RPL27A | ENSG00000166441 | NCBI 6157

Details for: RPL27A

Gene ID: 6157

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RPL27A

Ensembl ID: ENSG00000166441

Description: ribosomal protein L27a

Cell Significance Landscape

Display Count:

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Post-translational protein modification
(R-HSA-597592)
Protein hydroxylation
(R-HSA-9629569)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic large ribosomal subunit
(GO:0022625)
Cytosolic ribosome
(GO:0022626)
Endoplasmic reticulum
(GO:0005783)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 119.55

rCSI 79.46%

PRS 2.21
keratinocyte CL0000312

CSI 101.53

rCSI 85.1%

PRS 2.23
granulocyte monocyte progenitor cell CL0000557

CSI 101.1

rCSI 87.54%

PRS 2.07
mature T cell CL0002419

CSI 97.09

rCSI 75.51%

PRS 2.67
CD4-positive, alpha-beta thymocyte CL0000810

CSI 95.17

rCSI 76.23%

PRS 3.48
epithelial cell of lung CL0000082

CSI 93.01

rCSI 77.11%

PRS 1.74
intestinal epithelial cell CL0002563

CSI 92.07

rCSI 96.23%

PRS 2
common myeloid progenitor CL0000049

CSI 91.89

rCSI 74.3%

PRS 1.82
fallopian tube secretory epithelial cell CL4030006

CSI 90.25

rCSI 86.88%

PRS 1.93
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 88.47

rCSI 59.6%

PRS 2.24
epithelial cell of lower respiratory tract CL0002632

CSI 88.44

rCSI 68.56%

PRS 1.77
megakaryocyte-erythroid progenitor cell CL0000050

CSI 84.21

rCSI 76.05%

PRS 1.63
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 82.31

rCSI 57.81%

PRS 5.67
intestine goblet cell CL0019031

CSI 80.17

rCSI 71.16%

PRS 1.86
ciliated epithelial cell CL0000067

CSI 78.64

rCSI 69.16%

PRS 1.34
CD4-positive helper T cell CL0000492

CSI 78.33

rCSI 59.26%

PRS 2.6
mature B cell CL0000785

CSI 76.95

rCSI 66.89%

PRS 2.28
common dendritic progenitor CL0001029

CSI 76.46

rCSI 95.96%

PRS 2.35
transit amplifying cell of colon CL0009011

CSI 73.95

rCSI 86.85%

PRS 2.27
pancreatic A cell CL0000171

CSI 72.24

rCSI 75.68%

PRS 2
class switched memory B cell CL0000972

CSI 71.93

rCSI 53.7%

PRS 3.14
extravillous trophoblast CL0008036

CSI 71.74

rCSI 88.75%

PRS 1.64
plasmablast CL0000980

CSI 69.78

rCSI 54.9%

PRS 2.2
early lymphoid progenitor CL0000936

CSI 68.55

rCSI 60.2%

PRS 2.07
memory B cell CL0000787

CSI 66.05

rCSI 65.22%

PRS 8.24
peripheral nervous system neuron CL2000032

CSI 61.89

rCSI 84.32%

PRS 1.7
plasmacytoid dendritic cell, human CL0001058

CSI 61.55

rCSI 42.98%

PRS 1.95
neural crest cell CL0011012

CSI 59.95

rCSI 47.39%

PRS 1.29
mucous neck cell CL0000651

CSI 59.89

rCSI 86.32%

PRS 3.02
myeloid leukocyte CL0000766

CSI 59.75

rCSI 55.12%

PRS 1.88
skin fibroblast CL0002620

CSI 59.31

rCSI 51.13%

PRS 3.1
placental villous trophoblast CL2000060

CSI 57.3

rCSI 88.54%

PRS 1.75
CD14-low, CD16-positive monocyte CL0002396

CSI 57.17

rCSI 44.05%

PRS 1.67
pancreatic acinar cell CL0002064

CSI 57.13

rCSI 75.93%

PRS 2.04
fraction A pre-pro B cell CL0002045

CSI 57.09

rCSI 65.35%

PRS 3.87
enteroendocrine cell CL0000164

CSI 56.89

rCSI 77.74%

PRS 2.05
goblet cell CL0000160

CSI 56.54

rCSI 53.43%

PRS 1.94
promyelocyte CL0000836

CSI 56.02

rCSI 80.8%

PRS 2.57
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 55.99

rCSI 33.06%

