Details for: SH3GL1

Gene ID: 6455

Symbol: SH3GL1

Ensembl ID: ENSG00000141985

Description: SH3 domain containing GRB2 like 1, endophilin A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.5689
    Cell Significance Index: -27.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.8139
    Cell Significance Index: -30.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.6952
    Cell Significance Index: -34.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6046
    Cell Significance Index: -27.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.9563
    Cell Significance Index: -30.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7994
    Cell Significance Index: -28.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4260
    Cell Significance Index: -25.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9700
    Cell Significance Index: -31.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9458
    Cell Significance Index: -17.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8680
    Cell Significance Index: 129.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6874
    Cell Significance Index: 45.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4277
    Cell Significance Index: 141.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2320
    Cell Significance Index: 247.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0137
    Cell Significance Index: 52.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9627
    Cell Significance Index: 191.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9202
    Cell Significance Index: 100.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7850
    Cell Significance Index: 127.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6315
    Cell Significance Index: 17.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6030
    Cell Significance Index: 82.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5954
    Cell Significance Index: 15.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4790
    Cell Significance Index: 331.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4640
    Cell Significance Index: 13.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4237
    Cell Significance Index: 231.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4114
    Cell Significance Index: 50.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4030
    Cell Significance Index: 72.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4001
    Cell Significance Index: 11.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3894
    Cell Significance Index: 139.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3746
    Cell Significance Index: 10.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3700
    Cell Significance Index: 47.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3483
    Cell Significance Index: 2.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3234
    Cell Significance Index: 15.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3220
    Cell Significance Index: 21.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3133
    Cell Significance Index: 2.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3000
    Cell Significance Index: 132.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2857
    Cell Significance Index: 6.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2513
    Cell Significance Index: 226.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1911
    Cell Significance Index: 4.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1746
    Cell Significance Index: 8.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1705
    Cell Significance Index: 32.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1449
    Cell Significance Index: 6.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1395
    Cell Significance Index: 10.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1388
    Cell Significance Index: 3.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1118
    Cell Significance Index: 3.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0824
    Cell Significance Index: 6.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0591
    Cell Significance Index: 111.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0502
    Cell Significance Index: 8.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0502
    Cell Significance Index: 77.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0477
    Cell Significance Index: 30.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0469
    Cell Significance Index: 3.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0373
    Cell Significance Index: 4.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0351
    Cell Significance Index: 64.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0025
    Cell Significance Index: 3.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0207
    Cell Significance Index: -9.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0238
    Cell Significance Index: -17.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0312
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0326
    Cell Significance Index: -23.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0347
    Cell Significance Index: -25.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0537
    Cell Significance Index: -30.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0543
    Cell Significance Index: -7.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0586
    Cell Significance Index: -36.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0593
    Cell Significance Index: -6.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0843
    Cell Significance Index: -1.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0888
    Cell Significance Index: -9.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0949
    Cell Significance Index: -27.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0995
    Cell Significance Index: -2.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1086
    Cell Significance Index: -12.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1290
    Cell Significance Index: -8.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1540
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1708
    Cell Significance Index: -35.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1724
    Cell Significance Index: -19.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1858
    Cell Significance Index: -11.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1948
    Cell Significance Index: -6.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1950
    Cell Significance Index: -2.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1952
    Cell Significance Index: -6.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2088
    Cell Significance Index: -13.1600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2109
    Cell Significance Index: -1.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2195
    Cell Significance Index: -9.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2450
    Cell Significance Index: -1.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2480
    Cell Significance Index: -6.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2629
    Cell Significance Index: -14.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2635
    Cell Significance Index: -27.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2759
    Cell Significance Index: -7.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2910
    Cell Significance Index: -11.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3074
    Cell Significance Index: -16.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3369
    Cell Significance Index: -4.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3533
    Cell Significance Index: -27.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3879
    Cell Significance Index: -7.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4149
    Cell Significance Index: -7.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4401
    Cell Significance Index: -26.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4493
    Cell Significance Index: -11.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5020
    Cell Significance Index: -26.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5232
    Cell Significance Index: -8.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5266
    Cell Significance Index: -9.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5959
    Cell Significance Index: -17.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5991
    Cell Significance Index: -12.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6193
    Cell Significance Index: -13.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6462
    Cell Significance Index: -20.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6486
    Cell Significance Index: -21.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6531
    Cell Significance Index: -7.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6531
    Cell Significance Index: -33.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SH3GL1 is a member of the endophilin family, which is involved in the regulation of membrane trafficking and synaptic transmission. The SH3 domain of SH3GL1 is essential for its function, as it mediates interactions with other proteins, including clathrin, dynamin, and actin. SH3GL1 is also involved in the regulation of receptor tyrosine kinase (RTK) signaling, including EGFR and MET, which are critical for cell growth, differentiation, and survival. **Pathways and Functions:** SH3GL1 is involved in various cellular processes, including: 1. **Membrane trafficking:** SH3GL1 regulates the formation and fusion of clathrin-coated vesicles, which are essential for endocytosis, exocytosis, and synaptic transmission. 2. **Signaling:** SH3GL1 interacts with RTKs, including EGFR and MET, and regulates their signaling pathways, which are involved in cell growth, differentiation, and survival. 3. **Cell adhesion:** SH3GL1 interacts with cadherins and other adhesion molecules, which are essential for cell-cell adhesion and synaptic transmission. 4. **Neurotransmission:** SH3GL1 is involved in the regulation of synaptic vesicle uncoating and synaptic vesicle recycling, which are critical for neurotransmitter release and synaptic plasticity. **Clinical Significance:** SH3GL1 has been implicated in various human diseases, including: 1. **Cancer:** SH3GL1 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurodegenerative diseases:** SH3GL1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases:** SH3GL1 is involved in the entry of Listeria monocytogenes into host cells, which is a critical step in the pathogenesis of listeriosis. In conclusion, SH3GL1 is a multifaceted gene involved in various cellular processes, including membrane trafficking, signaling, and disease pathways. Its dysregulation has been implicated in various human diseases, highlighting the importance of SH3GL1 in maintaining cellular homeostasis and preventing disease. **Signaling Pathways:** 1. **EGFR signaling:** SH3GL1 interacts with EGFR and regulates its signaling pathway, which is involved in cell growth, differentiation, and survival. 2. **MET signaling:** SH3GL1 interacts with MET and regulates its signaling pathway, which is involved in cell growth, differentiation, and survival. 3. **Clathrin-mediated endocytosis:** SH3GL1 regulates the formation and fusion of clathrin-coated vesicles, which are essential for endocytosis, exocytosis, and synaptic transmission. 4. **RTK signaling:** SH3GL1 interacts with RTKs, including EGFR and MET, and regulates their signaling pathways, which are involved in cell growth, differentiation, and survival. **Protein-Protein Interactions:** 1. **Clathrin:** SH3GL1 interacts with clathrin, which is essential for the formation and fusion of clathrin-coated vesicles. 2. **Dynamin:** SH3GL1 interacts with dynamin, which is essential for the scission of clathrin-coated vesicles. 3. **Actin:** SH3GL1 interacts with actin, which is essential for the regulation of membrane trafficking and synaptic transmission. 4. **RTKs:** SH3GL1 interacts with RTKs, including EGFR and MET, and regulates their signaling pathways. **Regulation:** 1. **Post-translational modifications:** SH3GL1 is subject to various post-translational modifications, including phosphorylation, ubiquitination, and sumoylation. 2. **MicroRNA regulation:** SH3GL1 is regulated by various microRNAs, which are involved in the regulation of gene expression. 3. **Chromatin remodeling:** SH3GL1 is regulated by chromatin remodeling complexes, which are involved in the regulation of gene expression.

