Details for: RORB

Gene ID: 6096

Symbol: RORB

Ensembl ID: ENSG00000198963

Description: RAR related orphan receptor B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 147.1751
    Cell Significance Index: -37.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.3435
    Cell Significance Index: -26.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 19.4181
    Cell Significance Index: 1089.6500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 11.1588
    Cell Significance Index: 156.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4525
    Cell Significance Index: -37.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 7.3841
    Cell Significance Index: 465.4000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 7.3228
    Cell Significance Index: 76.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.3279
    Cell Significance Index: 174.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.2304
    Cell Significance Index: 70.7400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.2240
    Cell Significance Index: 24.8500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.8426
    Cell Significance Index: 39.7500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.4124
    Cell Significance Index: 17.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2907
    Cell Significance Index: 258.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0065
    Cell Significance Index: 361.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7491
    Cell Significance Index: 11.8900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.5107
    Cell Significance Index: 5.7700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3846
    Cell Significance Index: 6.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2098
    Cell Significance Index: 16.1000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1363
    Cell Significance Index: 1.7000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1170
    Cell Significance Index: 0.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0922
    Cell Significance Index: 63.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0612
    Cell Significance Index: 0.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0197
    Cell Significance Index: 0.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0086
    Cell Significance Index: -1.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0139
    Cell Significance Index: -26.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0210
    Cell Significance Index: -38.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0217
    Cell Significance Index: -13.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0250
    Cell Significance Index: -38.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0295
    Cell Significance Index: -40.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0319
    Cell Significance Index: -23.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0320
    Cell Significance Index: -24.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0400
    Cell Significance Index: -17.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0420
    Cell Significance Index: -5.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0513
    Cell Significance Index: -38.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0536
    Cell Significance Index: -24.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0618
    Cell Significance Index: -11.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0619
    Cell Significance Index: -33.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0651
    Cell Significance Index: -36.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0666
    Cell Significance Index: -41.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1101
    Cell Significance Index: -31.6700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1379
    Cell Significance Index: -1.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1385
    Cell Significance Index: -8.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1661
    Cell Significance Index: -2.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1763
    Cell Significance Index: -34.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1781
    Cell Significance Index: -1.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1908
    Cell Significance Index: -27.7300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1937
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1972
    Cell Significance Index: -41.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2111
    Cell Significance Index: -27.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2358
    Cell Significance Index: -40.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2585
    Cell Significance Index: -33.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2597
    Cell Significance Index: -3.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2720
    Cell Significance Index: -27.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2880
    Cell Significance Index: -33.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2958
    Cell Significance Index: -23.4300
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2995
    Cell Significance Index: -3.2200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3211
    Cell Significance Index: -3.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3469
    Cell Significance Index: -40.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3564
    Cell Significance Index: -37.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3603
    Cell Significance Index: -41.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3610
    Cell Significance Index: -5.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4274
    Cell Significance Index: -30.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4304
    Cell Significance Index: -9.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4464
    Cell Significance Index: -33.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4499
    Cell Significance Index: -23.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5008
    Cell Significance Index: -26.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5096
    Cell Significance Index: -32.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5348
    Cell Significance Index: -35.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5829
    Cell Significance Index: -5.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6099
