Gene RPL27A - ENSG00000166441 | NCBI Gene ID: 6157

Details for: RPL27A

Gene ID: 6157

Symbol: RPL27A

Ensembl ID: ENSG00000166441

Description: ribosomal protein L27a

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Post-translational protein modification
(R-HSA-597592)
Protein hydroxylation
(R-HSA-9629569)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Endoplasmic reticulum
(GO:0005783)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 7.45
Marker Score: 4202
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.65
Marker Score: 27754.5
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.57
Marker Score: 4040
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.41
Marker Score: 2779
Cell Name: acinar cell (CL0000622)
Fold Change: 5.4
Marker Score: 3806
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.36
Marker Score: 6978
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 5.35
Marker Score: 2760
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.21
Marker Score: 1920
Cell Name: mature T cell (CL0002419)
Fold Change: 5.1
Marker Score: 50534
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 5.08
Marker Score: 3833
Cell Name: naive T cell (CL0000898)
Fold Change: 5.05
Marker Score: 3255
Cell Name: malignant cell (CL0001064)
Fold Change: 4.93
Marker Score: 66195
Cell Name: taste receptor cell (CL0000209)
Fold Change: 4.93
Marker Score: 4256
Cell Name: theca cell (CL0000503)
Fold Change: 4.92
Marker Score: 3522.5
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 4.9
Marker Score: 20442
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.84
Marker Score: 14120
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.76
Marker Score: 4055
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.74
Marker Score: 161435
Cell Name: naive B cell (CL0000788)
Fold Change: 4.72
Marker Score: 4217
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.72
Marker Score: 24782
Cell Name: memory T cell (CL0000813)
Fold Change: 4.67
Marker Score: 2006
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.64
Marker Score: 7139
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.56
Marker Score: 7825
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.52
Marker Score: 1080
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.52
Marker Score: 1469
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 4.49
Marker Score: 3416
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.44
Marker Score: 9298
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.37
Marker Score: 2660
Cell Name: endocardial cell (CL0002350)
Fold Change: 4.32
Marker Score: 2439
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.3
Marker Score: 11878
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.23
Marker Score: 13353
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.23
Marker Score: 223540
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.22
Marker Score: 10306
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 4.21
Marker Score: 26856
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.15
Marker Score: 54723
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.14
Marker Score: 2427
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.14
Marker Score: 4996
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 4.07
Marker Score: 3838.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.06
Marker Score: 3460
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.05
Marker Score: 9219
Cell Name: supporting cell (CL0000630)
Fold Change: 4.03
Marker Score: 7574
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.02
Marker Score: 4295
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.02
Marker Score: 24410.5
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.98
Marker Score: 913
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.97
Marker Score: 2054
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 3.96
Marker Score: 1651.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.95
Marker Score: 11084
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.95
Marker Score: 25752
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.93
Marker Score: 3873.5
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.91
Marker Score: 1030
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 3.88
Marker Score: 903
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.87
Marker Score: 5627
Cell Name: club cell (CL0000158)
Fold Change: 3.85
Marker Score: 4491
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 3.85
Marker Score: 1051
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.82
Marker Score: 4248
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.82
Marker Score: 1085
Cell Name: hepatoblast (CL0005026)
Fold Change: 3.8
Marker Score: 12439.5
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.79
Marker Score: 1067
Cell Name: reticular cell (CL0000432)
Fold Change: 3.79
Marker Score: 1382.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.76
Marker Score: 13356
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.76
Marker Score: 2951.5
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.73
Marker Score: 1933
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.73
Marker Score: 1678
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.72
Marker Score: 15950
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.72
Marker Score: 3317.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.72
Marker Score: 5913
Cell Name: granulocyte (CL0000094)
Fold Change: 3.71
Marker Score: 1664
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.71
Marker Score: 3271
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.7
Marker Score: 4570
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.69
Marker Score: 978
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.69
Marker Score: 9185
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.68
Marker Score: 3843.5
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.68
Marker Score: 2030
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.67
Marker Score: 912
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.66
Marker Score: 1671
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.65
Marker Score: 1041
Cell Name: stromal cell (CL0000499)
Fold Change: 3.65
Marker Score: 4276
Cell Name: blood cell (CL0000081)
Fold Change: 3.64
Marker Score: 42332
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.63
Marker Score: 8246
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.63
Marker Score: 1194.5
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 3.62
Marker Score: 1070
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.61
Marker Score: 3998
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.6
Marker Score: 9151.5
Cell Name: memory B cell (CL0000787)
Fold Change: 3.6
Marker Score: 2723
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.6
Marker Score: 3869
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.6
Marker Score: 3446
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.58
Marker Score: 2410
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.58
Marker Score: 200364
Cell Name: fibroblast (CL0000057)
Fold Change: 3.58
Marker Score: 3459
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.58
Marker Score: 9591
Cell Name: paneth cell (CL0000510)
Fold Change: 3.58
Marker Score: 2490
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 3.56
Marker Score: 1005.5
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 3.56
Marker Score: 887
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 3.56
Marker Score: 1227
Cell Name: tendon cell (CL0000388)
Fold Change: 3.56
Marker Score: 875
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 3.55
Marker Score: 1141
Cell Name: basophil (CL0000767)
Fold Change: 3.55
Marker Score: 1688
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 3.55
Marker Score: 910
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 3.55
Marker Score: 772
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 3.54
Marker Score: 940

Hover over a box to see details here...

**Key characteristics:** * RPL27A is a ribosomal protein that is involved in the initiation of protein translation. * It is a key regulator of protein translation, and its expression is often upregulated in cancer cells. * RPL27A is also involved in the regulation of cell migration and invasion. **Pathways and functions:** * RPL27A is involved in the regulation of protein translation by binding to the 5' cap of mRNA and facilitating its interaction with the ribosome. * It also interacts with the eIF4E protein, which is a key regulator of translation initiation. * RPL27A is also involved in the regulation of cell migration and invasion. **Clinical significance:** RPL27A is a promising target for the treatment of cancer. Several studies have shown that blocking RPL27A expression or activity can inhibit cancer cell growth and metastasis. This has led to the development of several clinical trials of RPL27A inhibitors. However, the results of these trials have been mixed, and further research is needed to develop more effective therapies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L27a

Genular Protein ID: 2326940386

Symbol: RL27A_HUMAN

Name: 60S ribosomal protein L27a

UniProtKB Accession Codes:

P46776 B2R4B3

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 10449908

Title: Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A.

PubMed ID: 10449908

DOI: 10.1159/000015303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103944

Title: Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

PubMed ID: 23103944

DOI: 10.1038/nchembio.1093

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 148
Mass: 16561
Checksum: CB5E09C91507798F
Sequence:

MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH 
YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ 
PVIVKAKFFS RRAEEKIKSV GGACVLVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPL27A

Associated with

Cells (max top 100)

Other Information

Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. PubMed ID: 7772601

Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. PubMed ID: 10449908

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. PubMed ID: 23103944

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547