PRS 2.59
pancreatic D cell CL0000173

CSI 55.9

rCSI 54.98%

PRS 2.05
T follicular helper cell CL0002038

CSI 54.94

rCSI 41.11%

PRS 3.04
elicited macrophage CL0000861

CSI 52.93

rCSI 48.6%

PRS 2.12
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 52.78

rCSI 35.18%

PRS 5.27
double-positive, alpha-beta thymocyte CL0000809

CSI 50.36

rCSI 51.32%

PRS 2.7
enterocyte CL0000584

CSI 49.17

rCSI 79.28%

PRS 3.02
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 48.62

rCSI 61.09%

PRS 10.24
naive B cell CL0000788

CSI 48.23

rCSI 41.37%

PRS 6.03
acinar cell CL0000622

CSI 48.16

rCSI 70.62%

PRS 2.46
immature B cell CL0000816

CSI 48.09

rCSI 35.73%

PRS 2.77
perivascular cell CL4033054

CSI 47.88

rCSI 65.46%

PRS 2.13
CD1c-positive myeloid dendritic cell CL0002399

CSI 47.66

rCSI 57.57%

PRS 2.15
double negative thymocyte CL0002489

CSI 47.26

rCSI 32.86%

PRS 2.16
unswitched memory B cell CL0000970

CSI 46.73

rCSI 39.31%

PRS 3.13
respiratory basal cell CL0002633

CSI 46.47

rCSI 48.14%

PRS 2.17
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 46.14

rCSI 34.6%

PRS 5.6
mucosal invariant T cell CL0000940

CSI 45.43

rCSI 36.7%

PRS 4.87
promonocyte CL0000559

CSI 45.14

rCSI 77.33%

PRS 2.48
effector CD8-positive, alpha-beta T cell CL0001050

CSI 44.83

rCSI 34.1%

PRS 2.46
T-helper 17 cell CL0000899

CSI 44.79

rCSI 35.57%

PRS 3.3
conjunctival epithelial cell CL1000432

CSI 43.81

rCSI 66.92%

PRS 1.87
T-helper 1 cell CL0000545

CSI 43.69

rCSI 78.86%

PRS 5.83
kidney epithelial cell CL0002518

CSI 43.31

rCSI 82.66%

PRS 4.6
colon epithelial cell CL0011108

CSI 43.18

rCSI 45.24%

PRS 1.73
conventional dendritic cell CL0000990

CSI 42.97

rCSI 35.87%

PRS 6.25
group 3 innate lymphoid cell CL0001071

CSI 42.78

rCSI 32.15%

PRS 1.91
epithelial cell CL0000066

CSI 42.13

rCSI 64.74%

PRS 2.7
common lymphoid progenitor CL0000051

CSI 41.82

rCSI 55.88%

PRS 3.55
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 41.07

rCSI 70.26%

PRS 4.11
M cell of gut CL0000682

CSI 41.02

rCSI 43.58%

PRS 3.36
lung ciliated cell CL1000271

CSI 40.76

rCSI 47.13%

PRS 1.34
pro-B cell CL0000826

CSI 40.66

rCSI 33.67%

PRS 1.85
CD4-positive, alpha-beta T cell CL0000624

CSI 40.45

rCSI 51.76%

PRS 40.96
fibroblast of lung CL0002553

CSI 39.91

rCSI 37.14%

PRS 1.85
myeloid dendritic cell CL0000782

CSI 39.85

rCSI 57.73%

PRS 2.72
multi-ciliated epithelial cell CL0005012

CSI 39.74

rCSI 39.66%

PRS 1.57
colonocyte CL1000347

CSI 39.12

rCSI 56.07%

PRS 2.61
colon goblet cell CL0009039

CSI 38.97

rCSI 92.65%

PRS 2.84
paneth cell CL0000510

CSI 38.51

rCSI 56.86%

PRS 2.95
mesodermal cell CL0000222

CSI 38.44

rCSI 46.14%

PRS 1.86
plasma cell CL0000786

CSI 37.74

rCSI 49.46%

PRS 10.16
bronchus fibroblast of lung CL2000093

CSI 37.59

rCSI 30.55%

PRS 1.95
CD8-positive, alpha-beta thymocyte CL0000811

CSI 37.55

rCSI 58.56%

PRS 4.86
retinal blood vessel endothelial cell CL0002585

CSI 37.22

rCSI 59.44%

PRS 2.03
B cell CL0000236

CSI 37.19

rCSI 49.76%

PRS 11.52
mature NK T cell CL0000814

CSI 37

rCSI 47.33%

PRS 8.64
hematopoietic precursor cell CL0008001

CSI 36.5

rCSI 37.55%

PRS 2.99
foveolar cell of stomach CL0002179

CSI 36.14

rCSI 76.93%

PRS 3.03
secretory cell CL0000151

