Details for: CCL20

Gene ID: 6364

Symbol: CCL20

Ensembl ID: ENSG00000115009

Description: C-C motif chemokine ligand 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.6039
    Cell Significance Index: -19.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.6209
    Cell Significance Index: -15.6900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.5535
    Cell Significance Index: -19.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.8108
    Cell Significance Index: -16.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8985
    Cell Significance Index: -18.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8865
    Cell Significance Index: -18.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.6130
    Cell Significance Index: 537.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2371
    Cell Significance Index: 116.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7859
    Cell Significance Index: 26.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9484
    Cell Significance Index: 517.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8150
    Cell Significance Index: 42.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7098
    Cell Significance Index: 115.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6965
    Cell Significance Index: 79.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6297
    Cell Significance Index: 568.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5316
    Cell Significance Index: 68.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4059
    Cell Significance Index: 44.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3546
    Cell Significance Index: 21.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2446
    Cell Significance Index: 48.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2053
    Cell Significance Index: 25.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1761
    Cell Significance Index: 31.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1750
    Cell Significance Index: 7.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1626
    Cell Significance Index: 16.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1469
    Cell Significance Index: 27.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0701
    Cell Significance Index: 3.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0516
    Cell Significance Index: 32.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0181
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0164
    Cell Significance Index: 12.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0116
    Cell Significance Index: 5.1500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0030
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0036
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0091
    Cell Significance Index: -17.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0100
    Cell Significance Index: -1.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0108
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0123
    Cell Significance Index: -6.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0149
    Cell Significance Index: -22.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0170
    Cell Significance Index: -23.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0236
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0237
    Cell Significance Index: -17.3800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0242
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0301
    Cell Significance Index: -3.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0316
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0381
    Cell Significance Index: -5.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0406
    Cell Significance Index: -18.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0445
    Cell Significance Index: -9.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0447
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0512
    Cell Significance Index: -18.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0675
    Cell Significance Index: -4.1400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0675
    Cell Significance Index: -1.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0676
    Cell Significance Index: -19.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0766
    Cell Significance Index: -7.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0814
    Cell Significance Index: -2.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0888
    Cell Significance Index: -2.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0929
    Cell Significance Index: -18.6300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0931
    Cell Significance Index: -0.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1118
    Cell Significance Index: -16.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1519
    Cell Significance Index: -3.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1537
    Cell Significance Index: -3.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1651
    Cell Significance Index: -19.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1832
    Cell Significance Index: -23.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1855
    Cell Significance Index: -3.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1876
    Cell Significance Index: -5.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1993
    Cell Significance Index: -14.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2099
    Cell Significance Index: -3.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2462
    Cell Significance Index: -6.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2470
    Cell Significance Index: -17.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2539
    Cell Significance Index: -2.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2630
    Cell Significance Index: -20.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2640
    Cell Significance Index: -12.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2741
    Cell Significance Index: -3.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2803
    Cell Significance Index: -18.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2896
    Cell Significance Index: -3.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3025
    Cell Significance Index: -11.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3043
    Cell Significance Index: -19.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3256
    Cell Significance Index: -20.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3318
    Cell Significance Index: -18.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3681
    Cell Significance Index: -10.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3906
    Cell Significance Index: -20.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4074
    Cell Significance Index: -10.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4134
    Cell Significance Index: -11.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4251
    Cell Significance Index: -12.5200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.4666
    Cell Significance Index: -4.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4761
    Cell Significance Index: -21.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5067
    Cell Significance Index: -17.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5194
    Cell Significance Index: -9.6000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5228
    Cell Significance Index: -4.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5391
    Cell Significance Index: -12.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5548
    Cell Significance Index: -21.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5573
    Cell Significance Index: -13.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5618
    Cell Significance Index: -16.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5666
    Cell Significance Index: -18.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5777
    Cell Significance Index: -18.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5891
    Cell Significance Index: -25.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6630
    Cell Significance Index: -18.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6714
    Cell Significance Index: -17.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6797
    Cell Significance Index: -16.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7188
    Cell Significance Index: -18.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7219
    Cell Significance Index: -12.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine Structure and Function**: CCL20 is a small chemokine consisting of 8 amino acids with a unique C-terminal structure that allows it to bind to specific receptors. 2. **Receptor Binding**: CCL20 binds to three distinct receptors: CCR6, CCR1, and CCR3, which are expressed on different immune cells, such as T cells, dendritic cells, and eosinophils. 3. **Cellular Expression**: CCL20 is expressed in various cell types, including epithelial cells, immune cells, stem cells, and endothelial cells, indicating its wide-ranging role in immune regulation. 4. **Signaling Pathways**: CCL20's signaling pathways involve multiple intracellular signaling cascades, including calcium-mediated signaling, G-protein coupled receptor (GPCR) signaling, and MAPK/ERK signaling pathways. **Pathways and Functions:** 1. **Immune Cell Chemotaxis**: CCL20 attracts immune cells, such as T cells, dendritic cells, and eosinophils, to sites of inflammation, promoting the recruitment of immune cells to the site of infection or injury. 2. **T Cell Activation and Differentiation**: CCL20 promotes T cell activation, differentiation, and proliferation, particularly in the context of allergic inflammation and immune responses to pathogens. 3. **Dendritic Cell Maturation**: CCL20 is involved in the maturation of dendritic cells, which is essential for the induction of immune responses and the presentation of antigens to T cells. 4. **Stem Cell Regulation**: CCL20 may regulate the migration and differentiation of stem cells, including intestinal crypt stem cells and early T lineage precursors. 5. **Inflammation and Immune Response**: CCL20 plays a role in the regulation of inflammation and immune responses, including the production of cytokines and chemokines, which are essential for the resolution of inflammation. **Clinical Significance:** 1. **Allergic Diseases**: CCL20 is involved in the pathogenesis of allergic diseases, such as asthma, rhinitis, and atopic dermatitis, where it promotes the recruitment of eosinophils and the activation of T cells. 2. **Inflammatory Disorders**: CCL20 is implicated in inflammatory disorders, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease, where it contributes to the recruitment of immune cells and the production of pro-inflammatory cytokines. 3. **Cancer**: CCL20 has been associated with cancer progression, particularly in the context of immune evasion and metastasis. 4. **Infectious Diseases**: CCL20 plays a role in the regulation of immune responses to pathogens, including Mycobacterium tuberculosis and HIV-1, where it modulates the activity of immune cells and the production of cytokines. In conclusion, CCL20 is a complex chemokine that plays a multifaceted role in the regulation of the immune system. Its involvement in various immune-related disorders highlights the need for further research into the mechanisms of CCL20 signaling and its therapeutic potential in the treatment of immune-related diseases.

