Details for: SELL

Gene ID: 6402

Symbol: SELL

Ensembl ID: ENSG00000188404

Description: selectin L

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.6751
    Cell Significance Index: -8.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.7225
    Cell Significance Index: -13.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.8002
    Cell Significance Index: -14.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.9412
    Cell Significance Index: -14.2700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 10.7195
    Cell Significance Index: 68.4300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 7.7523
    Cell Significance Index: 51.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.8453
    Cell Significance Index: -8.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.2362
    Cell Significance Index: 65.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.0233
    Cell Significance Index: 118.1600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.9800
    Cell Significance Index: 12.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3177
    Cell Significance Index: 61.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4734
    Cell Significance Index: -9.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4353
    Cell Significance Index: -7.4800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.3949
    Cell Significance Index: 10.7100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.3078
    Cell Significance Index: 23.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.3294
    Cell Significance Index: 35.5600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.0616
    Cell Significance Index: 9.2900
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.5318
    Cell Significance Index: 2.6600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3796
    Cell Significance Index: 2.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3617
    Cell Significance Index: 42.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.3156
    Cell Significance Index: 5.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1136
    Cell Significance Index: 1.2900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.0874
    Cell Significance Index: 0.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0741
    Cell Significance Index: 4.7800
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0500
    Cell Significance Index: 0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0008
    Cell Significance Index: 0.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.1400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0079
    Cell Significance Index: -12.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -8.9800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0123
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0136
    Cell Significance Index: -10.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0154
    Cell Significance Index: -2.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0157
    Cell Significance Index: -8.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0171
    Cell Significance Index: -10.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0178
    Cell Significance Index: -10.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0192
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0210
    Cell Significance Index: -15.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0219
    Cell Significance Index: -4.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0248
    Cell Significance Index: -8.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0290
    Cell Significance Index: -13.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0302
    Cell Significance Index: -5.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0346
    Cell Significance Index: -1.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0349
    Cell Significance Index: -10.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0540
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0593
    Cell Significance Index: -10.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0599
    Cell Significance Index: -1.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0623
    Cell Significance Index: -7.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0629
    Cell Significance Index: -7.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0634
    Cell Significance Index: -6.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0642
    Cell Significance Index: -8.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0789
    Cell Significance Index: -9.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0848
    Cell Significance Index: -8.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0880
    Cell Significance Index: -11.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0903
    Cell Significance Index: -13.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0943
    Cell Significance Index: -10.8000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1071
    Cell Significance Index: -0.7700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1092
    Cell Significance Index: -4.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1275
    Cell Significance Index: -9.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1384
    Cell Significance Index: -1.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1411
    Cell Significance Index: -7.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1463
    Cell Significance Index: -2.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1475
    Cell Significance Index: -10.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1490
    Cell Significance Index: -2.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1571
    Cell Significance Index: -7.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1573
    Cell Significance Index: -10.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1578
    Cell Significance Index: -8.2200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1610
    Cell Significance Index: -2.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1637
    Cell Significance Index: -10.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1698
    Cell Significance Index: -7.5100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1773
    Cell Significance Index: -1.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1794
    Cell Significance Index: -11.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1850
    Cell Significance Index: -11.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1859
    Cell Significance Index: -10.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1915
    Cell Significance Index: -7.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1941
    Cell Significance Index: -15.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2011
    Cell Significance Index: -5.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2030
    Cell Significance Index: -7.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2089
    Cell Significance Index: -10.9700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.2103
    Cell Significance Index: -1.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2319
    Cell Significance Index: -10.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2354
    Cell Significance Index: -6.5800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2416
    Cell Significance Index: -2.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2473
    Cell Significance Index: -11.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2502
    Cell Significance Index: -8.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2572
    Cell Significance Index: -8.1900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2585
    Cell Significance Index: -1.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2599
    Cell Significance Index: -9.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2880
    Cell Significance Index: -10.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2927
    Cell Significance Index: -2.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2969
    Cell Significance Index: -9.3900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3017
    Cell Significance Index: -3.2100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3175
    Cell Significance Index: -3.4800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3272
    Cell Significance Index: -3.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3359
    Cell Significance Index: -4.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3416
    Cell Significance Index: -8.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell surface expression**: L-selectin is expressed on the surface of various immune cells, including mature alpha-beta T cells, pro-T cells, CD14-positive and CD16-negative classical monocytes, and immature natural killer cells. 2. **Leukocyte cell-cell adhesion**: L-selectin mediates the binding of leukocytes to endothelial cells and other leukocytes, enabling their recruitment to sites of inflammation. 3. **Homophilic and heterophilic binding**: L-selectin exhibits both homophilic (binding to itself) and heterophilic (binding to other selectins) binding properties, allowing for the interaction with other selectins and other adhesion molecules. 4. **Carbohydrate binding**: L-selectin recognizes and binds to specific carbohydrate ligands, such as sialyl Lewis X, which are expressed on the surface of endothelial cells and other leukocytes. **Pathways and Functions** 1. **Adaptive immune response**: L-selectin plays a crucial role in the recruitment of T cells and monocytes to lymphoid organs, facilitating their activation and proliferation in response to antigen presentation. 2. **Innate immune response**: L-selectin is involved in the recruitment of neutrophils and other leukocytes to sites of inflammation, contributing to the innate immune response. 3. **Leukocyte migration**: L-selectin mediates the rolling and adhesion of leukocytes to endothelial cells, allowing them to migrate through the blood vessel wall and into tissues. 4. **Immunoregulation**: L-selectin may also play a role in the regulation of immune responses by modulating the interaction between leukocytes and endothelial cells, influencing the intensity and duration of the immune response. **Clinical Significance** 1. **Inflammatory diseases**: Alterations in L-selectin expression or function have been implicated in various inflammatory diseases, including rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease. 2. **Cancer**: L-selectin has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it may contribute to tumor progression and metastasis. 3. **Transplantation**: L-selectin has been targeted as a potential therapeutic strategy for modulating the immune response in organ transplantation, where it may be used to prevent graft rejection. 4. **Autoimmune diseases**: L-selectin may also play a role in the pathogenesis of autoimmune diseases, such as multiple sclerosis and lupus, where it may contribute to the dysregulation of immune responses. In conclusion, the SELL gene and its product, L-selectin, play a critical role in the immune system, mediating leukocyte cell-cell adhesion and migration, and influencing the intensity and duration of the immune response. Alterations in L-selectin expression or function have been implicated in various inflammatory and autoimmune diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 929911993

