RFC2 | ENSG00000049541 | NCBI 5982

Details for: RFC2

Gene ID: 5982

Symbol: RFC2

Ensembl ID: ENSG00000049541

Description: replication factor C subunit 2

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chromosome maintenance
(R-HSA-73886)
Defective homologous recombination repair (hrr) due to brca2 loss of function
(R-HSA-9701190)
Disease
(R-HSA-1643685)
Diseases of dna double-strand break repair
(R-HSA-9675136)
Diseases of dna repair
(R-HSA-9675135)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna replication
(R-HSA-69306)
Dna strand elongation
(R-HSA-69190)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Extension of telomeres
(R-HSA-180786)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-HSA-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Hdr through single strand annealing (ssa)
(R-HSA-5685938)
Homologous dna pairing and strand exchange
(R-HSA-5693579)
Homology directed repair
(R-HSA-5693538)
Impaired brca2 binding to rad51
(R-HSA-9709570)
Lagging strand synthesis
(R-HSA-69186)
Leading strand synthesis
(R-HSA-69109)
Nucleotide excision repair
(R-HSA-5696398)
Pcna-dependent long patch base excision repair
(R-HSA-5651801)
Polymerase switching
(R-HSA-69091)
Polymerase switching on the c-strand of the telomere
(R-HSA-174411)
Presynaptic phase of homologous dna pairing and strand exchange
(R-HSA-5693616)
Processing of dna double-strand break ends
(R-HSA-5693607)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-HSA-110373)
Rna polymerase ii transcription
(R-HSA-73857)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Telomere maintenance
(R-HSA-157579)
Termination of translesion dna synthesis
(R-HSA-5656169)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translesion synthesis by polh
(R-HSA-110320)
Translesion synthesis by poli
(R-HSA-5656121)
Translesion synthesis by polk
(R-HSA-5655862)
Translesion synthesis by rev1
(R-HSA-110312)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Ctf18 rfc-like complex
(GO:0031390)
Dna-templated dna replication
(GO:0006261)
Dna binding
(GO:0003677)
Dna clamp loader activity
(GO:0003689)
Dna duplex unwinding
(GO:0032508)
Dna repair
(GO:0006281)
Dna replication factor c complex
(GO:0005663)
Enzyme binding
(GO:0019899)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-directed dna polymerase activity
(GO:1900264)
Protein binding
(GO:0005515)
Single-stranded dna helicase activity
(GO:0017116)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 94.3777
Cell Significance Index: -14.6800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 61.6220
Cell Significance Index: -15.6300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 46.7251
Cell Significance Index: -22.0600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 43.1992
Cell Significance Index: -17.5500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 39.8923
Cell Significance Index: -20.5200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.4448
Cell Significance Index: -17.6100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.6453
Cell Significance Index: -19.2900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.1776
Cell Significance Index: -13.8700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.1013
Cell Significance Index: -20.1300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.0958
Cell Significance Index: 207.3200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.3448
Cell Significance Index: 14.6200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.2108
Cell Significance Index: 72.6900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0564
Cell Significance Index: 114.9100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.8907
Cell Significance Index: 30.9500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8769
Cell Significance Index: 103.4100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8480
Cell Significance Index: 137.9300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7498
Cell Significance Index: 676.9800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6463
Cell Significance Index: 75.3200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6447
Cell Significance Index: 41.5900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5203
Cell Significance Index: 10.8900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4574
Cell Significance Index: 6.2400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3632
Cell Significance Index: 72.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3611
Cell Significance Index: 24.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3405
Cell Significance Index: 150.5500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3163
Cell Significance Index: 172.7300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2932
Cell Significance Index: 9.3900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2900
Cell Significance Index: 39.8200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2655
Cell Significance Index: 7.4200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2495
Cell Significance Index: 6.7900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2431
Cell Significance Index: 15.3200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2397
Cell Significance Index: 16.9500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2248
Cell Significance Index: 5.9100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2207
Cell Significance Index: 27.1400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2202
Cell Significance Index: 5.8900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1790
Cell Significance Index: 35.9000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1676
Cell Significance Index: 30.2100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1513
Cell Significance Index: 7.8600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1428
Cell Significance Index: 6.6600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1422
Cell Significance Index: 98.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1407
Cell Significance Index: 4.0600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1265
Cell Significance Index: 2.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1251
Cell Significance Index: 7.0200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1151
Cell Significance Index: 6.0500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1020
Cell Significance Index: 7.6000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0817
Cell Significance Index: 15.5400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0777
Cell Significance Index: 10.0400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0739
Cell Significance Index: 26.5100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0736
Cell Significance Index: 9.4300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0506
Cell Significance Index: 2.3800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0384
Cell Significance Index: 6.5700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0210
Cell Significance Index: 0.5600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0169