CSI 35.95

rCSI 37.51%

PRS 1.9
dendritic cell CL0000451

CSI 35.23

rCSI 43.41%

PRS 6.22
CD4-positive, alpha-beta memory T cell CL0000897

CSI 34.61

rCSI 24.85%

PRS 2.53
progenitor cell CL0011026

CSI 34.55

rCSI 73.47%

PRS 3.77
pancreatic ductal cell CL0002079

CSI 34.51

rCSI 67.11%

PRS 1.9
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 34.22

rCSI 68.22%

PRS 3.22
BEST4+ enteroycte CL4030026

CSI 34.11

rCSI 42.43%

PRS 1.99
intermediate monocyte CL0002393

CSI 33.81

rCSI 51.01%

PRS 1.82
natural T-regulatory cell CL0000903

CSI 33.73

rCSI 63.88%

PRS 5.34
plasmacytoid dendritic cell CL0000784

CSI 33.67

rCSI 34.1%

PRS 12.56
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 33.62

rCSI 45.8%

PRS 4.66
OFF-bipolar cell CL0000750

CSI 33.53

rCSI 45.84%

PRS 3.47
endothelial cell of artery CL1000413

CSI 33.37

rCSI 48.89%

PRS 11.46

retinal bipolar neuron CL0000748

CSI -48.7

rCSI -91.2%

PRS 1.6%
kidney interstitial alternatively activated macrophage CL1000695

CSI -27.1

rCSI -70.7%

PRS 2.3%
astrocyte of the cerebral cortex CL0002605

CSI -26.8

rCSI -60.1%

PRS 1.2%
alpha-beta T cell CL0000789

CSI -26.2

rCSI -30.7%

PRS 3.2%
inhibitory interneuron CL0000498

CSI -23.0

rCSI -53.1%

PRS 1.9%
cerebral cortex neuron CL0010012

CSI -17.4

rCSI -71.1%

PRS 2.7%
differentiation-committed oligodendrocyte precursor CL4023059

CSI -17.4

rCSI -31.6%

PRS 2.2%
cerebral cortex endothelial cell CL1001602

CSI -17.0

rCSI -29.3%

PRS 1.4%
hepatic stellate cell CL0000632

CSI -16.6

rCSI -62.0%

PRS 1.6%
neural cell CL0002319

CSI -15.4

rCSI -58.1%

PRS 4.4%
GABAergic neuron CL0000617

CSI -14.3

rCSI -47.9%

PRS 2.0%
rod bipolar cell CL0000751

CSI -14.0

rCSI -25.1%

PRS 1.6%
platelet CL0000233

CSI -12.4

rCSI -51.5%

PRS 5.9%
kidney interstitial fibroblast CL1000692

CSI -12.3

rCSI -65.4%

PRS 14.2%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -12.3

rCSI -29.9%

PRS 1.2%
squamous epithelial cell CL0000076

CSI -12.2

rCSI -29.1%

PRS 2.5%
pulmonary capillary endothelial cell CL4028001

CSI -12.0

rCSI -22.9%

PRS 3.0%
mature microglial cell CL0002629

CSI -11.6

rCSI -48.0%

PRS 6.2%
adipocyte CL0000136

CSI -11.3

rCSI -14.5%

PRS 2.5%
kidney collecting duct principal cell CL1001431

CSI -10.6

rCSI -53.5%

PRS 13.2%
kidney proximal convoluted tubule epithelial cell CL1000838

CSI -10.3

rCSI -100.0%

PRS 29.5%
epicardial adipocyte CL1000309

CSI -10.2

rCSI -33.3%

PRS 3.5%
mature astrocyte CL0002627

CSI -10.1

rCSI -42.8%

PRS 4.9%
Schwann cell CL0002573

CSI -9.5

rCSI -26.9%

PRS 2.6%
periportal region hepatocyte CL0019026

CSI -9.3

rCSI -36.3%

PRS 3.3%
OFFx cell CL4033036

CSI -8.8

rCSI -41.4%

PRS 5.4%
sncg GABAergic cortical interneuron CL4023015

CSI -8.1

rCSI -13.0%

PRS 1.4%
erythroid lineage cell CL0000764

CSI -7.7

rCSI -49.4%

PRS 5.4%
glutamatergic neuron CL0000679

CSI -7.6

rCSI -15.6%

PRS 2.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI -7.2

rCSI -27.1%

PRS 1.3%
starburst amacrine cell CL0004232

CSI -7.1

rCSI -59.8%

PRS 5.1%
invaginating midget bipolar cell CL4033034

CSI -5.5

rCSI -32.6%

PRS 4.7%
renal interstitial pericyte CL1001318

CSI -5.5

rCSI -15.2%

PRS 2.1%
diffuse bipolar 1 cell CL4033027

CSI -5.2

rCSI -38.7%

PRS 4.6%
