Details for: STIL

Gene ID: 6491

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: STIL

Ensembl ID: ENSG00000123473

Description: STIL centriolar assembly protein

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • multi-ciliated epithelial cell CL0005012
    CSI 4.99
    rCSI 4.98%
    PRS 95.31
  • erythroblast CL0000765
    CSI 4.14
    rCSI 10.99%
    PRS 97.34
  • large pre-B-II cell CL0000957
    CSI 3.03
    rCSI 8.66%
    PRS 97.16
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.01
    rCSI 3.48%
    PRS 94.63
  • ependymal cell CL0000065
    CSI 2.61
    rCSI 5.3%
    PRS 89.31
  • erythrocyte CL0000232
    CSI 2.35
    rCSI 5.34%
    PRS 96.53
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.34
    rCSI 2.91%
    PRS 92.09
  • basal cell of epidermis CL0002187
    CSI 1.52
    rCSI 2.69%
    PRS 79.9
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.42
    rCSI 1.72%
    PRS 85.35
  • deuterosomal cell CL4033044
    CSI 1.23
    rCSI 4.15%
    PRS 94.22
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.68
    rCSI 2.43%
    PRS 92.24

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [STIL](/details-gene/6491) (STIL centriolar assembly protein) is a protein-coding gene located on chromosome 1p33 that plays a fundamental role in cell cycle progression, centriole duplication, and embryonic development. Its function is critically linked to the formation and organization of the mitotic spindle and the microtubule organizing center. Consistent with this role, its expression is most significant in highly proliferative cells, such as [erythroblasts](/details-cell/CL0000765) and developing [B cells](/details-cell/CL0000957), as well as in specialized cells requiring numerous centrioles, like [multi-ciliated epithelial cells](/details-cell/CL0005012). Clinically, disruptions in [STIL](/details-gene/6491) function are associated with developmental disorders, and its chromosomal translocation or overexpression is implicated in certain cancers, notably T-cell acute lymphoblastic leukemia (T-ALL) ([Link](https://doi.org/10.1128/mcb.11.11.5462-5469.1991), [Link](https://doi.org/10.1182/blood-2003-05-1495)). Its involvement is also linked to holoprosencephaly via OMIM association ([181590](https://omim.org/entry/181590)). ## Cellular Roles and Expression Landscape The expression profile of [STIL](/details-gene/6491) underscores its essential function in processes requiring centriole synthesis and microtubule organization. **Overall**, the gene shows the highest significance in cell types characterized by rapid proliferation or the formation of cilia. The most significant expression is observed in [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 4.99), which require a massive amplification of centrioles to form basal bodies for cilia. This is followed by hematopoietic progenitors like [erythroblast](/details-cell/CL0000765) (CSI: 4.14) and [large pre-B-II cell](/details-cell/CL0000957) (CSI: 3.03), where high mitotic activity is essential for lineage expansion. The gene is also a key marker in neural progenitors, including [neuroblast (sensu Nematoda and Protostomia)](/details-cell/CL0000338) (CSI: 3.01) and [ependymal cell](/details-cell/CL0000065) (CSI: 2.61), which are ciliated cells lining the ventricles of the brain. Its relevance extends to renewing tissues like the skin, as evidenced by its significance in [basal cell of epidermis](/details-cell/CL0002187) (CSI: 1.52). The strong correlation between [STIL](/details-gene/6491) expression and cell growth has been previously noted ([Link](https://pubmed.ncbi.nlm.nih.gov/9372240/)). This expression pattern firmly establishes [STIL](/details-gene/6491) as a key regulator of cell division and centriole-dependent structures across diverse tissues. ## Pathways and Molecular Function The functional annotations for [STIL](/details-gene/6491) confirm its central role in cell cycle control and morphogenesis. Its molecular activities are primarily localized to the [Centrosome (GO:0005813)](https://www.ebi.ac.uk/QuickGO/term/GO:0005813), [Centriole (GO:0005814)](https://www.ebi.ac.uk/QuickGO/term/GO:0005814), and the broader [Microtubule organizing center (GO:0005815)](https://www.ebi.ac.uk/QuickGO/term/GO:0005815). Biologically, [STIL](/details-gene/6491) is a critical component of the machinery governing [Centrosome duplication (GO:0051298)](https://www.ebi.ac.uk/QuickGO/term/GO:0051298) and [Mitotic spindle organization (GO:0007052)](https://www.ebi.ac.uk/QuickGO/term/GO:0007052). It is involved in the positive regulation of these processes, including [Positive regulation of centriole replication (GO:0046601)](https://www.ebi.ac.uk/QuickGO/term/GO:0046601) and [Positive regulation of spindle assembly (GO:1905832)](https://www.ebi.ac.uk/QuickGO/term/GO:1905832). Its function is also tied to cell cycle checkpoint control, as it facilitates the [Positive regulation of g1/s transition of mitotic cell cycle (GO:1900087)](https://www.ebi.ac.uk/QuickGO/term/GO:1900087). Beyond cell division, [STIL](/details-gene/6491) has profound roles in embryonic development. It is annotated in processes such as [Determination of left/right symmetry (GO:0007368)](https://www.ebi.ac.uk/QuickGO/term/GO:0007368), [Forebrain development (GO:0030900)](https://www.ebi.ac.uk/QuickGO/term/GO:0030900), and [Neural tube closure (GO:0001843)](https://www.ebi.ac.uk/QuickGO/term/GO:0001843). This developmental importance aligns with its association with congenital disorders and its function within the [Smoothened signaling pathway (GO:0007224)](https://www.ebi.ac.uk/QuickGO/term/GO:0007224), a key pathway in embryogenesis. ## Research Directions The role of [STIL](/details-gene/6491) as a tightly regulated component of cell division machinery makes its dysregulation a significant factor in pathology, particularly cancer. Overexpression of [STIL](/details-gene/6491) has been observed in lung cancer, where it correlates with increased mitotic activity ([Link](https://doi.org/10.1038/sj.onc.1207685)), and chromosomal rearrangements involving [STIL](/details-gene/6491) are a known cause of T-cell acute lymphoblastic leukemia ([Link](https://doi.org/10.1126/science.2255914)). This suggests that cancer cells co-opt its pro-proliferative functions to drive malignant growth. Based on its known functions and expression patterns, several testable hypotheses can be proposed: 1. **Hypothesis 1:** Given that phosphorylation of [STIL](/details-gene/6491) affects spindle checkpoint duration ([Link](https://doi.org/10.1128/mcb.25.15.6660-6672.2005)), its overexpression in tumors may lead to premature exit from mitosis and chromosomal instability. We hypothesize that *overexpressed STIL titrates away key checkpoint proteins, weakening the spindle assembly checkpoint and promoting aneuploidy in lung cancer cells.* 2. **Hypothesis 2:** The high significance of [STIL](/details-gene/6491) in [multi-ciliated epithelial cells](/details-cell/CL0005012) suggests a role beyond canonical mitotic centriole duplication. We hypothesize that *STIL is essential for the deuterosome-dependent pathway of centriole amplification required for multiciliogenesis, and mutations in STIL could be an underlying cause of ciliopathies characterized by defects in mucociliary clearance.* **Experimental Approach for Hypothesis 1:** To investigate the role of [STIL](/details-gene/6491) overexpression in promoting aneuploidy, one could use lung adenocarcinoma cell lines (e.g., A549) engineered with a doxycycline-inducible [STIL](/details-gene/6491) expression vector. Upon induction, cells could be synchronized and treated with a microtubule-destabilizing agent (e.g., nocodazole) to activate the spindle assembly checkpoint. The duration of mitotic arrest could be monitored via live-cell imaging of a fluorescent histone marker (H2B-mCherry). The fidelity of chromosome segregation could then be assessed by immunofluorescence staining for mitotic spindle components and DNA, followed by quantification of lagging chromosomes and micronuclei formation. **Therapeutic Potential:** [STIL](/details-gene/6491) represents a compelling therapeutic target in oncology. As an intracellular protein essential for cell division, its overexpression is a vulnerability in cancer cells. The therapeutic strategy would be **inhibition**. Developing small molecule inhibitors that disrupt the protein-protein interactions of [STIL](/details-gene/6491) with its binding partners (such as Plk4 or SAS-6) could selectively induce mitotic catastrophe in rapidly dividing cancer cells while potentially sparing quiescent, non-cancerous cells. Such a strategy could be particularly effective in tumors that are genetically dependent on high levels of [STIL](/details-gene/6491) function.

Genular Protein ID: 3708441810

Symbol: STIL_HUMAN

Name: SCL-interrupting locus protein

UniProtKB Accession Codes:

Q15468 Q5T0C5 Q68CN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 23 Ensembl 2 ExpressionAtlas 1 GO 28 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 9 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1922059

Title: Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.

