Details for: ST8SIA1

Gene ID: 6489

Symbol: ST8SIA1

Ensembl ID: ENSG00000111728

Description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 204.4421
    Cell Significance Index: -31.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.6091
    Cell Significance Index: -34.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.8034
    Cell Significance Index: -33.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8217
    Cell Significance Index: -33.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7683
    Cell Significance Index: -34.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3088
    Cell Significance Index: -25.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6589
    Cell Significance Index: -12.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5352
    Cell Significance Index: 307.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4068
    Cell Significance Index: 504.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.1624
    Cell Significance Index: 19.9200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.9785
    Cell Significance Index: 13.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8967
    Cell Significance Index: 60.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7928
    Cell Significance Index: 30.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7398
    Cell Significance Index: 511.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6897
    Cell Significance Index: 38.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6258
    Cell Significance Index: 27.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5908
    Cell Significance Index: 16.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5726
    Cell Significance Index: 11.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2998
    Cell Significance Index: 18.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2222
    Cell Significance Index: 10.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1997
    Cell Significance Index: 4.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0884
    Cell Significance Index: 40.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0814
    Cell Significance Index: 1.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0480
    Cell Significance Index: 90.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0091
    Cell Significance Index: 0.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0043
    Cell Significance Index: 3.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0193
    Cell Significance Index: -12.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0207
    Cell Significance Index: -38.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0255
    Cell Significance Index: -39.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0260
    Cell Significance Index: -16.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0298
    Cell Significance Index: -40.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0320
    Cell Significance Index: -17.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0333
    Cell Significance Index: -24.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0342
    Cell Significance Index: -19.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0504
    Cell Significance Index: -38.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0521
    Cell Significance Index: -6.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0535
    Cell Significance Index: -23.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0597
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0624
    Cell Significance Index: -9.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0865
    Cell Significance Index: -1.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0898
    Cell Significance Index: -25.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0917
    Cell Significance Index: -19.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0959
    Cell Significance Index: -18.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0978
    Cell Significance Index: -16.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1037
    Cell Significance Index: -18.6900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1067
    Cell Significance Index: -0.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1197
    Cell Significance Index: -23.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1229
    Cell Significance Index: -1.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1267
    Cell Significance Index: -2.6900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1379
    Cell Significance Index: -1.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1635
    Cell Significance Index: -21.1200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1680
    Cell Significance Index: -1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1773
    Cell Significance Index: -24.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1849
    Cell Significance Index: -11.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1851
    Cell Significance Index: -30.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1893
    Cell Significance Index: -23.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2171
    Cell Significance Index: -11.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2336
    Cell Significance Index: -7.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2431
    Cell Significance Index: -7.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2586
    Cell Significance Index: -26.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2591
    Cell Significance Index: -30.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2760
    Cell Significance Index: -28.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2840
    Cell Significance Index: -30.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2912
    Cell Significance Index: -28.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3010
    Cell Significance Index: -34.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3132
    Cell Significance Index: -36.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3231
    Cell Significance Index: -9.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3350
    Cell Significance Index: -38.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3460
    Cell Significance Index: -8.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3522
    Cell Significance Index: -2.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3671
    Cell Significance Index: -28.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3778
    Cell Significance Index: -28.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3919
    Cell Significance Index: -27.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4465
    Cell Significance Index: -11.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4557
    Cell Significance Index: -7.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4577
    Cell Significance Index: -12.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4861
    Cell Significance Index: -31.3600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.4910
    Cell Significance Index: -3.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4932
    Cell Significance Index: -25.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4950
    Cell Significance Index: -34.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5021
    Cell Significance Index: -17.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5064
    Cell Significance Index: -10.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5689
    Cell Significance Index: -28.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5725
    Cell Significance Index: -36.0800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5752
    Cell Significance Index: -6.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5753
    Cell Significance Index: -11.5500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5844
    Cell Significance Index: -5.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5860
    Cell Significance Index: -30.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6049
    Cell Significance Index: -21.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6117
    Cell Significance Index: -28.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6373
    Cell Significance Index: -28.8900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.6928
    Cell Significance Index: -5.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7022
    Cell Significance Index: -24.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7200
    Cell Significance Index: -17.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.7216
    Cell Significance Index: -10.3400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.7387
    Cell Significance Index: -8.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7539
    Cell Significance Index: -19.3800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7605
    Cell Significance Index: -10.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ST8SIA1 is a type II transmembrane enzyme, consisting of a catalytic domain and a transmembrane domain. Its substrate specificity is unique, targeting alpha-2,8-sialylation of sialic acid residues on glycoproteins and glycolipids. The enzyme is expressed in various cell types, including neurons, astrocytes, and immune cells, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** ST8SIA1 plays a pivotal role in several cellular pathways, including: 1. **Alpha-n-acetylneuraminate alpha-2,8-sialyltransferase activity:** This pathway involves the transfer of sialic acid residues to specific carbohydrate moieties, modulating glycoprotein and glycolipid structure and function. 2. **Asparagine n-linked glycosylation:** ST8SIA1 regulates the formation of complex glycoproteins by influencing the assembly of N-glycans on nascent proteins. 3. **Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo):** The enzyme contributes to the formation of llo, a precursor to N-glycans, by regulating sialylation and glycosylation events. 4. **Sialic acid metabolism:** ST8SIA1 is involved in the degradation and recycling of sialic acid residues, modulating the availability of this essential sugar for glycosylation reactions. **Clinical Significance:** Dysregulation of ST8SIA1 has been implicated in various immune-related disorders, including: 1. **Neurological diseases:** Alterations in ST8SIA1 expression and activity have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** Aberrant sialylation patterns, influenced by ST8SIA1, have been observed in various cancers, including breast, lung, and colon cancer. 3. **Autoimmune disorders:** ST8SIA1 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where altered sialylation patterns contribute to immune dysregulation. In conclusion, ST8SIA1 is a multifunctional enzyme that plays a critical role in regulating glycoprotein and glycolipid structure and function. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of this enzyme in maintaining immune homeostasis and cellular proliferation. Further research is necessary to elucidate the mechanisms underlying ST8SIA1-mediated immune regulation and to explore its potential as a therapeutic target for immune-related diseases.

