Details for: STIL

Gene ID: 6491

Symbol: STIL

Ensembl ID: ENSG00000123473

Description: STIL centriolar assembly protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.0667
    Cell Significance Index: -5.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.0135
    Cell Significance Index: -8.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.3639
    Cell Significance Index: -8.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.9443
    Cell Significance Index: -7.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.6356
    Cell Significance Index: -7.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.6182
    Cell Significance Index: -8.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1186
    Cell Significance Index: -8.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9435
    Cell Significance Index: 93.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9426
    Cell Significance Index: 179.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8681
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6148
    Cell Significance Index: 99.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5847
    Cell Significance Index: 16.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5752
    Cell Significance Index: 32.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5737
    Cell Significance Index: 62.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5530
    Cell Significance Index: 109.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4973
    Cell Significance Index: 449.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4040
    Cell Significance Index: 18.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3925
    Cell Significance Index: 10.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3581
    Cell Significance Index: 21.5000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3377
    Cell Significance Index: 3.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2623
    Cell Significance Index: 3.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2601
    Cell Significance Index: 9.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2413
    Cell Significance Index: 28.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2228
    Cell Significance Index: 3.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2135
    Cell Significance Index: 11.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1908
    Cell Significance Index: 22.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1883
    Cell Significance Index: 4.0800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1764
    Cell Significance Index: 2.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1704
    Cell Significance Index: 34.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1605
    Cell Significance Index: 110.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1193
    Cell Significance Index: 2.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1164
    Cell Significance Index: 2.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1133
    Cell Significance Index: 7.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0938
    Cell Significance Index: 51.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0776
    Cell Significance Index: 2.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0631
    Cell Significance Index: 22.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0427
    Cell Significance Index: 7.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0385
    Cell Significance Index: 4.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0373
    Cell Significance Index: 2.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0305
    Cell Significance Index: 1.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0298
    Cell Significance Index: 0.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0226
    Cell Significance Index: 9.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0105
    Cell Significance Index: 16.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0088
    Cell Significance Index: 16.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0047
    Cell Significance Index: 8.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -4.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0080
    Cell Significance Index: -1.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0104
    Cell Significance Index: -7.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.7900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0139
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0147
    Cell Significance Index: -9.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0209
    Cell Significance Index: -2.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0249
    Cell Significance Index: -7.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0300
    Cell Significance Index: -0.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0367
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0395
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0422
    Cell Significance Index: -4.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0436
    Cell Significance Index: -1.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0458
    Cell Significance Index: -2.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0463
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0468
    Cell Significance Index: -9.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0555
    Cell Significance Index: -4.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0562
    Cell Significance Index: -2.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0569
    Cell Significance Index: -5.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0584
    Cell Significance Index: -3.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0664
    Cell Significance Index: -4.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0677
    Cell Significance Index: -4.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0698
    Cell Significance Index: -4.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0731
    Cell Significance Index: -2.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0733
    Cell Significance Index: -1.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0735
    Cell Significance Index: -4.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0764
    Cell Significance Index: -7.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1075
    Cell Significance Index: -2.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1079
    Cell Significance Index: -1.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1094
    Cell Significance Index: -8.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1201
    Cell Significance Index: -1.8100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1207
    Cell Significance Index: -0.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1343
    Cell Significance Index: -2.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1454
    Cell Significance Index: -4.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1500
    Cell Significance Index: -3.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1509
    Cell Significance Index: -3.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1527
    Cell Significance Index: -1.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1535
    Cell Significance Index: -4.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1539
    Cell Significance Index: -8.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1553
    Cell Significance Index: -5.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1596
    Cell Significance Index: -4.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1631
    Cell Significance Index: -5.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1653
    Cell Significance Index: -3.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1658
    Cell Significance Index: -2.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1718
    Cell Significance Index: -4.6000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1925
    Cell Significance Index: -1.1400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1939
    Cell Significance Index: -1.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2134
    Cell Significance Index: -4.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Centriolar Assembly Protein:** STIL is a centriolar assembly protein, which means it is involved in the formation and maintenance of centrioles, the core structures of the centrosome. 2. **Regulation of Centriole Replication:** STIL regulates centriole replication, ensuring that the correct number of centrioles is produced during cell division. 3. **Spindle Assembly and Mitotic Spindle Organization:** STIL is involved in the regulation of spindle assembly and mitotic spindle organization, which are critical for accurate cell division and proper chromosome segregation. 4. **Developmental Symmetry:** STIL plays a role in determining left/right symmetry and embryonic axis specification, highlighting its importance in embryonic development. 5. **Expression in Specific Cell Types:** STIL is expressed in various cell types, including cardiac endothelial cells, epithelial cells, and neural cells, underscoring its broad involvement in cellular development and function. **Pathways and Functions:** 1. **Cell Cortex and Cytoskeleton:** STIL is involved in the regulation of the cell cortex and cytoskeleton, which are essential for cell shape, movement, and division. 2. **Centrosome Duplication:** STIL regulates centrosome duplication, ensuring that the correct number of centrosomes is produced during cell division. 3. **Mitotic Spindle Organization:** STIL is involved in the regulation of mitotic spindle organization, which is critical for accurate cell division and proper chromosome segregation. 4. **Procentriole Replication Complex:** STIL is part of the procentriole replication complex, which is responsible for the replication of centrioles. 5. **Regulation of Apoptotic Process:** STIL is involved in the regulation of the apoptotic process, which is essential for cell survival and development. **Clinical Significance:** 1. **Developmental Abnormalities:** Abnormal expression of STIL has been linked to various developmental abnormalities, including left/right asymmetry, embryonic axis specification, and neural tube closure. 2. **Diseases:** STIL dysfunction has been implicated in various diseases, including heart looping, forebrain development, and neural tube development. 3. **Cancer:** STIL may play a role in cancer development and progression, as its dysregulation can lead to uncontrolled cell growth and division. 4. **Therapeutic Targets:** Understanding the role of STIL in development and disease may lead to the identification of new therapeutic targets for treating developmental abnormalities and diseases. In conclusion, the STIL gene is a crucial regulator of centriolar assembly, spindle assembly, and mitotic spindle organization, playing a pivotal role in developmental symmetry and cellular development. Its dysregulation has been implicated in various developmental abnormalities and diseases, highlighting its importance in maintaining proper cellular and organismal function.

