Details for: RING1

Gene ID: 6015

Symbol: RING1

Ensembl ID: ENSG00000204227

Description: ring finger protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.6975
    Cell Significance Index: -27.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.2766
    Cell Significance Index: -27.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.6371
    Cell Significance Index: -35.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 70.6695
    Cell Significance Index: -28.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.7047
    Cell Significance Index: -31.7400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.3514
    Cell Significance Index: -35.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.1338
    Cell Significance Index: -28.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.3537
    Cell Significance Index: -31.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9039
    Cell Significance Index: -29.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0891
    Cell Significance Index: -31.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.7882
    Cell Significance Index: 76.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.3034
    Cell Significance Index: 57.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4534
    Cell Significance Index: 19.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8531
    Cell Significance Index: 138.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7090
    Cell Significance Index: 142.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6712
    Cell Significance Index: 18.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6403
    Cell Significance Index: 87.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5302
    Cell Significance Index: 100.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5117
    Cell Significance Index: 23.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4840
    Cell Significance Index: 96.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4748
    Cell Significance Index: 32.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4667
    Cell Significance Index: 84.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4351
    Cell Significance Index: 55.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4193
    Cell Significance Index: 12.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4156
    Cell Significance Index: 21.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4097
    Cell Significance Index: 11.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3935
    Cell Significance Index: 20.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3895
    Cell Significance Index: 9.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3766
    Cell Significance Index: 205.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3363
    Cell Significance Index: 148.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3284
    Cell Significance Index: 117.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3176
    Cell Significance Index: 39.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2986
    Cell Significance Index: 38.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2986
    Cell Significance Index: 18.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2981
    Cell Significance Index: 13.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2864
    Cell Significance Index: 4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2753
    Cell Significance Index: 20.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2619
    Cell Significance Index: 13.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1992
    Cell Significance Index: 4.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1848
    Cell Significance Index: 6.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1576
    Cell Significance Index: 7.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1339
    Cell Significance Index: 15.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1110
    Cell Significance Index: 7.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1075
    Cell Significance Index: 2.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0961
    Cell Significance Index: 66.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0670
    Cell Significance Index: 60.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0637
    Cell Significance Index: 3.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0561
    Cell Significance Index: 5.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0488
    Cell Significance Index: 8.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0422
    Cell Significance Index: 1.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0263
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0158
    Cell Significance Index: 29.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0082
    Cell Significance Index: 15.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0146
    Cell Significance Index: -11.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0226
    Cell Significance Index: -10.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0297
    Cell Significance Index: -22.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0353
    Cell Significance Index: -2.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0386
    Cell Significance Index: -1.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0440
    Cell Significance Index: -24.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0612
    Cell Significance Index: -7.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0656
    Cell Significance Index: -40.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0732
    Cell Significance Index: -5.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1009
    Cell Significance Index: -14.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1145
    Cell Significance Index: -32.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1406
    Cell Significance Index: -7.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1448
    Cell Significance Index: -4.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1450
    Cell Significance Index: -16.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1690
    Cell Significance Index: -35.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2045
    Cell Significance Index: -6.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2263
    Cell Significance Index: -10.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2299
    Cell Significance Index: -3.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2338
    Cell Significance Index: -5.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2608
    Cell Significance Index: -7.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2733
    Cell Significance Index: -5.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2861
    Cell Significance Index: -29.7900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3144
    Cell Significance Index: -4.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3250
    Cell Significance Index: -25.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3415
    Cell Significance Index: -12.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3459
    Cell Significance Index: -14.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4069
    Cell Significance Index: -4.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4366
    Cell Significance Index: -4.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4508
    Cell Significance Index: -27.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5005
    Cell Significance Index: -6.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5598
    Cell Significance Index: -17.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5649
    Cell Significance Index: -11.9900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5753
    Cell Significance Index: -8.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5829
    Cell Significance Index: -20.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5925
    Cell Significance Index: -19.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6112
    Cell Significance Index: -14.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6769
    Cell Significance Index: -17.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6799
    Cell Significance Index: -9.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6977
    Cell Significance Index: -20.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7005
    Cell Significance Index: -17.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7087
    Cell Significance Index: -10.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RING1 is a member of the RING ( Really Interesting New Gene) family of E3 ubiquitin ligases, characterized by the presence of a RING finger domain. This domain is essential for the recognition and binding of ubiquitin-conjugating enzymes (E2s) and ubiquitin (Ub) to target proteins. RING1 is highly expressed in cells with high proliferative rates, such as cancer cells and neural progenitor cells. It is also present in cells with high oxidative stress levels, such as cardiac muscle cells and myeloid dendritic cells. **Pathways and Functions:** RING1 is involved in various cellular processes, including: 1. **Cell cycle regulation:** RING1 regulates the cell cycle by ubiquitinating and targeting proteins involved in cell cycle progression, such as p21 and p27. 2. **DNA damage response:** RING1 is involved in the DNA damage response by ubiquitinating and targeting proteins involved in DNA repair, such as BRCA1 and BRCA2. 3. **Transcriptional control:** RING1 regulates transcription by ubiquitinating and targeting transcription factors, such as E2F6 and Runx1. 4. **Protein degradation:** RING1 is involved in the ubiquitination and degradation of target proteins, such as p53 and p21. 5. **Chromatin remodeling:** RING1 regulates chromatin remodeling by ubiquitinating and targeting chromatin-modifying enzymes, such as histone deacetylases and histone methyltransferases. **Clinical Significance:** The dysregulation of RING1 has been implicated in various diseases, including: 1. **Cancer:** RING1 mutations and overexpression have been associated with cancer, including breast cancer, ovarian cancer, and leukemia. 2. **Neurodegenerative disorders:** RING1 mutations have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Autoimmune diseases:** RING1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cardiovascular disease:** RING1 has been associated with cardiovascular disease, including atherosclerosis and cardiac arrhythmias. In conclusion, RING1 is a critical gene involved in various cellular processes, including cell cycle regulation, DNA damage response, and transcriptional control. The dysregulation of RING1 has been implicated in various diseases, highlighting its importance in human health and disease. Further research is needed to fully understand the mechanisms by which RING1 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2017961484

