SEL1L | ENSG00000071537 | NCBI 6400

Details for: SEL1L

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Asparagine n-linked glycosylation
(R-HSA-446203)
Calnexin/calreticulin cycle
(R-HSA-901042)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Er quality control compartment (erqc)
(R-HSA-901032)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch processing in golgi
(R-HSA-1912420)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
Transport of small molecules
(R-HSA-382551)
Derlin-1 retrotranslocation complex
(GO:0036513)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Erad pathway
(GO:0036503)
Hrd1p ubiquitin ligase complex
(GO:0000836)
Hrd1p ubiquitin ligase erad-l complex
(GO:0000839)
Notch signaling pathway
(GO:0007219)
Protein binding
(GO:0005515)
Protein secretion
(GO:0009306)
Protein stabilization
(GO:0050821)
Retrograde protein transport, er to cytosol
(GO:0030970)
Triglyceride metabolic process
(GO:0006641)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pancreatic acinar cell CL0002064

CSI 19.62

rCSI 26.08%

PRS 30.5
plasma cell CL0000786

CSI 16.76

rCSI 21.97%

PRS 72.66
paneth cell CL0000510

CSI 12.53

rCSI 18.5%

PRS 42.1
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 12.15

rCSI 31.4%

PRS 25.53
transit amplifying cell CL0009010

CSI 10.15

rCSI 15.52%

PRS 43.01
Bergmann glial cell CL0000644

CSI 8.67

rCSI 11.86%

PRS 26.95
enteroendocrine cell CL0000164

CSI 7.43

rCSI 10.15%

PRS 30.41
astrocyte of the cerebral cortex CL0002605

CSI 7.1

rCSI 15.92%

PRS 17.66
intestinal tuft cell CL0019032

CSI 6.75

rCSI 10.31%

PRS 31.51
hepatic stellate cell CL0000632

CSI 6.04

rCSI 22.64%

PRS 23.4
parietal epithelial cell CL1000452

CSI 5.91

rCSI 15.79%

PRS 23.21
cerebral cortex endothelial cell CL1001602

CSI 5.9

rCSI 10.2%

PRS 21.3
lung neuroendocrine cell CL1000223

CSI 5.82

rCSI 8.61%

PRS 31.45
IgG plasma cell CL0000985

CSI 5.7

rCSI 6.83%

PRS 45.4
ionocyte CL0005006

CSI 5.51

rCSI 5.9%

PRS 25.64
mesenchymal cell CL0008019

CSI 5.48

rCSI 13.93%

PRS 26.87
regular ventricular cardiac myocyte CL0002131

CSI 5.02

rCSI 31.34%

PRS 22.34
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 4.89

rCSI 11.15%

PRS 27.93
kidney connecting tubule epithelial cell CL1000768

CSI 4.8

rCSI 12.18%

PRS 21.32
ON-bipolar cell CL0000749

CSI 4.18

rCSI 6.22%

PRS 31.15
lung ciliated cell CL1000271

CSI 3.62

rCSI 4.19%

PRS 20.65
ependymal cell CL0000065

CSI 3.58

rCSI 7.27%

PRS 15.53
goblet cell CL0000160

CSI 3.48

rCSI 3.28%

PRS 28.91
vascular leptomeningeal cell CL4023051

CSI 3.46

rCSI 6.06%

PRS 21.88
effector CD4-positive, alpha-beta T cell CL0001044

CSI 3.37

rCSI 9.67%

PRS 40.91
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.37

rCSI 2.56%

PRS 36.39
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 3.37

rCSI 8.18%

PRS 16.64
Hofbauer cell CL3000001

CSI 3.33

rCSI 6.29%

PRS 35.03
fibroblast of lung CL0002553

CSI 3.26

rCSI 3.03%

PRS 27.72
alternatively activated macrophage CL0000890

CSI 3.23

rCSI 4.07%

PRS 40.31
dendritic cell, human CL0001056

CSI 3.2

rCSI 4.91%

PRS 32.93
plasmablast CL0000980

CSI 3.19

rCSI 2.51%

PRS 33.11
pancreatic D cell CL0000173

CSI 3.19

rCSI 3.13%

PRS 29.67
transit amplifying cell of colon CL0009011

CSI 3.15

rCSI 3.7%

PRS 31.44
unswitched memory B cell CL0000970

CSI 3.14

rCSI 2.65%

PRS 42.34
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.12

rCSI 15.68%

PRS 36.29
myoepithelial cell CL0000185

CSI 2.91

rCSI 7.35%

PRS 33.9
secretory cell CL0000151

CSI 2.82