Genular Protein ID: 3708441810

Symbol: STIL_HUMAN

Name: SCL-interrupting locus protein

UniProtKB Accession Codes:

Q15468 Q5T0C5 Q68CN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 23 Ensembl 2 ExpressionAtlas 1 GO 28 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 9 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1922059

Title: Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.

PubMed ID: 1922059

DOI: 10.1128/mcb.11.11.5462-5469.1991

PubMed ID: 12438740

Title: The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly.

PubMed ID: 12438740

DOI: 10.1159/000064057

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2209547

Title: Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

PubMed ID: 2209547

DOI: 10.1002/j.1460-2075.1990.tb07535.x

PubMed ID: 2255914

Title: Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity.

PubMed ID: 2255914

DOI: 10.1126/science.2255914

PubMed ID: 1311214

Title: Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.

PubMed ID: 1311214

PubMed ID: 9372240

Title: Expression of the SIL gene is correlated with growth induction and cellular proliferation.

PubMed ID: 9372240

PubMed ID: 11390401

Title: Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints.

PubMed ID: 11390401

DOI: 10.1074/jbc.m103797200

PubMed ID: 12681356

Title: Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR.

PubMed ID: 12681356

DOI: 10.1016/s0145-2126(02)00260-6

PubMed ID: 14504110

Title: Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

PubMed ID: 14504110

DOI: 10.1182/blood-2003-05-1495

PubMed ID: 15107824

Title: Sil overexpression in lung cancer characterizes tumors with increased mitotic activity.

PubMed ID: 15107824

DOI: 10.1038/sj.onc.1207685

PubMed ID: 16024801

Title: Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint.

PubMed ID: 16024801

DOI: 10.1128/mcb.25.15.6660-6672.2005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19215732

Title: Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly.

PubMed ID: 19215732

DOI: 10.1016/j.ajhg.2009.01.017

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22020124

Title: The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.

PubMed ID: 22020124

DOI: 10.1038/emboj.2011.378

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25385835

Title: RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity.

PubMed ID: 25385835

DOI: 10.15252/embj.201488979

PubMed ID: 29712910

Title: Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.

PubMed ID: 29712910

DOI: 10.1038/s41467-018-04122-x

PubMed ID: 32107292

Title: Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.

PubMed ID: 32107292

DOI: 10.1242/jcs.238352

PubMed ID: 22989186

Title: Investigation of primary microcephaly in Bushehr province of Iran: novel STIL and ASPM mutations.