Genular Protein ID: 1093213025

Symbol: SIA8A_HUMAN

Name: Alpha-2,8-sialyltransferase 8A

UniProtKB Accession Codes:

Q92185 A8K4H6 Q17RL0 Q6PZN5 Q93064

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 46 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 17 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8195250

Title: Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).

PubMed ID: 8195250

DOI: 10.1016/s0021-9258(17)40773-3

PubMed ID: 8058740

Title: Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.

PubMed ID: 8058740

DOI: 10.1073/pnas.91.17.7952

PubMed ID: 7937974

Title: Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.

PubMed ID: 7937974

DOI: 10.1073/pnas.91.22.10455

PubMed ID: 8631981

Title: Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme.

PubMed ID: 8631981

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706663

Title: Acceptor substrate specificity of a cloned GD3 synthase that catalyzes the biosynthesis of both GD3 and GD1c/GT1a/GQ1b.

PubMed ID: 8706663

DOI: 10.1111/j.1432-1033.1996.0647w.x

PubMed ID: 15843597

Title: The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.

PubMed ID: 15843597

DOI: 10.1093/glycob/cwi063

PubMed ID: 18348864

Title: Identification and analysis of novel functional sites in human GD3-synthase.

PubMed ID: 18348864

DOI: 10.1016/j.bbrc.2008.03.029

PubMed ID: 22885356

Title: Accumulation of unusual gangliosides G(Q3) and G(P3) in breast cancer cells expressing the G(D3) synthase.

PubMed ID: 22885356

DOI: 10.3390/molecules17089559

Sequence Information:

  • Length: 356
  • Mass: 40519
  • Checksum: 452FE04856964395
  • Sequence:
    • MSPCGRARRQ TSRGAMAVLA WKFPRTRLPM GASALCVVVL CWLYIFPVYR LPNEKEIVQG 
VLQQGTAWRR NQTAARAFRK QMEDCCDPAH LFAMTKMNSP MGKSMWYDGE FLYSFTIDNS 
TYSLFPQATP FQLPLKKCAV VGNGGILKKS GCGRQIDEAN FVMRCNLPPL SSEYTKDVGS 
KSQLVTANPS IIRQRFQNLL WSRKTFVDNM KIYNHSYIYM PAFSMKTGTE PSLRVYYTLS 
DVGANQTVLF ANPNFLRSIG KFWKSRGIHA KRLSTGLFLV SAALGLCEEV AIYGFWPFSV 
NMHEQPISHH YYDNVLPFSG FHAMPEEFLQ LWYLHKIGAL RMQLDPCEDT SLQPTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.