rCSI 2.94%

PRS 28.44
group 3 innate lymphoid cell CL0001071

CSI 2.75

rCSI 2.06%

PRS 29.63
epithelial cell of lung CL0000082

CSI 2.73

rCSI 2.27%

PRS 26.4
enterocyte CL0000584

CSI 2.73

rCSI 4.4%

PRS 39.08
lung macrophage CL1001603

CSI 2.69

rCSI 6%

PRS 32.37
brush cell of tracheobronchial tree CL0002075

CSI 2.68

rCSI 7.96%

PRS 37.47
IgA plasma cell CL0000987

CSI 2.68

rCSI 2.74%

PRS 46.74
hepatocyte CL0000182

CSI 2.63

rCSI 4.7%

PRS 25.9
renal alpha-intercalated cell CL0005011

CSI 2.61

rCSI 3.49%

PRS 34.78
inhibitory interneuron CL0000498

CSI 2.59

rCSI 5.97%

PRS 22.65
blood vessel smooth muscle cell CL0019018

CSI 2.48

rCSI 20.21%

PRS 25.96
melanocyte CL0000148

CSI 2.47

rCSI 1.83%

PRS 23.82
early lymphoid progenitor CL0000936

CSI 2.47

rCSI 2.17%

PRS 31.59
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.4

rCSI 2.22%

PRS 47.05
mesodermal cell CL0000222

CSI 2.4

rCSI 2.88%

PRS 26.83
L6b glutamatergic cortical neuron CL4023038

CSI 2.38

rCSI 7.44%

PRS 17.88
intestine goblet cell CL0019031

CSI 2.35

rCSI 2.09%

PRS 27.71
ciliated cell CL0000064

CSI 2.28

rCSI 3.7%

PRS 27.53
podocyte CL0000653

CSI 2.28

rCSI 10.13%

PRS 26.79
lung endothelial cell CL1001567

CSI 2.24

rCSI 5.22%

PRS 56.22
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.2

rCSI 1.3%

PRS 38.65
enteric smooth muscle cell CL0002504

CSI 2.2

rCSI 3.14%

PRS 30.52
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.17

rCSI 1.56%

PRS 37.61
indirect pathway medium spiny neuron CL4023029

CSI 2.17

rCSI 52.3%

PRS 16.84
squamous epithelial cell CL0000076

CSI 2.16

rCSI 5.12%

PRS 33.33
interstitial cell of Cajal CL0002088

CSI 2.15

rCSI 2.74%

PRS 31.81
stem cell CL0000034

CSI 2.14

rCSI 2.06%

PRS 20.72
direct pathway medium spiny neuron CL4023026

CSI 2.12

rCSI 50.65%

PRS 16.03
fallopian tube secretory epithelial cell CL4030006

CSI 2.08

rCSI 2%

PRS 28.61
perivascular cell CL4033054

CSI 2.05

rCSI 2.8%

PRS 31.22
hematopoietic multipotent progenitor cell CL0000837

CSI 2.05

rCSI 4.93%

PRS 42.39
Kupffer cell CL0000091

CSI 2.04

rCSI 4.66%

PRS 27.14
mucus secreting cell CL0000319

CSI 2

rCSI 3.18%

PRS 35.47
naive T cell CL0000898

CSI 1.99

rCSI 1.38%

PRS 38.21
pulmonary ionocyte CL0017000

CSI 1.95

rCSI 2.38%

PRS 34.07
inflammatory macrophage CL0000863

CSI 1.92

rCSI 3.28%

PRS 52.49
retinal pigment epithelial cell CL0002586

CSI 1.91

rCSI 3.79%

PRS 28.68
cardiac endothelial cell CL0010008

CSI 1.9

rCSI 7.68%

PRS 26.16
midzonal region hepatocyte CL0019028

CSI 1.89

rCSI 4.44%

PRS 38.11
class switched memory B cell CL0000972

CSI 1.89

rCSI 1.41%

PRS 44.39
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.86

rCSI 3.52%

PRS 52.73
hematopoietic precursor cell CL0008001

CSI 1.86

rCSI 1.91%

PRS 42.78
centrilobular region hepatocyte CL0019029

CSI 1.85

rCSI 4.84%

PRS 39.03
alveolar type 1 fibroblast cell CL4028004

CSI 1.85

rCSI 2.03%

PRS 30.89
rod bipolar cell CL0000751

CSI 1.84

rCSI 3.31%

PRS 23.13
amacrine cell CL0000561

CSI 1.83

rCSI 5.31%

PRS 21.92
pulmonary capillary endothelial cell CL4028001

CSI 1.82

rCSI 3.47%

PRS 42.6
retinal bipolar neuron CL0000748

CSI 1.81

rCSI 3.39%

PRS 20.49
lung secretory cell CL1000272

CSI 1.77

rCSI 4.38%

PRS 25.88
interneuron CL0000099

CSI 1.76

rCSI 3.53%

PRS 20.7
alpha-beta T cell CL0000789

CSI 1.75

rCSI 2.05%

PRS 38.84
pro-B cell CL0000826

CSI 1.73

rCSI 1.43%

PRS 28.12
myeloid leukocyte CL0000766

CSI 1.71

rCSI 1.58%

PRS 28.79
retina horizontal cell CL0000745

CSI 1.66

