Details for: RNF2

Gene ID: 6045

Symbol: RNF2

Ensembl ID: ENSG00000121481

Description: ring finger protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.6179
    Cell Significance Index: -16.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.6718
    Cell Significance Index: -18.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.3121
    Cell Significance Index: -21.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.1900
    Cell Significance Index: -18.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.2531
    Cell Significance Index: -21.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.0578
    Cell Significance Index: -19.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.1498
    Cell Significance Index: -21.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0366
    Cell Significance Index: -18.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8441
    Cell Significance Index: -17.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5372
    Cell Significance Index: -21.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4275
    Cell Significance Index: -9.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.4525
    Cell Significance Index: 30.9400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3151
    Cell Significance Index: 9.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2110
    Cell Significance Index: 141.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1865
    Cell Significance Index: 31.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9625
    Cell Significance Index: 193.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8744
    Cell Significance Index: 11.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8362
    Cell Significance Index: 50.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7926
    Cell Significance Index: 86.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6918
    Cell Significance Index: 18.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5861
    Cell Significance Index: 95.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5596
    Cell Significance Index: 29.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5291
    Cell Significance Index: 29.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4712
    Cell Significance Index: 93.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4596
    Cell Significance Index: 9.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4389
    Cell Significance Index: 22.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3848
    Cell Significance Index: 24.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3788
    Cell Significance Index: 26.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3413
    Cell Significance Index: 64.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3159
    Cell Significance Index: 8.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2739
    Cell Significance Index: 18.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2620
    Cell Significance Index: 9.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2485
    Cell Significance Index: 109.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2384
    Cell Significance Index: 85.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2186
    Cell Significance Index: 5.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2028
    Cell Significance Index: 24.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1939
    Cell Significance Index: 105.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1893
    Cell Significance Index: 170.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1888
    Cell Significance Index: 18.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1824
    Cell Significance Index: 32.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1754
    Cell Significance Index: 3.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1721
    Cell Significance Index: 23.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1437
    Cell Significance Index: 6.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1096
    Cell Significance Index: 5.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1066
    Cell Significance Index: 18.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0848
    Cell Significance Index: 2.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0799
    Cell Significance Index: 6.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0775
    Cell Significance Index: 5.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0736
    Cell Significance Index: 2.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0513
    Cell Significance Index: 0.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0476
    Cell Significance Index: 3.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0427
    Cell Significance Index: 5.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0301
    Cell Significance Index: 2.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0218
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0120
    Cell Significance Index: 22.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0117
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0090
    Cell Significance Index: 16.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0083
    Cell Significance Index: 12.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0037
    Cell Significance Index: 2.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0027
    Cell Significance Index: 3.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0034
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0048
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0058
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0091
    Cell Significance Index: -1.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0114
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0135
    Cell Significance Index: -8.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0143
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0165
    Cell Significance Index: -2.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0185
    Cell Significance Index: -13.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0200
    Cell Significance Index: -0.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0208
    Cell Significance Index: -0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0429
    Cell Significance Index: -4.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0432
    Cell Significance Index: -1.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0478
    Cell Significance Index: -1.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0564
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0607
    Cell Significance Index: -12.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0639
    Cell Significance Index: -18.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0671
    Cell Significance Index: -2.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0774
    Cell Significance Index: -3.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1209
    Cell Significance Index: -4.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1222
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1232
    Cell Significance Index: -14.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1246
    Cell Significance Index: -6.5400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1465
    Cell Significance Index: -0.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1531
    Cell Significance Index: -1.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1650
    Cell Significance Index: -4.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1964
    Cell Significance Index: -20.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2276
    Cell Significance Index: -5.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2336
    Cell Significance Index: -18.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2442
    Cell Significance Index: -1.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2505
    Cell Significance Index: -6.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2539
    Cell Significance Index: -2.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2770
    Cell Significance Index: -16.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2983
    Cell Significance Index: -4.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3373
    Cell Significance Index: -8.0900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3408
    Cell Significance Index: -4.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF2 is a member of the RING (Ring Finger) family of proteins, characterized by the presence of a RING domain, a conserved structural motif that facilitates protein-protein interactions and E3 ubiquitin ligase activity. This domain is crucial for RNF2's ability to recognize and target specific substrates for ubiquitination, a post-translational modification that regulates protein activity and stability. RNF2's ubiquitin ligase activity is highly specific, allowing it to distinguish between different protein substrates and regulate their functions accordingly. **Pathways and Functions:** RNF2 is involved in various cellular pathways, including: 1. **Chromatin Regulation:** RNF2 plays a crucial role in chromatin remodeling and gene expression by targeting histone H2A ubiquitinated at lysine 119 (H2AK119ub), a key epigenetic mark that regulates chromatin structure and transcriptional activity. 2. **DNA Damage Response:** RNF2 is involved in the DNA damage response pathway, where it targets proteins involved in DNA repair and replication, ensuring the integrity of the genome. 3. **Immune Regulation:** RNF2 has been implicated in immune regulation, where it targets proteins involved in immune cell function, such as T cells and dendritic cells. 4. **Cellular Senescence:** RNF2 has been shown to regulate cellular senescence, a state of permanent cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. **Clinical Significance:** Dysregulation of RNF2 has been implicated in various diseases, including: 1. **Cancer:** RNF2's role in chromatin regulation and DNA damage response makes it a potential target for cancer therapy. 2. **Autoimmune Diseases:** RNF2's involvement in immune regulation suggests that it may play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative Diseases:** RNF2's role in cellular senescence and chromatin regulation makes it a potential target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. **Significantly Expressed Cells:** RNF2 is highly expressed in cells involved in: 1. **Germ Cell Development:** RNF2 is essential for germ cell development and fertility. 2. **Immune Cell Function:** RNF2 is expressed in immune cells, including T cells and dendritic cells. 3. **Neuronal Function:** RNF2 is expressed in neurons, including dopaminergic and glutamatergic cortical neurons. In conclusion, RNF2 is a complex and multifaceted protein that plays a critical role in various cellular processes, including chromatin regulation, DNA damage response, and immune regulation. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms of RNF2's functions and its role in human disease.

