Details for: RXRG

Gene ID: 6258

Symbol: RXRG

Ensembl ID: ENSG00000143171

Description: retinoid X receptor gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 6.3635
    Cell Significance Index: 89.3800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.7678
    Cell Significance Index: 4.7500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3946
    Cell Significance Index: 4.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3160
    Cell Significance Index: 113.3600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2831
    Cell Significance Index: 3.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2762
    Cell Significance Index: 10.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2743
    Cell Significance Index: 14.4000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.2083
    Cell Significance Index: 2.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2023
    Cell Significance Index: 8.9500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0977
    Cell Significance Index: 1.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0731
    Cell Significance Index: 1.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0717
    Cell Significance Index: 0.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0619
    Cell Significance Index: 0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0460
    Cell Significance Index: 2.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0368
    Cell Significance Index: 25.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0149
    Cell Significance Index: 1.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0113
    Cell Significance Index: 6.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0112
    Cell Significance Index: 0.2200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0087
    Cell Significance Index: 0.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0063
    Cell Significance Index: -8.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0065
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0118
    Cell Significance Index: -5.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0144
    Cell Significance Index: -0.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0206
    Cell Significance Index: -5.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0226
    Cell Significance Index: -4.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0240
    Cell Significance Index: -3.0800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0242
    Cell Significance Index: -0.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0283
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0311
    Cell Significance Index: -6.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0376
    Cell Significance Index: -2.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0382
    Cell Significance Index: -6.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0398
    Cell Significance Index: -5.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0446
    Cell Significance Index: -7.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0447
    Cell Significance Index: -1.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0473
    Cell Significance Index: -0.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0475
    Cell Significance Index: -6.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0555
    Cell Significance Index: -6.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0703
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0715
    Cell Significance Index: -8.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0718
    Cell Significance Index: -7.4800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0796
    Cell Significance Index: -0.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0862
    Cell Significance Index: -1.4200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0946
    Cell Significance Index: -0.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0948
    Cell Significance Index: -1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1007
    Cell Significance Index: -6.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1014
    Cell Significance Index: -7.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1144
    Cell Significance Index: -5.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1159
    Cell Significance Index: -7.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1340
    Cell Significance Index: -2.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1353
    Cell Significance Index: -2.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1548
    Cell Significance Index: -4.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1568
    Cell Significance Index: -7.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1680
    Cell Significance Index: -5.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1816
    Cell Significance Index: -3.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1888
    Cell Significance Index: -6.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1951
    Cell Significance Index: -4.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1975
    Cell Significance Index: -6.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2057
    Cell Significance Index: -6.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2068
    Cell Significance Index: -7.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2149
    Cell Significance Index: -5.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2153
    Cell Significance Index: -7.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2254
    Cell Significance Index: -5.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2269
    Cell Significance Index: -4.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2309
    Cell Significance Index: -2.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2400
    Cell Significance Index: -6.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2441
    Cell Significance Index: -5.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2448
    Cell Significance Index: -5.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2476
    Cell Significance Index: -6.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2502
    Cell Significance Index: -7.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2546
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2575
    Cell Significance Index: -7.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2651
    Cell Significance Index: -6.9700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2660
    Cell Significance Index: -3.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2668
    Cell Significance Index: -5.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2681
    Cell Significance Index: -8.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2723
    Cell Significance Index: -3.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2764
    Cell Significance Index: -2.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2767
    Cell Significance Index: -6.9000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2777
    Cell Significance Index: -3.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2850
    Cell Significance Index: -7.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2894
    Cell Significance Index: -7.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2896
    Cell Significance Index: -7.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2912
    Cell Significance Index: -7.4200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2938
    Cell Significance Index: -4.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2987
    Cell Significance Index: -4.4100
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.3001
    Cell Significance Index: -3.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3023
    Cell Significance Index: -5.9000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.3030
    Cell Significance Index: -3.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3046
    Cell Significance Index: -6.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3048
    Cell Significance Index: -2.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3141
    Cell Significance Index: -5.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RXRG, also known as retinoic acid receptor gamma, is a nuclear receptor protein that plays a crucial role in regulating gene expression. It is a member of the retinoid X receptor (RXR) family, which is characterized by its ability to bind to specific DNA sequences, known as retinoic acid-responsive elements (RAREs). RXRG is highly expressed in various cell types, including erythrocytes, photoreceptor cells, and megakaryocytes, suggesting its importance in development, differentiation, and cellular homeostasis. **Pathways and Functions:** RXRG is involved in a wide range of cellular processes, including: 1. **Anatomical structure development**: RXRG plays a crucial role in the development of various tissues and organs, including the nervous system, kidney, and heart. 2. **Cell differentiation**: RXRG is essential for the differentiation of cells, particularly in the development of photoreceptor cells and megakaryocytes. 3. **Chromatin remodeling**: RXRG interacts with chromatin-remodeling complexes to regulate gene expression. 4. **DNA binding**: RXRG binds to specific DNA sequences, influencing the transcription of target genes. 5. **Signaling pathways**: RXRG is involved in various signaling pathways, including the retinoic acid signaling pathway, which regulates cell growth, differentiation, and survival. **Clinical Significance:** RXRG's involvement in various cellular processes makes it a potential target for therapeutic interventions. Abnormalities in RXRG expression have been linked to several diseases, including: 1. **Retinoid-resistant cancer**: Mutations in RXRG can lead to resistance to retinoid-based therapies, highlighting the need for alternative treatment strategies. 2. **Neurodevelopmental disorders**: Alterations in RXRG expression have been implicated in neurodevelopmental disorders, such as autism and schizophrenia. 3. **Cardiovascular disease**: RXRG's role in cardiac development and function suggests its potential as a therapeutic target for cardiovascular disease. **Conclusion:** In conclusion, RXRG is a complex gene with far-reaching implications for various cellular processes. Further investigation into its mechanisms of action and clinical significance is necessary to unlock its full potential as a therapeutic target. As an expert immunologist, I emphasize the importance of continued research into RXRG, which may lead to innovative treatments for a range of diseases. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms of RXRG-mediated gene regulation and its role in various cellular processes. 2. Investigating the potential therapeutic applications of RXRG modulation, particularly in the context of retinoid-resistant cancer and neurodevelopmental disorders. 3. Elucidating the molecular mechanisms underlying RXRG's interaction with chromatin-remodeling complexes and its role in regulating gene expression. By exploring the intricacies of RXRG, we may uncover new avenues for therapeutic intervention and improve our understanding of the complex relationships between gene regulation, cellular processes, and disease.

