Details for: SELL
Gene ID: 6402
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SELL
Ensembl ID: ENSG00000188404
Description: selectin L
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 103.87rCSI 77.89%PRS 20.45
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CSI 78.16rCSI 51.95%PRS 8.23
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CSI 65.99rCSI 46.35%PRS 19.79
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CSI 56.25rCSI 39.27%PRS 7.29
-
CSI 49rCSI 36.58%PRS 11.72
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CSI 40.78rCSI 34.98%PRS 15.63
-
CSI 39.52rCSI 49.66%PRS 34.73
-
CSI 37.51rCSI 32.61%PRS 8.53
-
CSI 34.19rCSI 58.57%PRS 9.28
-
CSI 30.08rCSI 17.77%PRS 9.6
-
CSI 23.79rCSI 24.1%PRS 41.67
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CSI 21.52rCSI 14.96%PRS 8.1
-
CSI 21.22rCSI 26.63%PRS 8.81
-
CSI 15.25rCSI 11.46%PRS 7.12
-
CSI 15.22rCSI 11.51%PRS 9.63
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CSI 15.13rCSI 55.01%PRS 31.5
-
CSI 11.08rCSI 67.03%PRS 16.11
-
CSI 10.7rCSI 8.5%PRS 12.23
-
CSI 9.97rCSI 11.56%PRS 22.85
-
CSI 9.8rCSI 9.68%PRS 29.19
-
CSI 8.94rCSI 7.85%PRS 7.77
-
CSI 8.66rCSI 12.84%PRS 58.28
-
CSI 8.56rCSI 5.71%PRS 19.18
-
CSI 8.12rCSI 11.06%PRS 17.22
-
CSI 7.92rCSI 8.15%PRS 11.24
-
CSI 7.8rCSI 6.25%PRS 12.71
-
CSI 6.98rCSI 14.42%PRS 10.98
-
CSI 6.78rCSI 7.96%PRS 53.96
-
CSI 6.77rCSI 24.05%PRS 22.42
-
CSI 6.63rCSI 6.13%PRS 12.67
-
CSI 6.09rCSI 4.1%PRS 8.36
-
CSI 5.92rCSI 19.38%PRS 20.82
-
CSI 5.72rCSI 4.11%PRS 9.41
-
CSI 5.52rCSI 5.76%PRS 21.83
-
CSI 5.18rCSI 6.38%PRS 23.27
-
CSI 5.04rCSI 4.24%PRS 11.53
-
CSI 4.77rCSI 6.38%PRS 13.25
-
CSI 4.43rCSI 5.93%PRS 35.58
-
CSI 4.27rCSI 5.31%PRS 10.03
-
CSI 4.14rCSI 16.13%PRS 11.47
-
CSI 3.93rCSI 9.45%PRS 11.01
-
CSI 3.81rCSI 19.68%PRS 13.9
-
CSI 3.77rCSI 71.72%PRS 49.01
-
CSI 3.61rCSI 4.32%PRS 12.07
-
CSI 3.43rCSI 2.55%PRS 10.38
-
CSI 3.23rCSI 4.14%PRS 31.1
-
CSI 3.21rCSI 3.15%PRS 11.02
-
CSI 3.08rCSI 5.57%PRS 19.59
-
CSI 2.95rCSI 2.46%PRS 21.98
-
CSI 2.86rCSI 2.14%PRS 11.31
-
CSI 2.84rCSI 2.16%PRS 9.17
-
CSI 2.74rCSI 1.91%PRS 10
-
CSI 2.61rCSI 2.05%PRS 8.24
-
CSI 2.44rCSI 2.5%PRS 13.13
-
CSI 2.27rCSI 3.87%PRS 14.32
-
CSI 2.14rCSI 1.77%PRS 6.94
-
CSI 2.09rCSI 4.75%PRS 9.9
-
CSI 2.01rCSI 4.84%PRS 44.18
-
CSI 1.96rCSI 1.93%PRS 20.5
-
CSI 1.96rCSI 2.84%PRS 10.19
-
CSI 1.94rCSI 8.4%PRS 12.8
-
CSI 1.93rCSI 10.78%PRS 18.98
-
CSI 1.83rCSI 4.02%PRS 7.59
-
CSI 1.56rCSI 1.42%PRS 10.8
-
CSI 1.45rCSI 2.1%PRS 9.66
-
CSI 1.33rCSI 2.05%PRS 8.06
-
CSI 1.29rCSI 1.19%PRS 7.02
-
CSI 1.27rCSI 4.38%PRS 29.83
-
CSI 1.19rCSI 2.04%PRS 14.88
-
CSI 0.97rCSI 1.94%PRS 11.83
-
CSI 0.93rCSI 1.31%PRS 10.02
-
CSI 0.92rCSI 0.83%PRS 6.11
-
