Details for: RHD

Gene ID: 6007

Symbol: RHD

Ensembl ID: ENSG00000187010

Description: Rh blood group D antigen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.0205
    Cell Significance Index: -9.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.2640
    Cell Significance Index: -7.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.9871
    Cell Significance Index: -2.4500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2640
    Cell Significance Index: 11.2200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7748
    Cell Significance Index: 4.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5931
    Cell Significance Index: 19.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4869
    Cell Significance Index: 70.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4791
    Cell Significance Index: 9.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4281
    Cell Significance Index: 16.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4110
    Cell Significance Index: 18.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3815
    Cell Significance Index: 75.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3194
    Cell Significance Index: 60.7800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2878
    Cell Significance Index: 1.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2859
    Cell Significance Index: 7.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2731
    Cell Significance Index: 4.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2280
    Cell Significance Index: 7.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2242
    Cell Significance Index: 44.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1882
    Cell Significance Index: 3.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1399
    Cell Significance Index: 7.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1396
    Cell Significance Index: 3.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1345
    Cell Significance Index: 8.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1136
    Cell Significance Index: 1.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1060
    Cell Significance Index: 95.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0949
    Cell Significance Index: 1.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0940
    Cell Significance Index: 9.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0901
    Cell Significance Index: 5.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0776
    Cell Significance Index: 5.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0672
    Cell Significance Index: 7.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0653
    Cell Significance Index: 100.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0608
    Cell Significance Index: 21.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0571
    Cell Significance Index: 107.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0458
    Cell Significance Index: 1.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0449
    Cell Significance Index: 12.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0443
    Cell Significance Index: 81.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0432
    Cell Significance Index: 7.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0424
    Cell Significance Index: 2.3800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0345
    Cell Significance Index: 0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0317
    Cell Significance Index: 20.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0300
    Cell Significance Index: 0.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0270
    Cell Significance Index: 36.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0059
    Cell Significance Index: 1.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0039
    Cell Significance Index: 0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0040
    Cell Significance Index: -1.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0040
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0042
    Cell Significance Index: -0.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0057
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0097
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0100
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0103
    Cell Significance Index: -7.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0103
    Cell Significance Index: -0.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0131
    Cell Significance Index: -7.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0147
    Cell Significance Index: -9.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0165
    Cell Significance Index: -2.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0184
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0198
    Cell Significance Index: -1.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0226
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0241
    Cell Significance Index: -4.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0276
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0355
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0403
    Cell Significance Index: -8.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0420
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0539
    Cell Significance Index: -6.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0590
    Cell Significance Index: -8.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0733
    Cell Significance Index: -7.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0738
    Cell Significance Index: -5.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0743
    Cell Significance Index: -7.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0838
    Cell Significance Index: -5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0842
    Cell Significance Index: -3.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0876
    Cell Significance Index: -1.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0949
    Cell Significance Index: -4.9300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1070
    Cell Significance Index: -1.5200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1083
    Cell Significance Index: -1.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1279
    Cell Significance Index: -8.2500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1325
    Cell Significance Index: -1.5000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1418
    Cell Significance Index: -1.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1440
    Cell Significance Index: -7.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1500
    Cell Significance Index: -3.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1533
    Cell Significance Index: -5.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1598
    Cell Significance Index: -5.0900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1671
    Cell Significance Index: -1.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1717
    Cell Significance Index: -5.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1719
    Cell Significance Index: -4.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1720
    Cell Significance Index: -9.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1828
    Cell Significance Index: -3.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1863
    Cell Significance Index: -2.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1921
    Cell Significance Index: -5.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1948
    Cell Significance Index: -5.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2087
    Cell Significance Index: -4.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2129
    Cell Significance Index: -4.2800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2153
    Cell Significance Index: -2.6900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2170
    Cell Significance Index: -3.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2200
    Cell Significance Index: -4.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2323
    Cell Significance Index: -3.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2349
    Cell Significance Index: -4.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2408
    Cell Significance Index: -8.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2413
    Cell Significance Index: -3.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2461
    Cell Significance Index: -6.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane glycoprotein**: RHD_HUMAN is a transmembrane glycoprotein, with a large extracellular domain that contains the RhD antigen. 2. **Glycosylation**: The RHD_HUMAN protein undergoes glycosylation, which is essential for the formation of the RhD antigen. 3. **Variable expression**: The RHD gene is expressed in various cell types, including erythrocytes, epithelial cells, and neural cells. 4. **Conserved expression**: The RHD gene is also expressed in the placenta and in cells of the immune system. **Pathways and Functions** 1. **Blood group systems biosynthesis**: The RHD gene is involved in the biosynthesis of the Rh blood group system, which is essential for the formation of the RhD antigen. 2. **Ammonium homeostasis**: The RHD gene is also involved in the regulation of ammonium homeostasis, which is essential for maintaining proper cellular function. 3. **Metabolism**: The RHD gene is involved in various metabolic pathways, including carbohydrate metabolism and metabolism of other nutrients. 4. **Cell-cell interactions**: The RHD protein plays a role in cell-cell interactions, including adhesion and signaling. **Clinical Significance** 1. **Rh incompatibility**: The RHD gene is responsible for the Rh blood group system, which is a major cause of hemolytic disease of the newborn (HDN) in Rh-negative mothers who receive Rh-positive blood during pregnancy. 2. **Transfusion medicine**: The RHD gene is essential for ensuring the compatibility of blood transfusions, as mismatched blood can lead to hemolytic reactions. 3. **Cancer and autoimmune diseases**: The RHD gene has been implicated in various cancers and autoimmune diseases, including multiple sclerosis and lupus. 4. **Neurological disorders**: The RHD gene has also been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the RHD gene plays a crucial role in the Rh blood group system and is involved in various cellular processes, including blood group systems biosynthesis, ammonium homeostasis, metabolism, and cell-cell interactions. Its dysregulation has significant clinical implications, including Rh incompatibility, transfusion medicine, and various diseases. Further research is needed to fully understand the functions and clinical significance of the RHD gene.

