is dependent on its ability to bind and hydrolyze ATP ([GO:0005524](https://www.ebi.ac.uk/QuickGO/term/GO:0005524), [GO:0016887](https://www.ebi.ac.uk/QuickGO/term/GO:0016887)) and to recognize specific DNA structures via its N-terminal DNA binding domain [Link](https://doi.org/10.1093/nar/26.17.3877). The gene's involvement is most prominent in the [Cell cycle](/details-reactome/R-HSA-1640170), particularly during [S phase](/details-reactome/R-HSA-69242) for [Dna-templated dna replication](/details-go/GO0006261). It is a key component of the machinery for both [Leading strand synthesis](/details-reactome/R-HSA-69109) and [Lagging strand synthesis](/details-reactome/R-HSA-69186). Furthermore, [RFC1](/details-gene/5981) is a central player in virtually all major [Dna repair](/details-go/GO0006281) pathways. Reactome analysis shows its participation in [Base excision repair](/details-reactome/R-HSA-73884), [Nucleotide excision repair](/details-reactome/R-HSA-5696398), and [Homology directed repair](/details-reactome/R-HSA-5693538) of double-strand breaks. This extensive involvement in DNA damage response explains its high significance in non-proliferating cells like neurons, where maintaining genomic integrity over the organism's lifespan is paramount. The gene also contributes to [Telomere maintenance](/details-go/GO0007004), specifically in the [Extension of telomeres](/details-reactome/R-HSA-180786), a process critical for preventing replicative senescence in proliferating cell populations like lymphocytes. ## Research Directions The broad yet specific expression pattern of [RFC1](/details-gene/5981) suggests several avenues for future investigation, particularly concerning its roles in tissue homeostasis, aging, and disease. **Proposed Hypotheses:** 1. Given its top significance in post-mitotic [retinal cone cells](/details-cell/CL0000573) and its critical role in multiple DNA repair pathways, [RFC1](/details-gene/5981) may function as a master regulator of genomic integrity in the retina. Age-related decline in its expression or function could be a key contributor to the accumulation of DNA damage that underlies retinal degenerative diseases. 2. The high significance of [RFC1](/details-gene/5981) in both progenitor ([common dendritic progenitor](/details-cell/CL0001029)) and mature immune cells ([helper T cell](/details-cell/CL0000912)) suggests that its activity level is a critical determinant of immunological fitness. Subtle variations in [RFC1](/details-gene/5981) function may dictate the efficiency of both hematopoietic output and the subsequent clonal expansion required for effective adaptive immunity. **Suggested Experimental Approach:** To test the hypothesis regarding the role of [RFC1](/details-gene/5981) in retinal health (Hypothesis 1), a conditional knockout mouse model could be developed using a cone-specific Cre driver (e.g., *Opn1mw-Cre*) to delete [RFC1](/details-gene/5981) specifically in cone photoreceptors. These mice would be subjected to aging studies and functional assessments, including electroretinography (ERG) to measure retinal function and optical coherence tomography (OCT) to monitor retinal structure. At the molecular level, isolated cone cells could be analyzed for markers of DNA damage (e.g., γH2AX foci), apoptosis, and transcriptional dysregulation using immunohistochemistry and single-cell RNA sequencing. **Therapeutic Potential:** As a cornerstone of DNA replication, [RFC1](/details-gene/5981) represents a compelling, albeit challenging, therapeutic target in oncology. Inhibition of [RFC1](/details-gene/5981) would be expected to induce cell cycle arrest and apoptosis preferentially in rapidly dividing cancer cells. However, its essential role in healthy proliferating tissues (e.g., bone marrow, intestinal epithelium) predicts a narrow therapeutic window and high potential for on-target toxicity with systemic administration. A viable strategy might involve developing small molecule inhibitors for use in synthetic lethality approaches, for example, in combination with DNA-damaging agents or PARP inhibitors in tumors with specific DNA repair deficiencies. Thus, inhibition, rather than activation, would be the therapeutic goal, likely requiring highly targeted delivery systems to mitigate systemic side effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Replication factor C subunit 1

Genular Protein ID: 4003709449

Symbol: RFC1_HUMAN

Name: Replication factor C subunit 1

UniProtKB Accession Codes:

P35251 A8K6E7 Q5XKF5 Q6PKU0 Q86V41 Q86V46

Database IDs:

Citations:

PubMed ID: 8248204

Title: cDNAs encoding the large subunit of human replication factor C.

