Details for: RSU1

Gene ID: 6251

Symbol: RSU1

Ensembl ID: ENSG00000148484

Description: Ras suppressor protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 277.6363
    Cell Significance Index: -43.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.8909
    Cell Significance Index: -47.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.2545
    Cell Significance Index: -53.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.0319
    Cell Significance Index: -44.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.3512
    Cell Significance Index: -44.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 96.5813
    Cell Significance Index: -49.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.5413
    Cell Significance Index: -44.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.3762
    Cell Significance Index: -51.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.0874
    Cell Significance Index: -33.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0698
    Cell Significance Index: -40.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6770
    Cell Significance Index: -53.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5604
    Cell Significance Index: -41.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.6677
    Cell Significance Index: 39.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6851
    Cell Significance Index: 45.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5611
    Cell Significance Index: 313.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1603
    Cell Significance Index: 188.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9946
    Cell Significance Index: 76.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9922
    Cell Significance Index: 895.9300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9074
    Cell Significance Index: 17.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8285
    Cell Significance Index: 164.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7198
    Cell Significance Index: 21.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6451
    Cell Significance Index: 88.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6073
    Cell Significance Index: 217.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6062
    Cell Significance Index: 36.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5836
    Cell Significance Index: 16.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4778
    Cell Significance Index: 330.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4256
    Cell Significance Index: 76.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3657
    Cell Significance Index: 20.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3445
    Cell Significance Index: 42.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3423
    Cell Significance Index: 43.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3120
    Cell Significance Index: 36.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2698
    Cell Significance Index: 147.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2537
    Cell Significance Index: 11.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2472
    Cell Significance Index: 16.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2220
    Cell Significance Index: 4.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1958
    Cell Significance Index: 33.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1891
    Cell Significance Index: 83.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1259
    Cell Significance Index: 2.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1038
    Cell Significance Index: 4.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0820
    Cell Significance Index: 5.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0755
    Cell Significance Index: 142.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0748
    Cell Significance Index: 3.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0504
    Cell Significance Index: 6.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0486
    Cell Significance Index: 22.0800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0368
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0300
    Cell Significance Index: 5.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0223
    Cell Significance Index: 41.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0166
    Cell Significance Index: 1.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0103
    Cell Significance Index: 15.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0103
    Cell Significance Index: 14.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0092
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0084
    Cell Significance Index: 5.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0053
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0278
    Cell Significance Index: -0.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0449
    Cell Significance Index: -32.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0581
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0697
    Cell Significance Index: -51.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0781
    Cell Significance Index: -7.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0791
    Cell Significance Index: -4.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0908
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0954
    Cell Significance Index: -59.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0969
    Cell Significance Index: -54.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1128
    Cell Significance Index: -8.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1238
    Cell Significance Index: -1.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1350
    Cell Significance Index: -8.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1482
    Cell Significance Index: -2.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1503
    Cell Significance Index: -6.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1526
    Cell Significance Index: -43.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1685
    Cell Significance Index: -6.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1932
    Cell Significance Index: -13.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2500
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2619
    Cell Significance Index: -30.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2773
    Cell Significance Index: -19.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2807
    Cell Significance Index: -59.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2930
    Cell Significance Index: -4.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3338
    Cell Significance Index: -5.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3343
    Cell Significance Index: -7.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3380
    Cell Significance Index: -4.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3573
    Cell Significance Index: -18.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3904
    Cell Significance Index: -44.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4009
    Cell Significance Index: -5.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4300
    Cell Significance Index: -44.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4632
    Cell Significance Index: -9.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5548
    Cell Significance Index: -43.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5611
    Cell Significance Index: -14.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6125
    Cell Significance Index: -11.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6221
    Cell Significance Index: -16.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6278
    Cell Significance Index: -32.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6372
    Cell Significance Index: -3.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7321
    Cell Significance Index: -15.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7675
    Cell Significance Index: -38.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8109
    Cell Significance Index: -28.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8158
    Cell Significance Index: -22.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8575
    Cell Significance Index: -45.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8602
    Cell Significance Index: -22.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8811
    Cell Significance Index: -54.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9117
    Cell Significance Index: -29.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9119
    Cell Significance Index: -13.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RSU1 is a small, cytosolic protein that belongs to the Ras suppressor family. It is characterized by its ability to bind to Ras proteins, inhibiting their GTPase activity and subsequent signaling. RSU1 is also involved in regulating cell-substrate adhesion, cytoskeletal remodeling, and cell spreading. Its expression is tightly regulated, with varying levels found in different cell types. The protein is highly conserved across species, suggesting its evolutionary importance in maintaining cellular homeostasis. **Pathways and Functions:** RSU1 is integral to several signaling pathways, including: 1. **Ras signaling pathway:** RSU1 acts as a negative regulator, suppressing Ras protein activity and preventing excessive cell proliferation and survival. 2. **Cell-cell communication:** RSU1 modulates the interaction between cells, influencing cell adhesion, migration, and differentiation. 3. **Cytoskeletal remodeling:** RSU1 regulates the organization of the cytoskeleton, influencing cell shape, movement, and division. 4. **Positive regulation of cell-substrate adhesion:** RSU1 enhances cell adhesion to the extracellular matrix, promoting tissue integrity and function. **Functions:** The functions of RSU1 are multifaceted and far-reaching: 1. **Tumor suppression:** RSU1's ability to regulate Ras protein activity makes it a potential tumor suppressor, as its dysregulation can lead to uncontrolled cell growth and cancer. 2. **Inflammation regulation:** RSU1's role in modulating cell-cell communication and cytokine signaling suggests its involvement in regulating inflammatory responses. 3. **Cardiovascular health:** RSU1's influence on cell adhesion and cytoskeletal remodeling may contribute to maintaining vascular integrity and preventing cardiovascular diseases. **Clinical Significance:** Dysregulation of RSU1 has been implicated in various diseases, including: 1. **Cancer:** RSU1's tumor suppressor function is compromised in certain cancers, leading to uncontrolled cell growth and tumor formation. 2. **Inflammatory disorders:** RSU1's role in regulating inflammation suggests its involvement in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cardiovascular diseases:** RSU1's influence on cell adhesion and cytoskeletal remodeling may contribute to the development of cardiovascular diseases, such as atherosclerosis and hypertension. In conclusion, RSU1 is a critical regulator of cellular processes, and its dysregulation has significant clinical implications. Further research is needed to fully elucidate the functions and mechanisms of RSU1, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3247946333

Symbol: RSU1_HUMAN

Name: Ras suppressor protein 1

UniProtKB Accession Codes:

Q15404 A8KA46 D3DRU3 Q6FI17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 3 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8288261

Title: Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10.

PubMed ID: 8288261

DOI: 10.1006/geno.1993.1503

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 277
  • Mass: 31540
  • Checksum: 6EDB2E033F417468
  • Sequence:
    • MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN KLTMVPPNIA 
ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSLPA LEVLDLTYNN 
LSENSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT 
QLKELHIQGN RLTVLPPELG NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE 
TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.