Details for: RING1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 177.6975
Cell Significance Index: -27.6400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 107.2766
Cell Significance Index: -27.2100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 75.6371
Cell Significance Index: -35.7100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 70.6695
Cell Significance Index: -28.7100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 61.7047
Cell Significance Index: -31.7400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 53.3514
Cell Significance Index: -35.8000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.1338
Cell Significance Index: -28.7700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 25.3537
Cell Significance Index: -31.2600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.9039
Cell Significance Index: -29.2100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.0891
Cell Significance Index: -31.9200 - Cell Name: decidual cell (CL2000002)
Fold Change: 4.7882
Cell Significance Index: 76.8200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 2.3034
Cell Significance Index: 57.4400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.4534
Cell Significance Index: 19.8300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8531
Cell Significance Index: 138.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7090
Cell Significance Index: 142.2300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6712
Cell Significance Index: 18.2700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6403
Cell Significance Index: 87.9300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5302
Cell Significance Index: 100.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5117
Cell Significance Index: 23.8600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4840
Cell Significance Index: 96.0500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4748
Cell Significance Index: 32.8400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4667
Cell Significance Index: 84.1300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4351
Cell Significance Index: 55.7800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4193
Cell Significance Index: 12.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4156
Cell Significance Index: 21.8200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4097
Cell Significance Index: 11.4500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3935
Cell Significance Index: 20.4400 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.3895
Cell Significance Index: 9.9500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3766
Cell Significance Index: 205.6900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3363
Cell Significance Index: 148.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3284
Cell Significance Index: 117.7900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3176
Cell Significance Index: 39.0500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2986
Cell Significance Index: 38.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2986
Cell Significance Index: 18.8200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2981
Cell Significance Index: 13.5100 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.2864
Cell Significance Index: 4.3500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2753
Cell Significance Index: 20.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2619
Cell Significance Index: 13.6400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1992
Cell Significance Index: 4.1700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1848
Cell Significance Index: 6.4200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1576
Cell Significance Index: 7.4100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1339
Cell Significance Index: 15.7900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1110
Cell Significance Index: 7.1600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1075
Cell Significance Index: 2.3300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0961
Cell Significance Index: 66.4600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0670
Cell Significance Index: 60.4900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0637
Cell Significance Index: 3.2200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0561
Cell Significance Index: 5.5500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0488
Cell Significance Index: 8.3300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0422
Cell Significance Index: 1.1100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0263
Cell Significance Index: 0.4400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0158
Cell Significance Index: 29.7800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0154
Cell Significance Index: 0.5400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0082
Cell Significance Index: 15.1800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0002
Cell Significance Index: 0.2500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0055
Cell Significance Index: -3.5100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0146
Cell Significance Index: -10.6800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0146
Cell Significance Index: -11.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0151
Cell Significance Index: -20.5400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0226
Cell Significance Index: -10.2400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0297
Cell Significance Index: -22.0000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0353
Cell Significance Index: -2.5000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0386
Cell Significance Index: -1.0300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0406
Cell Significance Index: -4.1500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0440
Cell Significance Index: -24.8300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0612
Cell Significance Index: -7.0100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0656
Cell Significance Index: -40.9900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0732
Cell Significance Index: -5.6200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1009
Cell Significance Index: -14.6700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1145
Cell Significance Index: -32.9400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1406
Cell Significance Index: -7.8900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1448
Cell Significance Index: -4.1500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1450
Cell Significance Index: -16.9000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1690
Cell Significance Index: -35.6000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2045
Cell Significance Index: -6.5500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2263
Cell Significance Index: -10.0100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2299
Cell Significance Index: -3.9400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2338
Cell Significance Index: -5.1200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2608
Cell Significance Index: -7.6600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2733
Cell Significance Index: -5.8200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2861
Cell Significance Index: -29.7900 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.3144
Cell Significance Index: -4.4100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3250
Cell Significance Index: -25.7400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3415
Cell Significance Index: -12.9300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3459
Cell Significance Index: -14.1700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4069
Cell Significance Index: -4.8500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.4366
Cell Significance Index: -4.9600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4508
Cell Significance Index: -27.6400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5005
Cell Significance Index: -6.4100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5598
Cell Significance Index: -17.8300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5649
Cell Significance Index: -11.9900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5753
Cell Significance Index: -8.6200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5829
Cell Significance Index: -20.4200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5925
Cell Significance Index: -19.4000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.6112
Cell Significance Index: -14.1200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6769
Cell Significance Index: -17.4000 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.6799
Cell Significance Index: -9.5300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6977
Cell Significance Index: -20.5500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7005
Cell Significance Index: -17.5100 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.7087
Cell Significance Index: -10.0700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2017961484
Symbol: RING1_HUMAN
Name: E3 ubiquitin-protein ligase RING1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7681583
Title: Identification and preliminary characterization of a protein motif related to the zinc finger.
PubMed ID: 7681583
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9199346
Title: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
PubMed ID: 9199346
PubMed ID: 9858531
Title: RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.
PubMed ID: 9858531
DOI: 10.1128/mcb.19.1.57
PubMed ID: 12167161
Title: MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.
PubMed ID: 12167161
PubMed ID: 12167701
Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
PubMed ID: 12167701
PubMed ID: 12004135
Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
PubMed ID: 12004135
PubMed ID: 15386022
Title: Role of histone H2A ubiquitination in Polycomb silencing.
PubMed ID: 15386022
DOI: 10.1038/nature02985
PubMed ID: 16359901
Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
PubMed ID: 16359901
PubMed ID: 16943429
Title: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.
PubMed ID: 16943429
DOI: 10.1128/mcb.00630-06
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19636380
Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
PubMed ID: 19636380
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21282530
Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.
PubMed ID: 21282530
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31839203
Title: Gain-of-function MN1 truncation variants cause a recognizable syndrome with craniofacial and brain abnormalities.
PubMed ID: 31839203
PubMed ID: 28839133
Title: USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components.
PubMed ID: 28839133
PubMed ID: 25725044
Title: De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy.
PubMed ID: 25725044
Sequence Information:
- Length: 406
- Mass: 42429
- Checksum: 6959787479DE9DAB
- Sequence:
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH QDRVLIRLSR LHNQQALSSS IEEGLRMQAM HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE GDGEDVSSDS APDSAPGPAP KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG GGTLGPPSPP GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL PSLEGVSEKQ YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA PTKDPK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.