Details for: SCN7A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 17.4880
Cell Significance Index: 118.4900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 11.9490
Cell Significance Index: 171.5900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 4.2330
Cell Significance Index: 1217.9600 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 3.4267
Cell Significance Index: 21.2000 - Cell Name: theca cell (CL0000503)
Fold Change: 1.8962
Cell Significance Index: 11.1400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.2807
Cell Significance Index: 459.3600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.1650
Cell Significance Index: 8.9800 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.7181
Cell Significance Index: 7.4800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2333
Cell Significance Index: 161.3700 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.2324
Cell Significance Index: 2.8100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2281
Cell Significance Index: 6.5400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1443
Cell Significance Index: 11.0800 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.1274
Cell Significance Index: 1.6100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1256
Cell Significance Index: 25.1900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0553
Cell Significance Index: 1.0800 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.0119
Cell Significance Index: 0.1100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0064
Cell Significance Index: 4.0700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0039
Cell Significance Index: 7.4100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0060
Cell Significance Index: -10.9800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0088
Cell Significance Index: -13.5000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0096
Cell Significance Index: -0.1200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0109
Cell Significance Index: -14.8000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0128
Cell Significance Index: -5.8300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0171
Cell Significance Index: -12.5100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0175
Cell Significance Index: -12.9700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0205
Cell Significance Index: -2.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0241
Cell Significance Index: -18.2300 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0245
Cell Significance Index: -13.4000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0289
Cell Significance Index: -18.0400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0299
Cell Significance Index: -16.8500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0300
Cell Significance Index: -5.4100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0311
Cell Significance Index: -0.5200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0432
Cell Significance Index: -2.6600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0457
Cell Significance Index: -0.5800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0544
Cell Significance Index: -10.7900 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.0581
Cell Significance Index: -0.5600 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0586
Cell Significance Index: -0.7100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0734
Cell Significance Index: -3.7100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0750
Cell Significance Index: -10.3000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0768
Cell Significance Index: -11.1600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0832
Cell Significance Index: -4.6700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0851
Cell Significance Index: -17.9300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0915
Cell Significance Index: -15.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1084
Cell Significance Index: -13.3300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1093
Cell Significance Index: -2.3200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1277
Cell Significance Index: -16.5000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1404
Cell Significance Index: -14.6200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1405
Cell Significance Index: -16.5700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1418
Cell Significance Index: -1.7900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1443
Cell Significance Index: -16.5300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1497
Cell Significance Index: -3.5900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1529
Cell Significance Index: -3.9300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1626
Cell Significance Index: -16.6100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1817
Cell Significance Index: -7.4500 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.1935
Cell Significance Index: -2.5100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2101
Cell Significance Index: -16.6400 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.2135
Cell Significance Index: -2.3300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2192
Cell Significance Index: -16.3400 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.2280
Cell Significance Index: -3.2400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2310
Cell Significance Index: -10.7700 - Cell Name: invaginating midget bipolar cell (CL4033034)
Fold Change: -0.2386
Cell Significance Index: -2.9500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2511
Cell Significance Index: -2.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2533
Cell Significance Index: -17.0300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2567
Cell Significance Index: -16.1800 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.2616
Cell Significance Index: -3.5300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2760
Cell Significance Index: -16.9200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2770
Cell Significance Index: -7.7400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2838
Cell Significance Index: -14.9000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2847
Cell Significance Index: -13.3800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2903
Cell Significance Index: -12.8400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2958
Cell Significance Index: -11.2000 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.2970
Cell Significance Index: -3.0800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3140
Cell Significance Index: -6.8800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3149
Cell Significance Index: -11.0300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3179
Cell Significance Index: -7.7000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3362
Cell Significance Index: -4.8200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3372
Cell Significance Index: -6.7700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3402
Cell Significance Index: -7.1200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3519
Cell Significance Index: -11.5200 - Cell Name: mural cell (CL0008034)
Fold Change: -0.3623
Cell Significance Index: -4.4100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3628
Cell Significance Index: -4.5000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3648
Cell Significance Index: -11.6200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3689
Cell Significance Index: -12.8200 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.3704
Cell Significance Index: -7.7300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3747
Cell Significance Index: -10.2000 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3866
Cell Significance Index: -7.6100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.3975
Cell Significance Index: -6.1500 - Cell Name: neuron (CL0000540)
Fold Change: -0.4009
Cell Significance Index: -3.8000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4048
Cell Significance Index: -14.8600 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.4095
Cell Significance Index: -3.3800 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.4128
Cell Significance Index: -4.5600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4263
Cell Significance Index: -8.4300 - Cell Name: renal principal cell (CL0005009)
Fold Change: -0.4290
Cell Significance Index: -4.5400 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: -0.4399
Cell Significance Index: -4.9900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4420
Cell Significance Index: -9.5500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4540
Cell Significance Index: -6.5300 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.4576
Cell Significance Index: -5.1700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.4681
Cell Significance Index: -7.5100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4750
Cell Significance Index: -13.9900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4753
Cell Significance Index: -16.7000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3684867206
Symbol: SCN7A_HUMAN
Name: Sodium channel protein type VII subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1317577
Title: Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.