Genular Protein ID: 3007293221

Symbol: RHD_HUMAN

Name: Blood group Rh(D) polypeptide

UniProtKB Accession Codes:

Q02161 Q02162 Q07618 Q16147 Q16235 Q16355 Q5VSK0 Q5XLS9 Q5XLT1 Q5XLT2 Q9NPK0 Q9UQ20 Q9UQ21 Q9UQ22 Q9UQ23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 5 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SMR 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1438298

Title: Molecular cloning and primary structure of the human blood group RhD polypeptide.

PubMed ID: 1438298

DOI: 10.1073/pnas.89.22.10925

PubMed ID: 1379850

Title: Multiple Rh messenger RNA isoforms are produced by alternative splicing.

PubMed ID: 1379850

PubMed ID: 8329718

Title: Molecular cloning of RhD cDNA derived from a gene present in RhD-positive, but not RhD-negative individuals.

PubMed ID: 8329718

PubMed ID: 7916743

Title: Isolation of a new cDNA clone encoding an Rh polypeptide associated with the Rh blood group system.

PubMed ID: 7916743

DOI: 10.1007/bf00222717

PubMed ID: 8180407

Title: Identification of a new RhD-specific mRNA from K562 cells.

PubMed ID: 8180407

PubMed ID: 7606008

Title: Identification of a partial internal deletion in the RH locus causing the human erythrocyte D-phenotype.

PubMed ID: 7606008

PubMed ID: 8080999

Title: Rh(D) antigen expression and isolation of a new Rh(D) cDNA isoform in human erythroleukemic K562 cells.

PubMed ID: 8080999

PubMed ID: 16510313

Title: Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele.

PubMed ID: 16510313

DOI: 10.1016/j.transci.2005.10.001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 3146980

Title: Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane.

PubMed ID: 3146980

DOI: 10.1042/bj2561043

PubMed ID: 3131772

Title: Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes.

PubMed ID: 3131772

DOI: 10.1073/pnas.85.11.4042

PubMed ID: 3135863

Title: Determination of the N-terminal sequence of human red cell Rh(D) polypeptide and demonstration that the Rh(D), (c), and (E) antigens are carried by distinct polypeptide chains.

PubMed ID: 3135863

PubMed ID: 1898705

Title: Regarding the size of Rh proteins.

PubMed ID: 1898705

PubMed ID: 3142870

Title: The Rh polypeptide is a major fatty acid-acylated erythrocyte membrane protein.

PubMed ID: 3142870

DOI: 10.1016/s0021-9258(19)81344-3

PubMed ID: 1824267

Title: Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis.

PubMed ID: 1824267

PubMed ID: 1544931

Title: Mammalian red cell membrane Rh polypeptides are selectively palmitoylated subunits of a macromolecular complex.

PubMed ID: 1544931

DOI: 10.1016/s0021-9258(18)42803-7

PubMed ID: 9864185

Title: Molecular basis of weak D phenotypes.

PubMed ID: 9864185

PubMed ID: 10845894

Title: RHD gene deletion occurred in the Rhesus box.

PubMed ID: 10845894

PubMed ID: 10805260

Title: RhD haemolytic disease of the fetus and the newborn.

PubMed ID: 10805260

DOI: 10.1054/blre.1999.0123

PubMed ID: 7741145

Title: Leu110Pro substitution in the RhD polypeptide is responsible for the DVII category blood group phenotype.

