RFC1 | ENSG00000035928 | NCBI 5981

Details for: RFC1

Gene ID: 5981

Symbol: RFC1

Ensembl ID: ENSG00000035928

Description: replication factor C subunit 1

Associated with

Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromosome maintenance
(R-HSA-73886)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna replication
(R-HSA-69306)
Dna strand elongation
(R-HSA-69190)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Extension of telomeres
(R-HSA-180786)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-HSA-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Lagging strand synthesis
(R-HSA-69186)
Leading strand synthesis
(R-HSA-69109)
Nucleotide excision repair
(R-HSA-5696398)
Pcna-dependent long patch base excision repair
(R-HSA-5651801)
Polymerase switching
(R-HSA-69091)
Polymerase switching on the c-strand of the telomere
(R-HSA-174411)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-HSA-110373)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Telomere maintenance
(R-HSA-157579)
Termination of translesion dna synthesis
(R-HSA-5656169)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Translesion synthesis by polh
(R-HSA-110320)
Translesion synthesis by poli
(R-HSA-5656121)
Translesion synthesis by polk
(R-HSA-5655862)
Translesion synthesis by rev1
(R-HSA-110312)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated dna replication
(GO:0006261)
Dna binding
(GO:0003677)
Dna clamp loader activity
(GO:0003689)
Dna clamp unloader activity
(GO:0061860)
Dna clamp unloading
(GO:0090618)
Dna repair
(GO:0006281)
Dna replication factor c complex
(GO:0005663)
Double-stranded dna binding
(GO:0003690)
Elg1 rfc-like complex
(GO:0031391)
Enzyme activator activity
(GO:0008047)
Extracellular exosome
(GO:0070062)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Sequence-specific dna binding
(GO:0043565)
Telomere maintenance via telomerase
(GO:0007004)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 285.8333
Cell Significance Index: -44.4600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 183.8014
Cell Significance Index: -46.6200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 120.7102
Cell Significance Index: -56.9900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 114.8534
Cell Significance Index: -46.6600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 104.7464
Cell Significance Index: -53.8800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 49.2593
Cell Significance Index: -47.0300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 44.0000
Cell Significance Index: -54.2500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.9264
Cell Significance Index: -53.3800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.1255
Cell Significance Index: -55.7400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.5864
Cell Significance Index: -41.7300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.6331
Cell Significance Index: -25.4600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9314
Cell Significance Index: 383.3000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.7659
Cell Significance Index: 208.2500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.7095
Cell Significance Index: 102.6300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4100
Cell Significance Index: 193.6300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.3314
Cell Significance Index: 69.3500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.2852
Cell Significance Index: 231.6800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2724
Cell Significance Index: 156.4600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.1374
Cell Significance Index: 30.3700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8994
Cell Significance Index: 812.1200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8706
Cell Significance Index: 384.9300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8264
Cell Significance Index: 165.7700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7880
Cell Significance Index: 430.3300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7679
Cell Significance Index: 22.1300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7462
Cell Significance Index: 34.7900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7300
Cell Significance Index: 50.4800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6688
Cell Significance Index: 37.5300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6085
Cell Significance Index: 218.2500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5923
Cell Significance Index: 101.1500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5801
Cell Significance Index: 41.0300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5745
Cell Significance Index: 37.0700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5323
Cell Significance Index: 32.7200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5082
Cell Significance Index: 65.1500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4754
Cell Significance Index: 21.5500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4571
Cell Significance Index: 28.8100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4238
Cell Significance Index: 41.9200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3544
Cell Significance Index: 18.4100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3531
Cell Significance Index: 16.6000
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3510
Cell Significance Index: 6.8500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3235
Cell Significance Index: 223.7600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2680
Cell Significance Index: 51.0100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2538
Cell Significance Index: 13.3300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2301
Cell Significance Index: 433.3300
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2231
Cell Significance Index: 2.6600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2136
Cell Significance Index: 5.8200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1602
Cell Significance Index: 1.4800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1563
Cell Significance Index: 5.4300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0894
Cell Significance Index: 56.8100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0860
Cell Significance Index: 6.6000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0727
Cell Significance Index: 9.4000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0712
Cell Significance Index: 109.5500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0699
Cell Significance Index: 128.8300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0579
Cell Significance Index: 78.6900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0249
Cell Significance Index: 0.8800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0244