flat midget bipolar cell CL4033033

CSI -5.0

rCSI -35.4%

PRS 4.7%
kidney granular cell CL0000648

CSI -4.9

rCSI -70.8%

PRS 23.9%
diffuse bipolar 6 cell CL4033032

CSI -4.7

rCSI -24.9%

PRS 5.7%
cardiac endothelial cell CL0010008

CSI -4.7

rCSI -19.1%

PRS 2.2%
exhausted T cell CL0011025

CSI -4.5

rCSI -75.3%

PRS 10.7%
cell of skeletal muscle CL0000188

CSI -4.1

rCSI -44.4%

PRS 13.5%
midzonal region hepatocyte CL0019028

CSI -3.4

rCSI -8.0%

PRS 3.4%
kidney collecting duct intercalated cell CL1001432

CSI -3.4

rCSI -24.2%

PRS 8.6%
cardiac blood vessel endothelial cell CL0010006

CSI -3.3

rCSI -23.1%

PRS 6.3%
lung interstitial macrophage CL4033043

CSI -3.2

rCSI -7.2%

PRS 4.8%
ON midget ganglion cell CL4033046

CSI -3.2

rCSI -64.8%

PRS 2.4%
regular ventricular cardiac myocyte CL0002131

CSI -3.1

rCSI -19.3%

PRS 1.6%
S cone cell CL0003050

CSI -2.4

rCSI -10.7%

PRS 2.1%
OFF midget ganglion cell CL4033047

CSI -2.4

rCSI -48.3%

PRS 2.6%
fast muscle cell CL0000190

CSI -2.3

rCSI -8.9%

PRS 11.7%
diffuse bipolar 2 cell CL4033028

CSI -1.6

rCSI -12.5%

PRS 5.3%
collagen secreting cell CL0000667

CSI -1.5

rCSI -8.5%

PRS 11.1%
H1 horizontal cell CL0004217

CSI -1.0

rCSI -3.9%

PRS 5.4%
immature innate lymphoid cell CL0001082

CSI -0.4

rCSI -13.8%

PRS 34.4%
diffuse bipolar 3b cell CL4033030

CSI -0.3

rCSI -1.7%

PRS 4.9%
L6b glutamatergic cortical neuron CL4023038

CSI 0.0

rCSI 0.0%

PRS 1.3%
H2 horizontal cell CL0004218

CSI 0.3

rCSI 1.5%

PRS 3.8%
airway submucosal gland duct basal cell CL4033024

CSI 0.3

rCSI 2.1%

PRS 9.7%
endocardial cell CL0002350

CSI 0.3

rCSI 1.6%

PRS 3.4%
indirect pathway medium spiny neuron CL4023029

CSI 0.4

rCSI 9.9%

PRS 1.4%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.5

rCSI 4.0%

PRS 11.2%
group 3 innate lymphoid cell, human CL0001078

CSI 0.6

rCSI 12.4%

PRS 37.7%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.7

rCSI 1.2%

PRS 1.2%
glycinergic amacrine cell CL4030028

CSI 0.7

rCSI 1.9%

PRS 3.0%
GABAergic amacrine cell CL4030027

CSI 0.8

rCSI 2.8%

PRS 2.8%
amacrine cell CL0000561

CSI 1.1

rCSI 3.1%

PRS 1.8%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 1.1

rCSI 34.2%

PRS 26.5%
hepatic pit cell CL2000054

CSI 1.2

rCSI 16.9%

PRS 23.9%
cholangiocyte CL1000488

CSI 1.2

rCSI 7.4%

PRS 4.6%
neuroplacodal cell CL0000032

CSI 1.3

rCSI 11.6%

PRS 7.7%
follicular dendritic cell CL0000442

CSI 1.3

rCSI 20.7%

PRS 12.5%
diffuse bipolar 3a cell CL4033029

CSI 1.3

rCSI 9.1%

PRS 4.6%
Bergmann glial cell CL0000644

CSI 1.5

rCSI 2.0%

PRS 2.1%
lung resident memory CD4-positive, alpha-beta T cell CL4033038

CSI 1.6

rCSI 15.7%

PRS 24.8%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.6

rCSI 13.9%

PRS 5.3%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.8

rCSI 8.3%

PRS 7.6%
macula densa epithelial cell CL1000850

CSI 1.9

rCSI 26.5%

PRS 29.3%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.9

rCSI 21.0%

PRS 9.4%
cord blood hematopoietic stem cell CL2000095

CSI 2.0

rCSI 38.0%

PRS 16.4%
tracheobronchial goblet cell CL0019003

CSI 2.1

rCSI 32.9%

PRS 46.7%
forebrain neuroblast CL1000042

CSI 2.2

rCSI 23.4%

PRS 28.6%
NKp44-positive group 3 innate lymphoid cell, human CL0001079

CSI 2.2

rCSI 30.9%

PRS 51.4%
