Details for: SDHB
Gene ID: 6390
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SDHB
Ensembl ID: ENSG00000117118
Description: succinate dehydrogenase complex iron sulfur subunit B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 25.57rCSI 26.73%PRS 28.14
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CSI 24.84rCSI 29.18%PRS 31.12
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CSI 24.29rCSI 39.17%PRS 38.81
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CSI 16.19rCSI 16.96%PRS 25.6
-
CSI 16.15rCSI 15.57%PRS 20.49
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CSI 14.17rCSI 62.96%PRS 26.55
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CSI 13.96rCSI 20.61%PRS 41.68
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CSI 12.36rCSI 16.19%PRS 38.27
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CSI 10.93rCSI 13.12%PRS 26.54
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CSI 10.54rCSI 14.34%PRS 39.46
-
CSI 10.28rCSI 19.4%PRS 34.68
-
CSI 10.09rCSI 10.28%PRS 38.29
-
CSI 9.78rCSI 15.03%PRS 34.19
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CSI 9.51rCSI 13.49%PRS 25.5
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CSI 9.26rCSI 6.86%PRS 23.59
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CSI 8.46rCSI 13.37%PRS 27.67
-
CSI 8.23rCSI 23.83%PRS 30.44
-
CSI 8.06rCSI 21.73%PRS 35.15
-
CSI 7.84rCSI 16.09%PRS 51.36
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CSI 7.73rCSI 22.16%PRS 40.48
-
CSI 7.57rCSI 11.57%PRS 42.61
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CSI 7.23rCSI 9.31%PRS 17.46
-
CSI 6.99rCSI 10.85%PRS 38.61
-
CSI 6.68rCSI 6.43%PRS 28.3
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CSI 6.42rCSI 9.3%PRS 40.71
-
CSI 6.11rCSI 8.12%PRS 30.19
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CSI 5.84rCSI 14.84%PRS 26.65
-
CSI 5.66rCSI 13.49%PRS 30.4
-
CSI 5.63rCSI 13.36%PRS 33.01
-
CSI 5.39rCSI 40.49%PRS 46.81
-
CSI 5.38rCSI 7.87%PRS 29.18
-
CSI 5.26rCSI 4.67%PRS 27.44
-
CSI 5.09rCSI 9.7%PRS 42.22
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CSI 5.04rCSI 26.46%PRS 43.44
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CSI 5.01rCSI 7.34%PRS 30.15
-
CSI 4.99rCSI 4.64%PRS 27.42
-
CSI 4.87rCSI 6.98%PRS 35.54
-
CSI 4.87rCSI 28.34%PRS 38.82
-
CSI 4.85rCSI 27.81%PRS 38.5
-
CSI 4.76rCSI 3.69%PRS 26.79
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CSI 4.74rCSI 46.55%PRS 58.07
-
CSI 4.68rCSI 12.89%PRS 25.75
-
CSI 4.64rCSI 6.35%PRS 30.88
-
