Details for: SCN7A

Gene ID: 6332

Symbol: SCN7A

Ensembl ID: ENSG00000136546

Description: sodium voltage-gated channel alpha subunit 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 17.4880
    Cell Significance Index: 118.4900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 11.9490
    Cell Significance Index: 171.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.2330
    Cell Significance Index: 1217.9600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.4267
    Cell Significance Index: 21.2000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.8962
    Cell Significance Index: 11.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2807
    Cell Significance Index: 459.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1650
    Cell Significance Index: 8.9800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.7181
    Cell Significance Index: 7.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2333
    Cell Significance Index: 161.3700
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.2324
    Cell Significance Index: 2.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2281
    Cell Significance Index: 6.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1443
    Cell Significance Index: 11.0800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1274
    Cell Significance Index: 1.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1256
    Cell Significance Index: 25.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0553
    Cell Significance Index: 1.0800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0119
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0064
    Cell Significance Index: 4.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0039
    Cell Significance Index: 7.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -10.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0096
    Cell Significance Index: -0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0128
    Cell Significance Index: -5.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0175
    Cell Significance Index: -12.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0205
    Cell Significance Index: -2.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0245
    Cell Significance Index: -13.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0289
    Cell Significance Index: -18.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0300
    Cell Significance Index: -5.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0311
    Cell Significance Index: -0.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0432
    Cell Significance Index: -2.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0457
    Cell Significance Index: -0.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0544
    Cell Significance Index: -10.7900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0581
    Cell Significance Index: -0.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0586
    Cell Significance Index: -0.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0734
    Cell Significance Index: -3.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0750
    Cell Significance Index: -10.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0768
    Cell Significance Index: -11.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0832
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0851
    Cell Significance Index: -17.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0915
    Cell Significance Index: -15.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1084
    Cell Significance Index: -13.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1093
    Cell Significance Index: -2.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1277
    Cell Significance Index: -16.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1404
    Cell Significance Index: -14.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1405
    Cell Significance Index: -16.5700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1418
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1443
    Cell Significance Index: -16.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1497
    Cell Significance Index: -3.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1529
    Cell Significance Index: -3.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1626
    Cell Significance Index: -16.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1817
    Cell Significance Index: -7.4500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1935
    Cell Significance Index: -2.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2101
    Cell Significance Index: -16.6400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2135
    Cell Significance Index: -2.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2192
    Cell Significance Index: -16.3400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2280
    Cell Significance Index: -3.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2310
    Cell Significance Index: -10.7700
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.2386
    Cell Significance Index: -2.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2511
    Cell Significance Index: -2.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2533
    Cell Significance Index: -17.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2567
    Cell Significance Index: -16.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2616
    Cell Significance Index: -3.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2760
    Cell Significance Index: -16.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2770
    Cell Significance Index: -7.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2838
    Cell Significance Index: -14.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2847
    Cell Significance Index: -13.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2903
