Details for: RP9

Gene ID: 6100

Symbol: RP9

Ensembl ID: ENSG00000164610

Description: RP9 pre-mRNA splicing factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.7157
    Cell Significance Index: -22.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.3894
    Cell Significance Index: -23.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.1218
    Cell Significance Index: -23.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.6749
    Cell Significance Index: -20.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3790
    Cell Significance Index: -13.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6379
    Cell Significance Index: 162.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2735
    Cell Significance Index: 76.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1705
    Cell Significance Index: 136.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1287
    Cell Significance Index: 122.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0560
    Cell Significance Index: 11.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8816
    Cell Significance Index: 143.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8122
    Cell Significance Index: 17.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6793
    Cell Significance Index: 8.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6006
    Cell Significance Index: 41.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5560
    Cell Significance Index: 35.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5238
    Cell Significance Index: 23.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4524
    Cell Significance Index: 62.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3907
    Cell Significance Index: 172.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3633
    Cell Significance Index: 198.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3528
    Cell Significance Index: 63.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3448
    Cell Significance Index: 24.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3422
    Cell Significance Index: 68.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3401
    Cell Significance Index: 8.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3368
    Cell Significance Index: 9.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2630
    Cell Significance Index: 7.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2489
    Cell Significance Index: 8.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2463
    Cell Significance Index: 25.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2456
    Cell Significance Index: 5.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2409
    Cell Significance Index: 11.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2374
    Cell Significance Index: 28.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2119
    Cell Significance Index: 40.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2092
    Cell Significance Index: 41.5100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2026
    Cell Significance Index: 1.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1995
    Cell Significance Index: 24.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1970
    Cell Significance Index: 25.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1866
    Cell Significance Index: 12.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1811
    Cell Significance Index: 125.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1752
    Cell Significance Index: 9.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1682
    Cell Significance Index: 12.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1664
    Cell Significance Index: 7.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1492
    Cell Significance Index: 8.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1441
    Cell Significance Index: 51.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1012
    Cell Significance Index: 2.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0714
    Cell Significance Index: 2.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0469
    Cell Significance Index: 2.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0179
    Cell Significance Index: 3.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0084
    Cell Significance Index: 15.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0052
    Cell Significance Index: 0.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0165
    Cell Significance Index: -10.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0199
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0258
    Cell Significance Index: -3.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0268
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0364
    Cell Significance Index: -20.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0376
    Cell Significance Index: -1.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0379
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0410
    Cell Significance Index: -25.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0585
    Cell Significance Index: -16.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0611
    Cell Significance Index: -1.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0645
    Cell Significance Index: -9.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0921
    Cell Significance Index: -6.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1019
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1092
    Cell Significance Index: -12.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1172
    Cell Significance Index: -24.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1467
    Cell Significance Index: -4.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1747
    Cell Significance Index: -4.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1964
    Cell Significance Index: -20.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2001
    Cell Significance Index: -2.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2022
    Cell Significance Index: -5.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2195
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2333
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2388
    Cell Significance Index: -18.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2519
    Cell Significance Index: -11.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2573
    Cell Significance Index: -17.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2805
    Cell Significance Index: -14.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2836
    Cell Significance Index: -14.3300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.3026
    Cell Significance Index: -1.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3042
    Cell Significance Index: -7.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3071
    Cell Significance Index: -11.6300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3409
    Cell Significance Index: -2.7800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3558
    Cell Significance Index: -4.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3619
    Cell Significance Index: -8.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3627
    Cell Significance Index: -6.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3796
    Cell Significance Index: -23.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3917
    Cell Significance Index: -7.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4159
    Cell Significance Index: -11.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4277
    Cell Significance Index: -9.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4487
    Cell Significance Index: -10.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4676
    Cell Significance Index: -16.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4693
    Cell Significance Index: -13.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4804
    Cell Significance Index: -15.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4838
    Cell Significance Index: -15.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** RP9 is highly expressed in pancreatic acinar cells, male germ cells, neural progenitor cells, oogonial cells, gut endothelial cells, and primordial germ cells, suggesting its involvement in various cellular processes, including development, differentiation, and tissue homeostasis. 2. **Function:** RP9 is a pre-mRNA splicing factor, which means it regulates the splicing of pre-mRNA transcripts, influencing the production of mature mRNAs and, subsequently, the proteins they encode. 3. **Alternative Splicing:** RP9 has been implicated in the regulation of alternative splicing, a process that enables the production of diverse isoforms of proteins. This is critical for modulating cellular responses to environmental cues, such as changes in temperature, light, or nutrient availability. **Pathways and Functions:** RP9 is involved in several key pathways, including: 1. **RNA Splicing:** RP9 regulates the splicing of pre-mRNA transcripts, influencing the production of mature mRNAs and, subsequently, the proteins they encode. 2. **Cognition:** RP9 has been implicated in the regulation of alternative splicing, which is essential for modulating cellular responses to environmental cues, thereby influencing cognitive functions. 3. **Metal Ion Binding:** RP9 has been shown to bind to metal ions, which is crucial for its function as a pre-mRNA splicing factor. 4. **Protein Binding:** RP9 interacts with various proteins, including other pre-mRNA splicing factors, to regulate the splicing of pre-mRNA transcripts. **Clinical Significance:** The discovery of RP9 has significant implications for our understanding of human disease. Mutations in the RP9 gene have been associated with retinitis pigmentosa, a genetic disorder characterized by progressive vision loss. Additionally, RP9 has been implicated in other diseases, including cancer, where dysregulation of alternative splicing can lead to tumor progression. Furthermore, RP9 has been identified as a potential therapeutic target for the treatment of diseases characterized by abnormal splicing, such as muscular dystrophy and amyotrophic lateral sclerosis (ALS). In conclusion, RP9 is a critical pre-mRNA splicing factor that plays a pivotal role in regulating alternative splicing, a process essential for modulating cellular responses to environmental cues. Further research is necessary to fully elucidate the functions of RP9 and its role in human disease, with potential therapeutic applications in the treatment of diseases characterized by abnormal splicing.

Genular Protein ID: 3866470138

Symbol: RP9_HUMAN

Name: Retinitis pigmentosa 9 protein

UniProtKB Accession Codes:

Q8TA86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15556297

Title: A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase.

PubMed ID: 15556297

DOI: 10.1016/j.gene.2004.05.025

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 12032732

Title: Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa.

PubMed ID: 12032732

DOI: 10.1038/sj.ejhg.5200797

Sequence Information:

  • Length: 221
  • Mass: 26107
  • Checksum: 63774BDB40A63E4F
  • Sequence:
    • MSSRPGREDV GAAGARRPRE PPEQELQRRR EQKRRRHDAQ QLQQLKHLES FYEKPPPGLI 
KEDETKPEDC IPDVPGNEHA REFLAHAPTK GLWMPLGKEV KVMQCWRCKR YGHRTGDKEC 
PFFIKGNQKL EQFRVAHEDP MYDIIRDNKR HEKDVRIQQL KQLLEDSTSD EDRSSSSSSE 
GKEKHKKKKK KEKHKKRKKE KKKKKKRKHK SSKSNEGSDS E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.