Details for: SDHC

Gene ID: 6391

Symbol: SDHC

Ensembl ID: ENSG00000143252

Description: succinate dehydrogenase complex subunit C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 373.7820
    Cell Significance Index: -58.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 194.9982
    Cell Significance Index: -49.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 164.2442
    Cell Significance Index: -67.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.4373
    Cell Significance Index: -67.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 126.9671
    Cell Significance Index: -65.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.0132
    Cell Significance Index: -64.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7826
    Cell Significance Index: -66.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.6265
    Cell Significance Index: -44.5400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.0352
    Cell Significance Index: -46.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0453
    Cell Significance Index: 16.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7712
    Cell Significance Index: 24.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7069
    Cell Significance Index: 46.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6245
    Cell Significance Index: 121.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6179
    Cell Significance Index: 198.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6030
    Cell Significance Index: 42.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4635
    Cell Significance Index: 1321.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4305
    Cell Significance Index: 49.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4098
    Cell Significance Index: 254.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3620
    Cell Significance Index: 40.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3157
    Cell Significance Index: 261.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2791
    Cell Significance Index: 175.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2412
    Cell Significance Index: 65.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1335
    Cell Significance Index: 619.0100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.0880
    Cell Significance Index: 11.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0587
    Cell Significance Index: 49.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0531
    Cell Significance Index: 28.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0130
    Cell Significance Index: 52.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9779
    Cell Significance Index: 20.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9638
    Cell Significance Index: 277.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9473
    Cell Significance Index: 111.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9211
    Cell Significance Index: 118.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9026
    Cell Significance Index: 116.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8978
    Cell Significance Index: 180.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8901
    Cell Significance Index: 319.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8873
    Cell Significance Index: 144.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8643
    Cell Significance Index: 382.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8046
    Cell Significance Index: 79.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6999
    Cell Significance Index: 6.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6665
    Cell Significance Index: 47.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6476
    Cell Significance Index: 14.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5341
    Cell Significance Index: 40.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5201
    Cell Significance Index: 32.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3371
    Cell Significance Index: 21.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3015
    Cell Significance Index: 57.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2632
    Cell Significance Index: 3.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2549
    Cell Significance Index: 11.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1894
    Cell Significance Index: 130.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1789
    Cell Significance Index: 30.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1275
    Cell Significance Index: 5.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0737
    Cell Significance Index: 54.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0603
    Cell Significance Index: 113.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0545
    Cell Significance Index: 41.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0522
    Cell Significance Index: 1.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0237
    Cell Significance Index: 1.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0165
    Cell Significance Index: 0.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0096
    Cell Significance Index: 0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0131
    Cell Significance Index: -8.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0185
    Cell Significance Index: -11.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0194
    Cell Significance Index: -29.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0349
    Cell Significance Index: -47.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0365
    Cell Significance Index: -3.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0445
    Cell Significance Index: -1.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0477
    Cell Significance Index: -21.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0863
    Cell Significance Index: -48.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0934
    Cell Significance Index: -1.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1086
    Cell Significance Index: -1.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1582
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1688
    Cell Significance Index: -35.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2090
    Cell Significance Index: -11.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2104
    Cell Significance Index: -6.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2270
    Cell Significance Index: -15.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2420
    Cell Significance Index: -5.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2611
    Cell Significance Index: -37.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2646
    Cell Significance Index: -30.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3300
    Cell Significance Index: -38.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3545
    Cell Significance Index: -28.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3582
    Cell Significance Index: -9.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4050
    Cell Significance Index: -46.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4384
    Cell Significance Index: -4.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4427
    Cell Significance Index: -27.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4670
    Cell Significance Index: -31.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5784
    Cell Significance Index: -60.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7131
    Cell Significance Index: -13.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7991
    Cell Significance Index: -21.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8085
    Cell Significance Index: -12.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9115
    Cell Significance Index: -23.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9383
    Cell Significance Index: -15.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9557
    Cell Significance Index: -14.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0026
    Cell Significance Index: -12.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0264
    Cell Significance Index: -17.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0785
    Cell Significance Index: -26.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0899
    Cell Significance Index: -66.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1411
    Cell Significance Index: -33.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2034
    Cell Significance Index: -32.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2051
    Cell Significance Index: -12.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -1.2813
    Cell Significance Index: -17.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2889
    Cell Significance Index: -36.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.3129
    Cell Significance Index: -23.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit C of the Succinate Dehydrogenase Complex:** The SDHC gene encodes for a 17-kDa subunit of the SDHC complex, which is a critical component of the mitochondrial respiratory electron transport chain. 2. **Citric Acid Cycle (TCA Cycle) and Respiratory Electron Transport:** The SDHC complex is involved in both the TCA cycle and the respiratory electron transport chain, facilitating the conversion of succinate to ubiquinone and the generation of ATP through the proton motive force. 3. **High Expression in Various Tissues:** The SDHC gene is highly expressed in epithelial cells, kidney cells, placental cells, and erythroid progenitor cells, indicating its widespread importance in maintaining cellular homeostasis. 4. **Aerobic Respiration and Energy Production:** The SDHC complex plays a critical role in the production of ATP through aerobic respiration, highlighting its importance in energy production in cells. **Pathways and Functions:** 1. **Electron Transfer Activity:** The SDHC complex facilitates the transfer of electrons from succinate to ubiquinone, generating a proton gradient that drives the production of ATP. 2. **Heme Binding:** The SDHC complex binds heme, which is essential for the transfer of electrons and the generation of ATP. 3. **Mitochondrial Electron Transport:** The SDHC complex is a critical component of the mitochondrial respiratory electron transport chain, facilitating the transfer of electrons and the generation of ATP. 4. **Proton Motive Force-Driven ATP Synthesis:** The SDHC complex generates a proton motive force that drives the production of ATP through chemiosmotic coupling. **Clinical Significance:** 1. **Mitochondrial Diseases:** Mutations in the SDHC gene have been implicated in various mitochondrial diseases, including Leigh syndrome and MELAS syndrome, highlighting the importance of the SDHC complex in maintaining mitochondrial function. 2. **Cancer:** The SDHC complex has been implicated in cancer development and progression, with mutations in the SDHC gene being associated with an increased risk of cancer. 3. **Metabolic Disorders:** The SDHC complex plays a critical role in the regulation of pyruvate metabolism and the citric acid cycle, highlighting its importance in maintaining metabolic homeostasis. 4. **Neurological Disorders:** The SDHC complex has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, highlighting its importance in maintaining neuronal function. In conclusion, the SDHC gene plays a critical role in maintaining cellular homeostasis through its involvement in the citric acid cycle and the mitochondrial respiratory electron transport chain. Mutations in the SDHC gene have been implicated in various diseases, highlighting the importance of this gene in human health. Further research is needed to fully understand the implications of SDHC gene mutations and their role in human disease.