rCSI 2.52%

PRS 25.57
mature T cell CL0002419

CSI 1.65

rCSI 1.28%

PRS 40.25
neural crest cell CL0011012

CSI 1.64

rCSI 1.3%

PRS 19.21
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.63

rCSI 1.61%

PRS 41.45
respiratory suprabasal cell CL4033048

CSI 1.61

rCSI 2.07%

PRS 31.81
multi-ciliated epithelial cell CL0005012

CSI 1.61

rCSI 1.6%

PRS 23.73
pancreatic A cell CL0000171

CSI 1.59

rCSI 1.67%

PRS 29.44
elicited macrophage CL0000861

CSI 1.59

rCSI 1.46%

PRS 32.95
lung interstitial macrophage CL4033043

CSI 1.58

rCSI 3.55%

PRS 49.12
cerebral cortex neuron CL0010012

CSI 1.57

rCSI 6.38%

PRS 28.13

mesenchymal stem cell CL0000134

CSI 0.1

rCSI 0.7%

PRS 45.7%
medium spiny neuron CL1001474

CSI 0.1

rCSI 1.0%

PRS 17.0%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.8%

PRS 39.5%
erythroid progenitor cell CL0000038

CSI 0.2

rCSI 1.1%

PRS 38.8%
peptic cell CL0000155

CSI 0.2

rCSI 2.0%

PRS 59.4%
tracheal goblet cell CL1000329

CSI 0.3

rCSI 0.6%

PRS 48.9%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.3

rCSI 1.7%

PRS 54.6%
type B pancreatic cell CL0000169

CSI 0.3

rCSI 0.7%

PRS 25.6%
megakaryocyte CL0000556

CSI 0.3

rCSI 1.4%

PRS 44.2%
luminal cell of prostate epithelium CL0002340

CSI 0.3

rCSI 1.8%

PRS 44.3%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.4

rCSI 2.1%

PRS 17.9%
acinar cell CL0000622

CSI 0.4

rCSI 0.6%

PRS 36.0%
mesangial cell CL0000650

CSI 0.4

rCSI 1.7%

PRS 38.7%
transit amplifying cell of small intestine CL0009012

CSI 0.5

rCSI 2.0%

PRS 47.2%
pancreatic epsilon cell CL0005019

CSI 0.5

rCSI 2.2%

PRS 53.6%
antibody secreting cell CL0000946

CSI 0.5

rCSI 2.2%

PRS 75.6%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.5

rCSI 1.7%

PRS 19.7%
endothelial cell of placenta CL0009092

CSI 0.5

rCSI 2.7%

PRS 36.9%
central nervous system neuron CL2000029

CSI 0.6

rCSI 4.0%

PRS 18.2%
microcirculation associated smooth muscle cell CL0008035

CSI 0.6

rCSI 1.7%

PRS 30.7%
epicardial adipocyte CL1000309

CSI 0.6

rCSI 2.0%

PRS 32.1%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.6

rCSI 1.5%

PRS 19.8%
glial cell CL0000125

CSI 0.6

rCSI 2.4%

PRS 25.5%
cardiac muscle cell CL0000746

CSI 0.7

rCSI 1.0%

PRS 21.8%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.7

rCSI 2.5%

PRS 16.2%
pancreatic PP cell CL0002275

CSI 0.7

rCSI 2.8%

PRS 44.0%
enterocyte of epithelium of large intestine CL0002071

CSI 0.7

rCSI 3.8%

PRS 43.8%
pancreatic ductal cell CL0002079

CSI 0.7

rCSI 1.4%

PRS 28.6%
GABAergic neuron CL0000617

CSI 0.7

rCSI 2.5%

PRS 20.3%
renal interstitial pericyte CL1001318

CSI 0.7

rCSI 2.1%

PRS 26.0%
endocardial cell CL0002350

CSI 0.8

rCSI 3.6%

PRS 32.2%
intermediate monocyte CL0002393

CSI 0.8

rCSI 1.1%

PRS 28.4%
extravillous trophoblast CL0008036

CSI 0.8

rCSI 1.0%

PRS 24.5%
sst GABAergic cortical interneuron CL4023017

CSI 0.8

rCSI 1.0%

PRS 17.7%
glandular epithelial cell CL0000150

CSI 0.8

rCSI 2.1%

PRS 49.8%
epithelial cell of proximal tubule CL0002306

CSI 0.8

rCSI 2.0%

PRS 26.5%
respiratory basal cell CL0002633

CSI 0.8

rCSI 0.9%

PRS 32.5%
glycinergic amacrine cell CL4030028

CSI 0.9

rCSI 2.2%

PRS 27.8%
alveolar adventitial fibroblast CL4028006

CSI 0.9

rCSI 1.4%

PRS 28.0%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.9

rCSI 2.7%

PRS 39.5%
cardiac neuron CL0010022

CSI 0.9

rCSI 2.8%

PRS 24.2%
M cell of gut CL0000682

CSI 0.9

rCSI 1.0%

PRS 43.9%
conjunctival epithelial cell CL1000432

CSI 0.9

rCSI 1.4%

PRS 28.0%
glutamatergic neuron CL0000679

