Details for: RTN1

Gene ID: 6252

Symbol: RTN1

Ensembl ID: ENSG00000139970

Description: reticulon 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 478.7675
    Cell Significance Index: -74.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 294.9219
    Cell Significance Index: -74.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.6043
    Cell Significance Index: -63.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 60.4888
    Cell Significance Index: -74.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.5972
    Cell Significance Index: -27.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 11.1717
    Cell Significance Index: 191.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.7212
    Cell Significance Index: 405.3900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.8964
    Cell Significance Index: 48.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.6784
    Cell Significance Index: 1319.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.5778
    Cell Significance Index: 78.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.4725
    Cell Significance Index: 233.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.4282
    Cell Significance Index: 97.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2911
    Cell Significance Index: 660.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8143
    Cell Significance Index: 106.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8027
    Cell Significance Index: 123.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.7439
    Cell Significance Index: 1897.7900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.4537
    Cell Significance Index: 25.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5738
    Cell Significance Index: 71.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5232
    Cell Significance Index: 33.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.2077
    Cell Significance Index: 16.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.1326
    Cell Significance Index: 164.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6887
    Cell Significance Index: 621.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4965
    Cell Significance Index: 27.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4694
    Cell Significance Index: 46.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1958
    Cell Significance Index: 31.8400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1905
    Cell Significance Index: 2.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1567
    Cell Significance Index: 5.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1452
    Cell Significance Index: 197.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1312
    Cell Significance Index: 9.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0202
    Cell Significance Index: 12.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0138
    Cell Significance Index: -21.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0149
    Cell Significance Index: -0.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0233
    Cell Significance Index: -0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0275
    Cell Significance Index: -50.6500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0633
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0689
    Cell Significance Index: -51.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0822
    Cell Significance Index: -60.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0944
    Cell Significance Index: -10.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1100
    Cell Significance Index: -83.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1218
    Cell Significance Index: -55.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1268
    Cell Significance Index: -71.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1349
    Cell Significance Index: -73.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1509
    Cell Significance Index: -66.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1556
    Cell Significance Index: -29.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1557
    Cell Significance Index: -97.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1840
    Cell Significance Index: -11.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2223
    Cell Significance Index: -63.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2385
    Cell Significance Index: -47.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3253
    Cell Significance Index: -58.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3518
    Cell Significance Index: -7.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4065
    Cell Significance Index: -85.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4178
    Cell Significance Index: -5.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4679
    Cell Significance Index: -15.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4859
    Cell Significance Index: -49.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4945
    Cell Significance Index: -60.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.5219
    Cell Significance Index: -89.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5342
    Cell Significance Index: -5.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5351
    Cell Significance Index: -10.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.5380
    Cell Significance Index: -73.8800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.5465
    Cell Significance Index: -5.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5695
    Cell Significance Index: -73.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5869
    Cell Significance Index: -36.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6204
    Cell Significance Index: -19.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.6232
    Cell Significance Index: -79.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6480
    Cell Significance Index: -38.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6613
    Cell Significance Index: -77.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6691
    Cell Significance Index: -78.9100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6814
    Cell Significance Index: -7.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7371
    Cell Significance Index: -76.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7659
    Cell Significance Index: -60.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7790
    Cell Significance Index: -89.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8359
    Cell Significance Index: -62.3000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9151
    Cell Significance Index: -11.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9311
    Cell Significance Index: -71.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9381
    Cell Significance Index: -19.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9628
    Cell Significance Index: -19.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9728
    Cell Significance Index: -42.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0108
    Cell Significance Index: -62.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0475
    Cell Significance Index: -29.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.1330
    Cell Significance Index: -10.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1654
    Cell Significance Index: -16.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.1833
    Cell Significance Index: -76.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.2296
    Cell Significance Index: -64.0500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.3342
    Cell Significance Index: -8.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3679
    Cell Significance Index: -47.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3941
    Cell Significance Index: -72.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.4775
    Cell Significance Index: -69.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.4956
    Cell Significance Index: -37.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.5320
    Cell Significance Index: -33.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.6465
    Cell Significance Index: -57.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.7079
    Cell Significance Index: -79.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.7599
    Cell Significance Index: -36.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.8040
    Cell Significance Index: -21.5100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.8706
    Cell Significance Index: -15.4400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.9197
    Cell Significance Index: -21.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9525
    Cell Significance Index: -57.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.0137
    Cell Significance Index: -73.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.0900
    Cell Significance Index: -44.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.2139
    Cell Significance Index: -26.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RTN1 is a member of the reticulon family of proteins, which are characterized by their ability to form coiled-coil structures. This unique structure allows RTN1 to interact with other proteins and modulate various cellular processes. RTN1 is primarily expressed in neurons, particularly in the brain and spinal cord, where it plays a crucial role in neuronal development and function. **Pathways and Functions:** RTN1 is involved in several key pathways, including: 1. **Brain development:** RTN1 is essential for the proper development of the brain, particularly in the formation of dendrites and axons. 2. **Endoplasmic reticulum (ER) function:** RTN1 is localized to the ER, where it regulates the formation of ER tubular networks, which are critical for protein synthesis and folding. 3. **Neuronal differentiation:** RTN1 plays a key role in the differentiation of neurons, particularly in the development of Purkinje cells and inhibitory interneurons. 4. **Neuronal projection:** RTN1 is involved in the formation of axons and dendrites, which are essential for neuronal communication. 5. **Negative regulation of amyloid-beta formation:** RTN1 has been shown to inhibit the formation of amyloid-beta peptides, which are associated with Alzheimer's disease. **Clinical Significance:** Dysregulation of RTN1 has been implicated in various neurological disorders, including: 1. **Alzheimer's disease:** Reduced expression of RTN1 has been observed in Alzheimer's disease patients, suggesting a link between RTN1 dysfunction and amyloid-beta accumulation. 2. **Neurodegenerative diseases:** RTN1 has been implicated in other neurodegenerative diseases, including Parkinson's disease and Huntington's disease. 3. **Neurodevelopmental disorders:** RTN1 has been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, RTN1 is a critical gene that plays a pivotal role in neuronal development, function, and maintenance. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the mechanisms underlying RTN1 function and its potential as a therapeutic target. **Significantly expressed cells:** - Neuronal brush cell - Granule cell - Purkinje cell - Neuron associated cell (sensu Vertebrata) - Stellate neuron - Macroglial cell - Chromaffin cell - Glycinergic neuron - Glycinergic amacrine cell - Inhibitory interneuron