PubMed ID: 1922059

DOI: 10.1128/mcb.11.11.5462-5469.1991

PubMed ID: 12438740

Title: The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly.

PubMed ID: 12438740

DOI: 10.1159/000064057

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2209547

Title: Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

PubMed ID: 2209547

DOI: 10.1002/j.1460-2075.1990.tb07535.x

PubMed ID: 2255914

Title: Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity.

PubMed ID: 2255914

DOI: 10.1126/science.2255914

PubMed ID: 1311214

Title: Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.

PubMed ID: 1311214

PubMed ID: 9372240

Title: Expression of the SIL gene is correlated with growth induction and cellular proliferation.

PubMed ID: 9372240

PubMed ID: 11390401

Title: Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints.

PubMed ID: 11390401

DOI: 10.1074/jbc.m103797200

PubMed ID: 12681356

Title: Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR.

PubMed ID: 12681356

DOI: 10.1016/s0145-2126(02)00260-6

PubMed ID: 14504110

Title: Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

PubMed ID: 14504110

DOI: 10.1182/blood-2003-05-1495

PubMed ID: 15107824

Title: Sil overexpression in lung cancer characterizes tumors with increased mitotic activity.

PubMed ID: 15107824

DOI: 10.1038/sj.onc.1207685

PubMed ID: 16024801

Title: Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint.

PubMed ID: 16024801

DOI: 10.1128/mcb.25.15.6660-6672.2005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19215732

Title: Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly.

PubMed ID: 19215732

DOI: 10.1016/j.ajhg.2009.01.017

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22020124

Title: The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.

PubMed ID: 22020124

DOI: 10.1038/emboj.2011.378

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25385835

Title: RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity.

PubMed ID: 25385835

DOI: 10.15252/embj.201488979

PubMed ID: 29712910

Title: Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.

PubMed ID: 29712910

DOI: 10.1038/s41467-018-04122-x

PubMed ID: 32107292

Title: Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.

PubMed ID: 32107292

DOI: 10.1242/jcs.238352

PubMed ID: 22989186

Title: Investigation of primary microcephaly in Bushehr province of Iran: novel STIL and ASPM mutations.

PubMed ID: 22989186

DOI: 10.1111/j.1399-0004.2012.01949.x

Sequence Information:

  • Length: 1287
  • Mass: 142955
  • Checksum: 7F15BEDA8717659C
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 
QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN SSSKETEQPS 
TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK QLRSLGVKID SPTKVKKNAH 
NVDHASVLAC ISPEAVISGL NCMSFANVGM SGLSPNGVDL SMEANAIALK YLNENQLSQL 
SVTRSNQNNC DPFSLLHINT DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE 
PPDNADSKSE YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 
EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT IFPESLQPSE 
TLKQMNSMNS VGTFLDVKRL RQLPKLF