CSI 0.9

rCSI 1.8%

PRS 26.2%
BEST4+ enteroycte CL4030026

CSI 0.9

rCSI 1.1%

PRS 29.7%
small intestine goblet cell CL1000495

CSI 0.9

rCSI 2.0%

PRS 36.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.9

rCSI 1.6%

PRS 16.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.9

rCSI 3.5%

PRS 17.8%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.0

rCSI 1.3%

PRS 38.7%
intestinal epithelial cell CL0002563

CSI 1.0

rCSI 1.0%

PRS 28.4%
choroid plexus epithelial cell CL0000706

CSI 1.0

rCSI 1.6%

PRS 21.6%
stromal cell CL0000499

CSI 1.0

rCSI 2.8%

PRS 32.9%
retinal ganglion cell CL0000740

CSI 1.0

rCSI 2.2%

PRS 20.0%
CD4-positive helper T cell CL0000492

CSI 1.0

rCSI 0.8%

PRS 37.4%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.5%

PRS 29.5%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.0

rCSI 1.3%

PRS 16.0%
common dendritic progenitor CL0001029

CSI 1.0

rCSI 1.3%

PRS 35.5%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.0

rCSI 1.2%

PRS 33.2%
luminal epithelial cell of mammary gland CL0002326

CSI 1.1

rCSI 1.9%

PRS 41.4%
common myeloid progenitor CL0000049

CSI 1.1

rCSI 0.9%

PRS 27.9%
mononuclear phagocyte CL0000113

CSI 1.1

rCSI 2.4%

PRS 31.3%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.1

rCSI 0.7%

PRS 34.4%
Schwann cell CL0002573

CSI 1.1

rCSI 3.2%

PRS 29.8%
vascular associated smooth muscle cell CL0000359

CSI 1.1

rCSI 3.7%

PRS 32.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.1

rCSI 1.9%

PRS 17.1%
Langerhans cell CL0000453

CSI 1.2

rCSI 1.8%

PRS 45.5%
pancreatic stellate cell CL0002410

CSI 1.2

rCSI 6.7%

PRS 39.1%
VIP GABAergic cortical interneuron CL4023016

CSI 1.2

rCSI 1.4%

PRS 16.9%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.2

rCSI 3.6%

PRS 19.5%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.2

rCSI 3.0%

PRS 26.4%
cerebellar granule cell CL0001031

CSI 1.2

rCSI 1.8%

PRS 25.7%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.2

rCSI 2.2%

PRS 23.9%
alveolar macrophage CL0000583

CSI 1.2

rCSI 2.0%

PRS 32.3%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.2

rCSI 1.3%

PRS 38.7%
nasal mucosa goblet cell CL0002480

CSI 1.3

rCSI 1.5%

PRS 38.6%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.3

rCSI 1.1%

PRS 25.3%
periportal region hepatocyte CL0019026

CSI 1.3

rCSI 5.0%

PRS 37.0%
colon epithelial cell CL0011108

CSI 1.3

rCSI 1.4%

PRS 25.9%
placental villous trophoblast CL2000060

CSI 1.3

rCSI 2.0%

PRS 26.1%
sncg GABAergic cortical interneuron CL4023015

CSI 1.3

rCSI 2.1%

PRS 18.5%
retinal blood vessel endothelial cell CL0002585

CSI 1.3

rCSI 2.1%

PRS 30.3%
glioblast CL0000030

CSI 1.3

rCSI 2.1%

PRS 23.7%
renal beta-intercalated cell CL0002201

CSI 1.3

rCSI 3.1%

PRS 30.7%
foveolar cell of stomach CL0002179

CSI 1.3

rCSI 2.9%

PRS 41.8%
intrahepatic cholangiocyte CL0002538

CSI 1.3

rCSI 3.2%

PRS 45.3%
bronchus fibroblast of lung CL2000093

CSI 1.3

rCSI 1.1%

PRS 28.8%
lung pericyte CL0009089

CSI 1.3

rCSI 3.6%

PRS 33.0%
chondrocyte CL0000138

CSI 1.3

rCSI 2.1%

PRS 23.4%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.4

rCSI 1.0%

PRS 26.1%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.4

rCSI 1.7%

PRS 26.4%
blood vessel endothelial cell CL0000071

CSI 1.4

rCSI 2.8%

PRS 27.3%
retinal cone cell CL0000573

CSI 1.4

rCSI 2.2%

PRS 21.4%
Mueller cell CL0000636

CSI 1.4

rCSI 3.2%

PRS 23.8%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.4

rCSI 2.0%

PRS 25.8%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.4

rCSI 1.7%

