Details for: SDC2

Gene ID: 6383

Symbol: SDC2

Ensembl ID: ENSG00000169439

Description: syndecan 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 104.0351
    Cell Significance Index: -42.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.8909
    Cell Significance Index: -48.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2266
    Cell Significance Index: -42.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.0484
    Cell Significance Index: -48.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1812
    Cell Significance Index: -48.0700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.5642
    Cell Significance Index: 67.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5386
    Cell Significance Index: 95.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.1098
    Cell Significance Index: 186.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.9741
    Cell Significance Index: 31.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.4973
    Cell Significance Index: 694.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.0186
    Cell Significance Index: 574.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0107
    Cell Significance Index: 32.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7518
    Cell Significance Index: 88.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.2170
    Cell Significance Index: 43.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0819
    Cell Significance Index: 59.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0548
    Cell Significance Index: 203.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9144
    Cell Significance Index: 262.9000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.8036
    Cell Significance Index: 12.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1164
    Cell Significance Index: 18.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1035
    Cell Significance Index: 602.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0429
    Cell Significance Index: 36.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0378
    Cell Significance Index: 168.7800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.9833
    Cell Significance Index: 4.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9510
    Cell Significance Index: 25.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9323
    Cell Significance Index: 14.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8319
    Cell Significance Index: 42.0400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.7905
    Cell Significance Index: 4.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7615
    Cell Significance Index: 10.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7306
    Cell Significance Index: 79.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5713
    Cell Significance Index: 395.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4674
    Cell Significance Index: 59.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3755
    Cell Significance Index: 16.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3549
    Cell Significance Index: 24.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3407
    Cell Significance Index: 58.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3303
    Cell Significance Index: 5.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2781
    Cell Significance Index: 122.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2132
    Cell Significance Index: 38.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1115
    Cell Significance Index: 171.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0980
    Cell Significance Index: 1.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0887
    Cell Significance Index: 3.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0792
    Cell Significance Index: 50.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0648
    Cell Significance Index: 7.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0521
    Cell Significance Index: 96.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0428
    Cell Significance Index: 4.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0250
    Cell Significance Index: 1.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0248
    Cell Significance Index: 46.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0246
    Cell Significance Index: 11.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0238
    Cell Significance Index: 4.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0019
    Cell Significance Index: 2.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0011
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0135
    Cell Significance Index: -1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0137
    Cell Significance Index: -10.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0189
    Cell Significance Index: -6.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0215
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0228
    Cell Significance Index: -0.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0397
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0481
    Cell Significance Index: -27.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0653
    Cell Significance Index: -6.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0668
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0927
    Cell Significance Index: -19.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1026
    Cell Significance Index: -14.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1269
    Cell Significance Index: -16.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1295
    Cell Significance Index: -37.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1605
    Cell Significance Index: -11.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1836
    Cell Significance Index: -21.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1846
    Cell Significance Index: -21.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2751
    Cell Significance Index: -4.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3115
    Cell Significance Index: -19.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3734
    Cell Significance Index: -26.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3933
    Cell Significance Index: -10.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3961
    Cell Significance Index: -3.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3969
    Cell Significance Index: -41.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4038
    Cell Significance Index: -22.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4258
    Cell Significance Index: -20.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4294
    Cell Significance Index: -26.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4482
    Cell Significance Index: -30.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5076
    Cell Significance Index: -32.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5153
    Cell Significance Index: -26.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5622
    Cell Significance Index: -44.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6037
    Cell Significance Index: -16.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6571
    Cell Significance Index: -11.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6821
    Cell Significance Index: -14.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7001
    Cell Significance Index: -14.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7200
    Cell Significance Index: -37.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7266
    Cell Significance Index: -9.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7880
    Cell Significance Index: -23.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7893
    Cell Significance Index: -48.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8455
    Cell Significance Index: -44.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8691
    Cell Significance Index: -7.3000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8970
    Cell Significance Index: -15.5100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9114
    Cell Significance Index: -12.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9186
    Cell Significance Index: -10.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9257
    Cell Significance Index: -43.1600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0670
    Cell Significance Index: -18.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.1746
    Cell Significance Index: -17.7000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.2147
    Cell Significance Index: -20.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2377
    Cell Significance Index: -43.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane Glycoprotein**: Syndecan 2 is a transmembrane glycoprotein with a tetrasaccharide linker sequence, which is essential for its function. 2. **Attachment and Entry**: Syndecan 2 is involved in the attachment and entry of viruses, such as RSV and SARS-CoV-2, through its tetrasaccharide linker sequence. 3. **Cell Migration and Axon Guidance**: Syndecan 2 plays a role in cell migration and axon guidance, which are essential for neural development and tissue repair. 4. **Extracellular Matrix Organization**: Syndecan 2 regulates the organization of the extracellular matrix, which is crucial for tissue structure and function. 5. **Insulin-like Growth Factor (IGF) Transport and Uptake**: Syndecan 2 interacts with IGF binding proteins (IGFBPs) and regulates the transport and uptake of IGF. **Pathways and Functions** 1. **Glycosaminoglycan Metabolism**: Syndecan 2 is involved in the metabolism of glycosaminoglycans (GAGs), which are essential for cell signaling and extracellular matrix organization. 2. **Eph-ephrin Signaling**: Syndecan 2 interacts with Eph-ephrin signaling, which regulates cell migration and axon guidance. 3. **Extracellular Matrix Organization**: Syndecan 2 regulates the organization of the extracellular matrix, which is crucial for tissue structure and function. 4. **Insulin-like Growth Factor (IGF) Transport and Uptake**: Syndecan 2 interacts with IGF binding proteins (IGFBPs) and regulates the transport and uptake of IGF. 5. **Viral Infection Pathways**: Syndecan 2 is involved in the attachment and entry of viruses, such as RSV and SARS-CoV-2. **Clinical Significance** 1. **Metabolic Disorders**: Dysregulation of syndecan 2 has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 2. **Cancer**: Syndecan 2 is overexpressed in various types of cancer, including breast, lung, and colon cancer. 3. **Cardiovascular Diseases**: Syndecan 2 is involved in the regulation of blood pressure and cardiovascular disease, including atherosclerosis and hypertension. 4. **Neurological Disorders**: Syndecan 2 is involved in the regulation of neural development and function, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 5. **Infectious Diseases**: Syndecan 2 is involved in the attachment and entry of viruses, such as RSV and SARS-CoV-2, and its dysregulation has been implicated in infectious diseases, such as respiratory syncytial virus (RSV) and SARS-CoV-2 infection.

Genular Protein ID: 2207526738

Symbol: SDC2_HUMAN

Name: Syndecan-2

UniProtKB Accession Codes:

P34741 B3KQA3 Q6PIS6 Q9H6V1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 17 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2523388

Title: Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts.

PubMed ID: 2523388

DOI: 10.1016/s0021-9258(18)83534-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 201
  • Mass: 22160
  • Checksum: 7DA4159D54741054
  • Sequence:
    • MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD 
EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK 
MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD 
LGERKPSSAA YQKAPTKEFY A

Genular Protein ID: 2130133535

Symbol: E9PBI9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PBI9

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 2 SMART 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 172
  • Mass: 18972
  • Checksum: 616D44AC7977D6A2
  • Sequence:
    • MYLDNSSIEE ASGVYPIDDD DYASASGSGA DEDVESPELT TSRPLPKILL TSAAPKVETT 
TLNIQNKIPA QTKSPEETDK EKVHLSDSER KMDPAEEDTN VYTEKHSDSL FKRTEVLAAV 
IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF YA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.