Details for: RTN1

Gene ID: 6252

Symbol: RTN1

Ensembl ID: ENSG00000139970

Description: reticulon 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 7.51
    Marker Score: 25186
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.98
    Marker Score: 45113
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.93
    Marker Score: 200239
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.83
    Marker Score: 30606
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.71
    Marker Score: 30652
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.1
    Marker Score: 11718
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.77
    Marker Score: 6706
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.32
    Marker Score: 5218
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.05
    Marker Score: 3819.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.63
    Marker Score: 16814
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.19
    Marker Score: 1535
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3
    Marker Score: 6098
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.76
    Marker Score: 54966
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.61
    Marker Score: 20039.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.61
    Marker Score: 99206
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.61
    Marker Score: 39031
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.61
    Marker Score: 876
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.47
    Marker Score: 3078
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.43
    Marker Score: 1412
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.42
    Marker Score: 6911
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.39
    Marker Score: 9919.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.35
    Marker Score: 86512
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.27
    Marker Score: 8771
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.26
    Marker Score: 686
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.24
    Marker Score: 939
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.23
    Marker Score: 3749
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20425.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.15
    Marker Score: 1284
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.14
    Marker Score: 1202
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.07
    Marker Score: 797
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127456
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.05
    Marker Score: 21167
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.01
    Marker Score: 8203
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.99
    Marker Score: 1161
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18277
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16098.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.8
    Marker Score: 2026
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.78
    Marker Score: 879
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.74
    Marker Score: 4163
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.74
    Marker Score: 3291
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.69
    Marker Score: 884
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.67
    Marker Score: 2071
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.66
    Marker Score: 454
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2544
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.58
    Marker Score: 3211
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.55
    Marker Score: 802
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.54
    Marker Score: 1531
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168146
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.44
    Marker Score: 1081
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.39
    Marker Score: 440
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.36
    Marker Score: 1569
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.19
    Marker Score: 25482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.14
    Marker Score: 512
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.12
    Marker Score: 446
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.12
    Marker Score: 416
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.06
    Marker Score: 557
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.06
    Marker Score: 4408
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251768
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 330
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.02
    Marker Score: 608
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.02
    Marker Score: 411
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48015
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.99
    Marker Score: 653.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.98
    Marker Score: 940
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.98
    Marker Score: 2531
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5234
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.92
    Marker Score: 817
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 550
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9
    Marker Score: 14136
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.9
    Marker Score: 263
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.89
    Marker Score: 308
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 410
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.87
    Marker Score: 275
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 639
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.8
    Marker Score: 233
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.79
    Marker Score: 684
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.75
    Marker Score: 438
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1189
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.72
    Marker Score: 264
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.71
    Marker Score: 1245
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.7
    Marker Score: 157
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.69
    Marker Score: 332
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.64
    Marker Score: 212

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Other Information

**Key Characteristics:** RTN1 is a member of the reticulon family of proteins, which are characterized by their ability to form coiled-coil structures. This unique structure allows RTN1 to interact with other proteins and modulate various cellular processes. RTN1 is primarily expressed in neurons, particularly in the brain and spinal cord, where it plays a crucial role in neuronal development and function. **Pathways and Functions:** RTN1 is involved in several key pathways, including: 1. **Brain development:** RTN1 is essential for the proper development of the brain, particularly in the formation of dendrites and axons. 2. **Endoplasmic reticulum (ER) function:** RTN1 is localized to the ER, where it regulates the formation of ER tubular networks, which are critical for protein synthesis and folding. 3. **Neuronal differentiation:** RTN1 plays a key role in the differentiation of neurons, particularly in the development of Purkinje cells and inhibitory interneurons. 4. **Neuronal projection:** RTN1 is involved in the formation of axons and dendrites, which are essential for neuronal communication. 5. **Negative regulation of amyloid-beta formation:** RTN1 has been shown to inhibit the formation of amyloid-beta peptides, which are associated with Alzheimer's disease. **Clinical Significance:** Dysregulation of RTN1 has been implicated in various neurological disorders, including: 1. **Alzheimer's disease:** Reduced expression of RTN1 has been observed in Alzheimer's disease patients, suggesting a link between RTN1 dysfunction and amyloid-beta accumulation. 2. **Neurodegenerative diseases:** RTN1 has been implicated in other neurodegenerative diseases, including Parkinson's disease and Huntington's disease. 3. **Neurodevelopmental disorders:** RTN1 has been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, RTN1 is a critical gene that plays a pivotal role in neuronal development, function, and maintenance. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of further research into the mechanisms underlying RTN1 function and its potential as a therapeutic target. **Significantly expressed cells:** - Neuronal brush cell - Granule cell - Purkinje cell - Neuron associated cell (sensu Vertebrata) - Stellate neuron - Macroglial cell - Chromaffin cell - Glycinergic neuron - Glycinergic amacrine cell - Inhibitory interneuron