Genular Protein ID: 3757788795

Symbol: RING2_HUMAN

Name: E3 ubiquitin-protein ligase RING2

UniProtKB Accession Codes:

Q99496 B2RBS7 B3KRH1 Q5TEN1 Q5TEN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 50 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11513855

Title: E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme.

PubMed ID: 11513855

DOI: 10.1016/s0014-5793(01)02689-8

PubMed ID: 11865070

Title: Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors.

PubMed ID: 11865070

DOI: 10.1128/mcb.22.6.1936-1946.2002

PubMed ID: 12167701

Title: The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.

PubMed ID: 12167701

DOI: 10.1128/mcb.22.17.6070-6078.2002

PubMed ID: 12004135

Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.

PubMed ID: 12004135

DOI: 10.1126/science.1069861

PubMed ID: 15386022

Title: Role of histone H2A ubiquitination in Polycomb silencing.

PubMed ID: 15386022

DOI: 10.1038/nature02985

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16943429

Title: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.

PubMed ID: 16943429

DOI: 10.1128/mcb.00630-06

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19636380

Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

PubMed ID: 19636380

DOI: 10.1371/journal.pone.0006380

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21282530

Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.

PubMed ID: 21282530

DOI: 10.1074/mcp.m110.002642

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25519132

Title: An AUTS2-polycomb complex activates gene expression in the CNS.

PubMed ID: 25519132

DOI: 10.1038/nature13921

PubMed ID: 26687479

Title: The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PubMed ID: 26687479

DOI: 10.1038/srep18388

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28720707

Title: Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

PubMed ID: 28720707

DOI: 10.1073/pnas.1619932114

PubMed ID: 33864376

Title: Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features.

PubMed ID: 33864376

DOI: 10.1093/hmg/ddab110

PubMed ID: 16714294

Title: Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.

PubMed ID: 16714294

DOI: 10.1074/jbc.m602461200

PubMed ID: 19791798

Title: Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.

PubMed ID: 19791798

DOI: 10.1021/bi901131u

PubMed ID: 20696397

Title: Polycomb group targeting through different binding partners of RING1B C-terminal domain.

PubMed ID: 20696397

DOI: 10.1016/j.str.2010.04.013

PubMed ID: 21772249

Title: Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.

PubMed ID: 21772249

DOI: 10.1038/emboj.2011.243

PubMed ID: 25355358

Title: Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.

PubMed ID: 25355358

DOI: 10.1038/nature13890

PubMed ID: 26151332

Title: BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.

PubMed ID: 26151332

DOI: 10.1038/ncomms8621

Sequence Information:

  • Length: 336
  • Mass: 37655
  • Checksum: 90EA546E1F4DB7EC
  • Sequence:
    • MSQAVQTNGT QPLSKTWELS LYELQRTPQE AITDGLEIVV SPRSLHSELM CPICLDMLKN 
TMTTKECLHR FCADCIITAL RSGNKECPTC RKKLVSKRSL RPDPNFDALI SKIYPSRDEY 
EAHQERVLAR INKHNNQQAL SHSIEEGLKI QAMNRLQRGK KQQIENGSGA EDNGDSSHCS 
NASTHSNQEA GPSNKRTKTS DDSGLELDNN NAAMAIDPVM DGASEIELVF RPHPTLMEKD 
DSAQTRYIKT SGNATVDHLS KYLAVRLALE ELRSKGESNQ MNLDTASEKQ YTIYIATASG 
QFTVLNGSFS LELVSEKYWK VNKPMELYYA PTKEHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.