Details for: ROM1

Gene ID: 6094

Symbol: ROM1

Ensembl ID: ENSG00000149489

Description: retinal outer segment membrane protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 45.7745
    Cell Significance Index: -7.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.8881
    Cell Significance Index: -6.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 11.6639
    Cell Significance Index: 735.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.7829
    Cell Significance Index: -7.1300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.9498
    Cell Significance Index: 69.5200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.4873
    Cell Significance Index: 26.8800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.2660
    Cell Significance Index: 28.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8043
    Cell Significance Index: -7.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9467
    Cell Significance Index: 15.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.8695
    Cell Significance Index: 10.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8438
    Cell Significance Index: 83.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6578
    Cell Significance Index: 593.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4920
    Cell Significance Index: 53.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4557
    Cell Significance Index: 27.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4428
    Cell Significance Index: 72.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4063
    Cell Significance Index: 21.3300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.3465
    Cell Significance Index: 4.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3341
    Cell Significance Index: 5.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3023
    Cell Significance Index: 3.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2585
    Cell Significance Index: 17.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2181
    Cell Significance Index: 2.6000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1626
    Cell Significance Index: 2.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1092
    Cell Significance Index: 1.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0982
    Cell Significance Index: 13.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0879
    Cell Significance Index: 16.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0872
    Cell Significance Index: 10.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0821
    Cell Significance Index: 10.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0740
    Cell Significance Index: 2.0200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0654
    Cell Significance Index: 0.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0649
    Cell Significance Index: 2.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0592
    Cell Significance Index: 26.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0466
    Cell Significance Index: 1.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0407
    Cell Significance Index: 0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0316
    Cell Significance Index: 5.6900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0310
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0131
    Cell Significance Index: 0.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0124
    Cell Significance Index: 0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0116
    Cell Significance Index: 1.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0110
    Cell Significance Index: 0.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0086
    Cell Significance Index: 4.7200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0039
    Cell Significance Index: 0.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0010
    Cell Significance Index: 0.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0007
    Cell Significance Index: -0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0068
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0072
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0100
    Cell Significance Index: -5.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0102
    Cell Significance Index: -3.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0110
    Cell Significance Index: -6.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0121
    Cell Significance Index: -0.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0122
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0144
    Cell Significance Index: -2.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0173
    Cell Significance Index: -4.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0250
    Cell Significance Index: -5.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0292
    Cell Significance Index: -4.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0310
    Cell Significance Index: -5.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0326
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0340
    Cell Significance Index: -7.1600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0362
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0449
    Cell Significance Index: -5.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0454
    Cell Significance Index: -0.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0487
    Cell Significance Index: -5.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0493
    Cell Significance Index: -3.0200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0493
    Cell Significance Index: -0.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0515
    Cell Significance Index: -3.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0563
    Cell Significance Index: -1.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0580
    Cell Significance Index: -2.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0633
    Cell Significance Index: -4.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0671
    Cell Significance Index: -6.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0747
    Cell Significance Index: -5.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0748
    Cell Significance Index: -4.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0773
    Cell Significance Index: -2.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0787
    Cell Significance Index: -3.9800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0810
    Cell Significance Index: -1.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0898
    Cell Significance Index: -6.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0898
    Cell Significance Index: -3.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0957
    Cell Significance Index: -7.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1107
    Cell Significance Index: -2.9100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1194
    Cell Significance Index: -1.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1224
    Cell Significance Index: -4.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1242
    Cell Significance Index: -4.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1286
    Cell Significance Index: -3.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1307
    Cell Significance Index: -2.2400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1351
    Cell Significance Index: -1.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1432
    Cell Significance Index: -2.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1463
    Cell Significance Index: -6.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1535
    Cell Significance Index: -2.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1553
    Cell Significance Index: -2.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1570
    Cell Significance Index: -4.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1627
    Cell Significance Index: -5.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ROM1 is a transmembrane protein, specifically localized to the outer segment membrane of photoreceptor cells in the retina. Its structure is characterized by two distinct domains: an extracellular domain and an intracellular domain. The extracellular domain is responsible for protein-protein interactions, while the intracellular domain regulates gene expression and protein localization. ROM1 is highly expressed in retinal rod cells, eye photoreceptor cells, and other neuronal cells, including cerebral cortex GABAergic interneurons and forebrain radial glial cells. **Pathways and Functions:** ROM1's involvement in various cellular pathways underscores its multifaceted role in photoreceptor cell development and function. Notably, ROM1 is: 1. **Photoreceptor cell outer segment organization**: ROM1 plays a crucial role in the organization and maintenance of the outer segment membrane, essential for phototransduction and visual perception. 2. **Cell adhesion**: ROM1 interacts with other proteins to regulate cell adhesion, influencing the interaction between photoreceptor cells and their environment. 3. **Protein binding**: ROM1 binds to various proteins, including those involved in phototransduction, gene expression, and cell signaling. 4. **Regulation of gene expression**: ROM1 modulates gene expression by interacting with transcription factors and other regulatory proteins. 5. **Visual perception**: ROM1's involvement in photoreceptor cell function and organization is essential for the detection of light stimuli and visual perception. **Clinical Significance:** The ROM1 gene's implications extend beyond the visual system, with potential roles in: 1. **Retinal degeneration**: Alterations in ROM1 expression or function may contribute to retinal degenerative diseases, such as retinitis pigmentosa. 2. **Neurological disorders**: ROM1's involvement in neuronal cell differentiation and function may be relevant to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Intestinal health**: ROM1's expression in intestinal epithelial cells suggests a potential role in maintaining intestinal homeostasis and preventing diseases, such as inflammatory bowel disease. In conclusion, the ROM1 gene is a vital component of the photoreceptor cell machinery, with far-reaching implications in visual perception, neuronal development, and intestinal health. Further research into the ROM1 protein will undoubtedly uncover its intricate mechanisms of action and shed light on the complex relationships between photoreceptor cells, neurons, and the broader immune system.