PubMed ID: 7741145

DOI: 10.1002/ajh.2830490115

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 417
  • Mass: 45211
  • Checksum: 38721BFA664AE199
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMIG 
FQVLLSIGEL SLAIVIALMS GLLTGLLLNL KIWKAPHEAK YFDDQVFWKF PHLAVGF

Genular Protein ID: 3335593126

Symbol: Q1KT12_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q1KT12

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 17029192

Title: Study on the molecular background of Del phenotype in Chinese population.

PubMed ID: 17029192

Sequence Information:

  • Length: 417
  • Mass: 45164
  • Checksum: 8673376322123310
  • Sequence:
    • MSSKYPRSVR RCLPLWAPTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMIG 
FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHEAK YFDDQVFWKF PHLAVGF

Genular Protein ID: 4047634724

Symbol: Q9UPC8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UPC8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 165
  • Mass: 18141
  • Checksum: 85D3FBB113A49CAC
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTTT

Genular Protein ID: 3096663598

Symbol: Q5XLT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XLT0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 iPTMnet 1

Citations:

PubMed ID: 16510313

Title: Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele.

PubMed ID: 16510313

DOI: 10.1016/j.transci.2005.10.001

Sequence Information:

  • Length: 463
  • Mass: 50214
  • Checksum: 6DD1216A0AB85159
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMIG 
FQVLLSIGEL SLAIVIALTS GLLTVSSFGC WILSKSIQEK QGLFKNKTTS SHCCLHLYVR 
NAHDSKVSNV RAGTGVRENG VESFLCHSLR RISPFIMHCR IQQ

Genular Protein ID: 3004188668

Symbol: Q5XLT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XLT3

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 2 Gene3D 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16510313

Title: Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele.

PubMed ID: 16510313

DOI: 10.1016/j.transci.2005.10.001

Sequence Information:

  • Length: 321
  • Mass: 34837
  • Checksum: 79E9FB671F8F84E8
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPFPHLAVG F

Genular Protein ID: 3261114734

Symbol: B4DLT8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLT8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 8 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 382
  • Mass: 41341
  • Checksum: 49A54FC0C218EC08
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMWV 
TGLTPHPLNT PLQLRKKCVQ SP

Genular Protein ID: 807178860

Symbol: Q5XLS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XLS8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 16510313

Title: Multiple isoforms excluding normal RhD mRNA detected in Rh blood group Del phenotype with RHD 1227A allele.

PubMed ID: 16510313

DOI: 10.1016/j.transci.2005.10.001

Sequence Information:

  • Length: 431
  • Mass: 46335
  • Checksum: 42215654ECD242F2
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMSL 
GWNLAVKMAE AGDEELMRLD VSQRNHGGAA VPTGSWMPST ETTIAPNYRD HISVGLASRP 
SSALGNSAWP S

Genular Protein ID: 3621451738

Symbol: Q7RU08_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7RU08

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 49 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 9864185

Title: Molecular basis of weak D phenotypes.

PubMed ID: 9864185

PubMed ID: 10845894

Title: RHD gene deletion occurred in the Rhesus box.

PubMed ID: 10845894

PubMed ID: 11902138

Title: RHCE represents the ancestral RH position, while RHD is the duplicated gene.

PubMed ID: 11902138

DOI: 10.1182/blood-2001-12-0153

PubMed ID: 19364677

Title: Sequencing analysis of RHD intron 7 and 9.

PubMed ID: 19364677

DOI: 10.1016/j.transci.2009.03.004

PubMed ID: 28671325

Title: Serologic and molecular characterization of weak D type 29.

PubMed ID: 28671325

PubMed ID: 30337299

Title: Complete RHD next-generation sequencing: establishment of reference RHD alleles.

PubMed ID: 30337299

PubMed ID: 29479713

Title: Molecular basis of weak D expression in the Indian population and report of a novel, predominant variant RHD allele.

PubMed ID: 29479713

Sequence Information:

  • Length: 417
  • Mass: 45180
  • Checksum: 649F1BFA664AF7DB
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMIG 
FQVLLSIGEL SLAIVIALTS GLLTGLLLNL KIWKAPHEAK YFDDQVFWKF PHLAVGF

Genular Protein ID: 1199957202

Symbol: E7EVW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EVW1

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 431
  • Mass: 46325
  • Checksum: 4221565723D242F2
  • Sequence:
    • MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV GQDLTVMAAI 
GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ FPSGKVVITL FSIRLATMSA 
LSVLISVDAV LGKVNLAQLV VMVLVEVTAL GNLRMVISNI FNTDYHMNMM HIYVFAAYFG 
LSVAWCLPKP LPEGTEDKDQ TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN 
TYYAVAVSVV TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV 
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD TVGAGNGMSL 
GWNLAVKMAE AGDEELMRLD VSQRNHGGAA VPTGSWMPST ETTIAPNYRD HISVGLASRS 
SSALGNSAWP S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.