CSI 4.61rCSI 7.9%PRS 36.07
-
CSI 4.57rCSI 8.2%PRS 22.89
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CSI 4.37rCSI 3.44%PRS 32.74
-
CSI 4.3rCSI 12.04%PRS 41.15
-
CSI 4.24rCSI 3.35%PRS 19
-
CSI 4.14rCSI 20.78%PRS 35.9
-
CSI 4.1rCSI 18.01%PRS 46.82
-
CSI 4.04rCSI 9.21%PRS 27.65
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CSI 4.03rCSI 3.49%PRS 30.57
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CSI 3.93rCSI 3.18%PRS 27.57
-
CSI 3.87rCSI 9.8%PRS 33.59
-
CSI 3.82rCSI 4.75%PRS 29.35
-
CSI 3.79rCSI 3.78%PRS 23.5
-
CSI 3.77rCSI 6.04%PRS 60.54
-
CSI 3.69rCSI 2.96%PRS 46.44
-
CSI 3.66rCSI 19.74%PRS 42.82
-
CSI 3.64rCSI 2.53%PRS 37.84
-
CSI 3.59rCSI 8.29%PRS 22.39
-
CSI 3.58rCSI 5.69%PRS 23.1
-
CSI 3.55rCSI 3.2%PRS 25
-
CSI 3.47rCSI 5.63%PRS 27.26
-
CSI 3.42rCSI 2.57%PRS 29.32
-
CSI 3.41rCSI 5.98%PRS 21.61
-
CSI 3.4rCSI 4.71%PRS 35.4
-
CSI 3.39rCSI 6.88%PRS 15.31
-
CSI 3.33rCSI 8.62%PRS 25.26
-
CSI 3.31rCSI 2.52%PRS 35.97
-
CSI 3.26rCSI 4.18%PRS 31.49
-
CSI 3.25rCSI 4.97%PRS 34.95
-
CSI 3.23rCSI 2.62%PRS 28.49
-
CSI 3.15rCSI 2.19%PRS 33.09
-
CSI 3.11rCSI 7.11%PRS 23.56
-
CSI 3.07rCSI 2.82%PRS 32.61
-
CSI 3.06rCSI 14.05%PRS 53.05
-
CSI 3.04rCSI 2.67%PRS 20.15
-
CSI 2.99rCSI 2.01%PRS 34.07
-
CSI 2.99rCSI 2.72%PRS 40.43
-
CSI 2.96rCSI 6.46%PRS 48.54
-
CSI 2.94rCSI 3.51%PRS 45.4
-
CSI 2.91rCSI 3.62%PRS 15.84
-
CSI 2.88rCSI 2.29%PRS 46.65
-
CSI 2.86rCSI 2.98%PRS 28.15
-
CSI 2.85rCSI 2.22%PRS 39.84
-
CSI 2.84rCSI 2.62%PRS 28.49
-
CSI 2.83rCSI 2.48%PRS 31.26
-
CSI 2.82rCSI 6.76%PRS 45.02
-
CSI 2.75rCSI 5.51%PRS 20.47
-
CSI 2.74rCSI 3.75%PRS 30.11
-
CSI 2.7rCSI 5.24%PRS 28.32
-
CSI 2.68rCSI 1.87%PRS 28.97
-
CSI 2.67rCSI 4.39%PRS 31.97
-
CSI 2.65rCSI 41.06%PRS 57.33
-
CSI 2.65rCSI 2.5%PRS 28.61
-
CSI 2.64rCSI 2.83%PRS 25.36
-
CSI 2.63rCSI 1.97%PRS 44
-
CSI 2.62rCSI 4.01%PRS 31.2
-
CSI 2.62rCSI 3.51%PRS 29.56
-
CSI 0.1rCSI 0.6%PRS 59.0%
-
CSI 0.1rCSI 2.4%PRS 48.5%
-
CSI 0.1rCSI 2.5%PRS 65.8%
-
CSI 0.2rCSI 0.9%PRS 39.1%
-
CSI 0.3rCSI 2.7%PRS 48.4%
-
CSI 0.3rCSI 6.1%PRS 16.6%
-
CSI 0.3rCSI 1.6%PRS 17.7%
-
CSI 0.3rCSI 6.6%PRS 15.8%
-
CSI 0.3rCSI 1.8%PRS 22.1%
-
CSI 0.3rCSI 1.0%PRS 40.1%
-
CSI 0.4rCSI 0.3%PRS 34.1%
-
CSI 0.4rCSI 3.7%PRS 62.0%
-
CSI 0.4rCSI 3.3%PRS 16.7%
-
CSI 0.4rCSI 2.1%PRS 54.4%
-
CSI 0.4rCSI 0.8%PRS 52.1%
-
CSI 0.4rCSI 0.5%PRS 45.0%
-
CSI 0.4rCSI 8.1%PRS 23.0%
-
CSI 0.4rCSI 3.2%PRS 47.6%
-
CSI 0.5rCSI 0.8%PRS 16.8%
-
CSI 0.5rCSI 1.3%PRS 21.7%
-
CSI 0.5rCSI 4.2%PRS 86.6%
-
CSI 0.5rCSI 2.2%PRS 57.5%
-
CSI 0.5rCSI 2.0%PRS 43.7%
