Details for: RPS9

Gene ID: 6203

Symbol: RPS9

Ensembl ID: ENSG00000170889

Description: ribosomal protein S9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 8.28
    Marker Score: 5539
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 7.68
    Marker Score: 3965
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 6.53
    Marker Score: 3679
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 6.27
    Marker Score: 1839
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.12
    Marker Score: 30084
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 5.72
    Marker Score: 23758
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 5.54
    Marker Score: 3785
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.47
    Marker Score: 11472
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.39
    Marker Score: 72436
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.35
    Marker Score: 8231.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.25
    Marker Score: 3703
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.22
    Marker Score: 4085
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.17
    Marker Score: 51207
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.13
    Marker Score: 6683
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.12
    Marker Score: 3718
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.1
    Marker Score: 14884
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.03
    Marker Score: 171139
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.98
    Marker Score: 8545
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.94
    Marker Score: 2541
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.93
    Marker Score: 3531
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.86
    Marker Score: 1793
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.79
    Marker Score: 2905.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.76
    Marker Score: 15021
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.74
    Marker Score: 4041
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.7
    Marker Score: 4199
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.68
    Marker Score: 247605
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.54
    Marker Score: 23848
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.49
    Marker Score: 2892
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.49
    Marker Score: 251037
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.46
    Marker Score: 58818
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.45
    Marker Score: 15796
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 4.42
    Marker Score: 2018
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.38
    Marker Score: 11745
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.33
    Marker Score: 2632
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.32
    Marker Score: 4804
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.3
    Marker Score: 1847
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.29
    Marker Score: 26095
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.27
    Marker Score: 49681
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.26
    Marker Score: 11759
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.24
    Marker Score: 1377
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.21
    Marker Score: 1006
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.19
    Marker Score: 10226
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.18
    Marker Score: 11717
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.16
    Marker Score: 9476
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.15
    Marker Score: 3520
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 4.12
    Marker Score: 2736
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.1
    Marker Score: 10327
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.08
    Marker Score: 2903
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.06
    Marker Score: 25934
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.06
    Marker Score: 3462
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.05
    Marker Score: 17361
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 4.04
    Marker Score: 6418.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 4.02
    Marker Score: 7547
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.99
    Marker Score: 9734
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.98
    Marker Score: 3921
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.98
    Marker Score: 4246
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.97
    Marker Score: 5851
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.96
    Marker Score: 3109
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.95
    Marker Score: 10028
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.93
    Marker Score: 2396.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.92
    Marker Score: 1253
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.91
    Marker Score: 29077
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.9
    Marker Score: 25439
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.86
    Marker Score: 3432
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.84
    Marker Score: 3708
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.79
    Marker Score: 2023
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.78
    Marker Score: 2084
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.77
    Marker Score: 3547
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.74
    Marker Score: 4521
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.74
    Marker Score: 3530.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 3.74
    Marker Score: 3880
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.72
    Marker Score: 2502
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.7
    Marker Score: 1217
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.7
    Marker Score: 2432
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.69
    Marker Score: 24023
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.69
    Marker Score: 3023.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.69
    Marker Score: 3289.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.69
    Marker Score: 3966
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.68
    Marker Score: 4071
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.68
    Marker Score: 2053
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.68
    Marker Score: 843
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.67
    Marker Score: 1903
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.67
    Marker Score: 3275
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.67
    Marker Score: 3222
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.66
    Marker Score: 1336
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.65
    Marker Score: 1173
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.64
    Marker Score: 2752.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.64
    Marker Score: 4159
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.62
    Marker Score: 8223
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.58
    Marker Score: 1605
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.58
    Marker Score: 2973
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.58
    Marker Score: 2490
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.57
    Marker Score: 2364.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 3.57
    Marker Score: 1386
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 3.56
    Marker Score: 937
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.55
    Marker Score: 3708
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.55
    Marker Score: 1001
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.55
    Marker Score: 27752
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.55
    Marker Score: 1009
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.55
    Marker Score: 1225

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Other Information

**Key characteristics:** - RS9 is a large protein with a molecular weight of approximately 100 kDa. - It is a member of the RPS9 family of ribosomal proteins. - RS9 is present in both the cytoplasm and the nucleus. - It forms part of the translation initiation complex, which includes other proteins such as RNAP, eIF4E, and eIF2. **Pathways and functions:** - RS9 is involved in the initiation of protein synthesis. - It is required for the binding of initiator proteins to the 5' cap of mRNA. - It is also involved in the recognition of stop codons. - RS9 is a key regulator of translation initiation. - It can be inhibited by eIF2, which is an upstream regulator of translation initiation. **Clinical significance:** - Mutations in the RPS9 gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - In some cases, mutations in RPS9 can lead to the production of a defective protein that is unable to initiate translation. - This can result in a variety of symptoms, including muscle weakness, growth problems, and developmental delays. **Additional notes:** - RS9 is also involved in the regulation of mRNA stability. - It is a target for a number of anti-cancer drugs. - It is a promising target for the treatment of cancer and other diseases that are characterized by abnormal translation.

Genular Protein ID: 3196690881

Symbol: RS9_HUMAN

Name: 40S ribosomal protein S9

UniProtKB Accession Codes:

P46781 A9C4C1 Q4QRK7 Q9BVZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 13 EMDB 67 EPD 1 Ensembl 18 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 89 PDBsum 83 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 19 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 194
  • Mass: 22591
  • Checksum: E9CE3CBD59524F81
  • Sequence:
    • MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL 
LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA 
KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK 
GQGGAGAGDD EEED

Genular Protein ID: 3029939726

Symbol: A8MXK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MXK4

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 3 GO 4 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 79
  • Mass: 9534
  • Checksum: 56088115EFDC6F9B
  • Sequence:
    • MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL 
LTLDEKDPRR LFEGSASRW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.