Genular Protein ID: 609501456

Symbol: CCL20_HUMAN

Name: C-C motif chemokine 20

UniProtKB Accession Codes:

P78556 Q53S51 Q99664

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013939

Title: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.

PubMed ID: 9013939

PubMed ID: 9038201

Title: Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2.

PubMed ID: 9038201

DOI: 10.1074/jbc.272.9.5846

PubMed ID: 9129037

Title: Cloning and characterization of Exodus, a novel beta-chemokine.

PubMed ID: 9129037

PubMed ID: 11352563

Title: Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization.

PubMed ID: 11352563

DOI: 10.1006/geno.2001.6482

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11035086

Title: Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells.

PubMed ID: 11035086

DOI: 10.4049/jimmunol.165.8.4470

PubMed ID: 20068036

Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

PubMed ID: 20068036

DOI: 10.1074/jbc.m109.091090

PubMed ID: 21376174

Title: CCR6 as a mediator of immunity in the lung and gut.

PubMed ID: 21376174

DOI: 10.1016/j.yexcr.2010.12.018

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 12149255

Title: The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.

PubMed ID: 12149255

DOI: 10.1074/jbc.m203907200

Sequence Information:

  • Length: 96
  • Mass: 10762
  • Checksum: 1ED19EC2E1AC70AD
  • Sequence:
    • MCCTKSLLLA ALMSVLLLHL CGESEAASNF DCCLGYTDRI LHPKFIVGFT RQLANEGCDI 
NAIIFHTKKK LSVCANPKQT WVKYIVRLLS KKVKNM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.