PRS 45.9%
ciliated epithelial cell CL0000067

CSI 1.5

rCSI 1.3%

PRS 20.4%
epithelial cell of lower respiratory tract CL0002632

CSI 1.5

rCSI 1.1%

PRS 27.1%
granulocyte CL0000094

CSI 1.5

rCSI 2.3%

PRS 35.3%
paneth cell of epithelium of small intestine CL1000343

CSI 1.5

rCSI 4.2%

PRS 41.6%
plasmacytoid dendritic cell, human CL0001058

CSI 1.5

rCSI 1.1%

PRS 29.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

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Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SEL1L](/details-gene/6400) (SEL1L adaptor subunit of SYVN1 ubiquitin ligase) is a protein-coding gene located on chromosome 14q31.1. It encodes a critical adaptor protein that is an integral component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Functioning as part of the HRD1-SEL1L ubiquitin ligase complex, [SEL1L](/details-gene/6400) is essential for recognizing and targeting misfolded or unassembled proteins within the ER lumen for ubiquitination and subsequent degradation by the proteasome. Reflecting its central role in protein quality control, the gene shows exceptionally high expression in cells with a high secretory load, such as [pancreatic acinar cells](/details-cell/CL0002064) and [plasma cells](/details-cell/CL0000786). Its dysfunction is associated with human disease, as indicated by its OMIM entry ([602329](https://omim.org/entry/602329)). ## Cellular Roles and Expression Landscape The expression profile of [SEL1L](/details-gene/6400) underscores its fundamental role in managing protein synthesis and secretion. **Overall**, the gene is most significant in cell types characterized by high rates of protein production and secretion. Its highest significance is observed in [pancreatic acinar cells](/details-cell/CL0002064) (CSI: 19.62), which synthesize and secrete large quantities of digestive enzymes, and [plasma cells](/details-cell/CL0000786) (CSI: 16.76), which are professional antibody-secreting cells. This pattern extends to other specialized secretory cells, including [Paneth cells](/details-cell/CL0000510) of the intestine, which produce antimicrobial peptides, and [enteroendocrine cells](/details-cell/CL0000164), which secrete hormones. The high expression in these cell types is consistent with a critical requirement for a robust ERAD system to handle the high flux of proteins through the secretory pathway and maintain cellular homeostasis. The gene's significance is also noted in various other metabolically active cell types, such as [Bergmann glial cells](/details-cell/CL0000644) and [astrocytes of the cerebral cortex](/details-cell/CL0002605), suggesting a vital housekeeping function in protein quality control across diverse tissues. ## Pathways and Molecular Function Functionally, [SEL1L](/details-gene/6400) is deeply integrated into the machinery of protein metabolism within the endoplasmic reticulum. Gene Ontology annotations highlight its involvement in the [Erad pathway](/details-go/GO:0036503), [retrograde protein transport, er to cytosol](/details-go/GO:0030970), and [protein stabilization](/details-go/GO:0050821). As a key component of the [Hrd1p ubiquitin ligase complex](/details-go/GO:0000836), it acts as a luminal sensor that recognizes and delivers misfolded glycoprotein substrates to the core ubiquitination machinery ([Link](https://doi.org/10.1016/j.molcel.2009.05.018); [Link](https://doi.org/10.1038/ncb1689)). Reactome pathway analysis further details its role within the broader context of [Metabolism of