Details for: RNASE4

Gene ID: 6038

Symbol: RNASE4

Ensembl ID: ENSG00000258818

Description: ribonuclease A family member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.5364
    Cell Significance Index: -11.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 22.1781
    Cell Significance Index: -9.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.6989
    Cell Significance Index: -9.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3028
    Cell Significance Index: -11.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.8630
    Cell Significance Index: 28.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.1391
    Cell Significance Index: 163.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.1076
    Cell Significance Index: 398.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9219
    Cell Significance Index: -11.5300
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 2.1729
    Cell Significance Index: 14.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8189
    Cell Significance Index: 52.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4450
    Cell Significance Index: 157.1700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.1921
    Cell Significance Index: 7.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0525
    Cell Significance Index: 950.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9987
    Cell Significance Index: 190.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8008
    Cell Significance Index: 55.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6988
    Cell Significance Index: 113.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5672
    Cell Significance Index: 5.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5502
    Cell Significance Index: 54.4300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.4663
    Cell Significance Index: 5.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4513
    Cell Significance Index: 7.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4398
    Cell Significance Index: 11.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4339
    Cell Significance Index: 2.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3578
    Cell Significance Index: 26.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3547
    Cell Significance Index: 4.0300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.2616
    Cell Significance Index: 2.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2409
    Cell Significance Index: 3.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1868
    Cell Significance Index: 2.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1863
    Cell Significance Index: 22.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1416
    Cell Significance Index: 6.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1332
    Cell Significance Index: 24.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1162
    Cell Significance Index: 3.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0799
    Cell Significance Index: 1.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0634
    Cell Significance Index: 1.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0488
    Cell Significance Index: 2.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0444
    Cell Significance Index: 1.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0213
    Cell Significance Index: 0.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0190
    Cell Significance Index: 0.6100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0169
    Cell Significance Index: 0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0109
    Cell Significance Index: 4.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0034
    Cell Significance Index: 0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0055
    Cell Significance Index: -0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0080
    Cell Significance Index: -14.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0095
    Cell Significance Index: -14.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0134
    Cell Significance Index: -9.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0153
    Cell Significance Index: -8.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0155
    Cell Significance Index: -9.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0195
    Cell Significance Index: -12.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0228
    Cell Significance Index: -10.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0237
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0269
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0277
    Cell Significance Index: -3.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0296
    Cell Significance Index: -0.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0309
    Cell Significance Index: -11.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0336
    Cell Significance Index: -1.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0347
    Cell Significance Index: -3.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0376
    Cell Significance Index: -0.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0395
    Cell Significance Index: -11.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0420
    Cell Significance Index: -0.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0443
    Cell Significance Index: -5.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0509
    Cell Significance Index: -2.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0546
    Cell Significance Index: -10.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0629
    Cell Significance Index: -13.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0680
    Cell Significance Index: -9.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0697
    Cell Significance Index: -7.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0710
    Cell Significance Index: -5.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0718
    Cell Significance Index: -1.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0753
    Cell Significance Index: -1.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0935
    Cell Significance Index: -11.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1057
    Cell Significance Index: -4.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1140
    Cell Significance Index: -11.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1280
    Cell Significance Index: -10.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1313
    Cell Significance Index: -6.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1346
    Cell Significance Index: -8.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1351
    Cell Significance Index: -2.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1409
    Cell Significance Index: -2.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1422
    Cell Significance Index: -10.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1554
    Cell Significance Index: -9.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1783
    Cell Significance Index: -11.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1852
    Cell Significance Index: -1.7100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1861
    Cell Significance Index: -2.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1862
    Cell Significance Index: -12.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1985
    Cell Significance Index: -11.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1997
    Cell Significance Index: -5.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2030
    Cell Significance Index: -2.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2142
    Cell Significance Index: -3.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2207
    Cell Significance Index: -4.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2269
    Cell Significance Index: -6.0700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.2320
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2398
    Cell Significance Index: -5.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2466
    Cell Significance Index: -12.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2498
    Cell Significance Index: -6.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2499
    Cell Significance Index: -4.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2682
    Cell Significance Index: -9.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2710
    Cell Significance Index: -4.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2826
    Cell Significance Index: -12.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3000
    Cell Significance Index: -8.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNASE4 is a small, secreted protein with a molecular weight of approximately 40 kDa. It belongs to the ribonuclease A family, which is characterized by its ability to cleave RNA molecules. RNASE4 exhibits a high degree of specificity towards bacterial RNA, making it an essential component of the innate immune response. Its expression is restricted to various cell types, including fibroblasts, endothelial cells, and epithelial cells, which are involved in different aspects of immune defense. **Pathways and Functions:** RNASE4 is involved in several key pathways that contribute to its immunological functions. These include: 1. **Antibacterial humoral response:** RNASE4 is secreted by various cells and targets bacterial RNA, thereby inhibiting bacterial growth and replication. 2. **Defense response to gram-positive bacterium:** RNASE4 has been shown to be effective against gram-positive bacteria, such as Staphylococcus aureus, by cleaving their RNA molecules. 3. **Extracellular region and extracellular space:** RNASE4 is secreted into the extracellular space, where it can interact with bacterial RNA molecules. 4. **Nucleic acid binding:** RNASE4 exhibits a high affinity for nucleic acids, allowing it to bind and cleave RNA molecules. 5. **Ribonuclease A activity and RNA nuclease activity:** RNASE4 possesses ribonuclease A activity, which enables it to cleave RNA molecules, and RNA nuclease activity, which allows it to degrade RNA. **Clinical Significance:** RNASE4 has been implicated in various diseases, including: 1. **Prostate cancer:** Elevated expression of RNASE4 has been observed in prostate cancer tissues, suggesting its potential role as a biomarker for early detection. 2. **Respiratory infections:** RNASE4 has been shown to be effective against respiratory pathogens, such as influenza and respiratory syncytial virus. 3. **Kidney disease:** RNASE4 has been implicated in kidney disease, including chronic kidney disease and acute kidney injury. In conclusion, RNASE4 plays a crucial role in the immune system's defense against bacterial infections. Its expression in various cell types and its ability to cleave bacterial RNA molecules make it an essential component of the innate immune response. Further research is needed to fully elucidate the mechanisms of RNASE4 and its potential applications in clinical settings. **References:** * [Insert references to studies that have investigated RNASE4's role in immune defense and its clinical significance]