Genular Protein ID: 2766591145

Symbol: RXRG_HUMAN

Name: Retinoic acid receptor RXR-gamma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17761950

Title: Orphan receptor TR3 attenuates the p300-induced acetylation of retinoid X receptor-alpha.

PubMed ID: 17761950

DOI: 10.1210/me.2007-0107

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

Sequence Information:

  • Length: 463
  • Mass: 50871
  • Checksum: AED5C94BB62A3157
  • Sequence:
  • MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG 
    TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG 
    IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD 
    CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL 
    EAELAVEPKT ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI 
    LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD 
    MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL 
    LRLPALRSIG LKCLEHLFFF KLIGDTPIDT FLMEMLETPL QIT

Genular Protein ID: 1804640041

Symbol: A0A087WZ88_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 340
  • Mass: 38608
  • Checksum: 508D0490B0F5C2E6
  • Sequence:
  • MNYPSTSPGS LVKHICAICG DRSSGKHYGV YSCEGCKGFF KRTIRKDLIY TCRDNKDCLI 
    DKRQRNRCQY CRYQKCLVMG MKREAVQEER QRSRERAESE AECATSGHED MPVERILEAE 
    LAVEPKTESY GDMNMENSTN DPVTNICHAA DKQLFTLVEW AKRIPHFSDL TLEDQVILLR 
    AGWNELLIAS FSHRSVSVQD GILLATGLHV HRSSAHSAGV GSIFDRVLTE LVSKMKDMQM 
    DKSELGCLRA IVLFNPDAKG LSNPSEVETL REKVYATLEA YTKQKYPEQP GRFAKLLLRL 
    PALRSIGLKC LEHLFFFKLI GDTPIDTFLM EMLETPLQIT

Genular Protein ID: 462416717

Symbol: F1T097_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 106
  • Mass: 10768
  • Checksum: C3EEEF1C66CA9B5D
  • Sequence:
  • MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG 
    TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQD WSERDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.