Details for: SCO1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 143.4952
Cell Significance Index: -22.3200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 82.2020
Cell Significance Index: -20.8500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 54.6892
Cell Significance Index: -25.8200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 51.9376
Cell Significance Index: -21.1000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 48.7183
Cell Significance Index: -25.0600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 22.3516
Cell Significance Index: -21.3400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.7493
Cell Significance Index: -24.3500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.5596
Cell Significance Index: -22.9300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.3278
Cell Significance Index: -24.9700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.1995
Cell Significance Index: -15.9700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.2036
Cell Significance Index: -9.2000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4850
Cell Significance Index: 161.5200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.4025
Cell Significance Index: 12.9200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1126
Cell Significance Index: 180.9500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8455
Cell Significance Index: 23.0200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6821
Cell Significance Index: 122.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6636
Cell Significance Index: 17.7200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6601
Cell Significance Index: 34.2900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6473
Cell Significance Index: 128.4500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.6202
Cell Significance Index: 39.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5914
Cell Significance Index: 72.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5670
Cell Significance Index: 16.3400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5266
Cell Significance Index: 36.4200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4386
Cell Significance Index: 60.2300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4073
Cell Significance Index: 222.4300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4048
Cell Significance Index: 365.5500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4024
Cell Significance Index: 20.9600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3389
Cell Significance Index: 67.9800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2699
Cell Significance Index: 17.4200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2681
Cell Significance Index: 118.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.2601
Cell Significance Index: 74.8500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2213
Cell Significance Index: 15.6500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2194
Cell Significance Index: 21.7000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2174
Cell Significance Index: 10.1400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2114
Cell Significance Index: 11.8700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1812
Cell Significance Index: 2.1600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1729
Cell Significance Index: 32.9100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1263
Cell Significance Index: 2.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1245
Cell Significance Index: 44.6700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1090
Cell Significance Index: 75.4200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0934
Cell Significance Index: 11.0100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0894
Cell Significance Index: 2.4000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0758
Cell Significance Index: 3.4400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0690
Cell Significance Index: 8.8400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0681
Cell Significance Index: 0.7400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0495
Cell Significance Index: 2.3300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0485
Cell Significance Index: 3.7300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0421
Cell Significance Index: 1.3500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0390
Cell Significance Index: 1.3700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0279
Cell Significance Index: 0.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0115
Cell Significance Index: 0.8600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0048
Cell Significance Index: 3.4900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0032
Cell Significance Index: 5.9500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0009
Cell Significance Index: 1.4300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0026
Cell Significance Index: -0.3400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0036
Cell Significance Index: -6.7200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0056
Cell Significance Index: -3.5700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0096
Cell Significance Index: -0.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0123
Cell Significance Index: -16.7900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0177
Cell Significance Index: -13.3600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0277
Cell Significance Index: -20.5000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0315
Cell Significance Index: -14.3000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0373
Cell Significance Index: -21.0300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0442
Cell Significance Index: -4.5200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0464
Cell Significance Index: -29.0000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0553
Cell Significance Index: -1.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0597
Cell Significance Index: -10.2000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0751
Cell Significance Index: -1.7400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0851
Cell Significance Index: -9.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0969
Cell Significance Index: -14.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1039
Cell Significance Index: -2.6700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1187
Cell Significance Index: -13.6000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1264
Cell Significance Index: -3.2300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1334
Cell Significance Index: -28.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1357
Cell Significance Index: -8.3400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1410
Cell Significance Index: -2.3600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2104
Cell Significance Index: -2.8700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2158
Cell Significance Index: -17.0900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2172
Cell Significance Index: -5.7100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2185
Cell Significance Index: -11.4700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2244
Cell Significance Index: -15.0900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2316
Cell Significance Index: -3.4700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2316
Cell Significance Index: -24.1100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2492
Cell Significance Index: -6.2300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2738
Cell Significance Index: -7.8500 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2774
Cell Significance Index: -2.3300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2916
Cell Significance Index: -12.9000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3286
Cell Significance Index: -7.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3425
Cell Significance Index: -21.0000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3451
Cell Significance Index: -17.4400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3515
Cell Significance Index: -13.3100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3548
Cell Significance Index: -10.4200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4047
Cell Significance Index: -3.3000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4126
Cell Significance Index: -11.0400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4258
Cell Significance Index: -7.8700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4540
Cell Significance Index: -8.8600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4816
Cell Significance Index: -4.9900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4833
Cell Significance Index: -2.9200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5067
Cell Significance Index: -7.4800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5164
Cell Significance Index: -8.8500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4237425801
Symbol: SCO1_HUMAN
Name: Protein SCO1 homolog, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9878253
Title: Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.
PubMed ID: 9878253
PubMed ID: 11027508
Title: Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency.
PubMed ID: 11027508
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15229189
Title: Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.
PubMed ID: 15229189
DOI: 10.1093/hmg/ddh197
PubMed ID: 17189203
Title: The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.
PubMed ID: 17189203
PubMed ID: 19336478
Title: Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1.
PubMed ID: 19336478
DOI: 10.1093/hmg/ddp158
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24403053
Title: Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
PubMed ID: 24403053
DOI: 10.1093/hmg/ddu003
PubMed ID: 26160915
Title: COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2.
PubMed ID: 26160915
DOI: 10.1093/hmg/ddv265
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29154948
Title: The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
PubMed ID: 29154948
PubMed ID: 28330871
Title: Human mitochondrial cytochrome c oxidase assembly factor COX18 acts transiently as a membrane insertase within the subunit 2 maturation module.
PubMed ID: 28330871
PubMed ID: 29381136
Title: COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.
PubMed ID: 29381136
DOI: 10.7554/elife.32572
PubMed ID: 15659396
Title: Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein.
PubMed ID: 15659396
PubMed ID: 16735468
Title: A hint for the function of human Sco1 from different structures.
PubMed ID: 16735468
PubMed ID: 11579424
PubMed ID: 11013136
Title: Mutations of the SCO1 gene in mitochondrial cytochrome c oxidase deficiency with neonatal-onset hepatic failure and encephalopathy.
PubMed ID: 11013136
PubMed ID: 17182746
Title: Human Sco1 functional studies and pathological implications of the P174L mutant.
PubMed ID: 17182746
Sequence Information:
- Length: 301
- Mass: 33814
- Checksum: C4A0F35A1741894F
- Sequence:
MAMLVLVPGR VMRPLGGQLW RFLPRGLEFW GPAEGTARVL LRQFCARQAE AWRASGRPGY CLGTRPLSTA RPPPPWSQKG PGDSTRPSKP GPVSWKSLAI TFAIGGALLA GMKHVKKEKA EKLEKERQRH IGKPLLGGPF SLTTHTGERK TDKDYLGQWL LIYFGFTHCP DVCPEELEKM IQVVDEIDSI TTLPDLTPLF ISIDPERDTK EAIANYVKEF SPKLVGLTGT REEVDQVARA YRVYYSPGPK DEDEDYIVDH TIIMYLIGPD GEFLDYFGQN KRKGEIAASI ATHMRPYRKK S
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.