Genular Protein ID: 2435262289

Symbol: RNAS4_HUMAN

Name: Ribonuclease 4

UniProtKB Accession Codes:

P34096

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7742370

Title: Molecular cloning and expression of human ribonuclease 4 cDNA.

PubMed ID: 7742370

DOI: 10.1016/0167-4781(95)00040-n

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7501448

Title: Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues.

PubMed ID: 7501448

DOI: 10.1093/nar/23.21.4290

PubMed ID: 8223579

Title: The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine.

PubMed ID: 8223579

DOI: 10.1111/j.1432-1033.1993.tb18259.x

PubMed ID: 3467790

Title: Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity.

PubMed ID: 3467790

DOI: 10.1021/bi00371a002

PubMed ID: 30418175

Title: Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.

PubMed ID: 30418175

DOI: 10.1172/jci98595

PubMed ID: 33818125

Title: Expression and function of human ribonuclease 4 in the kidney and urinary tract.

PubMed ID: 33818125

DOI: 10.1152/ajprenal.00592.2020

PubMed ID: 9878400

Title: The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity.

PubMed ID: 9878400

DOI: 10.1006/jmbi.1998.2288

Sequence Information:

  • Length: 147
  • Mass: 16840
  • Checksum: 4C24FEA249F3EC2F
  • Sequence:
    • MALQRTHSLL LLLLLTLLGL GLVQPSYGQD GMYQRFLRQH VHPEETGGSD RYCNLMMQRR 
KMTLYHCKRF NTFIHEDIWN IRSICSTTNI QCKNGKMNCH EGVVKVTDCR DTGSSRAPNC 
RYRAIASTRR VVIACEGNPQ VPVHFDG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.