Symbol: LYAM1_HUMAN

Name: L-selectin

UniProtKB Accession Codes:

P14151 A0A024R8Z0 B2R6Q8 P15023 Q9UJ43

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2664786

Title: Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains.

PubMed ID: 2664786

DOI: 10.1073/pnas.86.14.5562

PubMed ID: 2473156

Title: Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.

PubMed ID: 2473156

DOI: 10.1084/jem.170.1.123

PubMed ID: 2509939

Title: Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.

PubMed ID: 2509939

DOI: 10.1038/342078a0

PubMed ID: 2663882

Title: Characterization of a human homologue of the murine peripheral lymph node homing receptor.

PubMed ID: 2663882

DOI: 10.1083/jcb.109.1.421

PubMed ID: 1692315

Title: Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.

PubMed ID: 1692315

DOI: 10.1016/s0021-9258(19)38994-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 12403782

Title: Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.

PubMed ID: 12403782

DOI: 10.1074/jbc.m204360200

PubMed ID: 12736247

Title: Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.

PubMed ID: 12736247

DOI: 10.1074/jbc.m303551200

PubMed ID: 18606703

Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.

PubMed ID: 18606703

DOI: 10.4049/jimmunol.181.2.1480

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 7488174

Title: A template for generation and comparison of three-dimensional selectin models.

PubMed ID: 7488174

DOI: 10.1006/bbrc.1995.2722

PubMed ID: 28489325

Title: Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 A Resolution.

PubMed ID: 28489325

DOI: 10.1002/cbic.201700220

PubMed ID: 28011641

Title: Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

PubMed ID: 28011641

DOI: 10.1074/jbc.m116.767186

Sequence Information:

  • Length: 372
  • Mass: 42187
  • Checksum: 6EA9918ECA2D3643
  • Sequence:
    • MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW QRARRFCRDN 
YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN 
NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC 
NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT 
CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK 
TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK 
GKKSKRSMND PY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.