Details for: RGS10

Gene ID: 6001

Symbol: RGS10

Ensembl ID: ENSG00000148908

Description: regulator of G protein signaling 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.1800
    Cell Significance Index: -34.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 83.4572
    Cell Significance Index: -34.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.2805
    Cell Significance Index: -37.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.8698
    Cell Significance Index: -32.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.6974
    Cell Significance Index: -13.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 49.4432
    Cell Significance Index: -33.1800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.7961
    Cell Significance Index: -7.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.5347
    Cell Significance Index: -22.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0827
    Cell Significance Index: -34.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8087
    Cell Significance Index: -17.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8027
    Cell Significance Index: -30.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.3866
    Cell Significance Index: 128.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.2322
    Cell Significance Index: 59.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.7128
    Cell Significance Index: 127.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4635
    Cell Significance Index: 1345.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.3780
    Cell Significance Index: 63.6100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.2368
    Cell Significance Index: 11.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2244
    Cell Significance Index: 262.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.4382
    Cell Significance Index: 30.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1219
    Cell Significance Index: 154.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0965
    Cell Significance Index: 990.0600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0781
    Cell Significance Index: 10.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0724
    Cell Significance Index: 138.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0043
    Cell Significance Index: 99.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9257
    Cell Significance Index: 26.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8556
    Cell Significance Index: 93.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8337
    Cell Significance Index: 38.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8270
    Cell Significance Index: 49.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7855
    Cell Significance Index: 127.7600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.7309
    Cell Significance Index: 3.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6784
    Cell Significance Index: 50.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4786
    Cell Significance Index: 61.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3799
    Cell Significance Index: 26.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3629
    Cell Significance Index: 42.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3529
    Cell Significance Index: 156.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3475
    Cell Significance Index: 24.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2402
    Cell Significance Index: 8.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2069
    Cell Significance Index: 5.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1684
    Cell Significance Index: 32.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0997
    Cell Significance Index: 35.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0700
    Cell Significance Index: 12.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0679
    Cell Significance Index: 13.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0567
    Cell Significance Index: 6.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0404
    Cell Significance Index: 2.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0292
    Cell Significance Index: 18.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0040
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0186
    Cell Significance Index: -12.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0186
    Cell Significance Index: -34.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0189
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0221
    Cell Significance Index: -34.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0256
    Cell Significance Index: -34.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0347
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0351
    Cell Significance Index: -26.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0369
    Cell Significance Index: -20.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0419
    Cell Significance Index: -1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0489
    Cell Significance Index: -31.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0748
    Cell Significance Index: -33.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0816
    Cell Significance Index: -17.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0845
    Cell Significance Index: -14.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0854
    Cell Significance Index: -8.7300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0895
    Cell Significance Index: -0.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0948
    Cell Significance Index: -2.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1032
    Cell Significance Index: -29.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1090
    Cell Significance Index: -2.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1182
    Cell Significance Index: -3.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1207
    Cell Significance Index: -5.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1438
    Cell Significance Index: -28.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1575
    Cell Significance Index: -22.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1595
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1729
    Cell Significance Index: -2.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2171
    Cell Significance Index: -11.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2201
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2526
    Cell Significance Index: -28.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2635
    Cell Significance Index: -8.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2817
    Cell Significance Index: -32.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2861
    Cell Significance Index: -29.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3057
    Cell Significance Index: -4.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3119
    Cell Significance Index: -19.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3242
    Cell Significance Index: -2.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3412
    Cell Significance Index: -13.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3490
    Cell Significance Index: -7.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3528
    Cell Significance Index: -22.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3669
    Cell Significance Index: -29.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4207
    Cell Significance Index: -32.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4217
    Cell Significance Index: -2.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4734
    Cell Significance Index: -13.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4816
    Cell Significance Index: -32.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4881
    Cell Significance Index: -6.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4908
    Cell Significance Index: -30.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.5037
    Cell Significance Index: -3.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5099
    Cell Significance Index: -32.1400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5142
    Cell Significance Index: -4.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5442
    Cell Significance Index: -30.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5507
    Cell Significance Index: -16.2200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6242
    Cell Significance Index: -9.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6577
    Cell Significance Index: -34.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6657
    Cell Significance Index: -34.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS10 is a member of the regulator of G protein signaling (RGS) family, which is characterized by its ability to regulate G protein signaling by accelerating the GTP hydrolysis of Gα subunits. RGS10 is specifically expressed in various immune cells, including mature T cells, naive thymus-derived CD8-positive T cells, and eurydendroid cells. Its expression is also observed in non-immune cells, such as lung macrophages and blood cells. **Pathways and Functions:** RGS10 is involved in several signaling pathways, including G protein-coupled acetylcholine receptor signaling pathway, G protein-coupled receptor signaling pathway, and G protein-coupled receptor downstream signaling pathway. RGS10 acts as a negative regulator of G protein signaling by accelerating the GTP hydrolysis of Gα subunits, thereby modulating the activity of GPCRs. This regulation is essential for maintaining the balance of immune responses and preventing excessive inflammation. RGS10 also interacts with other proteins, such as Gβγ subunits and GTPase-activating proteins (GAPs), to regulate G protein signaling. These interactions are critical for modulating the activity of GPCRs and maintaining the homeostasis of immune responses. **Clinical Significance:** Dysregulation of RGS10 has been implicated in several immune-related disorders, including autoimmune diseases, allergies, and inflammatory conditions. For example, studies have shown that RGS10 expression is reduced in patients with rheumatoid arthritis, multiple sclerosis, and asthma. These findings suggest that RGS10 plays a crucial role in regulating immune responses and maintaining the balance of inflammation. Furthermore, RGS10 has been identified as a potential target for the treatment of immune-related disorders. For instance, small molecule inhibitors of RGS10 have been shown to modulate G protein signaling and reduce inflammation in animal models of autoimmune diseases. These findings suggest that RGS10 may be a promising therapeutic target for the treatment of immune-related disorders. In conclusion, RGS10 is a critical regulator of G protein signaling that plays a pivotal role in immune responses and signaling pathways. Its dysregulation has been implicated in several immune-related disorders, and its potential as a therapeutic target is an area of active research. Further studies are needed to fully understand the mechanisms of RGS10 and its role in immune-related diseases.

Genular Protein ID: 564087494

Symbol: RGS10_HUMAN

Name: Regulator of G-protein signaling 10

UniProtKB Accession Codes:

O43665 A8K408 B1AMR8 Q6IAZ6 Q96GN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8774883

Title: RGS10 is a selective activator of G alpha i GTPase activity.

PubMed ID: 8774883

DOI: 10.1038/383175a0

PubMed ID: 10791963

Title: Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.

PubMed ID: 10791963

DOI: 10.1074/jbc.m002082200

PubMed ID: 11443111

Title: Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).

PubMed ID: 11443111

DOI: 10.1074/jbc.m100960200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10608901

Title: Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.

PubMed ID: 10608901

DOI: 10.1074/jbc.274.53.38260

PubMed ID: 9353196

Title: Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.

PubMed ID: 9353196

DOI: 10.1126/science.278.5340.1132

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

Sequence Information:

  • Length: 181
  • Mass: 21210
  • Checksum: D83CCB98A6EE2182
  • Sequence:
    • MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ SLKSTAKWAA SLENLLEDPE GVKRFREFLK 
KEFSEENVLF WLACEDFKKM QDKTQMQEKA KEIYMTFLSS KASSQVNVEG QSRLNEKILE 
EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKHKRTEE EEEDLPDAQT AAKRASRIYN 
T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.