    Cell Significance Index: -37.3900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.6771
    Cell Significance Index: -5.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6809
    Cell Significance Index: -32.0000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.6867
    Cell Significance Index: -8.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7252
    Cell Significance Index: -25.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7299
    Cell Significance Index: -31.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7514
    Cell Significance Index: -34.0600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7587
    Cell Significance Index: -10.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8035
    Cell Significance Index: -37.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8210
    Cell Significance Index: -30.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8357
    Cell Significance Index: -27.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8558
    Cell Significance Index: -29.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8591
    Cell Significance Index: -38.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8893
    Cell Significance Index: -22.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9075
    Cell Significance Index: -10.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9100
    Cell Significance Index: -31.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.9416
    Cell Significance Index: -6.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9463
    Cell Significance Index: -30.1400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.9476
    Cell Significance Index: -11.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9479
    Cell Significance Index: -27.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9590
    Cell Significance Index: -27.4900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.9931
    Cell Significance Index: -7.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9972
    Cell Significance Index: -23.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.0044
    Cell Significance Index: -15.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0093
    Cell Significance Index: -38.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0247
    Cell Significance Index: -17.5600
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -1.0261
    Cell Significance Index: -11.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0675
    Cell Significance Index: -34.1900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -1.0816
    Cell Significance Index: -11.1200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -1.0878
    Cell Significance Index: -13.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0916
    Cell Significance Index: -31.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Gene Structure**: RORB is a nuclear receptor orphan receptor, meaning it lacks a known ligand-binding domain. Its structure is characterized by a DNA-binding domain, which allows it to interact with specific DNA sequences. 2. **Expression Patterns**: RORB is highly expressed in photoreceptor cells, Mueller cells, Purkinje cells, retinal ganglion cells, astrocytes, and macroglial cells, highlighting its role in retinal development and maintenance. 3. **Function**: RORB acts as a transcription factor, regulating gene expression by binding to specific DNA sequences. It also modulates the activity of RNA polymerase II, influencing the transcription of target genes. **Pathways and Functions** 1. **Retinoic Acid Signaling**: RORB is activated by retinoic acid, a derivative of vitamin A, which plays a crucial role in cell development, differentiation, and survival. 2. **Gene Expression Regulation**: RORB regulates the expression of genes involved in photoreceptor development, retinal development, and circadian rhythm regulation. 3. **Transcriptional Regulation**: RORB interacts with RNA polymerase II, modulating the transcription of target genes and influencing the expression of genes involved in various cellular processes. 4. **Visual Perception**: RORB's involvement in photoreceptor cell development and maintenance underscores its critical role in visual perception and overall retinal function. **Clinical Significance** 1. **Retinal Diseases**: RORB's role in photoreceptor cell development and maintenance highlights its potential as a therapeutic target for retinal diseases, such as retinitis pigmentosa and age-related macular degeneration. 2. **Circadian Rhythm Disorders**: RORB's involvement in circadian rhythm regulation suggests its potential as a therapeutic target for disorders related to circadian rhythm dysregulation, such as delayed sleep phase syndrome. 3. **Cancer and Metabolic Disorders**: RORB's role in regulating gene expression and transcription suggests its potential as a therapeutic target for cancer and metabolic disorders, such as obesity and diabetes. In conclusion, RORB is a critical component of the nuclear receptor family, playing a pivotal role in various cellular processes, including gene expression regulation, transcriptional regulation, and response to retinoic acid. Its involvement in photoreceptor cell development, retinal development, and regulation of circadian rhythms underscores its importance in visual perception and overall health. Further research is necessary to fully elucidate the function and clinical significance of RORB.

Genular Protein ID: 142935994

Symbol: Q58EY0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q58EY0

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BindingDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 ExpressionAtlas 1 GO 9 Gene3D 2 HOGENOM 1 IntAct 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 459
  • Mass: 52073
  • Checksum: E15FD91422CCD67C
  • Sequence:
    • MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR NCLIDRTNRN 
RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH QQRLQEQRQQ QSGEAEALAR 
VYSSSISNGL SNLNNETSGT YANGHVIDLP KSEGYYNVDS GQPSPDQSGL DMTGIKQIKQ 
EPIYDLTSVP NLFTYSSFNN GQLAPGITMT EIDRIAQNII KSHLETCQYT MEELHQLAWQ 
THTYEEIKAY QSKSREALWQ QCAIQITHAI QYVVEFAKRI TGFMELCQND QILLLKSGCL 
EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGSDDLVN EAFDFAKNLC SLQLTEEEIA 
LFSSAVLISP DRAWLIEPRK VQKLQEKIYF ALQHVIQKNH LDDETLAKLI AKIPTITAVC 
NLHGEKLQVF KQSHPEIVNT LFPPLYKELF NPDCATGCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.