SHC1 | ENSG00000160691 | NCBI 6464

Details for: SHC1

Gene ID: 6464

Symbol: SHC1

Ensembl ID: ENSG00000160691

Description: SHC adaptor protein 1

Associated with

Activated ntrk2 signals through ras
(R-HSA-9026519)
Activated ntrk3 signals through ras
(R-HSA-9034864)
Axon guidance
(R-HSA-422475)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Erythropoietin activates ras
(R-HSA-9027284)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Integrin signaling
(R-HSA-354192)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-2 signaling
(R-HSA-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin receptor shc signaling
(R-HSA-912526)
Ire1alpha activates chaperones
(R-HSA-381070)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Met activates ras signaling
(R-HSA-8851805)
Nervous system development
(R-HSA-9675108)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Raf/map kinase cascade
(R-HSA-5673001)
Ret signaling
(R-HSA-8853659)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Shc-related events triggered by igf1r
(R-HSA-2428933)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signal attenuation
(R-HSA-74749)
Signaling by alk
(R-HSA-201556)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by ltk
(R-HSA-9842663)
Signaling by met
(R-HSA-6806834)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signalling to erks
(R-HSA-187687)
Signalling to ras
(R-HSA-167044)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Unfolded protein response (upr)
(R-HSA-381119)
Xbp1(s) activates chaperone genes
(R-HSA-381038)
Epidermal growth factor receptor binding
(GO:0005154)
Phosphotyrosine residue binding
(GO:0001784)
Transmembrane receptor protein tyrosine kinase adaptor activity
(GO:0005068)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 139.3164
Cell Significance Index: -21.6700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 89.5746
Cell Significance Index: -22.7200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.4379
Cell Significance Index: -24.2900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 48.7622
Cell Significance Index: -19.8100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 45.2287
Cell Significance Index: -23.2700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 36.1836
Cell Significance Index: -24.2800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.8538
Cell Significance Index: -19.9100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.0599
Cell Significance Index: -23.5000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.5297
Cell Significance Index: -22.8500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9959
Cell Significance Index: -23.6600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.7074
Cell Significance Index: -17.5300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4075
Cell Significance Index: 65.5300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.2327
Cell Significance Index: 116.3000
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.6695
Cell Significance Index: 11.9900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.4744
Cell Significance Index: 16.7500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3915
Cell Significance Index: 24.5900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9713
Cell Significance Index: 58.3100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9291
Cell Significance Index: 119.1000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8885
Cell Significance Index: 25.4700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8261
Cell Significance Index: 89.8600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7708
Cell Significance Index: 16.7000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7202
Cell Significance Index: 37.4100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.7035
Cell Significance Index: 6.0500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6157
Cell Significance Index: 8.4000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5579
Cell Significance Index: 68.6000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5508
Cell Significance Index: 89.5800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5365
Cell Significance Index: 14.3800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5277
Cell Significance Index: 15.2100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4837
Cell Significance Index: 47.8500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4732
Cell Significance Index: 10.1200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3685
Cell Significance Index: 26.0600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3554
Cell Significance Index: 48.8000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3428
Cell Significance Index: 61.7900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3184
Cell Significance Index: 287.4900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2899
Cell Significance Index: 13.1400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2663
Cell Significance Index: 3.4100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2571
Cell Significance Index: 113.6700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2467
Cell Significance Index: 134.7500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2390
Cell Significance Index: 16.5300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2134
Cell Significance Index: 9.9500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1823
Cell Significance Index: 36.5700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1776
Cell Significance Index: 4.4400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1530
Cell Significance Index: 18.0400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1362
Cell Significance Index: 10.1500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1274
Cell Significance Index: 14.6000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1085
Cell Significance Index: 5.1000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1063
Cell Significance Index: 20.2400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0920
Cell Significance Index: 18.2600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0902
Cell Significance Index: 15.4100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0676
Cell Significance Index: 24.2400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0657
Cell Significance Index: 1.4000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0531
Cell Significance Index: 1.5600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0530
Cell Significance Index: 1.1100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0477
Cell Significance Index: 33.0000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0137
Cell Significance Index: 0.6900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0111
Cell Significance Index: 0.1900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0057
Cell Significance Index: 0.7400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0008
Cell Significance Index: 1.6000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0043
Cell Significance Index: -0.2800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0055
Cell Significance Index: -4.1500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0062
Cell Significance Index: -3.8900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0091
Cell Significance Index: -13.9900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0095
Cell Significance Index: -17.5200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0117
Cell Significance Index: -8.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0171
Cell Significance Index: -23.2700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0181
Cell Significance Index: -13.2500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0251
Cell Significance Index: -15.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0287
Cell Significance Index: -2.9300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0302
Cell Significance Index: -17.0400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0330
Cell Significance Index: -3.7700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0360
Cell Significance Index: -0.2400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0405
Cell Significance Index: -0.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0457
Cell Significance Index: -20.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0551
Cell Significance Index: -11.6100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0582
Cell Significance Index: -16.7600
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.0824
Cell Significance Index: -0.5100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1176
Cell Significance Index: -17.0900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1295
Cell Significance Index: -15.0900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1511
Cell Significance Index: -11.6000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1727
Cell Significance Index: -4.6200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1791
Cell Significance Index: -4.7100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1851
Cell Significance Index: -6.5100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2123
Cell Significance Index: -1.9600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2194
Cell Significance Index: -22.8400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2215
Cell Significance Index: -13.9600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2443
Cell Significance Index: -19.3500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2487
Cell Significance Index: -6.6400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2551
Cell Significance Index: -15.6400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2582
Cell Significance Index: -8.2700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2934
Cell Significance Index: -8.2000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3022
Cell Significance Index: -10.5000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3133
Cell Significance Index: -5.7900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3408
Cell Significance Index: -20.9500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3582
Cell Significance Index: -20.1000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3797
Cell Significance Index: -25.5300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3971
Cell Significance Index: -20.8500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4365
Cell Significance Index: -8.5200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4416
Cell Significance Index: -11.3500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5055
Cell Significance Index: -17.7100
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: -0.5206
Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Adaptor function**: SHC1 acts as an adaptor protein, bridging the signal transduction events initiated by RTKs with downstream effectors, such as phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), and protein kinase B (Akt). 2. **Expression in various cell types**: SHC1 is expressed in multiple cell types, including endothelial cells, neural cells, and immune cells, highlighting its broad functional significance. 3. **Regulation of cell growth and differentiation**: SHC1's involvement in signal transduction events initiated by RTKs, such as EGFR and FGFRs, suggests its role in regulating cell growth and differentiation. 4. **Involvement in cancer**: SHC1's expression and activity have been implicated in various cancers, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. **Pathways and Functions** SHC1 mediates signal transduction events initiated by multiple RTKs, including: 1. **EGFR signaling**: SHC1 interacts with EGFR and mediates the signal transduction events initiated by EGFR activation. 2. **FGFR signaling**: SHC1 interacts with FGFRs and mediates the signal transduction events initiated by FGFR activation. 3. **NTKR signaling**: SHC1 interacts with NTKRs and mediates the signal transduction events initiated by NTKR activation. 4. **Cytokine signaling**: SHC1 interacts with cytokine receptors and mediates the signal transduction events initiated by cytokine activation. 5. **Stress signaling**: SHC1 interacts with stress sensors and mediates the signal transduction events initiated by stress signals. **Clinical Significance** SHC1's involvement in various signaling pathways makes it a potential therapeutic target for the treatment of various diseases, including cancer. SHC1's expression and activity have been implicated in: 1. **Cancer progression**: SHC1's expression and activity have been linked to cancer progression, including tumor growth, invasion, and metastasis. 2. **Inflammatory diseases**: SHC1's involvement in cytokine signaling pathways suggests its potential role in inflammatory diseases, such as rheumatoid arthritis and asthma. 3. **Neurological disorders**: SHC1's expression and activity have been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, SHC1 is a critical adaptor protein that mediates signal transduction events initiated by multiple RTKs, influencing various cellular processes, including cell growth, differentiation, and survival. Its involvement in cancer, inflammatory diseases, and neurological disorders highlights its potential as a therapeutic target for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