    Cell Significance Index: -12.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2958
    Cell Significance Index: -11.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2970
    Cell Significance Index: -3.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3140
    Cell Significance Index: -6.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3149
    Cell Significance Index: -11.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3179
    Cell Significance Index: -7.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3362
    Cell Significance Index: -4.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3372
    Cell Significance Index: -6.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3402
    Cell Significance Index: -7.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3519
    Cell Significance Index: -11.5200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3623
    Cell Significance Index: -4.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3628
    Cell Significance Index: -4.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3648
    Cell Significance Index: -11.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3689
    Cell Significance Index: -12.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3704
    Cell Significance Index: -7.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3747
    Cell Significance Index: -10.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3866
    Cell Significance Index: -7.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3975
    Cell Significance Index: -6.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4009
    Cell Significance Index: -3.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4048
    Cell Significance Index: -14.8600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4095
    Cell Significance Index: -3.3800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.4128
    Cell Significance Index: -4.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4263
    Cell Significance Index: -8.4300
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.4290
    Cell Significance Index: -4.5400
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: -0.4399
    Cell Significance Index: -4.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4420
    Cell Significance Index: -9.5500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4540
    Cell Significance Index: -6.5300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4576
    Cell Significance Index: -5.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4681
    Cell Significance Index: -7.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4750
    Cell Significance Index: -13.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4753
    Cell Significance Index: -16.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Voltage-gated sodium channel**: SCN7A is a voltage-gated sodium channel, which means it allows the flow of sodium ions into the cell in response to changes in membrane potential. 2. **Alpha subunit**: The SCN7A gene encodes for the alpha subunit of the sodium channel, which is the primary component of the channel. 3. **High-conductance channel**: SCN7A is a high-conductance channel, meaning it allows a large number of sodium ions to flow through the cell membrane, enabling rapid depolarization. 4. **Critical for action potential generation**: The SCN7A channel is essential for the generation of action potentials in cardiac muscle cells and neurons, allowing for the transmission of electrical impulses. 5. **Regulated by multiple mechanisms**: SCN7A is regulated by various mechanisms, including calcium-dependent inactivation, magnesium block, and modulation by other proteins. **Pathways and Functions** 1. **Cardiac conduction**: SCN7A plays a critical role in the transmission of electrical impulses in cardiac muscle cells, enabling the coordinated contraction of the heart. 2. **Nervous system development**: SCN7A is involved in the development of the nervous system, particularly in the migration and differentiation of neurons. 3. **Muscle contraction**: SCN7A is essential for the contraction of skeletal muscle fibers, allowing for rapid movement and response to stimuli. 4. **Cellular homeostasis**: SCN7A helps maintain cellular homeostasis by regulating the flow of sodium ions, which is essential for maintaining proper cell volume and function. 5. **Sodium ion homeostasis**: SCN7A is involved in the regulation of sodium ion homeostasis, which is critical for maintaining proper muscle and nerve function. **Clinical Significance** 1. **Arrhythmias**: Mutations in the SCN7A gene have been associated with various arrhythmias, including long QT syndrome, which can increase the risk of sudden cardiac death. 2. **Muscle disorders**: SCN7A mutations have been linked to muscle disorders, such as myotonia congenita, which is characterized by muscle stiffness and weakness. 3. **Neuropathy**: SCN7A mutations can cause peripheral neuropathy, a condition characterized by numbness, tingling, and weakness in the hands and feet. 4. **Congenital conditions**: SCN7A mutations can cause congenital conditions, such as developmental delay and intellectual disability. 5. **Therapeutic targeting**: SCN7A is a potential target for therapeutic interventions, such as sodium channel blockers, which can be used to treat various cardiovascular and neuromuscular disorders. In conclusion, the SCN7A gene plays a critical role in the transmission of electrical impulses in various tissues, including the nervous system and cardiac muscle. Mutations in the SCN7A gene have been associated with various clinical conditions, highlighting its importance in maintaining proper physiological function. Further research is needed to fully understand the mechanisms of SCN7A and its role in human disease.