proteins](/details-pathway/R-HSA-392499), particularly in processes like the [Calnexin/calreticulin cycle](/details-pathway/R-HSA-901042) and [Asparagine n-linked glycosylation](/details-pathway/R-HSA-446203), which are upstream steps in protein quality control. Its participation in the [Signaling by notch](/details-pathway/R-HSA-157118) and [Signaling by hedgehog](/details-pathway/R-HSA-5358351) pathways suggests that by ensuring the proper folding and processing of key receptors and ligands, [SEL1L](/details-gene/6400) indirectly influences critical developmental and signaling cascades. Furthermore, its role in lipid metabolism has been demonstrated, with studies showing it regulates lipoprotein lipase (LPL) secretion ([Link](https://doi.org/10.1016/j.cmet.2014.06.015)). ## Research Directions The high and specific expression of [SEL1L](/details-gene/6400) in cells under high proteotoxic stress presents several avenues for future research, particularly concerning diseases characterized by protein misfolding. **Proposed Hypotheses:** 1. Given its peak expression in [plasma cells](/details-cell/CL0000786) and the dependence of multiple myeloma on managing massive immunoglobulin production, it is hypothesized that [SEL1L](/details-gene/6400) is a critical survival factor for malignant plasma cells. Its inhibition may selectively induce lethal ER stress in these cancer cells. 2. Based on its premier expression in [pancreatic acinar cells](/details-cell/CL0002064) and the established role of ER stress in pancreatitis, we hypothesize that genetic or functional defects in [SEL1L](/details-gene/6400) could be a predisposing factor for pancreatitis by impairing the clearance of misfolded digestive zymogens. **Experimental Approach:** To test the first hypothesis regarding the role of [SEL1L](/details-gene/6400) in multiple myeloma, one could employ a multi-pronged approach. First, shRNA or CRISPR-Cas9 could be used to knock down or knock out [SEL1L](/details-gene/6400) expression in a panel of human multiple myeloma cell lines. The consequences could be assessed by measuring key indicators of ER stress (e.g., XBP1 splicing, CHOP and BiP protein levels), cell proliferation, and apoptosis rates. In parallel, a conditional knockout mouse model, deleting *Sel1l* in malignant plasma cells (e.g., using a Vk*MYC model), would allow for in vivo validation of its role in tumor progression and survival. **Therapeutic Potential:** As an intracellular adaptor protein, [SEL1L](/details-gene/6400) represents a challenging but potentially valuable therapeutic target. The therapeutic strategy would focus on **inhibition**. For cancers like multiple myeloma that are addicted to a high-functioning ERAD pathway, small molecule inhibitors that disrupt the SEL1L-HRD1 interaction could prove effective. Such a drug would likely create a synthetic lethal phenotype by pushing cancer cells beyond their capacity to cope with proteotoxic stress, leading to apoptosis, while having a lesser effect on normal cells with lower protein synthesis loads.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein sel-1 homolog 1
Q3ZCU6_HUMAN

Genular Protein ID: 2127860278

Symbol: SE1L1_HUMAN

Name: Protein sel-1 homolog 1

UniProtKB Accession Codes:

Q9UBV2 Q6UWT6 Q9P1T9 Q9UHK7

Database IDs:

Citations:

PubMed ID: 10496078

Title: Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1.

PubMed ID: 10496078

DOI: 10.1007/s100380050171

PubMed ID: 10746565

Title: SEL1L, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers.