SHC-transforming protein 1

Genular Protein ID: 264215999

Symbol: SHC1_HUMAN

Name: SHC-transforming protein 1

UniProtKB Accession Codes:

P29353 B5BU19 D3DV78 O15290 Q5T180 Q5T183 Q5T184 Q5T185 Q5T186 Q8N4K5 Q96CL1

Database IDs:

Citations:

PubMed ID: 1623525

Title: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

PubMed ID: 1623525

DOI: 10.1016/0092-8674(92)90536-l

PubMed ID: 9049300

Title: Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

PubMed ID: 9049300

DOI: 10.1093/emboj/16.4.706

PubMed ID: 9192859

Title: Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1.

PubMed ID: 9192859

DOI: 10.1006/geno.1997.4728

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8195171

Title: Direct interaction between Shc and the platelet-derived growth factor beta-receptor.

PubMed ID: 8195171

DOI: 10.1016/s0021-9258(17)36611-5

PubMed ID: 8155326

Title: Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.

PubMed ID: 8155326

DOI: 10.1016/0896-6273(94)90223-2

PubMed ID: 7541045

Title: Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.

PubMed ID: 7541045

DOI: 10.1074/jbc.270.26.15639

PubMed ID: 7559478

Title: Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.

PubMed ID: 7559478

DOI: 10.1074/jbc.270.40.23258

PubMed ID: 7537849

Title: Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.

PubMed ID: 7537849

DOI: 10.1128/mcb.15.5.2500

PubMed ID: 8874179

Title: Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.

PubMed ID: 8874179

PubMed ID: 8939605

Title: The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.

PubMed ID: 8939605

DOI: 10.1016/s0960-9822(96)00748-8

PubMed ID: 8940081

Title: Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.

PubMed ID: 8940081

DOI: 10.1074/jbc.271.48.30942

PubMed ID: 9038210

Title: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

PubMed ID: 9038210

DOI: 10.1074/jbc.272.9.5915

PubMed ID: 9148935

Title: Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.

