Details for: SDHC
Gene ID: 6391
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SDHC
Ensembl ID: ENSG00000143252
Description: succinate dehydrogenase complex subunit C
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 43.7rCSI 45.67%PRS 14.25
-
CSI 42.41rCSI 40.9%PRS 9.43
-
CSI 40.71rCSI 42.65%PRS 14.5
-
CSI 35.64rCSI 68.04%PRS 31.49
-
CSI 31.82rCSI 30.63%PRS 14.04
-
CSI 24.58rCSI 21.61%PRS 9.83
-
CSI 23.85rCSI 24.98%PRS 12.63
-
CSI 21.85rCSI 19.73%PRS 11.99
-
CSI 21.44rCSI 21.09%PRS 14.75
-
CSI 16.68rCSI 43.93%PRS 26.46
-
CSI 16.32rCSI 24.1%PRS 21.33
-
CSI 16.15rCSI 31.41%PRS 13.84
-
CSI 11.34rCSI 32.82%PRS 15.38
-
CSI 11.32rCSI 13.29%PRS 15.93
-
CSI 11.31rCSI 7.52%PRS 16.15
-
CSI 11.24rCSI 39.44%PRS 24.44
-
CSI 11.12rCSI 16.03%PRS 21.75
-
CSI 10.2rCSI 22.53%PRS 9.77
-
CSI 8.65rCSI 50.34%PRS 20.35
-
CSI 8.32rCSI 91.06%PRS 24.45
-
CSI 7.73rCSI 8.94%PRS 9.92
-
CSI 7.62rCSI 24.45%PRS 19.82
-
CSI 7.58rCSI 11.59%PRS 22.01
-
CSI 6.5rCSI 5.25%PRS 13.39
-
CSI 6.34rCSI 25.22%PRS 23.84
-
CSI 6.29rCSI 10.14%PRS 21.6
-
CSI 6.15rCSI 14.03%PRS 14.13
-
CSI 5.86rCSI 8.45%PRS 18.83
-
CSI 5.81rCSI 8.86%PRS 12.68
-
CSI 5.69rCSI 12.6%PRS 12.62
-
CSI 5.65rCSI 7.55%PRS 17.98
-
CSI 5.29rCSI 5.62%PRS 23.95
-
CSI 5.29rCSI 8.12%PRS 19.23
-
CSI 5.23rCSI 11.12%PRS 21.83
-
CSI 5.2rCSI 7.63%PRS 17.79
-
CSI 5.14rCSI 12.55%PRS 13.5
-
CSI 5.08rCSI 38.17%PRS 24.82
-
CSI 4.93rCSI 28.26%PRS 20.8
-
CSI 4.74rCSI 11.11%PRS 20.31
-
CSI 4.63rCSI 23.9%PRS 26.57
-
CSI 4.47rCSI 6.53%PRS 14.32
-
CSI 4.42rCSI 8.04%PRS 20.74
-
CSI 4.3rCSI 8.14%PRS 36.7
-
CSI 4.24rCSI 6.83%PRS 10.43
-
CSI 4.23rCSI 3.28%PRS 12.93
-
CSI 4.23rCSI 6.54%PRS 12.7
-
CSI 4.23rCSI 8.16%PRS 30.24
-
CSI 4.23rCSI 13.6%PRS 14.4
-
CSI 3.97rCSI 3.02%PRS 17.72
-
CSI 3.73rCSI 2.94%PRS 16.11
-
CSI 3.7rCSI 2.59%PRS 14.21
-
CSI 3.61rCSI 35.69%PRS 46.54
-
CSI 3.56rCSI 2.64%PRS 12.01
-
CSI 3.56rCSI 85.23%PRS 6.22
-
CSI 3.54rCSI 2.46%PRS 15.91
-
CSI 3.48rCSI 10.29%PRS 16.58
-
CSI 3.43rCSI 82.8%PRS 7.12
-
CSI 3.41rCSI 4.83%PRS 18.88
-
CSI 3.4rCSI 2.82%PRS 12.78
-
CSI 3.37rCSI 8.01%PRS 20.37
-
CSI 3.21rCSI 2.85%PRS 13.56
-
CSI 3.13rCSI 8.94%PRS 23.33
-
CSI 3.1rCSI 7.85%PRS 16.85
-
CSI 3.08rCSI 5.53%PRS 11.33
-
CSI 3.04rCSI 2.67%PRS 15.24
-
CSI 3.02rCSI 10.2%PRS 22.62
-
CSI 2.91rCSI 15.69%PRS 25.24
-
CSI 2.88rCSI 4.55%PRS 13.57
-
CSI 2.87rCSI 3.29%PRS 27.73
-
CSI 2.82rCSI 12.37%PRS 25.26
-
CSI 2.74rCSI 3.93%PRS 18.62
-
CSI 2.7rCSI 10.13%PRS 11.48
-
CSI 2.7rCSI 3.75%PRS 13.96
-
CSI 2.69rCSI 3.94%PRS 15.81
-
CSI 2.65rCSI 12.38%PRS 32.04
-
CSI 2.64rCSI 25.9%PRS 37.91