PubMed ID: 1317577
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26537257
Title: Sodium channel Nax is a regulator in epithelial sodium homeostasis.
PubMed ID: 26537257
PubMed ID: 35301303
Title: Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel.
PubMed ID: 35301303
Sequence Information:
- Length: 1682
- Mass: 193493
- Checksum: 38CD8D41975BCE18
- Sequence:
MLASPEPKGL VPFTKESFEL IKQHIAKTHN EDHEEEDLKP TPDLEVGKKL PFIYGNLSQG MVSEPLEDVD PYYYKKKNTF IVLNKNRTIF RFNAASILCT LSPFNCIRRT TIKVLVHPFF QLFILISVLI DCVFMSLTNL PKWRPVLENT LLGIYTFEIL VKLFARGVWA GSFSFLGDPW NWLDFSVTVF EVIIRYSPLD FIPTLQTART LRILKIIPLN QGLKSLVGVL IHCLKQLIGV IILTLFFLSI FSLIGMGLFM GNLKHKCFRW PQENENETLH NRTGNPYYIR ETENFYYLEG ERYALLCGNR TDAGQCPEGY VCVKAGINPD QGFTNFDSFG WALFALFRLM AQDYPEVLYH QILYASGKVY MIFFVVVSFL FSFYMASLFL GILAMAYEEE KQRVGEISKK IEPKFQQTGK ELQEGNETDE AKTIQIEMKK RSPISTDTSL DVLEDATLRH KEELEKSKKI CPLYWYKFAK TFLIWNCSPC WLKLKEFVHR IIMAPFTDLF LIICIILNVC FLTLEHYPMS KQTNTLLNIG NLVFIGIFTA EMIFKIIAMH PYGYFQVGWN IFDSMIVFHG LIELCLANVA GMALLRLFRM LRIFKLGKYW PTFQILMWSL SNSWVALKDL VLLLFTFIFF SAAFGMKLFG KNYEEFVCHI DKDCQLPRWH MHDFFHSFLN VFRILCGEWV ETLWDCMEVA GQSWCIPFYL MVILIGNLLV LYLFLALVSS FSSCKDVTAE ENNEAKNLQL AVARIKKGIN YVLLKILCKT QNVPKDTMDH VNEVYVKEDI SDHTLSELSN TQDFLKDKEK SSGTEKNATE NESQSLIPSP SVSETVPIAS GESDIENLDN KEIQSKSGDG GSKEKIKQSS SSECSTVDIA ISEEEEMFYG GERSKHLKNG CRRGSSLGQI SGASKKGKIW QNIRKTCCKI VENNWFKCFI GLVTLLSTGT LAFEDIYMDQ RKTIKILLEY ADMIFTYIFI LEMLLKWMAY GFKAYFSNGW YRLDFVVVIV FCLSLIGKTR EELKPLISMK FLRPLRVLSQ FERMKVVVRA LIKTTLPTLN VFLVCLMIWL IFSIMGVDLF AGRFYECIDP TSGERFPSSE VMNKSRCESL LFNESMLWEN AKMNFDNVGN GFLSLLQVAT FNGWITIMNS AIDSVAVNIQ PHFEVNIYMY CYFINFIIFG VFLPLSMLIT VIIDNFNKHK IKLGGSNIFI TVKQRKQYRR LKKLMYEDSQ RPVPRPLNKL QGFIFDVVTS QAFNVIVMVL ICFQAIAMMI DTDVQSLQMS IALYWINSIF VMLYTMECIL KLIAFRCFYF TIAWNIFDFM VVIFSITGLC LPMTVGSYLV PPSLVQLILL SRIIHMLRLG KGPKVFHNLM LPLMLSLPAL LNIILLIFLV MFIYAVFGMY NFAYVKKEAG INDVSNFETF GNSMLCLFQV AIFAGWDGML DAIFNSKWSD CDPDKINPGT QVRGDCGNPS VGIFYFVSYI LISWLIIVNM YIVVVMEFLN IASKKKNKTL SEDDFRKFFQ VWKRFDPDRT QYIDSSKLSD FAAALDPPLF MAKPNKGQLI ALDLPMAVGD RIHCLDILLA FTKRVMGQDV RMEKVVSEIE SGFLLANPFK ITCEPITTTL KRKQEAVSAT IIQRAYKNYR LRRNDKNTSD IHMIDGDRDV HATKEGAYFD KAKEKSPIQS QI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.