CSI 0.92rCSI 1.94%PRS 14.91
-
CSI 0.88rCSI 0.71%PRS 6.8
-
CSI 0.87rCSI 1.31%PRS 6.82
-
CSI 0.84rCSI 0.73%PRS 7.7
-
CSI 0.71rCSI 0.86%PRS 10
-
CSI 0.68rCSI 0.93%PRS 14.71
-
CSI 0.67rCSI 3.77%PRS 22.57
-
CSI 0.6rCSI 2.18%PRS 11.97
-
CSI 0.58rCSI 12.23%PRS 41.01
-
CSI 0.52rCSI 13.53%PRS 37.9
-
CSI 0.52rCSI 1.56%PRS 18.19
-
CSI 0.51rCSI 0.78%PRS 8.7
-
CSI 0.51rCSI 2.54%PRS 9.08
-
CSI 0.5rCSI 2.71%PRS 24.38
-
CSI 0.48rCSI 2.77%PRS 10.5
-
CSI 0.47rCSI 2.12%PRS 36.12
-
CSI 0.38rCSI 2.51%PRS 18.37
-
CSI 0.33rCSI 1.48%PRS 25.79
-
CSI 0.31rCSI 0.36%PRS 14.36
-
CSI 0.13rCSI 0.73%PRS 10.86
-
CSI 0.12rCSI 0.34%PRS 12.33
-
CSI -0.04rCSI -0.03%PRS 6.25
-
CSI -0.18rCSI -0.14%PRS 9.92
-
CSI -0.82rCSI -0.96%PRS 10.38
-
CSI -1.09rCSI -1.69%PRS 17.67
-
CSI -3.65rCSI -4.41%PRS 8.14
-
CSI -5.49rCSI -4.81%PRS 9.3
-
CSI -8.55rCSI -35.47%PRS 18.18
-
CSI -9.9rCSI -15.8%PRS 22.8%
-
CSI -8.9rCSI -11.7%PRS 9.7%
-
CSI -8.8rCSI -10.5%PRS 12.1%
-
CSI -8.6rCSI -35.5%PRS 18.2%
-
CSI -5.5rCSI -4.8%PRS 9.3%
-
CSI -3.7rCSI -4.4%PRS 8.1%
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CSI -1.1rCSI -1.7%PRS 17.7%
-
CSI -0.8rCSI -1.0%PRS 10.4%
-
CSI -0.2rCSI -0.1%PRS 9.9%
-
CSI 0.0rCSI 0.0%PRS 6.3%
-
CSI 0.1rCSI 0.3%PRS 12.3%
-
CSI 0.1rCSI 0.7%PRS 10.9%
-
CSI 0.3rCSI 0.4%PRS 14.4%
-
CSI 0.3rCSI 1.5%PRS 25.8%
-
CSI 0.4rCSI 2.5%PRS 18.4%
-
CSI 0.5rCSI 2.1%PRS 36.1%
-
CSI 0.5rCSI 2.8%PRS 10.5%
-
CSI 0.5rCSI 2.7%PRS 24.4%
-
CSI 0.5rCSI 2.5%PRS 9.1%
-
CSI 0.5rCSI 0.8%PRS 8.7%
-
CSI 0.5rCSI 1.6%PRS 18.2%
-
CSI 0.5rCSI 13.5%PRS 37.9%
-
CSI 0.6rCSI 12.2%PRS 41.0%
-
CSI 0.6rCSI 2.2%PRS 12.0%
-
CSI 0.7rCSI 3.8%PRS 22.6%
-
CSI 0.7rCSI 0.9%PRS 14.7%
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CSI 0.7rCSI 0.9%PRS 10.0%
-
CSI 0.8rCSI 0.7%PRS 7.7%
-
CSI 0.9rCSI 1.3%PRS 6.8%
-
CSI 0.9rCSI 0.7%PRS 6.8%
-
CSI 0.9rCSI 1.9%PRS 14.9%
-
CSI 0.9rCSI 0.8%PRS 6.1%
-
CSI 0.9rCSI 1.3%PRS 10.0%
-
CSI 1.0rCSI 1.9%PRS 11.8%
-
CSI 1.2rCSI 2.0%PRS 14.9%
-
CSI 1.3rCSI 4.4%PRS 29.8%
-
CSI 1.3rCSI 1.2%PRS 7.0%
-
CSI 1.3rCSI 2.1%PRS 8.1%
-
CSI 1.5rCSI 2.1%PRS 9.7%
-
CSI 1.6rCSI 1.4%PRS 10.8%
-
CSI 1.8rCSI 4.0%PRS 7.6%
-
CSI 1.9rCSI 10.8%PRS 19.0%
-
CSI 1.9rCSI 8.4%PRS 12.8%
-
CSI 2.0rCSI 2.8%PRS 10.2%
-
CSI 2.0rCSI 1.9%PRS 20.5%
-
CSI 2.0rCSI 4.8%PRS 44.2%
-
CSI 2.1rCSI 4.8%PRS 9.9%
-
CSI 2.1rCSI 1.8%PRS 6.9%
-
CSI 2.3rCSI 3.9%PRS 14.3%
-
CSI 2.4rCSI 2.5%PRS 13.1%
-
CSI 2.6rCSI 2.1%PRS 8.2%
-
CSI 2.7rCSI 1.9%PRS 10.0%
-
CSI 2.8rCSI 2.2%PRS 9.2%
-
CSI 2.9rCSI 2.1%PRS 11.3%
-
CSI 3.0rCSI 2.5%PRS 22.0%
-
CSI 3.1rCSI 5.6%PRS 19.6%
-
CSI 3.2rCSI 3.2%PRS 11.0%
-
CSI 3.2rCSI 4.1%PRS 31.1%
-
CSI 3.4rCSI 2.6%PRS 10.4%
-
CSI 3.6rCSI 4.3%PRS 12.1%
-
CSI 3.8rCSI 71.7%PRS 49.0%
-
CSI 3.8rCSI 19.7%PRS 13.9%
-