mesenchymal lymphangioblast CL0005021

CSI 2.3

rCSI 59.5%

PRS 10.9%
retinal ganglion cell CL0000740

CSI 2.3

rCSI 5.1%

PRS 1.4%
parietal epithelial cell CL1000452

CSI 2.4

rCSI 6.4%

PRS 2.0%
cone retinal bipolar cell CL0000752

CSI 2.4

rCSI 31.4%

PRS 13.4%
Purkinje cell CL0000121

CSI 2.4

rCSI 31.6%

PRS 19.2%
kidney resident macrophage CL1000698

CSI 2.4

rCSI 48.5%

PRS 48.4%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.5

rCSI 26.2%

PRS 3.3%
kidney connecting tubule epithelial cell CL1000768

CSI 2.5

rCSI 6.3%

PRS 1.5%
endothelial cell of vascular tree CL0002139

CSI 2.5

rCSI 13.9%

PRS 5.1%
uterine smooth muscle cell CL0002601

CSI 2.6

rCSI 17.4%

PRS 14.8%
lung microvascular endothelial cell CL2000016

CSI 2.7

rCSI 51.7%

PRS 6.9%
slow muscle cell CL0000189

CSI 2.7

rCSI 35.9%

PRS 26.0%
kidney loop of Henle epithelial cell CL1000909

CSI 2.7

rCSI 57.1%

PRS 17.8%
double negative T regulatory cell CL0011024

CSI 2.7

rCSI 51.7%

PRS 17.1%
odontoblast CL0000060

CSI 2.8

rCSI 63.1%

PRS 11.3%
pluripotent stem cell CL0002248

CSI 2.9

rCSI 85.4%

PRS 4.8%
retinal rod cell CL0000604

CSI 2.9

rCSI 5.2%

PRS 2.2%
osteoblast CL0000062

CSI 3.0

rCSI 73.5%

PRS 18.6%
B-1 B cell CL0000819

CSI 3.0

rCSI 76.3%

PRS 11.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [RPL27A](/details-gene/6157) (Ribosomal Protein L27a) is a protein-coding gene located on chromosome 11p15.4 that encodes a core component of the 60S large ribosomal subunit. As a structural constituent of the ribosome, its primary function is integral to protein synthesis, specifically cytoplasmic [translation](/details-go/GO:0006412). Reflecting this fundamental housekeeping role, [RPL27A](/details-gene/6157) shows significant expression in a wide range of cell types, particularly those with high metabolic activity, rapid proliferation, or high protein secretion demands. These include [hematopoietic stem cell](/details-cell/CL0000037)s, various progenitor cells, T cells, and epithelial cells of barrier tissues such as skin ([keratinocyte](/details-cell/CL0000312)) and lung ([epithelial cell of lung](/details-cell/CL0000082)). Its broad yet essential function is highlighted by its involvement in numerous fundamental cellular processes, from development to stress responses. ## Cellular Roles and Expression Landscape The expression profile of [RPL27A](/details-gene/6157) underscores its critical role in maintaining translational machinery across diverse cell lineages. **Overall**, the gene exhibits its highest significance in cell populations characterized by high rates of division and protein production. A prominent signature is observed within the hematopoietic system, where [RPL27A](/details-gene/6157) is a top marker in [hematopoietic stem cell](/details-cell/CL0000037)s (CSI: 119.55), [granulocyte monocyte progenitor cell](/details-cell/CL0000557)s (CSI: 101.10), and [common myeloid progenitor](/details-cell/CL0000049)s (CSI: 91.89). Its significance extends to mature lymphoid lineages, including [mature T cell](/details-cell/CL0002419)s (CSI: 97.09) and [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907)s (CSI: 88.47), consistent with the need for rapid protein synthesis during immune cell activation