-
CSI 2.51rCSI 3.33%PRS 14.82
-
CSI 2.48rCSI 74.48%PRS 31.02
-
CSI 2.45rCSI 8.69%PRS 22.17
-
CSI 2.43rCSI 2.03%PRS 16.22
-
CSI 2.42rCSI 2.24%PRS 13.78
-
CSI 2.34rCSI 3.75%PRS 40.62
-
CSI 2.33rCSI 2.92%PRS 17.27
-
CSI 2.31rCSI 2.4%PRS 15.92
-
CSI 2.28rCSI 4.36%PRS 21.63
-
CSI 2.26rCSI 19.43%PRS 62.39
-
CSI 2.25rCSI 3.11%PRS 19.47
-
CSI 2.19rCSI 2.98%PRS 32.4
-
CSI 2.14rCSI 28.34%PRS 42.87
-
CSI 2.09rCSI 3.95%PRS 29.27
-
CSI 2.07rCSI 2.33%PRS 21.73
-
CSI 2.03rCSI 2.9%PRS 15.29
-
CSI 1.96rCSI 17.45%PRS 75.82
-
CSI 1.95rCSI 5.64%PRS 10.57
-
CSI 1.92rCSI 2.29%PRS 7.81
-
CSI 1.91rCSI 4.53%PRS 17.12
-
CSI 1.91rCSI 1.55%PRS 14.31
-
CSI 1.88rCSI 2.99%PRS 17.51
-
CSI 1.85rCSI 3%PRS 13.8
-
CSI 1.85rCSI 4.22%PRS 13.08
-
CSI -9.6rCSI -16.6%PRS 10.3%
-
CSI -7.0rCSI -9.1%PRS 19.0%
-
CSI -4.2rCSI -6.8%PRS 8.8%
-
CSI -3.0rCSI -4.8%PRS 14.8%
-
CSI -2.9rCSI -3.9%PRS 20.7%
-
CSI -2.8rCSI -2.1%PRS 14.1%
-
CSI -2.4rCSI -7.8%PRS 16.6%
-
CSI -1.7rCSI -4.8%PRS 19.7%
-
CSI -1.6rCSI -4.3%PRS 16.2%
-
CSI -1.3rCSI -11.2%PRS 4.7%
-
CSI -0.3rCSI -0.7%PRS 8.4%
-
CSI -0.2rCSI -1.2%PRS 10.6%
-
CSI 0.0rCSI 0.7%PRS 24.5%
-
CSI 0.0rCSI 0.9%PRS 57.4%
-
CSI 0.0rCSI 0.8%PRS 44.8%
-
CSI 0.1rCSI 0.1%PRS 18.8%
-
CSI 0.1rCSI 0.3%PRS 25.8%
-
CSI 0.1rCSI 0.4%PRS 33.3%
-
CSI 0.1rCSI 0.2%PRS 7.9%
-
CSI 0.1rCSI 0.5%PRS 8.4%
-
CSI 0.1rCSI 0.2%PRS 7.6%
-
CSI 0.1rCSI 0.2%PRS 26.7%
-
CSI 0.1rCSI 0.8%PRS 34.8%
-
CSI 0.1rCSI 0.4%PRS 33.2%
-
CSI 0.1rCSI 0.2%PRS 20.7%
-
CSI 0.1rCSI 2.6%PRS 38.8%
-
CSI 0.2rCSI 0.6%PRS 24.2%
-
CSI 0.2rCSI 1.0%PRS 26.5%
-
CSI 0.2rCSI 1.7%PRS 26.0%
-
CSI 0.2rCSI 0.9%PRS 44.8%
-
CSI 0.2rCSI 1.6%PRS 53.9%
-
CSI 0.2rCSI 1.1%PRS 43.2%
-
CSI 0.2rCSI 2.7%PRS 41.6%
-
CSI 0.2rCSI 0.4%PRS 9.9%
-
CSI 0.2rCSI 1.2%PRS 24.4%
-
CSI 0.2rCSI 2.2%PRS 39.2%
-
CSI 0.2rCSI 0.3%PRS 10.5%
-
CSI 0.2rCSI 1.6%PRS 40.8%
-
CSI 0.2rCSI 0.9%PRS 8.2%
-
CSI 0.2rCSI 0.3%PRS 20.0%
-
CSI 0.3rCSI 0.2%PRS 18.4%
-
CSI 0.3rCSI 1.1%PRS 58.2%
-
CSI 0.3rCSI 0.8%PRS 7.1%
-
CSI 0.3rCSI 0.3%PRS 23.3%
-
CSI 0.3rCSI 1.0%PRS 22.2%
-
CSI 0.3rCSI 0.2%PRS 16.7%
-
CSI 0.3rCSI 0.7%PRS 21.0%
-
CSI 0.3rCSI 0.7%PRS 12.6%
-
CSI 0.3rCSI 6.2%PRS 73.8%
-
CSI 0.3rCSI 0.7%PRS 12.5%
-
CSI 0.3rCSI 1.2%PRS 13.4%
-
CSI 0.3rCSI 0.3%PRS 25.1%
-
CSI 0.3rCSI 0.2%PRS 24.0%
-
CSI 0.3rCSI 1.4%PRS 35.8%
-
CSI 0.3rCSI 0.5%PRS 10.5%
-
CSI 0.3rCSI 2.4%PRS 52.1%
-
CSI 0.3rCSI 0.4%PRS 25.9%
-
CSI 0.3rCSI 0.7%PRS 21.4%
-
CSI 0.3rCSI 1.0%PRS 8.5%
-
CSI 0.3rCSI 1.3%PRS 18.9%
-
CSI 0.3rCSI 0.5%PRS 15.5%
-
CSI 0.3rCSI 8.6%PRS 59.0%
-
CSI 0.3rCSI 1.7%PRS 52.2%
-
CSI 0.4rCSI 0.9%PRS 17.8%
-