-
CSI 0.5rCSI 8.6%PRS 68.2%
-
CSI 0.5rCSI 2.0%PRS 51.3%
-
CSI 0.5rCSI 2.7%PRS 49.8%
-
CSI 0.5rCSI 2.5%PRS 53.3%
-
CSI 0.6rCSI 2.0%PRS 41.9%
-
CSI 0.6rCSI 2.2%PRS 17.6%
-
CSI 0.6rCSI 3.6%PRS 54.2%
-
CSI 0.6rCSI 1.9%PRS 19.2%
-
CSI 0.7rCSI 1.2%PRS 41.1%
-
CSI 0.7rCSI 3.4%PRS 36.5%
-
CSI 0.7rCSI 2.7%PRS 44.4%
-
CSI 0.7rCSI 1.2%PRS 18.3%
-
CSI 0.8rCSI 3.3%PRS 43.8%
-
CSI 0.8rCSI 1.4%PRS 49.0%
-
CSI 0.8rCSI 1.7%PRS 25.3%
-
CSI 0.8rCSI 1.2%PRS 21.1%
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CSI 0.8rCSI 2.8%PRS 16.0%
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CSI 0.8rCSI 1.8%PRS 19.8%
-
CSI 0.8rCSI 1.2%PRS 28.1%
-
CSI 0.8rCSI 2.1%PRS 27.6%
-
CSI 0.8rCSI 1.1%PRS 23.9%
-
CSI 0.9rCSI 1.2%PRS 39.2%
-
CSI 0.9rCSI 3.0%PRS 44.0%
-
CSI 0.9rCSI 2.5%PRS 42.7%
-
CSI 0.9rCSI 3.4%PRS 44.0%
-
CSI 0.9rCSI 3.5%PRS 36.6%
-
CSI 0.9rCSI 1.9%PRS 41.5%
-
CSI 0.9rCSI 2.8%PRS 17.7%
-
CSI 0.9rCSI 3.2%PRS 67.3%
-
CSI 0.9rCSI 3.0%PRS 36.4%
-
CSI 1.0rCSI 3.4%PRS 65.0%
-
CSI 1.0rCSI 1.4%PRS 30.3%
-
CSI 1.0rCSI 1.2%PRS 50.2%
-
CSI 1.0rCSI 1.5%PRS 41.1%
-
CSI 1.0rCSI 2.7%PRS 38.8%
-
CSI 1.0rCSI 1.7%PRS 21.3%
-
CSI 1.0rCSI 2.2%PRS 37.0%
-
CSI 1.0rCSI 1.2%PRS 16.7%
-
CSI 1.1rCSI 1.6%PRS 45.1%
-
CSI 1.1rCSI 1.6%PRS 35.7%
-
CSI 1.1rCSI 2.7%PRS 16.5%
-
CSI 1.1rCSI 3.3%PRS 53.7%
-
CSI 1.1rCSI 1.7%PRS 31.1%
-
CSI 1.1rCSI 2.2%PRS 56.6%
-
CSI 1.1rCSI 2.9%PRS 33.0%
-
CSI 1.2rCSI 1.8%PRS 25.3%
-
CSI 1.2rCSI 4.7%PRS 25.9%
-
CSI 1.2rCSI 2.6%PRS 36.0%
-
CSI 1.2rCSI 3.5%PRS 46.1%
-
CSI 1.2rCSI 3.1%PRS 21.1%
-
CSI 1.2rCSI 6.3%PRS 69.3%
-
CSI 1.2rCSI 2.5%PRS 28.4%
-
CSI 1.2rCSI 1.6%PRS 26.3%
-
CSI 1.2rCSI 4.0%PRS 31.9%
-
CSI 1.2rCSI 4.0%PRS 23.8%
-
CSI 1.3rCSI 2.6%PRS 57.3%
-
CSI 1.3rCSI 1.6%PRS 33.7%
-
CSI 1.4rCSI 1.1%PRS 32.0%
-
CSI 1.4rCSI 1.4%PRS 32.2%
-
CSI 1.4rCSI 5.9%PRS 45.5%
-
CSI 1.4rCSI 2.3%PRS 23.4%
-
CSI 1.5rCSI 3.8%PRS 33.6%
-
CSI 1.5rCSI 3.2%PRS 31.0%
-
CSI 1.5rCSI 2.1%PRS 25.4%
-
CSI 1.5rCSI 2.5%PRS 52.0%
-
CSI 1.5rCSI 2.2%PRS 36.9%
-
CSI 1.5rCSI 1.1%PRS 37.3%
-
CSI 1.5rCSI 3.5%PRS 26.9%
-
CSI 1.6rCSI 20.6%PRS 64.5%
-
CSI 1.6rCSI 1.0%PRS 31.9%
-
CSI 1.6rCSI 3.5%PRS 32.0%
-
CSI 1.6rCSI 1.2%PRS 38.9%
-
CSI 1.6rCSI 1.3%PRS 26.1%
-
CSI 1.6rCSI 1.7%PRS 43.5%
-
CSI 1.6rCSI 1.9%PRS 23.7%
-
CSI 1.6rCSI 2.3%PRS 27.6%
-
CSI 1.7rCSI 1.7%PRS 46.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 58464758
Symbol: SDHB_HUMAN
Name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7622059
Title: Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase.