PubMed ID: 9148935

DOI: 10.1074/jbc.272.20.13189

PubMed ID: 9121430

Title: Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.

PubMed ID: 9121430

DOI: 10.1128/mcb.17.4.1824

PubMed ID: 9233773

Title: Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.

PubMed ID: 9233773

DOI: 10.1038/sj.onc.1201163

PubMed ID: 9660833

Title: Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.

PubMed ID: 9660833

DOI: 10.1074/jbc.273.29.18605

PubMed ID: 9488479

Title: Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.

PubMed ID: 9488479

DOI: 10.1128/mcb.18.3.1622

PubMed ID: 9566877

Title: Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events.

PubMed ID: 9566877

DOI: 10.1128/mcb.18.5.2571

PubMed ID: 10194451

Title: A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.

PubMed ID: 10194451

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 11349134

Title: The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.

PubMed ID: 11349134

DOI: 10.1074/jbc.m103537200

PubMed ID: 11980671

Title: Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples.

PubMed ID: 11980671

PubMed ID: 11948181

Title: The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.

PubMed ID: 11948181

DOI: 10.1074/jbc.m200280200

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 15488758

Title: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

PubMed ID: 15488758

DOI: 10.1016/j.ccr.2004.09.011

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 14665640

Title: Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.

PubMed ID: 14665640

DOI: 10.1074/jbc.m307456200

PubMed ID: 15102829

Title: Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

PubMed ID: 15102829

DOI: 10.1074/jbc.m314015200

PubMed ID: 15316024

Title: Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.

PubMed ID: 15316024

DOI: 10.1074/jbc.m404537200

PubMed ID: 14573619

Title: A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria.

PubMed ID: 14573619

DOI: 10.1074/jbc.m307655200

PubMed ID: 15272003

Title: Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.

PubMed ID: 15272003

DOI: 10.1074/jbc.m407592200

PubMed ID: 15837797

Title: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.

PubMed ID: 15837797

DOI: 10.1083/jcb.200410041

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17274988

Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

PubMed ID: 17274988

DOI: 10.1016/j.febslet.2007.01.039

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20010870

Title: Copine-III interacts with ErbB2 and promotes tumor cell migration.

PubMed ID: 20010870

DOI: 10.1038/onc.2009.456

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23946459

Title: Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

PubMed ID: 23946459

DOI: 10.1128/jvi.01702-13

PubMed ID: 23846654

Title: Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

PubMed ID: 23846654

DOI: 10.1038/nature12308

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

PubMed ID: 7473762

Title: Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data.

PubMed ID: 7473762

DOI: 10.1006/jmbi.1995.0601

PubMed ID: 8524391

Title: Structure and ligand recognition of the phosphotyrosine binding domain of Shc.

PubMed ID: 8524391

DOI: 10.1038/378584a0

PubMed ID: 7544002

Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.

PubMed ID: 7544002

DOI: 10.1073/pnas.92.17.7784

Sequence Information:

Length: 583
Mass: 62822
Checksum: 7EFA5CB185A548D1
Sequence:

MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS 
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR 
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD 
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS 
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV 
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL 
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE 
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA 
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG 
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SHC1

Associated with

Cells (max top 100)

Other Information

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. PubMed ID: 1623525

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. PubMed ID: 9049300

Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13.1. PubMed ID: 9192859

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Direct interaction between Shc and the platelet-derived growth factor beta-receptor. PubMed ID: 8195171

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. PubMed ID: 8155326

Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. PubMed ID: 7541045

Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. PubMed ID: 7559478

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. PubMed ID: 7537849

Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. PubMed ID: 8874179

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. PubMed ID: 8939605

Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors. PubMed ID: 8940081

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. PubMed ID: 9038210

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. PubMed ID: 9148935

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation. PubMed ID: 9121430

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. PubMed ID: 9233773

Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein. PubMed ID: 9660833

Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. PubMed ID: 9488479

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. PubMed ID: 9566877

A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. PubMed ID: 10194451

Ligand discrimination in signaling through an ErbB4 receptor homodimer. PubMed ID: 10867024

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells. PubMed ID: 11349134

Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. PubMed ID: 11980671

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. PubMed ID: 11948181

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. PubMed ID: 12925710

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. PubMed ID: 15488758

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells. PubMed ID: 14665640

Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress. PubMed ID: 15102829

Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4. PubMed ID: 15316024

A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria. PubMed ID: 14573619

Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. PubMed ID: 15272003

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. PubMed ID: 15837797

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. PubMed ID: 17274988

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Copine-III interacts with ErbB2 and promotes tumor cell migration. PubMed ID: 20010870

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc. PubMed ID: 23946459

Temporal regulation of EGF signalling networks by the scaffold protein Shc1. PubMed ID: 23846654

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins. PubMed ID: 35687021

Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data. PubMed ID: 7473762

Structure and ligand recognition of the phosphotyrosine binding domain of Shc. PubMed ID: 8524391

Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. PubMed ID: 7544002