Genular Protein ID: 2178983036

Symbol: Q5T0C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T0C7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1223
  • Mass: 135858
  • Checksum: 5FE7491D3EE2CAC6
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCALARN LSSNLNISQV 
QGTYKYGYLT MDETRKLLLL LESDPKVYSL PLVGIWLSGI THIYSPQVWA CCLRYIFNSS 
VQERVFSESG NFIIVLYSMT HKEPEFYECF PCDGKIPDFR FQLLTSKETL HLFKNVEPPD 
KNPIRCELSA ESQNAETEFF SKASKNFSIK RSSQKLSSGK MPIHDHDSGV EDEDFSPRPI 
PSPHPVSQKI SKIQPSVPEL SLVLDGNFIE SNPLPTPLEM VNNENPPLIN HLEHLKPLQP 
QLYDEKHSPE VEAGEPSLRG IPNQLNQDKP ALLRHCKVRQ PPAYKKGNPH TRNSIKPSSH 
NGPSHDIFEK LQTVSAGNVQ NEEYPIRPST LNSRQSSLAP QSQPHDFVFS PHNSGRPMEL 
QIPTPPLPSY CSTNVCRCCQ HHSHIQYSPL NSWQGANTVG SIQDVQSEAL QKHSLFHPSG 
CPALYCNAFC SSSSPIALRP QGDMGSCSPH SNIEPSPVAR PPSHMDLCNP QPCTVCMHTP 
KTESDNGMMG LSPDAYRFLT EQDRQLRLLQ AQIQRLLEAQ SLMPCSPKTT AVEDTVQAGR 
QMELVSVEAQ SSPGLHMRKG VSIAVSTGAS LFWNAAGEDQ EPDSQMKQDD TKISSEDMNF 
SVDINNEVTS LPGSASSLKA VDIPSFEESN IAVEEEFNQP LSVSNGQLAE SVSMCLQTGP 
TGGASNNSET SEEPKIEHVM QPLLHQPSDN QKIYQDLLGQ VNHLLNSSSK ETEQPSTKAV 
IISHECTRTQ NVYHTKKKTH HSRLVDKDCV LNATLKQLRS LGVKIDSPTK VKKNAHNVDH 
ASVLACISPE AVISGLNCMS FANVGMSGLS PNGVDLSMEA NAIALKYLNE NQLSQLSVTR 
SNQNNCDPFS LLHINTDRST VGLSLISPNN MSFATKKYMK RYGLLQSSDN SEDEEEPPDN 
ADSKSEYLLN QNLRSIPEQL GGQKEPSKND HEIINCSNCE SVGTNADTPV LRNITNEVLQ 
TKAKQQLTEK PAFLVKNLKP SPAVNLRTGK AEFTQHPEKE NEGDITIFPE SLQPSETLKQ 
MNSMNSVGTF LDVKRLRQLP KLF

Genular Protein ID: 1968002639

Symbol: A0A0A0MR87_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR87

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 GO 2 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1241
  • Mass: 137831
  • Checksum: DD533F31CF91A6BD
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCALARN LSSNLNISQV 
QGTYKYGYLT MDETRKLLLL LESDPKVYSL PLVGIWLSGI THIYSPQVWA CCLRYIFNSS 
VQERVFSESG NFIIVLYSMT HKEPEFYECF PCDGKIPDFR FQLLTSKETL HLFKNVEPPD 
KNPIRCELSA ESQNAETEFF SKASKNFSIK RSSQKLSSGK MPIHDHDSGV EDEDFSPRPI 
PSPHPVSQKI SKIQPSVPEL SLVLDGNFIE SNPLPTPLEM VNNENPPLIN HLEHLKPLQP 
QLYDEKHSPE VEAGEPSLRG IPNQLNQDKP ALLRHCKVRQ PPAYKKGNPH TRNSIKPSSH 
NGPSHDIFEK LQTVSAGNVQ NEEYPIRPST LNSRQSSLAP QSQPHDFVFS PHNSGRPMEL 
QIPTPPLPSY CSTNVCRCCQ HHSHIQYSPL NSWQGANTVG SIQDVQSEAL QKHSLFHPSG 
CPALYCNAFC SSSSPIALRP QGDMGSCSPH SNIEPSPVAR PPSHMDLCNP QPCTVCMHTP 
KTESDNGMMG LSPDAYRFLT EQDRQLRLLQ AQIQRLLEAQ SLMPCSPKTT AVEDTVQAGR 
QMELVSVEAQ SSPGLHMRKG VSIAVSTGAS LFWNAAGEDQ EPDSQMKQDD TKISSEDMNF 
SVDINNEVTS LPGSASSLKA VDIPSFEESN IAVEEEFNQP LSVSNSSSLV VRKEPDVPVF 
FPSGQLAESV SMCLQTGPTG GASNNSETSE EPKIEHVMQP LLHQPSDNQK IYQDLLGQVN 
HLLNSSSKET EQPSTKAVII SHECTRTQNV YHTKKKTHHS RLVDKDCVLN ATLKQLRSLG 
VKIDSPTKVK KNAHNVDHAS VLACISPEAV ISGLNCMSFA NVGMSGLSPN GVDLSMEANA 
IALKYLNENQ LSQLSVTRSN QNNCDPFSLL HINTDRSTVG LSLISPNNMS FATKKYMKRY 
GLLQSSDNSE DEEEPPDNAD SKSEYLLNQN LRSIPEQLGG QKEPSKNDHE IINCSNCESV 
GTNADTPVLR NITNEVLQTK AKQQLTEKPA FLVKNLKPSP AVNLRTGKAE FTQHPEKENE 
GDITIFPESL QPSETLKQMN SMNSVGTFLD VKRLRQLPKL F