PubMed ID: 7622059
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16751257
Title: Housekeeping genes for phylogenetic analysis of eutherian relationships.
PubMed ID: 16751257
PubMed ID: 2302193
Title: Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria.
PubMed ID: 2302193
PubMed ID: 2494655
Title: Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species.
PubMed ID: 2494655
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26749241
Title: Disease-causing SDHAF1 mutations impair transfer of Fe-S clusters to SDHB.
PubMed ID: 26749241
PubMed ID: 33092197
Title: A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions.
PubMed ID: 33092197
DOI: 10.3390/v12101192
PubMed ID: 37098072
Title: Structure of the human respiratory complex II.
PubMed ID: 37098072
PubMed ID: 11404820
Title: Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma.
PubMed ID: 11404820
DOI: 10.1086/321282
PubMed ID: 12213855
Title: Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene.
PubMed ID: 12213855
PubMed ID: 11897817
Title: Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas.
PubMed ID: 11897817
DOI: 10.1136/jmg.39.3.178
PubMed ID: 12000816
Title: Germ-line mutations in nonsyndromic pheochromocytoma.
PubMed ID: 12000816
DOI: 10.1056/nejmoa020152
PubMed ID: 14500403
Title: Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.
PubMed ID: 14500403
PubMed ID: 14974914
Title: Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility.
PubMed ID: 14974914
PubMed ID: 12618761
Title: Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas.
PubMed ID: 12618761
PubMed ID: 15473885
Title: K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma.
PubMed ID: 15473885
PubMed ID: 15328326
Title: Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.
PubMed ID: 15328326
PubMed ID: 14715873
Title: A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas.
PubMed ID: 14715873
PubMed ID: 17634472
Title: Somatic SDHB mutation in an extraadrenal pheochromocytoma.
PubMed ID: 17634472
DOI: 10.1056/nejmc070010
PubMed ID: 17804857
Title: Familial gastrointestinal stromal tumors and germ-line mutations.
PubMed ID: 17804857
DOI: 10.1056/nejmc071191
PubMed ID: 18678321
Title: Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes.
PubMed ID: 18678321
PubMed ID: 22972948
Title: Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency.
PubMed ID: 22972948
PubMed ID: 26925370
Title: Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance.
PubMed ID: 26925370
PubMed ID: 26642834
Title: Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy.
PubMed ID: 26642834
DOI: 10.1002/ana.24572
PubMed ID: 27604842
Title: Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
PubMed ID: 27604842
PubMed ID: 32124427
Title: Novel variant p.(Ala102Thr) in SDHB causes mitochondrial complex II deficiency: Case report and review of the literature.
PubMed ID: 32124427
DOI: 10.1111/ahg.12377
Sequence Information:
- Length: 280
- Mass: 31630
- Checksum: ED12E7C3BA7B6D13
- Sequence:
MAAVVALSLR RRLPATTLGG ACLQASRGAQ TAAATAPRIK KFAIYRWDPD KAGDKPHMQT YEVDLNKCGP MVLDALIKIK NEVDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN LNKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQEGKQQY LQSIEEREKL DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL YRCHTIMNCT RTCPKGLNPG KAIAEIKKMM ATYKEKKASV