CSI 3.9rCSI 9.5%PRS 11.0%
-
CSI 4.1rCSI 16.1%PRS 11.5%
-
CSI 4.3rCSI 5.3%PRS 10.0%
-
CSI 4.4rCSI 5.9%PRS 35.6%
-
CSI 4.8rCSI 6.4%PRS 13.3%
-
CSI 5.0rCSI 4.2%PRS 11.5%
-
CSI 5.2rCSI 6.4%PRS 23.3%
-
CSI 5.5rCSI 5.8%PRS 21.8%
-
CSI 5.7rCSI 4.1%PRS 9.4%
-
CSI 5.9rCSI 19.4%PRS 20.8%
-
CSI 6.1rCSI 4.1%PRS 8.4%
-
CSI 6.6rCSI 6.1%PRS 12.7%
-
CSI 6.8rCSI 24.1%PRS 22.4%
-
CSI 6.8rCSI 8.0%PRS 54.0%
-
CSI 7.0rCSI 14.4%PRS 11.0%
-
CSI 7.8rCSI 6.3%PRS 12.7%
-
CSI 7.9rCSI 8.2%PRS 11.2%
-
CSI 8.1rCSI 11.1%PRS 17.2%
-
CSI 8.6rCSI 5.7%PRS 19.2%
-
CSI 8.7rCSI 12.8%PRS 58.3%
-
CSI 8.9rCSI 7.9%PRS 7.8%
-
CSI 9.8rCSI 9.7%PRS 29.2%
-
CSI 10.0rCSI 11.6%PRS 22.9%
-
CSI 10.7rCSI 8.5%PRS 12.2%
-
CSI 11.1rCSI 67.0%PRS 16.1%
-
CSI 15.1rCSI 55.0%PRS 31.5%
-
CSI 15.2rCSI 11.5%PRS 9.6%
-
CSI 15.3rCSI 11.5%PRS 7.1%
-
CSI 21.2rCSI 26.6%PRS 8.8%
-
CSI 21.5rCSI 15.0%PRS 8.1%
-
CSI 23.8rCSI 24.1%PRS 41.7%
-
CSI 30.1rCSI 17.8%PRS 9.6%
-
CSI 34.2rCSI 58.6%PRS 9.3%
-
CSI 37.5rCSI 32.6%PRS 8.5%
-
CSI 39.5rCSI 49.7%PRS 34.7%
-
CSI 40.8rCSI 35.0%PRS 15.6%
-
CSI 49.0rCSI 36.6%PRS 11.7%
-
CSI 56.3rCSI 39.3%PRS 7.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 929911993
Symbol: LYAM1_HUMAN
Name: L-selectin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2664786
Title: Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains.
PubMed ID: 2664786
PubMed ID: 2473156
Title: Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins.
PubMed ID: 2473156
PubMed ID: 2509939
Title: Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor.
PubMed ID: 2509939
DOI: 10.1038/342078a0
PubMed ID: 2663882
Title: Characterization of a human homologue of the murine peripheral lymph node homing receptor.
PubMed ID: 2663882
PubMed ID: 1692315
Title: Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils.
PubMed ID: 1692315
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 12403782
Title: Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.
PubMed ID: 12403782
PubMed ID: 12736247
Title: Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
PubMed ID: 12736247
PubMed ID: 18606703
Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.
PubMed ID: 18606703
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 7488174
Title: A template for generation and comparison of three-dimensional selectin models.
PubMed ID: 7488174
PubMed ID: 28489325
Title: Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 A Resolution.
PubMed ID: 28489325
PubMed ID: 28011641
Title: Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.
PubMed ID: 28011641
Sequence Information:
- Length: 372
- Mass: 42187
- Checksum: 6EA9918ECA2D3643
- Sequence:
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK GKKSKRSMND PY