Genular Protein ID: 297162404

Symbol: E9PSF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PSF2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1270
  • Mass: 141069
  • Checksum: 5DC00F8F75409A72
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNGQLAESVS MCLQTGPTGG ASNNSETSEE 
PKIEHVMQPL LHQPSDNQKI YQDLLGQVNH LLNSSSKETE QPSTKAVIIS HECTRTQNVY 
HTKKKTHHSR LVDKDCVLNA TLKQLRSLGV KIDSPTKVKK NAHNVDHASV LACISPEAVI 
SGLNCMSFAN VGMSGLSPNG VDLSMEANAI ALKYLNENQL SQLSVTRSNQ NNCDPFSLLH 
INTDRSTVGL SLISPNNMSF ATKKYMKRYG LLQSSDNSED EEEPPDNADS KSEYLLNQNL 
RSIPEQLGGQ KEPSKNDHEI INCSNCESVG TNADTPVLRN ITNEVLQTKA KQQLTEKPAF 
LVKNLKPSPA VNLRTGKAEF TQHPEKENEG DITIFPESLQ PSETLKQMNS MNSVGTFLDV 
KRLRQLPKLF

Genular Protein ID: 2324414953

Symbol: Q7Z626_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z626

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 919
  • Mass: 102385
  • Checksum: E5ACBEEE134B1F35
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTVDEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCALARN LSSNLNISQV 
QGTYKYGYLT MDETRKLLLL LESDPKVYSL PLVGIWLSGI THIYSPQVWA CCLRYIFNSS 
VQERVFSESG NFIIVLYSMT HKEPEFYECF PCDGKIPDFR FQLLTSKETL HLFKNVEPPD 
KNPIRCELSA ESQNAETEFF SKASKNFSIK RSSQKLSSGK MPIHDHDSGV EDEDFSPRPI 
PSPHPVSQKI SKIQPSVPEL SLVLDGNFIE SNPLPTPLEM VNNENPPLIN HLEHLKPLQP 
QLYDEKHSPE VEAGEPSLRG IPNQLNQDKP ALLRHCKVRQ PPAYKKGNPH TRNSIKPSSH 
NGPSHDIFEK LQTVSAGNVQ NEEYPIRPST LNSRQSSLAP QSQPHDFVFS PHNSGRPMEL 
QIPTPPLPSY CSTNVCRCCQ HHSHIQYSPL NSWQGANTVG SIQDVQSEAL QKHSLFHPSG 
CPALYCNAFC SSSSPIALRP QGDMGSCSPH SNIEPSPVAR PPSHMDLCNP QPCTVCMHTP 
KTESDNGMMG LSPDAYRFLT EQDRQLRLLQ AQIQRLLEAQ SLMPCSPKTT AVEDTVQAGR 
QMELVSVEAQ SSPGLHMRKG VSIAVSTGAS LFWNAAGEDQ EPDSQMKQDD TKISSEDMNF 
SVDINNEVTS LPGSASSLKA VDIPSFEESN IAVEEEFNQP LSVSNGQLAE SVSMCLQTGP 
TGGASNNSET SEEPKIEHVM QPLLHQPSDN QKIYQDLLGQ VNHLLNSSSK ETEQPSTKAV 
IISHECTRTQ NVYHTKKKK

Genular Protein ID: 3019953756

Symbol: B7ZLW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLW5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMR 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1270
  • Mass: 141116
  • Checksum: 7CD09826D50D9441
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTVDEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNGQLAESVS MCLQTGPTGG ASNNSETSEE 
PKIEHVMQPL LHQPSDNQKI YQDLLGQVNH LLNSSSKETE QPSTKAVIIS HECTRTQNVY 
HTKKKTRHSR LVDKDCVLNA TLKQLRSLGV KIDSPTKVKK NAHNVDHASV LACISPEAVI 
SGLNCMSFAN VGMSGLSPNG VDLSMEANAI ALKYLNENQL SQLSVTRSNQ NNCDPFSLLH 
INTDRSTVGL SLISPNNMSF ATKKYMKRYG LLQSSDNSED EEEPPDNADS KSEYLLNQNL 
RSIPEQLGGQ KEPSKNDHEI INCSNCESVG TNADTPVLRN ITNEVLQTKA KQQLTEKPAF 
LVKNLKPSPA VNLRTGKAEF TQHPEKENEG DITIFPESLQ PSETLKQMNS MNSVGTFLDV 
KRLRQLPKLF