PubMed ID: 8248204

DOI: 10.1073/pnas.90.23.11014

PubMed ID: 8512577

Title: Cloning and expression of a novel human DNA binding protein, PO-GA.

PubMed ID: 8512577

DOI: 10.1006/bbrc.1993.1693

PubMed ID: 7914507

Title: The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA.

PubMed ID: 7914507

DOI: 10.1016/0378-1119(94)90017-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999859

Title: Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen.

PubMed ID: 8999859

DOI: 10.1074/jbc.272.3.1769

PubMed ID: 9705493

Title: DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C.

PubMed ID: 9705493

DOI: 10.1093/nar/26.17.3877

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 31230722

Title: Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS.

PubMed ID: 31230722

DOI: 10.1016/j.ajhg.2019.05.016

PubMed ID: 30926972

Title: Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia.

PubMed ID: 30926972

DOI: 10.1038/s41588-019-0372-4

Sequence Information:

Length: 1148
Mass: 128255
Checksum: 485F0332FB56819B
Sequence:

MDIRKFFGVI PSGKKLVSET VKKNEKTKSD EETLKAKKGI KEIKVNSSRK EDDFKQKQPS 
KKKRIIYDSD SESEETLQVK NAKKPPEKLP VSSKPGKISR QDPVTYISET DEEDDFMCKK 
AASKSKENGR STNSHLGTSN MKKNEENTKT KNKPLSPIKL TPTSVLDYFG TGSVQRSNKK 
MVASKRKELS QNTDESGLND EAIAKQLQLD EDAELERQLH EDEEFARTLA MLDEEPKTKK 
ARKDTEAGET FSSVQANLSK AEKHKYPHKV KTAQVSDERK SYSPRKQSKY ESSKESQQHS 
KSSADKIGEV SSPKASSKLA IMKRKEESSY KEIEPVASKR KENAIKLKGE TKTPKKTKSS 
PAKKESVSPE DSEKKRTNYQ AYRSYLNREG PKALGSKEIP KGAENCLEGL IFVITGVLES 
IERDEAKSLI ERYGGKVTGN VSKKTNYLVM GRDSGQSKSD KAAALGTKII DEDGLLNLIR 
TMPGKKSKYE IAVETEMKKE SKLERTPQKN VQGKRKISPS KKESESKKSR PTSKRDSLAK 
TIKKETDVFW KSLDFKEQVA EETSGDSKAR NLADDSSENK VENLLWVDKY KPTSLKTIIG 
QQGDQSCANK LLRWLRNWQK SSSEDKKHAA KFGKFSGKDD GSSFKAALLS GPPGVGKTTT 
ASLVCQELGY SYVELNASDT RSKSSLKAIV AESLNNTSIK GFYSNGAASS VSTKHALIMD 
EVDGMAGNED RGGIQELIGL IKHTKIPIIC MCNDRNHPKI RSLVHYCFDL RFQRPRVEQI 
KGAMMSIAFK EGLKIPPPAM NEIILGANQD IRQVLHNLSM WCARSKALTY DQAKADSHRA 
KKDIKMGPFD VARKVFAAGE ETAHMSLVDK SDLFFHDYSI APLFVQENYI HVKPVAAGGD 
MKKHLMLLSR AADSICDGDL VDSQIRSKQN WSLLPAQAIY ASVLPGELMR GYMTQFPTFP 
SWLGKHSSTG KHDRIVQDLA LHMSLRTYSS KRTVNMDYLS LLRDALVQPL TSQGVDGVQD 
VVALMDTYYL MKEDFENIME ISSWGGKPSP FSKLDPKVKA AFTRAYNKEA HLTPYSLQAI 
KASRHSTSPS LDSEYNEELN EDDSQSDEKD QDAIETDAMI KKKTKSSKPS KPEKDKEPRK 
GKGKSSKK

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: RFC1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

cDNAs encoding the large subunit of human replication factor C. PubMed ID: 8248204

Cloning and expression of a novel human DNA binding protein, PO-GA. PubMed ID: 8512577

The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA. PubMed ID: 7914507

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. PubMed ID: 8999859

DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C. PubMed ID: 9705493

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS. PubMed ID: 31230722

Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia. PubMed ID: 30926972