Genular Protein ID: 3684867206

Symbol: SCN7A_HUMAN

Name: Sodium channel protein type VII subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1317577

Title: Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.

PubMed ID: 1317577

DOI: 10.1073/pnas.89.11.4893

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26537257

Title: Sodium channel Nax is a regulator in epithelial sodium homeostasis.

PubMed ID: 26537257

DOI: 10.1126/scitranslmed.aad0286

PubMed ID: 35301303

Title: Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel.

PubMed ID: 35301303

DOI: 10.1038/s41467-022-28984-4

Sequence Information:

  • Length: 1682
  • Mass: 193493
  • Checksum: 38CD8D41975BCE18
  • Sequence:
  • MLASPEPKGL VPFTKESFEL IKQHIAKTHN EDHEEEDLKP TPDLEVGKKL PFIYGNLSQG 
    MVSEPLEDVD PYYYKKKNTF IVLNKNRTIF RFNAASILCT LSPFNCIRRT TIKVLVHPFF 
    QLFILISVLI DCVFMSLTNL PKWRPVLENT LLGIYTFEIL VKLFARGVWA GSFSFLGDPW 
    NWLDFSVTVF EVIIRYSPLD FIPTLQTART LRILKIIPLN QGLKSLVGVL IHCLKQLIGV 
    IILTLFFLSI FSLIGMGLFM GNLKHKCFRW PQENENETLH NRTGNPYYIR ETENFYYLEG 
    ERYALLCGNR TDAGQCPEGY VCVKAGINPD QGFTNFDSFG WALFALFRLM AQDYPEVLYH 
    QILYASGKVY MIFFVVVSFL FSFYMASLFL GILAMAYEEE KQRVGEISKK IEPKFQQTGK 
    ELQEGNETDE AKTIQIEMKK RSPISTDTSL DVLEDATLRH KEELEKSKKI CPLYWYKFAK 
    TFLIWNCSPC WLKLKEFVHR IIMAPFTDLF LIICIILNVC FLTLEHYPMS KQTNTLLNIG 
    NLVFIGIFTA EMIFKIIAMH PYGYFQVGWN IFDSMIVFHG LIELCLANVA GMALLRLFRM 
    LRIFKLGKYW PTFQILMWSL SNSWVALKDL VLLLFTFIFF SAAFGMKLFG KNYEEFVCHI 
    DKDCQLPRWH MHDFFHSFLN VFRILCGEWV ETLWDCMEVA GQSWCIPFYL MVILIGNLLV 
    LYLFLALVSS FSSCKDVTAE ENNEAKNLQL AVARIKKGIN YVLLKILCKT QNVPKDTMDH 
    VNEVYVKEDI SDHTLSELSN TQDFLKDKEK SSGTEKNATE NESQSLIPSP SVSETVPIAS 
    GESDIENLDN KEIQSKSGDG GSKEKIKQSS SSECSTVDIA ISEEEEMFYG GERSKHLKNG 
    CRRGSSLGQI SGASKKGKIW QNIRKTCCKI VENNWFKCFI GLVTLLSTGT LAFEDIYMDQ 
    RKTIKILLEY ADMIFTYIFI LEMLLKWMAY GFKAYFSNGW YRLDFVVVIV FCLSLIGKTR 
    EELKPLISMK FLRPLRVLSQ FERMKVVVRA LIKTTLPTLN VFLVCLMIWL IFSIMGVDLF 
    AGRFYECIDP TSGERFPSSE VMNKSRCESL LFNESMLWEN AKMNFDNVGN GFLSLLQVAT 
    FNGWITIMNS AIDSVAVNIQ PHFEVNIYMY CYFINFIIFG VFLPLSMLIT VIIDNFNKHK 
    IKLGGSNIFI TVKQRKQYRR LKKLMYEDSQ RPVPRPLNKL QGFIFDVVTS QAFNVIVMVL 
    ICFQAIAMMI DTDVQSLQMS IALYWINSIF VMLYTMECIL KLIAFRCFYF TIAWNIFDFM 
    VVIFSITGLC LPMTVGSYLV PPSLVQLILL SRIIHMLRLG KGPKVFHNLM LPLMLSLPAL 
    LNIILLIFLV MFIYAVFGMY NFAYVKKEAG INDVSNFETF GNSMLCLFQV AIFAGWDGML 
    DAIFNSKWSD CDPDKINPGT QVRGDCGNPS VGIFYFVSYI LISWLIIVNM YIVVVMEFLN 
    IASKKKNKTL SEDDFRKFFQ VWKRFDPDRT QYIDSSKLSD FAAALDPPLF MAKPNKGQLI 
    ALDLPMAVGD RIHCLDILLA FTKRVMGQDV RMEKVVSEIE SGFLLANPFK ITCEPITTTL 
    KRKQEAVSAT IIQRAYKNYR LRRNDKNTSD IHMIDGDRDV HATKEGAYFD KAKEKSPIQS 
    QI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.