and proliferation. Furthermore, [RPL27A](/details-gene/6157) is highly significant in epithelial cells that form critical barrier tissues and undergo constant renewal. This includes high CSI values in [keratinocyte](/details-cell/CL0000312)s of the skin (CSI: 101.53), [epithelial cell of lung](/details-cell/CL0000082) (CSI: 93.01), and [intestinal epithelial cell](/details-cell/CL0002563)s (CSI: 92.07). Conversely, the gene's expression is markedly lower in terminally differentiated, post-mitotic cells with lower overall protein synthesis requirements. This is most evident in the nervous system, where it is an anti-marker for various neuronal subtypes, including [retinal bipolar neuron](/details-cell/CL0000748) (CSI: -48.68), [inhibitory interneuron](/details-cell/CL0000498) (CSI: -22.99), and [cerebral cortex neuron](/details-cell/CL0010012) (CSI: -17.44). This pattern suggests that while essential, the baseline requirement for [RPL27A](/details-gene/6157) is substantially lower in quiescent neural tissues compared to actively dividing hematopoietic or epithelial populations. ## Pathways and Molecular Function Functionally, [RPL27A](/details-gene/6157) is annotated as a [structural constituent of ribosome](/details-go/GO:0003735) and is a key player in the process of [translation](/details-go/GO:0006412). Its molecular functions include both [RNA binding](/details-go/GO:0003723) and [protein binding](/details-go/GO:0005515), which are essential for its role in assembling and stabilizing the ribosomal complex and facilitating protein synthesis. The gene product is a component of the [cytosolic large ribosomal subunit](/details-go/GO:0022625). The Reactome pathway analysis reveals its ubiquitous involvement in all stages of protein synthesis, including [eukaryotic translation initiation](/details-reactome/R-HSA-72613), [elongation](/details-reactome/R-HSA-156842), and [termination](/details-reactome/R-HSA-72764). Beyond this core function, its role extends to broader biological contexts that rely heavily on controlled protein production. These include [developmental biology](/details-reactome/R-HSA-1266738), [cellular responses to stress](/details-reactome/R-HSA-2262752), and host-pathogen interactions, such as [influenza infection](/details-reactome/R-HSA-168255) and [viral mRNA translation](/details-reactome/R-HSA-192823). This indicates that the translational machinery, of which [RPL27A](/details-gene/6157) is a part, is a central hub for cellular response and is often co-opted during disease states. ## Research Directions Given that [RPL27A](/details-gene/6157) is a fundamental component of the ribosome, its dysregulation is likely to have profound cellular consequences, particularly in diseases characterized by altered protein synthesis, such as cancer and viral infections. **Proposed Hypotheses:** 1. Given its high significance in hematopoietic stem and progenitor cells, subtle variations in [RPL27A](/details-gene/6157) expression levels may critically regulate the balance between self-renewal and differentiation. Reduced expression could impair the rapid proteome remodeling required for lineage commitment, leading to hematopoietic defects. 