Details for: SH3BGR

Gene ID: 6450

Symbol: SH3BGR

Ensembl ID: ENSG00000185437

Description: SH3 domain binding glutamate rich protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.6687
    Cell Significance Index: -10.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.5975
    Cell Significance Index: -9.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.4999
    Cell Significance Index: -10.4800
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 6.1868
    Cell Significance Index: 17.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.1087
    Cell Significance Index: 100.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5146
    Cell Significance Index: -9.4200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.7604
    Cell Significance Index: 44.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6989
    Cell Significance Index: -10.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4016
    Cell Significance Index: 37.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0262
    Cell Significance Index: 8.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9378
    Cell Significance Index: 71.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4980
    Cell Significance Index: 29.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4845
    Cell Significance Index: 10.0500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4818
    Cell Significance Index: 7.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4375
    Cell Significance Index: 43.2800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.4104
    Cell Significance Index: 4.3600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.4017
    Cell Significance Index: 6.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3862
    Cell Significance Index: 111.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3825
    Cell Significance Index: 345.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3759
    Cell Significance Index: 40.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3549
    Cell Significance Index: 5.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3289
    Cell Significance Index: 65.9700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2735
    Cell Significance Index: 2.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2627
    Cell Significance Index: 11.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2516
    Cell Significance Index: 40.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2466
    Cell Significance Index: 9.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1649
    Cell Significance Index: 11.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1309
    Cell Significance Index: 46.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1176
    Cell Significance Index: 22.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1159
    Cell Significance Index: 3.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1031
    Cell Significance Index: 13.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0876
    Cell Significance Index: 17.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0663
    Cell Significance Index: 7.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0571
    Cell Significance Index: 2.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0559
    Cell Significance Index: 10.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0488
    Cell Significance Index: 3.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0453
    Cell Significance Index: 5.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0432
    Cell Significance Index: 23.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0410
    Cell Significance Index: 5.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0288
    Cell Significance Index: 0.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0276
    Cell Significance Index: 0.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0263
    Cell Significance Index: 0.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0242
    Cell Significance Index: 10.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0092
    Cell Significance Index: 6.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0047
    Cell Significance Index: 0.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0002
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0086
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0116
    Cell Significance Index: -0.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0136
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0138
    Cell Significance Index: -8.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0154
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0156
    Cell Significance Index: -9.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0209
    Cell Significance Index: -9.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0325
    Cell Significance Index: -3.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0396
    Cell Significance Index: -2.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0398
    Cell Significance Index: -1.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0485
    Cell Significance Index: -10.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0590
    Cell Significance Index: -8.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0609
    Cell Significance Index: -4.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0666
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0768
    Cell Significance Index: -8.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0831
    Cell Significance Index: -2.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0872
    Cell Significance Index: -1.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0873
    Cell Significance Index: -1.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0985
    Cell Significance Index: -5.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0991
    Cell Significance Index: -7.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1061
    Cell Significance Index: -6.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1273
    Cell Significance Index: -8.2200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.1306
    Cell Significance Index: -0.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1383
    Cell Significance Index: -2.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1429
    Cell Significance Index: -7.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1489
    Cell Significance Index: -10.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1507
    Cell Significance Index: -3.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1538
    Cell Significance Index: -2.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1683
    Cell Significance Index: -5.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1870
    Cell Significance Index: -2.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1951
    Cell Significance Index: -5.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2047
    Cell Significance Index: -4.9100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2051
    Cell Significance Index: -3.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2068
    Cell Significance Index: -6.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2104
    Cell Significance Index: -6.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2105
    Cell Significance Index: -5.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2141
    Cell Significance Index: -5.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2264
    Cell Significance Index: -8.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2296
    Cell Significance Index: -3.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2365
    Cell Significance Index: -6.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2384
    Cell Significance Index: -8.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2438
    Cell Significance Index: -7.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2459
    Cell Significance Index: -5.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2508
    Cell Significance Index: -5.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2622
    Cell Significance Index: -6.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SH3BGR gene is a non-coding RNA transcript that is significantly expressed in fetal cardiomyocytes, type B pancreatic cells, mural cells, skeletal muscle cells, choroid plexus epithelial cells, cardiac muscle myoblasts, cardiac endothelial cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and absorptive cells. Its high expression levels in these cell types suggest a crucial role in regulating cellular processes, particularly in the development and maintenance of various tissues. **Pathways and Functions:** The SH3BGR gene is primarily involved in regulating the cytoplasmic localization of proteins through its binding to the SH3 domain of other proteins. This interaction is thought to modulate the activity of proteins involved in various cellular processes, including cell signaling, migration, and differentiation. The SH3BGR gene's ability to bind to SH3 domain-containing proteins suggests that it plays a key role in regulating the cytoskeleton, which is essential for maintaining cellular shape, movement, and intracellular transport. Furthermore, the SH3BGR gene is involved in the regulation of protein-protein interactions, which is critical for maintaining cellular homeostasis. By binding to SH3 domain-containing proteins, the SH3BGR gene can modulate the activity of these proteins, leading to changes in cellular behavior and function. **Clinical Significance:** The SH3BGR gene's involvement in various cellular processes and its high expression levels in disease-relevant cell types suggest that it may play a role in the pathogenesis of various diseases. For instance, dysregulation of the SH3BGR gene has been implicated in cardiovascular diseases, such as heart failure and atherosclerosis. Additionally, the SH3BGR gene's involvement in the regulation of protein-protein interactions suggests that it may also play a role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. Furthermore, the SH3BGR gene's expression in absorptive cells suggests that it may also play a role in gastrointestinal diseases, such as inflammatory bowel disease and cancer. Overall, the SH3BGR gene's involvement in various cellular processes and its high expression levels in disease-relevant cell types make it an attractive target for therapeutic intervention in various diseases. In conclusion, the SH3BGR gene is a novel player in cellular regulation and disease pathogenesis. Further research is needed to fully elucidate the molecular mechanisms underlying the SH3BGR gene's role in maintaining cellular homeostasis and its potential implications in disease pathogenesis. As an expert immunologist, I believe that the SH3BGR gene holds great promise as a therapeutic target for various diseases, and its study will provide valuable insights into the complex mechanisms underlying human disease.

Genular Protein ID: 804233073

Symbol: SH3BG_HUMAN

Name: SH3 domain-binding glutamic acid-rich protein

UniProtKB Accession Codes:

P55822 A6ND59 D3DSI2 Q9BRB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9050928

Title: Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle.

PubMed ID: 9050928

DOI: 10.1007/s004390050377

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 239
  • Mass: 26086
  • Checksum: BA57B1C8034D6BBC
  • Sequence:
    • MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD RGVLGGVLFP 
TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL DIAGDEDNRR WMRENVPGEK 
KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE ENIIYSFLGL APPPDSKGSE KAEEGGETEA 
QKEGSEDVGN LPEAQEKNEE EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS

Genular Protein ID: 3020435337

Symbol: C9JJT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JJT2

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 97
  • Mass: 10746
  • Checksum: 9601E6C20165085B
  • Sequence:
    • MRENVPGEKK PQNGIPLPPQ IFNEEQYCGD FDSFFSAKEE NIIYSFLGLA PPPDSKEEEG 
ETATEETEEI AMEGAEGEAE EEEETAEGEE PGEDEDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.