Genular Protein ID: 1805448839

Symbol: SH3G1_HUMAN

Name: Endophilin-A2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9169142

Title: A novel SH3-containing human gene family preferentially expressed in the central nervous system.

PubMed ID: 9169142

DOI: 10.1006/geno.1997.4645

PubMed ID: 9122235

Title: EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.

PubMed ID: 9122235

DOI: 10.1073/pnas.94.6.2563

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10542231

Title: The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.

PubMed ID: 10542231

DOI: 10.1074/jbc.274.45.32001

PubMed ID: 17350572

Title: Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.

PubMed ID: 17350572

DOI: 10.1016/j.cell.2007.01.035

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23285027

Title: Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.

PubMed ID: 23285027

DOI: 10.1371/journal.pone.0052401

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 368
  • Mass: 41490
  • Checksum: 6E5BE978BC955077
  • Sequence:
  • MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKEMEKKV DVTSKAVTEV LARTIEYLQP 
    NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMIRH GKELGGESNF GDALLDAGES 
    MKRLAEVKDS LDIEVKQNFI DPLQNLCEKD LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD 
    EELRQALEKF EESKEVAETS MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILDELAEKL 
    KRRMREASSR PKREYKPKPR EPFDLGEPEQ SNGGFPCTTA PKIAASSSFR SSDKPIRTPS 
    RSMPPLDQPS CKALYDFEPE NDGELGFHEG DVITLTNQID ENWYEGMLDG QSGFFPLSYV 
    EVLVPLPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.