Genular Protein ID: 1734065389

Symbol: RTN1_HUMAN

Name: Reticulon-1

UniProtKB Accession Codes:

Q16799 Q16800 Q16801 Q5BKZ4 Q9BQ59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7685762

Title: Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product.

PubMed ID: 7685762

DOI: 10.1016/s0021-9258(19)38669-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8833145

Title: Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons.

PubMed ID: 8833145

DOI: 10.1006/geno.1996.0105

PubMed ID: 9560466

Title: Neuronal differentiation is accompanied by NSP-C expression.

PubMed ID: 9560466

DOI: 10.1007/s004410051054

PubMed ID: 12873973

Title: Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.

PubMed ID: 12873973

PubMed ID: 15286784

Title: Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.

PubMed ID: 15286784

DOI: 10.1038/nm1088

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25612671

Title: Identification and characterization of TMEM33 as a reticulon-binding protein.

PubMed ID: 25612671

Sequence Information:

  • Length: 776
  • Mass: 83618
  • Checksum: CA5B6232353096FE
  • Sequence:
    • MAAPGDPQDE LLPLAGPGSQ WLRHRGEGEN EAVTPKGATP APQAGEPSPG LGARAREAAS 
REAGSGPARQ SPVAMETAST GVAGVSSAMD HTFSTTSKDG EGSCYTSLIS DICYPPQEDS 
TYFTGILQKE NGHVTISESP EELGTPGPSL PDVPGIESRG LFSSDSGIEM TPAESTEVNK 
ILADPLDQMK AEAYKYIDIT RPEEVKHQEQ HHPELEDKDL DFKNKDTDIS IKPEGVREPD 
KPAPVEGKII KDHLLEESTF APYIDDLSEE QRRAPQITTP VKITLTEIEP SVETTTQEKT 
PEKQDICLKP SPDTVPTVTV SEPEDDSPGS ITPPSSGTEP SAAESQGKGS ISEDELITAI 
KEAKGLSYET AENPRPVGQL ADRPEVKARS GPPTIPSPLD HEASSAESGD SEIELVSEDP 
MAAEDALPSG YVSFGHVGGP PPSPASPSIQ YSILREEREA ELDSELIIES CDASSASEES 
PKREQDSPPM KPSALDAIRE ETGVRAEERA PSRRGLAEPG SFLDYPSTEP QPGPELPPGD 
GALEPETPML PRKPEEDSSS NQSPAATKGP GPLGPGAPPP LLFLNKQKAI DLLYWRDIKQ 
TGIVFGSFLL LLFSLTQFSV VSVVAYLALA ALSATISFRI YKSVLQAVQK TDEGHPFKAY 
LELEITLSQE QIQKYTDCLQ FYVNSTLKEL RRLFLVQDLV DSLKFAVLMW LLTYVGALFN 
GLTLLLMAVV SMFTLPVVYV KHQAQIDQYL GLVRTHINAV VAKIQAKIPG AKRHAE

Genular Protein ID: 3677104028

Symbol: A8K3B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3B9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMR 1

Sequence Information:

  • Length: 208
  • Mass: 23560
  • Checksum: 2419669525220A02
  • Sequence:
    • MQATADSTKM DCVWSNWKSQ AIDLLYWRDI KQTGIVFGSF LLLLFSLTQF SVVSVVAYLA 
LAALSATISF RIYKSVLQAV QKTDEGHPFK AYLELEITLS QEQIQKYTDC LQFYVNSTLK 
ELRRPFLVQD LVDSLKFAVL MWLLTYVGAL FNGLTLLLMA VVSMFTLPVV YVKHQAQIDQ 
YLGLVRTHIN AVVAKIQAKI PGAKRHAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.