Details for: SCO1

Gene ID: 6341

Symbol: SCO1

Ensembl ID: ENSG00000133028

Description: synthesis of cytochrome C oxidase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.4952
    Cell Significance Index: -22.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.2020
    Cell Significance Index: -20.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.6892
    Cell Significance Index: -25.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.9376
    Cell Significance Index: -21.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.7183
    Cell Significance Index: -25.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.3516
    Cell Significance Index: -21.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.7493
    Cell Significance Index: -24.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5596
    Cell Significance Index: -22.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3278
    Cell Significance Index: -24.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1995
    Cell Significance Index: -15.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2036
    Cell Significance Index: -9.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4850
    Cell Significance Index: 161.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4025
    Cell Significance Index: 12.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1126
    Cell Significance Index: 180.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8455
    Cell Significance Index: 23.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6821
    Cell Significance Index: 122.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6636
    Cell Significance Index: 17.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6601
    Cell Significance Index: 34.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6473
    Cell Significance Index: 128.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6202
    Cell Significance Index: 39.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5914
    Cell Significance Index: 72.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5670
    Cell Significance Index: 16.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5266
    Cell Significance Index: 36.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4386
    Cell Significance Index: 60.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4073
    Cell Significance Index: 222.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4048
    Cell Significance Index: 365.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4024
    Cell Significance Index: 20.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3389
    Cell Significance Index: 67.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2699
    Cell Significance Index: 17.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2681
    Cell Significance Index: 118.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2601
    Cell Significance Index: 74.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2213
    Cell Significance Index: 15.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2194
    Cell Significance Index: 21.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2174
    Cell Significance Index: 10.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2114
    Cell Significance Index: 11.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1812
    Cell Significance Index: 2.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1729
    Cell Significance Index: 32.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1263
    Cell Significance Index: 2.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1245
    Cell Significance Index: 44.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1090
    Cell Significance Index: 75.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0934
    Cell Significance Index: 11.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0894
    Cell Significance Index: 2.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0758
    Cell Significance Index: 3.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0690
    Cell Significance Index: 8.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0681
    Cell Significance Index: 0.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0495
    Cell Significance Index: 2.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0485
    Cell Significance Index: 3.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0421
    Cell Significance Index: 1.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0390
    Cell Significance Index: 1.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0279
    Cell Significance Index: 0.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0115
    Cell Significance Index: 0.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0048
    Cell Significance Index: 3.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0032
    Cell Significance Index: 5.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0026
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0096
    Cell Significance Index: -0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0277
    Cell Significance Index: -20.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0315
    Cell Significance Index: -14.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0373
    Cell Significance Index: -21.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0442
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0464
    Cell Significance Index: -29.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0553
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0597
    Cell Significance Index: -10.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0751
    Cell Significance Index: -1.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0851
    Cell Significance Index: -9.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0969
    Cell Significance Index: -14.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1039
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1187
    Cell Significance Index: -13.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1264
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1334
    Cell Significance Index: -28.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1357
    Cell Significance Index: -8.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1410
    Cell Significance Index: -2.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2104
    Cell Significance Index: -2.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2158
    Cell Significance Index: -17.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2172
    Cell Significance Index: -5.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2185
    Cell Significance Index: -11.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2244
    Cell Significance Index: -15.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2316
    Cell Significance Index: -3.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2316
    Cell Significance Index: -24.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2492
    Cell Significance Index: -6.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2738
    Cell Significance Index: -7.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2774
    Cell Significance Index: -2.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2916
    Cell Significance Index: -12.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3286
    Cell Significance Index: -7.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3425
    Cell Significance Index: -21.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3451
    Cell Significance Index: -17.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3515
    Cell Significance Index: -13.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3548
    Cell Significance Index: -10.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4047
    Cell Significance Index: -3.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4126
    Cell Significance Index: -11.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4258
    Cell Significance Index: -7.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4540
    Cell Significance Index: -8.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4816
    Cell Significance Index: -4.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4833
    Cell Significance Index: -2.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5067
    Cell Significance Index: -7.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5164
    Cell Significance Index: -8.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** SCO1 is a mitochondrial protein, specifically targeting to the inner membrane of mitochondria. 2. **Copper-dependent:** SCO1 requires copper ions to assemble and function, highlighting its role in copper homeostasis within cells. 3. **Assembly of respiratory complex IV:** SCO1 is a key component of the mitochondrial respiratory complex IV, which is responsible for the transfer of electrons from cytochrome c to oxygen, resulting in the production of ATP. 4. **Regulation of cellular stress responses:** SCO1 is involved in cellular responses to stress, including oxidative stress, heat stress, and chemical stress, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Mitochondrial biogenesis and function:** SCO1 is essential for the assembly and function of mitochondrial respiratory complex IV, which is critical for mitochondrial biogenesis and function. 2. **Oxidative phosphorylation:** SCO1 plays a central role in the production of ATP through oxidative phosphorylation, which is essential for cellular energy metabolism. 3. **Cellular stress responses:** SCO1 is involved in cellular responses to stress, including oxidative stress, heat stress, and chemical stress, highlighting its role in maintaining cellular homeostasis. 4. **Copper homeostasis:** SCO1 is required for the proper distribution and utilization of copper ions within cells, highlighting its role in copper homeostasis. **Clinical Significance:** 1. **Neurodegenerative disorders:** Dysregulation of SCO1 has been implicated in various neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. 2. **Metabolic disorders:** SCO1 is also involved in metabolic disorders, including diabetes and metabolic syndrome, highlighting its role in glucose metabolism and energy homeostasis. 3. **Cancer:** SCO1 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. 4. **Genetic disorders:** SCO1 mutations have been associated with genetic disorders, including mitochondrial myopathies and neurodegenerative disorders, highlighting its critical role in maintaining mitochondrial function and cellular homeostasis. In conclusion, SCO1 is a vital gene involved in maintaining mitochondrial function, cellular homeostasis, and overall organismal health. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Further research is needed to fully understand the role of SCO1 in human health and disease.