2. Based on its annotated role in [viral mRNA translation](/details-reactome/R-HSA-192823), [RPL27A](/details-gene/6157) may function as a non-essential but enhancing host factor for specific viruses that rely on the host's translational machinery for replication. Cells with higher basal levels of [RPL27A](/details-gene/6157), such as [epithelial cell of lung](/details-cell/CL0000082), may be more permissive to infection by certain respiratory viruses. **Experimental Approach:** To test the first hypothesis regarding its role in hematopoiesis, one could utilize a CRISPR-interference (CRISPRi) system to achieve graded knockdown of [RPL27A](/details-gene/6157) in primary human CD34+ hematopoietic stem and progenitor cells (HSPCs). These modified HSPCs would then be cultured in vitro under differentiation-promoting conditions for myeloid and erythroid lineages. The impact on differentiation could be quantified via colony-forming unit (CFU) assays and multi-parameter flow cytometry for lineage-specific surface markers. Concurrently, ribosome profiling (Ribo-seq) could be performed to determine if [RPL27A](/details-gene/6157) knockdown leads to global translational repression or affects the translation of specific subsets of mRNAs essential for differentiation. **Therapeutic Potential:** As a ubiquitous and essential ribosomal protein, direct inhibition of [RPL27A](/details-gene/6157) is unlikely to be a viable therapeutic strategy due to the high probability of systemic toxicity. However, its expression level could serve as a valuable prognostic biomarker. In cancers characterized by high translational demand (e.g., multiple myeloma or rapidly proliferating solid tumors), elevated [RPL27A](/details-gene/6157) expression might correlate with tumor aggressiveness, metabolic activity, and resistance to therapy. Therefore, monitoring [RPL27A](/details-gene/6157) levels could aid in patient stratification or in assessing the efficacy of therapies that indirectly target protein synthesis pathways.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L27a

Genular Protein ID: 2326940386

Symbol: RL27A_HUMAN

Name: 60S ribosomal protein L27a

UniProtKB Accession Codes:

P46776 B2R4B3

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 10449908

Title: Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A.

PubMed ID: 10449908

DOI: 10.1159/000015303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23103944

Title: Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

PubMed ID: 23103944

DOI: 10.1038/nchembio.1093

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

Length: 148
Mass: 16561
Checksum: CB5E09C91507798F
Sequence:

MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH 
YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ 
PVIVKAKFFS RRAEEKIKSV GGACVLVA

Details for: RPL27A

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. PubMed ID: 7772601

Genomic structure and chromosome location of RPL27A/Rpl27a, the genes encoding human and mouse ribosomal protein L27A. PubMed ID: 10449908

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. PubMed ID: 23103944

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A new system for naming ribosomal proteins. PubMed ID: 24524803

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. PubMed ID: 32669547