Genular Protein ID: 3234362187

Symbol: C560_HUMAN

Name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

UniProtKB Accession Codes:

Q99643 O75609 Q3C259 Q3C2D8 Q3C2H4 Q5VTH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CPTC 1 CTD 1 ChEBI 3 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 20 EMDB 1 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9533030

Title: Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23.

PubMed ID: 9533030

DOI: 10.1159/000134700

PubMed ID: 9714607

Title: Characterization of the human SDHC gene encoding one of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria.

PubMed ID: 9714607

DOI: 10.1016/s0378-1119(98)00186-3

PubMed ID: 9851882

Title: A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene.

PubMed ID: 9851882

DOI: 10.1006/mgme.1998.2752

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11062460

Title: Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

PubMed ID: 11062460

DOI: 10.1038/81551

PubMed ID: 17804857

Title: Familial gastrointestinal stromal tumors and germ-line mutations.

PubMed ID: 17804857

DOI: 10.1056/nejmc071191

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 37098072

Title: Structure of the human respiratory complex II.

PubMed ID: 37098072

DOI: 10.1073/pnas.2216713120

Sequence Information:

  • Length: 169
  • Mass: 18610
  • Checksum: DF7CBD6D0CD49500
  • Sequence:
    • MAALLLRHVG RHCLRAHFSP QLCIRNAVPL GTTAKEEMER FWNKNIGSNR PLSPHITIYS 
WSLPMAMSIC HRGTGIALSA GVSLFGMSAL LLPGNFESYL ELVKSLCLGP ALIHTAKFAL 
VFPLMYHTWN GIRHLMWDLG KGLKIPQLYQ SGVVVLVLTV LSSMGLAAM

Genular Protein ID: 3129529695

Symbol: A0A0S2Z4C9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4C9

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 Pfam 1 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 116
  • Mass: 12474
  • Checksum: AC702AE33DD1F118
  • Sequence:
    • MAALLLSWSL PMAMSICHRG TGIALSAGVS LFGMSALLLP GNFESYLELV KSLCLGPALI 
HTAKFALVFP LMYHTWNGIR HLMWDLGKGL KIPQLYQSGV VVLVLTVLSS MGLAAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.