Genular Protein ID: 1734065389

Symbol: RTN1_HUMAN

Name: Reticulon-1

UniProtKB Accession Codes:

Q16799 Q16800 Q16801 Q5BKZ4 Q9BQ59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7685762

Title: Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product.

PubMed ID: 7685762

DOI: 10.1016/s0021-9258(19)38669-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8833145

Title: Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.

PubMed ID: 8833145

DOI: 10.1006/geno.1996.0105

PubMed ID: 9560466

Title: Neuronal differentiation is accompanied by NSP-C expression.

PubMed ID: 9560466

DOI: 10.1007/s004410051054

PubMed ID: 12873973

Title: Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.

PubMed ID: 12873973

PubMed ID: 15286784

Title: Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.

PubMed ID: 15286784

DOI: 10.1038/nm1088

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25612671

Title: Identification and characterization of TMEM33 as a reticulon-binding protein.

PubMed ID: 25612671

Sequence Information:

  • Length: 776
  • Mass: 83618
  • Checksum: CA5B6232353096FE
  • Sequence:
    • MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG LGARAREAAS 
REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG EGSCYTSLIS DICYPPQEDS 
TYFTGILQKE NGHVTISESP EELGTPGPSL PDVPGIESRG LFSSDSGIEM TPAESTEVNK 
ILADPLDQMK AEAYKYIDIT RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD 
KPAPVEGKII KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT 
PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS ISEDELITAI 
KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD HEASSAESGD SEIELVSEDP 
MAAEDALPSG YVSFGHVGGP PPSPASPSIQ YSILREEREA ELDSELIIES CDASSASEES 
PKREQDSPPM KPSALDAIRE ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD 
GALEPETPML PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ 
TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK TDEGHPFKAY 
LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV DSLKFAVLMW LLTYVGALFN 
GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL GLVRTHINAV VAKIQAKIPG AKRHAE

Genular Protein ID: 3677104028

Symbol: A8K3B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3B9

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1

Sequence Information:

  • Length: 208
  • Mass: 23560
  • Checksum: 2419669525220A02
  • Sequence:
    • MQATADSTKM DCVWSNWKSQ AIDLLYWRDI KQTGIVFGSF LLLLFSLTQF SVVSVVAYLA 
LAALSATISF RIYKSVLQAV QKTDEGHPFK AYLELEITLS QEQIQKYTDC LQFYVNSTLK 
ELRRPFLVQD LVDSLKFAVL MWLLTYVGAL FNGLTLLLMA VVSMFTLPVV YVKHQAQIDQ 
YLGLVRTHIN AVVAKIQAKI PGAKRHAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.