Cell Significance Index: 11.0900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0182
Cell Significance Index: 13.3500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0015
Cell Significance Index: -0.1100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0037
Cell Significance Index: -2.8100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0278
Cell Significance Index: -20.5800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0316
Cell Significance Index: -0.8300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0479
Cell Significance Index: -1.3400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0491
Cell Significance Index: -30.6500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0554
Cell Significance Index: -1.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0594
Cell Significance Index: -33.5200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0899
Cell Significance Index: -9.1800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1255
Cell Significance Index: -2.1000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1319
Cell Significance Index: -27.7900
Cell Name: peg cell (CL4033014)
Fold Change: -0.1359
Cell Significance Index: -3.1400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1587
Cell Significance Index: -45.6800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1764
Cell Significance Index: -25.6400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1797
Cell Significance Index: -20.5900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2619
Cell Significance Index: -17.6100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3100
Cell Significance Index: -36.1300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3324
Cell Significance Index: -8.3100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3801
Cell Significance Index: -10.1900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3864
Cell Significance Index: -44.1100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3891
Cell Significance Index: -40.5100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4280
Cell Significance Index: -5.8400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4716
Cell Significance Index: -11.3100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4749
Cell Significance Index: -37.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5030
Cell Significance Index: -22.2500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6102
Cell Significance Index: -19.5500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6404
Cell Significance Index: -16.3600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6465
Cell Significance Index: -24.4800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.6498
Cell Significance Index: -19.0900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6733
Cell Significance Index: -34.0300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.7026
Cell Significance Index: -12.0400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7074
Cell Significance Index: -10.6000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8302
Cell Significance Index: -50.9000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.8324
Cell Significance Index: -23.8600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.9273
Cell Significance Index: -15.6200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.0255
Cell Significance Index: -21.8400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0321
Cell Significance Index: -26.5300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.0525
Cell Significance Index: -31.0000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.2163
Cell Significance Index: -32.5400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.2227
Cell Significance Index: -26.4900
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.2587
Cell Significance Index: -15.6100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.2602
Cell Significance Index: -46.2600
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.2675
Cell Significance Index: -9.7700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.2841
Cell Significance Index: -18.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **DNA Replication:** RFC1 is a key component of the RFC complex, which is responsible for loading DNA polymerase α onto the template strands during DNA replication. This process is essential for the accurate and efficient replication of DNA. 2. **DNA Repair:** RFC1 is involved in various DNA repair pathways, including base excision repair, nucleotide excision repair, and homologous recombination repair. These pathways are critical for maintaining genome stability and preventing mutations and cancer. 3. **Cell Cycle Regulation:** RFC1 is also involved in regulating the cell cycle, particularly during the S phase, when DNA replication occurs. Dysregulation of RFC1 can lead to abnormal cell cycle progression and increased risk of cancer. 4. **Protein Binding:** RFC1 interacts with various proteins, including DNA polymerase α, PCNA, and other replication and repair enzymes, to facilitate DNA replication and repair. **Pathways and Functions:** 1. **DNA Replication:** RFC1 is involved in the loading of DNA polymerase α onto the template strands during DNA replication. This process is essential for the accurate and efficient replication of DNA. 2. **Base Excision Repair:** RFC1 is involved in the base excision repair pathway, which repairs damaged bases in DNA. 3. **Nucleotide Excision Repair:** RFC1 is involved in the nucleotide excision repair pathway, which repairs large DNA lesions, such as those caused by ultraviolet light. 4. **Homologous Recombination Repair:** RFC1 is involved in the homologous recombination repair pathway, which repairs double-strand breaks in DNA. 5. **Cell Cycle Regulation:** RFC1 regulates the cell cycle, particularly during the S phase, when DNA replication occurs. 6. **Protein Binding:** RFC1 interacts with various proteins, including DNA polymerase α, PCNA, and other replication and repair enzymes, to facilitate DNA replication and repair. **Clinical Significance:** 1. **Cancer:** Dysregulation of RFC1 has been implicated in various types of cancer, including breast cancer, ovarian cancer, and colon cancer. 2. **Neurodegenerative Disorders:** RFC1 has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunodeficiency Diseases:** Dysregulation of RFC1 has been implicated in immunodeficiency diseases, such as X-linked agammaglobulinemia. 4. **Genetic Disorders:** RFC1 has been implicated in genetic disorders, such as Fanconi anemia and Bloom syndrome. In conclusion, the RFC1 gene plays a critical role in DNA replication and repair, and dysregulation of this gene has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which RFC1 regulates DNA replication and repair and to develop therapeutic strategies to target RFC1 in the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Replication factor C subunit 1