CSI 0.4rCSI 1.6%PRS 46.1%
-
CSI 0.4rCSI 0.6%PRS 8.0%
-
CSI 0.4rCSI 1.4%PRS 41.9%
-
CSI 0.4rCSI 1.5%PRS 27.9%
-
CSI 0.4rCSI 1.1%PRS 22.3%
-
CSI 0.4rCSI 1.6%PRS 13.7%
-
CSI 0.4rCSI 1.1%PRS 11.4%
-
CSI 0.4rCSI 0.5%PRS 7.4%
-
CSI 0.4rCSI 1.2%PRS 52.0%
-
CSI 0.4rCSI 1.0%PRS 16.1%
-
CSI 0.4rCSI 0.7%PRS 13.4%
-
CSI 0.4rCSI 1.1%PRS 7.8%
-
CSI 0.4rCSI 1.3%PRS 30.1%
-
CSI 0.5rCSI 0.5%PRS 17.1%
-
CSI 0.5rCSI 1.3%PRS 26.2%
-
CSI 0.5rCSI 9.2%PRS 11.4%
-
CSI 0.5rCSI 1.7%PRS 23.3%
-
CSI 0.5rCSI 1.2%PRS 38.8%
-
CSI 0.5rCSI 0.4%PRS 19.5%
-
CSI 0.5rCSI 1.8%PRS 29.6%
-
CSI 0.5rCSI 0.7%PRS 15.8%
-
CSI 0.5rCSI 1.7%PRS 7.4%
-
CSI 0.5rCSI 3.5%PRS 36.6%
-
CSI 0.5rCSI 2.4%PRS 18.4%
-
CSI 0.5rCSI 0.9%PRS 18.0%
-
CSI 0.5rCSI 1.1%PRS 27.2%
-
CSI 0.5rCSI 1.1%PRS 31.1%
-
CSI 0.5rCSI 1.1%PRS 18.1%
-
CSI 0.5rCSI 1.9%PRS 48.2%
-
CSI 0.5rCSI 0.9%PRS 13.5%
-
CSI 0.5rCSI 0.7%PRS 13.4%
-
CSI 0.5rCSI 1.7%PRS 9.8%
-
CSI 0.5rCSI 1.4%PRS 13.8%
-
CSI 0.5rCSI 0.7%PRS 8.4%
-
CSI 0.6rCSI 0.9%PRS 32.4%
-
CSI 0.6rCSI 11.6%PRS 10.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3234362187
Symbol: C560_HUMAN
Name: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9533030
Title: Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23.
PubMed ID: 9533030
DOI: 10.1159/000134700
PubMed ID: 9714607
Title: Characterization of the human SDHC gene encoding one of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria.
PubMed ID: 9714607
PubMed ID: 9851882
Title: A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene.
PubMed ID: 9851882
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11062460
Title: Mutations in SDHC cause autosomal dominant paraganglioma, type 3.
PubMed ID: 11062460
DOI: 10.1038/81551
PubMed ID: 17804857
Title: Familial gastrointestinal stromal tumors and germ-line mutations.
PubMed ID: 17804857
DOI: 10.1056/nejmc071191
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 37098072
Title: Structure of the human respiratory complex II.
PubMed ID: 37098072
Sequence Information:
- Length: 169
- Mass: 18610
- Checksum: DF7CBD6D0CD49500
- Sequence:
MAALLLRHVG RHCLRAHFSP QLCIRNAVPL GTTAKEEMER FWNKNIGSNR PLSPHITIYS WSLPMAMSIC HRGTGIALSA GVSLFGMSAL LLPGNFESYL ELVKSLCLGP ALIHTAKFAL VFPLMYHTWN GIRHLMWDLG KGLKIPQLYQ SGVVVLVLTV LSSMGLAAM
Genular Protein ID: 3129529695
Symbol: A0A0S2Z4C9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 116
- Mass: 12474
- Checksum: AC702AE33DD1F118
- Sequence:
MAALLLSWSL PMAMSICHRG TGIALSAGVS LFGMSALLLP GNFESYLELV KSLCLGPALI HTAKFALVFP LMYHTWNGIR HLMWDLGKGL KIPQLYQSGV VVLVLTVLSS MGLAAM