Genular Protein ID: 4237425801

Symbol: SCO1_HUMAN

Name: Protein SCO1 homolog, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9878253

Title: Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.

PubMed ID: 9878253

DOI: 10.1006/geno.1998.5580

PubMed ID: 11027508

Title: Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency.

PubMed ID: 11027508

DOI: 10.1006/bbrc.2000.3495

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15229189

Title: Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.

PubMed ID: 15229189

DOI: 10.1093/hmg/ddh197

PubMed ID: 17189203

Title: The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.

PubMed ID: 17189203

DOI: 10.1016/j.cmet.2006.12.001

PubMed ID: 19336478

Title: Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.

PubMed ID: 19336478

DOI: 10.1093/hmg/ddp158

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24403053

Title: Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.

PubMed ID: 24403053

DOI: 10.1093/hmg/ddu003

PubMed ID: 26160915

Title: COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.

PubMed ID: 26160915

DOI: 10.1093/hmg/ddv265

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29154948

Title: The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.

PubMed ID: 29154948

DOI: 10.1016/j.bbamcr.2017.11.010

PubMed ID: 28330871

Title: Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.

PubMed ID: 28330871

DOI: 10.1074/jbc.m117.778514

PubMed ID: 29381136

Title: COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.

PubMed ID: 29381136

DOI: 10.7554/elife.32572

PubMed ID: 15659396

Title: Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein.

PubMed ID: 15659396

DOI: 10.1074/jbc.m410705200

PubMed ID: 16735468

Title: A hint for the function of human Sco1 from different structures.

PubMed ID: 16735468

DOI: 10.1073/pnas.0601375103

PubMed ID: 11579424

Title: Cytochrome c oxidase deficiency.

PubMed ID: 11579424

DOI: 10.1002/ajmg.1378

PubMed ID: 11013136

Title: Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy.

PubMed ID: 11013136

DOI: 10.1016/s0002-9297(07)62940-1

PubMed ID: 17182746

Title: Human Sco1 functional studies and pathological implications of the P174L mutant.

PubMed ID: 17182746

DOI: 10.1073/pnas.0606189103

Sequence Information:

  • Length: 301
  • Mass: 33814
  • Checksum: C4A0F35A1741894F
  • Sequence:
  • MAMLVLVPGR VMRPLGGQLW RFLPRGLEFW GPAEGTARVL LRQFCARQAE AWRASGRPGY 
    CLGTRPLSTA RPPPPWSQKG PGDSTRPSKP GPVSWKSLAI TFAIGGALLA GMKHVKKEKA 
    EKLEKERQRH IGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM 
    IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA 
    YRVYYSPGPK DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK 
    S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.