Genular Protein ID: 4003709449

Symbol: RFC1_HUMAN

Name: Replication factor C subunit 1

UniProtKB Accession Codes:

P35251 A8K6E7 Q5XKF5 Q6PKU0 Q86V41 Q86V46

Database IDs:

Citations:

PubMed ID: 8248204

Title: cDNAs encoding the large subunit of human replication factor C.

PubMed ID: 8248204

DOI: 10.1073/pnas.90.23.11014

PubMed ID: 8512577

Title: Cloning and expression of a novel human DNA binding protein, PO-GA.

PubMed ID: 8512577

DOI: 10.1006/bbrc.1993.1693

PubMed ID: 7914507

Title: The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA.

PubMed ID: 7914507

DOI: 10.1016/0378-1119(94)90017-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8999859

Title: Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen.

PubMed ID: 8999859

DOI: 10.1074/jbc.272.3.1769

PubMed ID: 9705493

Title: DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C.

PubMed ID: 9705493

DOI: 10.1093/nar/26.17.3877

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 31230722

Title: Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS.

PubMed ID: 31230722

DOI: 10.1016/j.ajhg.2019.05.016

PubMed ID: 30926972

Title: Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia.

PubMed ID: 30926972

DOI: 10.1038/s41588-019-0372-4

Sequence Information:

Length: 1148
Mass: 128255
Checksum: 485F0332FB56819B
Sequence:

MDIRKFFGVI PSGKKLVSET VKKNEKTKSD EETLKAKKGI KEIKVNSSRK EDDFKQKQPS 
KKKRIIYDSD SESEETLQVK NAKKPPEKLP VSSKPGKISR QDPVTYISET DEEDDFMCKK 
AASKSKENGR STNSHLGTSN MKKNEENTKT KNKPLSPIKL TPTSVLDYFG TGSVQRSNKK 
MVASKRKELS QNTDESGLND EAIAKQLQLD EDAELERQLH EDEEFARTLA MLDEEPKTKK 
ARKDTEAGET FSSVQANLSK AEKHKYPHKV KTAQVSDERK SYSPRKQSKY ESSKESQQHS 
KSSADKIGEV SSPKASSKLA IMKRKEESSY KEIEPVASKR KENAIKLKGE TKTPKKTKSS 
PAKKESVSPE DSEKKRTNYQ AYRSYLNREG PKALGSKEIP KGAENCLEGL IFVITGVLES 
IERDEAKSLI ERYGGKVTGN VSKKTNYLVM GRDSGQSKSD KAAALGTKII DEDGLLNLIR 
TMPGKKSKYE IAVETEMKKE SKLERTPQKN VQGKRKISPS KKESESKKSR PTSKRDSLAK 
TIKKETDVFW KSLDFKEQVA EETSGDSKAR NLADDSSENK VENLLWVDKY KPTSLKTIIG 
QQGDQSCANK LLRWLRNWQK SSSEDKKHAA KFGKFSGKDD GSSFKAALLS GPPGVGKTTT 
ASLVCQELGY SYVELNASDT RSKSSLKAIV AESLNNTSIK GFYSNGAASS VSTKHALIMD 
EVDGMAGNED RGGIQELIGL IKHTKIPIIC MCNDRNHPKI RSLVHYCFDL RFQRPRVEQI 
KGAMMSIAFK EGLKIPPPAM NEIILGANQD IRQVLHNLSM WCARSKALTY DQAKADSHRA 
KKDIKMGPFD VARKVFAAGE ETAHMSLVDK SDLFFHDYSI APLFVQENYI HVKPVAAGGD 
MKKHLMLLSR AADSICDGDL VDSQIRSKQN WSLLPAQAIY ASVLPGELMR GYMTQFPTFP 
SWLGKHSSTG KHDRIVQDLA LHMSLRTYSS KRTVNMDYLS LLRDALVQPL TSQGVDGVQD 
VVALMDTYYL MKEDFENIME ISSWGGKPSP FSKLDPKVKA AFTRAYNKEA HLTPYSLQAI 
KASRHSTSPS LDSEYNEELN EDDSQSDEKD QDAIETDAMI KKKTKSSKPS KPEKDKEPRK 
GKGKSSKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RFC1

Associated with

Cells (max top 100)

Other Information

cDNAs encoding the large subunit of human replication factor C. PubMed ID: 8248204

Cloning and expression of a novel human DNA binding protein, PO-GA. PubMed ID: 8512577

The human DNA-binding protein, PO-GA, is homologous to the large subunit of mouse replication factor C: regulation by alternate 3' processing of mRNA. PubMed ID: 7914507

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. PubMed ID: 8999859

DNA recognition properties of the N-terminal DNA binding domain within the large subunit of replication factor C. PubMed ID: 9705493

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS. PubMed ID: 31230722

Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia. PubMed ID: 30926972