Details for: RPL27A

Gene ID: 6157

Symbol: RPL27A

Ensembl ID: ENSG00000166441

Description: ribosomal protein L27a

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 663.4824
    Cell Significance Index: -273.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 544.7737
    Cell Significance Index: -257.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 502.7069
    Cell Significance Index: -258.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 385.3971
    Cell Significance Index: -258.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.8572
    Cell Significance Index: -63.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 19.9497
    Cell Significance Index: 509.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.3718
    Cell Significance Index: 1570.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 14.0497
    Cell Significance Index: 375.8200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 13.3957
    Cell Significance Index: 78.7000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.7230
    Cell Significance Index: 207.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.6728
    Cell Significance Index: 370.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 9.4510
    Cell Significance Index: 444.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.9813
    Cell Significance Index: 1160.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.5184
    Cell Significance Index: 223.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.3392
    Cell Significance Index: 1025.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 8.3176
    Cell Significance Index: 1499.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.0381
    Cell Significance Index: 168.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.8339
    Cell Significance Index: 62.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.6999
    Cell Significance Index: 573.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.6963
    Cell Significance Index: 177.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 7.4627
    Cell Significance Index: 84.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 7.1605
    Cell Significance Index: 506.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 7.0439
    Cell Significance Index: 967.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 6.9226
    Cell Significance Index: 3780.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 6.6925
    Cell Significance Index: 2958.9100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.2888
    Cell Significance Index: 54.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.0449
    Cell Significance Index: 281.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.8230
    Cell Significance Index: 305.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.7895
    Cell Significance Index: 62.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.4376
    Cell Significance Index: 697.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.3126
    Cell Significance Index: 152.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.1038
    Cell Significance Index: 329.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.0822
    Cell Significance Index: 46.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.7040
    Cell Significance Index: 128.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.3989
    Cell Significance Index: 3329.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.3813
    Cell Significance Index: 516.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.9289
    Cell Significance Index: 113.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.5231
    Cell Significance Index: 3181.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.3466
    Cell Significance Index: 571.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0459
    Cell Significance Index: 81.3300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.7493
    Cell Significance Index: 16.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6098
    Cell Significance Index: 517.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.9524
    Cell Significance Index: 57.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4532
    Cell Significance Index: 65.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1173
    Cell Significance Index: 212.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6886
    Cell Significance Index: 504.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5173
    Cell Significance Index: 26.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3368
    Cell Significance Index: 4.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2262
    Cell Significance Index: 65.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0323
    Cell Significance Index: -23.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0513
    Cell Significance Index: -96.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0896
    Cell Significance Index: -165.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1423
    Cell Significance Index: -219.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1528
    Cell Significance Index: -12.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2148
    Cell Significance Index: -292.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2297
    Cell Significance Index: -129.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2355
    Cell Significance Index: -147.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2485
    Cell Significance Index: -7.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3265
    Cell Significance Index: -207.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3458
    Cell Significance Index: -124.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4697
    Cell Significance Index: -46.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4741
    Cell Significance Index: -215.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.5295
    Cell Significance Index: -106.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5411
    Cell Significance Index: -113.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6658
    Cell Significance Index: -37.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7364
    Cell Significance Index: -13.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7603
    Cell Significance Index: -82.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8051
    Cell Significance Index: -130.9400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8110
    Cell Significance Index: -13.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8188
    Cell Significance Index: -93.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.0475
    Cell Significance Index: -120.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1828
    Cell Significance Index: -72.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2374
    Cell Significance Index: -77.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5022
    Cell Significance Index: -37.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5680
    Cell Significance Index: -227.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.7394
    Cell Significance Index: -29.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9017
    Cell Significance Index: -28.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.9318
    Cell Significance Index: -133.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.0813
    Cell Significance Index: -12.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.3484
    Cell Significance Index: -82.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.4153
    Cell Significance Index: -251.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9721
    Cell Significance Index: -64.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.1449
    Cell Significance Index: -241.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -3.2378
    Cell Significance Index: -41.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.4888
    Cell Significance Index: -234.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.5360
    Cell Significance Index: -216.7900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -3.5534
    Cell Significance Index: -25.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.6046
    Cell Significance Index: -49.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.7154
    Cell Significance Index: -138.8900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -4.7409
    Cell Significance Index: -21.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -5.1227
    Cell Significance Index: -31.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -5.5879
    Cell Significance Index: -95.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -5.7130
    Cell Significance Index: -153.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -5.8517
    Cell Significance Index: -124.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.9309
    Cell Significance Index: -262.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.1075
    Cell Significance Index: -224.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -6.2110
    Cell Significance Index: -121.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -6.5688
    Cell Significance Index: -68.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -6.5706
    Cell Significance Index: -136.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -7.1101
    Cell Significance Index: -269.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL27A is a small, highly conserved protein that is part of the 60S ribosomal subunit. It is essential for the proper functioning of the ribosome, which is responsible for protein synthesis. RPL27A has a unique structure, consisting of four alpha-helices and a beta-sheet, which allows it to interact with other ribosomal proteins and RNA molecules. This protein is highly expressed in cells that require rapid protein synthesis, such as immune cells and epithelial cells. **Pathways and Functions:** RPL27A is involved in several key pathways, including: 1. **Translation**: RPL27A plays a critical role in the translation process, ensuring the accurate and efficient synthesis of proteins. 2. **Post-translational protein modification**: RPL27A is involved in the hydroxylation and arylsulfatase activation of proteins, which is essential for protein function and regulation. 3. **Cellular responses to stimuli**: RPL27A is involved in the response of cells to various stimuli, including amino acid deficiency and stress. 4. **Viral infection pathways**: RPL27A has been implicated in the translation of viral RNAs, making it a potential target for antiviral therapy. **Functions:** The functions of RPL27A include: 1. **Regulation of protein synthesis**: RPL27A regulates the rate of protein synthesis by controlling the translation of mRNAs. 2. **Cellular differentiation**: RPL27A is involved in the differentiation of cells, particularly in the context of immune cell development. 3. **Antigen presentation**: RPL27A is expressed in professional antigen-presenting cells, making it a potential target for immunotherapy. 4. **Cancer development**: RPL27A has been implicated in the development and progression of various cancers, including pancreatic cancer. **Clinical Significance:** RPL27A has significant clinical implications, particularly in the context of: 1. **Cancer therapy**: RPL27A is a potential target for cancer therapy, given its overexpression in various cancers. 2. **Infectious diseases**: RPL27A is involved in the translation of viral RNAs, making it a potential target for antiviral therapy. 3. **Immune system disorders**: RPL27A plays a critical role in the development and function of immune cells, making it a potential target for immunotherapy. 4. **Neurological disorders**: RPL27A has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RPL27A is a crucial component of the 60S ribosomal subunit, playing a vital role in the translation process and various cellular processes. Its dysregulation has been implicated in various diseases, including cancer and infectious diseases, making it a potential target for therapy. Further research is needed to fully understand the functions and clinical significance of RPL27A.

Genular Protein ID: 2326940386

Symbol: RL27A_HUMAN

Name: 60S ribosomal protein L27a

UniProtKB Accession Codes:

P46776 B2R4B3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 78 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 94 PDBsum 94 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 14 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 10449908

Title: Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A.

PubMed ID: 10449908

DOI: 10.1159/000015303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103944

Title: Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

PubMed ID: 23103944

DOI: 10.1038/nchembio.1093

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 148
  • Mass: 16561
  • Checksum: CB5E09C91507798F
  • Sequence:
    • MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH 
YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ 
PVIVKAKFFS RRAEEKIKSV GGACVLVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.