Genular Protein ID: 1954912058

Symbol: ROM1_HUMAN

Name: Rod outer segment membrane protein 1

UniProtKB Accession Codes:

Q03395 B2R978

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1610568

Title: Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies.

PubMed ID: 1610568

DOI: 10.1016/0896-6273(92)90137-3

PubMed ID: 8504299

Title: Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation.

PubMed ID: 8504299

DOI: 10.1093/hmg/2.4.385

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8202715

Title: Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci.

PubMed ID: 8202715

DOI: 10.1126/science.8202715

PubMed ID: 7904211

Title: Polymorphisms and rare sequence variants at the ROM1 locus.

PubMed ID: 7904211

DOI: 10.1093/hmg/2.11.1975

PubMed ID: 8595413

Title: Mutation analysis of the ROM1 gene in retinitis pigmentosa.

PubMed ID: 8595413

DOI: 10.1093/hmg/4.10.1895

PubMed ID: 9331261

Title: Dominant and digenic mutations in the peripherin/RDS and ROM1 genes in retinitis pigmentosa.

PubMed ID: 9331261

PubMed ID: 20335603

Title: ABCA4 and ROM1: implications for modification of the PRPH2-associated macular dystrophy phenotype.

PubMed ID: 20335603

DOI: 10.1167/iovs.09-4655

Sequence Information:

  • Length: 351
  • Mass: 37205
  • Checksum: 895C33382B681E84
  • Sequence:
    • MAPVLPLVLP LQPRIRLAQG LWLLSWLLAL AGGVILLCSG HLLVQLRHLG TFLAPSCQFP 
VLPQAALAAG AVALGTGLVG VGASRASLNA ALYPPWRGVL GPLLVAGTAG GGGLLVVGLG 
LALALPGSLD EALEEGLVTA LAHYKDTEVP GHCQAKRLVD ELQLRYHCCG RHGYKDWFGV 
QWVSSRYLDP GDRDVADRIQ SNVEGLYLTD GVPFSCCNPH SPRPCLQNRL SDSYAHPLFD 
PRQPNQNLWA QGCHEVLLEH LQDLAGTLGS MLAVTFLLQA LVLLGLRYLQ TALEGLGGVI 
DAGGETQGYL FPSGLKDMLK TAWLQGGVAC RPAPEEAPPG EAPPKEDLSE A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.