Cell Significance Index: 0.1800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0090
Cell Significance Index: 0.1500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0061
Cell Significance Index: 0.1300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0031
Cell Significance Index: 0.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0011
Cell Significance Index: 2.1500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0040
Cell Significance Index: -2.4700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0040
Cell Significance Index: -6.1300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0052
Cell Significance Index: -9.5100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0055
Cell Significance Index: -4.0700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0101
Cell Significance Index: -13.6800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0108
Cell Significance Index: -0.2700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0110
Cell Significance Index: -8.3200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0142
Cell Significance Index: -1.4500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0148
Cell Significance Index: -9.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0175
Cell Significance Index: -9.8500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0180
Cell Significance Index: -0.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0182
Cell Significance Index: -13.3200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0336
Cell Significance Index: -3.8500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0344
Cell Significance Index: -15.6200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0382
Cell Significance Index: -1.7300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0503
Cell Significance Index: -10.5900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0686
Cell Significance Index: -9.9700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0705
Cell Significance Index: -2.0700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0720
Cell Significance Index: -20.7300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0842
Cell Significance Index: -5.1800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1150
Cell Significance Index: -13.1300
Cell Name: glioblast (CL0000030)
Fold Change: -0.1178
Cell Significance Index: -0.7400
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1312
Cell Significance Index: -1.0700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1396
Cell Significance Index: -8.5600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1641
Cell Significance Index: -12.5900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1884
Cell Significance Index: -19.6200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2280
Cell Significance Index: -18.0600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2336
Cell Significance Index: -3.5200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2479
Cell Significance Index: -16.6700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2772
Cell Significance Index: -14.4400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2990
Cell Significance Index: -8.5700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3147
Cell Significance Index: -4.0300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3222
Cell Significance Index: -9.4900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3523
Cell Significance Index: -15.5900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3595
Cell Significance Index: -6.1600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3694
Cell Significance Index: -9.5000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4224
Cell Significance Index: -9.2500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4275
Cell Significance Index: -16.1900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.4595
Cell Significance Index: -3.8600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4723
Cell Significance Index: -5.6300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4813
Cell Significance Index: -17.6700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4864
Cell Significance Index: -17.0400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4966
Cell Significance Index: -16.2600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4978
Cell Significance Index: -9.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RFC2 is a subunit of the RFC complex, which is composed of four subunits (α, β, γ, and δ). The RFC complex is responsible for loading single-stranded DNA (ssDNA) onto the DNA polymerase ε complex, allowing for the efficient synthesis of leading-strand DNA during DNA replication. RFC2 is also involved in the repair of DNA double-strand breaks through homologous recombination (HR) and non-homologous end joining (NHEJ). Additionally, RFC2 plays a role in the maintenance of telomeres by facilitating the synthesis of telomere c-strand (lagging strand) DNA. **Pathways and Functions** RFC2 is involved in various cellular pathways, including: 1. **DNA Replication**: RFC2 is essential for the efficient progression of DNA replication through the cell cycle. 2. **Base Excision Repair (BER)**: RFC2 is involved in the repair of DNA damage through the BER pathway. 3. **Homologous Recombination Repair (HRR)**: RFC2 plays a role in the repair of DNA double-strand breaks through HRR. 4. **Telomere Maintenance**: RFC2 facilitates the synthesis of telomere c-strand (lagging strand) DNA. 5. **Cell Cycle Checkpoints**: RFC2 is involved in the regulation of cell cycle checkpoints, including the G2/M checkpoint. 6. **DNA Damage Response**: RFC2 is activated in response to DNA damage, allowing for the efficient repair of DNA lesions. **Clinical Significance** Dysregulation of RFC2 has been implicated in various diseases, including: 1. **Cancer**: RFC2 mutations have been identified in certain types of cancer, including breast and ovarian cancer. 2. **Genetic Disorders**: RFC2 mutations have been associated with genetic disorders, including BRCA2-related disorders. 3. **Telomere Disorders**: RFC2 dysfunction has been implicated in telomere disorders, including telomere shortening and telomere-related diseases. 4. **DNA Repair Defects**: RFC2 mutations have been identified in individuals with DNA repair defects, including those with BRCA2 mutations. In conclusion, RFC2 is a crucial gene involved in DNA replication, repair, and maintenance. Its dysregulation has been implicated in various diseases, highlighting the importance of RFC2 in maintaining genomic stability. Further research is needed to fully understand the role of RFC2 in human disease and to develop therapeutic strategies to target RFC2 in cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 2073504482

Symbol: RFC2_HUMAN

Name: Replication factor C subunit 2

UniProtKB Accession Codes:

P35250 B5BU07 D3DXG3 P32846 Q9BU93

Database IDs:

Citations:

PubMed ID: 1313560

Title: Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells.