PubMed ID: 10746565

DOI: 10.1007/s004390051032

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16186509

Title: Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.

PubMed ID: 16186509

DOI: 10.1073/pnas.0505014102

PubMed ID: 18502753

Title: Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.

PubMed ID: 18502753

DOI: 10.1074/jbc.m709336200

PubMed ID: 18264092

Title: OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD.

PubMed ID: 18264092

DOI: 10.1038/ncb1689

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19524542

Title: EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex.

PubMed ID: 19524542

DOI: 10.1016/j.molcel.2009.05.018

PubMed ID: 19706418

Title: A luminal flavoprotein in endoplasmic reticulum-associated degradation.

PubMed ID: 19706418

DOI: 10.1073/pnas.0900742106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25066055

Title: The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism.

PubMed ID: 25066055

DOI: 10.1016/j.cmet.2014.06.015

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26471130

Title: Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L.

PubMed ID: 26471130

DOI: 10.1111/febs.13564

PubMed ID: 28827405

Title: Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD).

PubMed ID: 28827405

DOI: 10.1242/jcs.206847

PubMed ID: 29997207

Title: Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO.

PubMed ID: 29997207

DOI: 10.1128/jvi.00688-18

Sequence Information:

Length: 794
Mass: 88755
Checksum: 323EB03DC7485459
Sequence:

MRVRIGLTLL LCAVLLSLAS ASSDEEGSQD ESLDSKTTLT SDESVKDHTT AGRVVAGQIF 
LDSEESELES SIQEEEDSLK SQEGESVTED ISFLESPNPE NKDYEEPKKV RKPALTAIEG 
TAHGEPCHFP FLFLDKEYDE CTSDGREDGR LWCATTYDYK ADEKWGFCET EEEAAKRRQM 
QEAEMMYQTG MKILNGSNKK SQKREAYRYL QKAASMNHTK ALERVSYALL FGDYLPQNIQ 
AAREMFEKLT EEGSPKGQTA LGFLYASGLG VNSSQAKALV YYTFGALGGN LIAHMVLGYR 
YWAGIGVLQS CESALTHYRL VANHVASDIS LTGGSVVQRI RLPDEVENPG MNSGMLEEDL 
IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV EQNHQRAFDY FNLAANAGNS HAMAFLGKMY 
SEGSDIVPQS NETALHYFKK AADMGNPVGQ SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ 
GWVDGQLQLG SMYYNGIGVK RDYKQALKYF NLASQGGHIL AFYNLAQMHA SGTGVMRSCH 
TAVELFKNVC ERGRWSERLM TAYNSYKDGD YNAAVIQYLL LAEQGYEVAQ SNAAFILDQR 
EASIVGENET YPRALLHWNR AASQGYTVAR IKLGDYHFYG FGTDVDYETA FIHYRLASEQ 
QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF YDMAAEASPD AQVPVFLALC KLGVVYFLQY 
IRETNIRDMF TQLDMDQLLG PEWDLYLMTI IALLLGTVIA YRQRQHQDMP APRPPGPRPA 
PPQQEGPPEQ QPPQ

Genular Protein ID: 735409917

Symbol: Q3ZCU6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3ZCU6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 195
Mass: 22239
Checksum: 5E61FC72BAEA5471
Sequence:

SEASIVGENE TYPRALLHWN RAASQGYTVA RIKLGDYHFY GFGTDVDYET AFIHYRLASE 
QQHSAQAMFN LGYMHEKGLG IKQDIHLAKR FYDMAAEASP DAQVPVFLAL CKLGVVYFLQ 
YIRETNIRDM FTQLDMDQLL GPEWDLYLMT IIALLLGTVI AYRQRQHQDM PAPRPPGPRP 
APPQQEGPPE QQPPQ

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: SEL1L

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1. PubMed ID: 10496078

SEL1L, the human homolog of C. elegans sel-1: refined physical mapping, gene structure and identification of polymorphic markers. PubMed ID: 10746565

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. PubMed ID: 16186509

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. PubMed ID: 18502753

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. PubMed ID: 18264092

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. PubMed ID: 19524542

A luminal flavoprotein in endoplasmic reticulum-associated degradation. PubMed ID: 19706418

Initial characterization of the human central proteome. PubMed ID: 21269460

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. PubMed ID: 25066055

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L. PubMed ID: 26471130

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). PubMed ID: 28827405

Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO. PubMed ID: 29997207

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334