Details for: RPS9

Gene ID: 6203

Symbol: RPS9

Ensembl ID: ENSG00000170889

Description: ribosomal protein S9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 708.3668
    Cell Significance Index: -291.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 577.6783
    Cell Significance Index: -272.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 549.4034
    Cell Significance Index: -282.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 408.7980
    Cell Significance Index: -274.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 38.1282
    Cell Significance Index: -102.1400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 19.3906
    Cell Significance Index: 113.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 18.4110
    Cell Significance Index: 470.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 15.0382
    Cell Significance Index: 1536.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.5472
    Cell Significance Index: 636.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 12.8452
    Cell Significance Index: 337.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.2902
    Cell Significance Index: 323.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.1446
    Cell Significance Index: 196.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 11.0243
    Cell Significance Index: 254.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 10.0571
    Cell Significance Index: 1299.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.0498
    Cell Significance Index: 114.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 9.5923
    Cell Significance Index: 333.3300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 9.4175
    Cell Significance Index: 100.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.1865
    Cell Significance Index: 169.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 8.8806
    Cell Significance Index: 1219.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.7331
    Cell Significance Index: 617.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.7289
    Cell Significance Index: 182.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.6385
    Cell Significance Index: 110.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.4425
    Cell Significance Index: 393.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 8.2521
    Cell Significance Index: 615.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 8.1513
    Cell Significance Index: 1002.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.0937
    Cell Significance Index: 49.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 7.9653
    Cell Significance Index: 1435.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 7.7513
    Cell Significance Index: 3427.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 7.5936
    Cell Significance Index: 4147.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.0377
    Cell Significance Index: 191.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.0304
    Cell Significance Index: 76.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.7826
    Cell Significance Index: 799.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.4532
    Cell Significance Index: 416.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.3869
    Cell Significance Index: 818.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.1574
    Cell Significance Index: 880.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.0417
    Cell Significance Index: 148.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.3669
    Cell Significance Index: 229.2800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.9163
    Cell Significance Index: 33.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3170
    Cell Significance Index: 30.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 3.3107
    Cell Significance Index: 2505.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9872
    Cell Significance Index: 135.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9624
    Cell Significance Index: 587.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6490
    Cell Significance Index: 21.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.5179
    Cell Significance Index: 2273.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0080
    Cell Significance Index: 57.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.0077
    Cell Significance Index: 230.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9778
    Cell Significance Index: 102.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.3291
    Cell Significance Index: 974.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1240
    Cell Significance Index: 111.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0993
    Cell Significance Index: 209.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.3852
    Cell Significance Index: 30.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1251
    Cell Significance Index: 3.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0682
    Cell Significance Index: -128.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1061
    Cell Significance Index: -17.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1219
    Cell Significance Index: -8.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1274
    Cell Significance Index: -94.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1489
    Cell Significance Index: -274.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1779
    Cell Significance Index: -273.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1920
    Cell Significance Index: -108.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2010
    Cell Significance Index: -40.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2181
    Cell Significance Index: -296.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2310
    Cell Significance Index: -11.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2352
    Cell Significance Index: -8.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3164
    Cell Significance Index: -200.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3195
    Cell Significance Index: -114.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.3531
    Cell Significance Index: -220.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4375
    Cell Significance Index: -17.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4838
    Cell Significance Index: -30.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.5294
    Cell Significance Index: -240.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7372
    Cell Significance Index: -155.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9212
    Cell Significance Index: -15.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9332
    Cell Significance Index: -29.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9820
    Cell Significance Index: -282.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1214
    Cell Significance Index: -62.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.5369
    Cell Significance Index: -223.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.8177
    Cell Significance Index: -30.4200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.8310
    Cell Significance Index: -13.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.8892
    Cell Significance Index: -215.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.5656
    Cell Significance Index: -267.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.8705
    Cell Significance Index: -71.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.8931
    Cell Significance Index: -43.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.2698
    Cell Significance Index: -70.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.4250
    Cell Significance Index: -262.8300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.5904
    Cell Significance Index: -74.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.6713
    Cell Significance Index: -50.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.7453
    Cell Significance Index: -224.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.7467
    Cell Significance Index: -229.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.9318
    Cell Significance Index: -46.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.0566
    Cell Significance Index: -148.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -5.7677
    Cell Significance Index: -255.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -6.3616
    Cell Significance Index: -109.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.4924
    Cell Significance Index: -238.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -6.6177
    Cell Significance Index: -36.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -6.6702
    Cell Significance Index: -69.0500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -6.6750
    Cell Significance Index: -85.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -6.8711
    Cell Significance Index: -260.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -7.2069
    Cell Significance Index: -149.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -7.2543
    Cell Significance Index: -186.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -7.4341
    Cell Significance Index: -260.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -7.5018
    Cell Significance Index: -245.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPS9 is a 40S ribosomal protein that is highly conserved across species, with a high degree of sequence similarity to its homologs in other organisms. It is a small protein, consisting of 107 amino acids, and is localized to the cytosol. RPS9 has been shown to bind to mRNA and the cap-binding complex, facilitating the recruitment of the 40S subunit to the mRNA. It also interacts with other proteins, including eIFs, to form the 43S complex and the translation initiation complex. RPS9 has been implicated in various cellular processes, including translation, cell proliferation, and response to starvation. **Pathways and Functions** RPS9 is involved in several key pathways, including: 1. **Translation initiation**: RPS9 plays a crucial role in the initiation of translation, binding to mRNA and the cap-binding complex to facilitate the recruitment of the 40S subunit. 2. **Cell proliferation**: RPS9 has been implicated in the regulation of cell proliferation, particularly in response to starvation. 3. **Response to starvation**: RPS9 has been shown to play a role in the response to starvation, regulating the expression of genes involved in amino acid metabolism. 4. **Viral infection**: RPS9 has been implicated in the modulation of the host translation machinery in response to viral infections, including SARS-CoV-1 and SARS-CoV-2. 5. **Ribosome biogenesis**: RPS9 is involved in the formation of the 40S subunit and the subsequent biogenesis of the ribosome. **Clinical Significance** RPS9 has been implicated in various diseases, including: 1. **Cancer**: RPS9 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 2. **Neurological disorders**: RPS9 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Viral infections**: RPS9 has been shown to play a role in the modulation of the host translation machinery in response to viral infections, including SARS-CoV-1 and SARS-CoV-2. 4. **Metabolic disorders**: RPS9 has been implicated in the regulation of amino acid metabolism and has been shown to be involved in the pathogenesis of metabolic disorders, including type 2 diabetes. In conclusion, RPS9 is a critical component of the 40S small subunit of the ribosome, playing a vital role in the initiation of translation in eukaryotic cells. Its involvement in various cellular processes, including translation, cell proliferation, and response to starvation, makes it an important target for the development of therapeutic strategies for various diseases.

Genular Protein ID: 3196690881

Symbol: RS9_HUMAN

Name: 40S ribosomal protein S9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7772601

Title: Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

PubMed ID: 7772601

DOI: 10.1016/0167-4781(95)00045-i

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 194
  • Mass: 22591
  • Checksum: E9CE3CBD59524F81
  • Sequence:
  • MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL 
    LTLDEKDPRR LFEGNALLRR LVRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA 
    KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS LRSPYGGGRP GRVKRKNAKK 
    GQGGAGAGDD EEED

Genular Protein ID: 3029939726

Symbol: A8MXK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 79
  • Mass: 9534
  • Checksum: 56088115EFDC6F9B
  • Sequence:
  • MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL 
    LTLDEKDPRR LFEGSASRW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.