Symbol: RING1_HUMAN

Name: E3 ubiquitin-protein ligase RING1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7681583

Title: Identification and preliminary characterization of a protein motif related to the zinc finger.

PubMed ID: 7681583

DOI: 10.1073/pnas.90.6.2112

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9199346

Title: RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.

PubMed ID: 9199346

DOI: 10.1128/mcb.17.7.4105

PubMed ID: 9858531

Title: RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.

PubMed ID: 9858531

DOI: 10.1128/mcb.19.1.57

PubMed ID: 12167161

Title: MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.

PubMed ID: 12167161

DOI: 10.1046/j.1365-2443.2002.00565.x

PubMed ID: 12167701

Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PubMed ID: 12167701

DOI: 10.1128/mcb.22.17.6070-6078.2002

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16943429

Title: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.

PubMed ID: 16943429

DOI: 10.1128/mcb.00630-06

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31839203

Title: Gain-of-function MN1 truncation variants cause a recognizable syndrome with craniofacial and brain abnormalities.

PubMed ID: 31839203

DOI: 10.1016/j.ajhg.2019.11.011

PubMed ID: 28839133

Title: USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components.

PubMed ID: 28839133

DOI: 10.1038/s41467-017-00301-4

PubMed ID: 25725044

Title: De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy.

PubMed ID: 25725044

DOI: 10.1136/jmedgenet-2014-102813

Sequence Information:

  • Length: 406
  • Mass: 42429
  • Checksum: 6959787479DE9DAB
  • Sequence:
  • MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT 
    TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH 
    QDRVLIRLSR LHNQQALSSS IEEGLRMQAM HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE 
    GDGEDVSSDS APDSAPGPAP KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG 
    GGTLGPPSPP GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA 
    LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL PSLEGVSEKQ 
    YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA PTKDPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.