PubMed ID: 1313560

DOI: 10.1073/pnas.89.7.2516

PubMed ID: 11003705

Title: Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.

PubMed ID: 11003705

DOI: 10.1007/s003350010166

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15655353

Title: The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.

PubMed ID: 15655353

PubMed ID: 18499658

Title: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.

PubMed ID: 18499658

DOI: 10.1074/jbc.m802696200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 354
Mass: 39157
Checksum: B50AC8EEF89F64A9
Sequence:

MEVEAVCGGA GEVEAQDSDP APAFSKAPGS AGHYELPWVE KYRPVKLNEI VGNEDTVSRL 
EVFAREGNVP NIIIAGPPGT GKTTSILCLA RALLGPALKD AMLELNASND RGIDVVRNKI 
KMFAQQKVTL PKGRHKIIIL DEADSMTDGA QQALRRTMEI YSKTTRFALA CNASDKIIEP 
IQSRCAVLRY TKLTDAQILT RLMNVIEKER VPYTDDGLEA IIFTAQGDMR QALNNLQSTF 
SGFGFINSEN VFKVCDEPHP LLVKEMIQHC VNANIDEAYK ILAHLWHLGY SPEDIIGNIF 
RVCKTFQMAE YLKLEFIKEI GYTHMKIAEG VNSLLQMAGL LARLCQKTMA PVAS

Genular Protein ID: 1208500598

Symbol: A0A087WVY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVY3

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 251
Mass: 28377
Checksum: D094805B36DECB6D
Sequence:

MCPTSSLRGI DVVRNKIKMF AQQKVTLPKG RHKIIILDEA DSMTDGAQQA LRRTMEIYSK 
TTRFALACNA SDKIIEPIQS RCAVLRYTKL TDAQILTRLM NVIEKERVPY TDDGLEAIIF 
TAQGDMRQAL NNLQSTFSGF GFINSENVFK VCDEPHPLLV KEMIQHCVNA NIDEAYKILA 
HLWHLGYSPE DIIGNIFRVC KTFQMAEYLK LEFIKEIGYT HMKIAEGVNS LLQMAGLLAR 
LCQKTMAPVA S

Genular Protein ID: 2331664810

Symbol: Q75MT5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q75MT5

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

Length: 320
Mass: 35244
Checksum: D6E72DD28EA014E8
Sequence:

MEVEAVCGGA GEVEAQDSDP APAFSKAPGS AGHYELPWVE KYRPVKLNEI VGNEDTVSRL 
EVFAREGNVP NIIIAGPPGT GKTTSILCLA RALLGPALKD AMLELNASND SMTDGAQQAL 
RRTMEIYSKT TRFALACNAS DKIIEPIQSR CAVLRYTKLT DAQILTRLMN VIEKERVPYT 
DDGLEAIIFT AQGDMRQALN NLQSTFSGFG FINSENVFKV CDEPHPLLVK EMIQHCVNAN 
IDEAYKILAH LWHLGYSPED IIGNIFRVCK TFQMAEYLKL EFIKEIGYTH MKIAEGVNSL 
LQMAGLLARL CQKTMAPVAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RFC2

Associated with

Cells (max top 100)

Other Information

Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. PubMed ID: 1313560

Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. PubMed ID: 11003705

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. PubMed ID: 15655353

Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. PubMed ID: 18499658

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

The sequence of the human genome. PubMed ID: 11181995

The DNA sequence of human chromosome 7. PubMed ID: 12853948

Database document:

PubMed ID: 1313560

PubMed ID: 11003705

PubMed ID: 19054851

PubMed ID: 12853948

PubMed ID: 15489334

PubMed ID: 15655353

PubMed ID: 18499658

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 22223895

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 11237011

PubMed ID: 12853948

PubMed ID: 15496913

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 11181995

PubMed ID: 12853948