PubMed ID: 22989186

DOI: 10.1111/j.1399-0004.2012.01949.x

Sequence Information:

  • Length: 1287
  • Mass: 142955
  • Checksum: 7F15BEDA8717659C
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 
QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN SSSKETEQPS 
TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK QLRSLGVKID SPTKVKKNAH 
NVDHASVLAC ISPEAVISGL NCMSFANVGM SGLSPNGVDL SMEANAIALK YLNENQLSQL 
SVTRSNQNNC DPFSLLHINT DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE 
PPDNADSKSE YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 
EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT IFPESLQPSE 
TLKQMNSMNS VGTFLDVKRL RQLPKLF

Genular Protein ID: 2178983036

Symbol: Q5T0C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T0C7

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1223
  • Mass: 135858
  • Checksum: 5FE7491D3EE2CAC6
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCALARN LSSNLNISQV 
QGTYKYGYLT MDETRKLLLL LESDPKVYSL PLVGIWLSGI THIYSPQVWA CCLRYIFNSS 
VQERVFSESG NFIIVLYSMT HKEPEFYECF PCDGKIPDFR FQLLTSKETL HLFKNVEPPD 
KNPIRCELSA ESQNAETEFF SKASKNFSIK RSSQKLSSGK MPIHDHDSGV EDEDFSPRPI 
PSPHPVSQKI SKIQPSVPEL SLVLDGNFIE SNPLPTPLEM VNNENPPLIN HLEHLKPLQP 
QLYDEKHSPE VEAGEPSLRG IPNQLNQDKP ALLRHCKVRQ PPAYKKGNPH TRNSIKPSSH 
NGPSHDIFEK LQTVSAGNVQ NEEYPIRPST LNSRQSSLAP QSQPHDFVFS PHNSGRPMEL 
QIPTPPLPSY CSTNVCRCCQ HHSHIQYSPL NSWQGANTVG SIQDVQSEAL QKHSLFHPSG 
CPALYCNAFC SSSSPIALRP QGDMGSCSPH SNIEPSPVAR PPSHMDLCNP QPCTVCMHTP 
KTESDNGMMG LSPDAYRFLT EQDRQLRLLQ AQIQRLLEAQ SLMPCSPKTT AVEDTVQAGR 
QMELVSVEAQ SSPGLHMRKG VSIAVSTGAS LFWNAAGEDQ EPDSQMKQDD TKISSEDMNF 
SVDINNEVTS LPGSASSLKA VDIPSFEESN IAVEEEFNQP LSVSNGQLAE SVSMCLQTGP 
TGGASNNSET SEEPKIEHVM QPLLHQPSDN QKIYQDLLGQ VNHLLNSSSK ETEQPSTKAV 
IISHECTRTQ NVYHTKKKTH HSRLVDKDCV LNATLKQLRS LGVKIDSPTK VKKNAHNVDH 
ASVLACISPE AVISGLNCMS FANVGMSGLS PNGVDLSMEA NAIALKYLNE NQLSQLSVTR 
SNQNNCDPFS LLHINTDRST VGLSLISPNN MSFATKKYMK RYGLLQSSDN SEDEEEPPDN 
ADSKSEYLLN QNLRSIPEQL GGQKEPSKND HEIINCSNCE SVGTNADTPV LRNITNEVLQ 
TKAKQQLTEK PAFLVKNLKP SPAVNLRTGK AEFTQHPEKE NEGDITIFPE SLQPSETLKQ 
MNSMNSVGTF LDVKRLRQLP KLF

Genular Protein ID: 1968002639

Symbol: A0A0A0MR87_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR87

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 3 GO 2 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1241
  • Mass: 137831
  • Checksum: DD533F31CF91A6BD
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCALARN LSSNLNISQV 
QGTYKYGYLT MDETRKLLLL LESDPKVYSL PLVGIWLSGI THIYSPQVWA CCLRYIFNSS 
VQERVFSESG NFIIVLYSMT HKEPEFYECF PCDGKIPDFR FQLLTSKETL HLFKNVEPPD 
KNPIRCELSA ESQNAETEFF SKASKNFSIK RSSQKLSSGK MPIHDHDSGV EDEDFSPRPI 
PSPHPVSQKI SKIQPSVPEL SLVLDGNFIE SNPLPTPLEM VNNENPPLIN HLEHLKPLQP 
QLYDEKHSPE VEAGEPSLRG IPNQLNQDKP ALLRHCKVRQ PPAYKKGNPH TRNSIKPSSH 
NGPSHDIFEK LQTVSAGNVQ NEEYPIRPST LNSRQSSLAP QSQPHDFVFS PHNSGRPMEL 
QIPTPPLPSY CSTNVCRCCQ HHSHIQYSPL NSWQGANTVG SIQDVQSEAL QKHSLFHPSG 
CPALYCNAFC SSSSPIALRP QGDMGSCSPH SNIEPSPVAR PPSHMDLCNP QPCTVCMHTP 
KTESDNGMMG LSPDAYRFLT EQDRQLRLLQ AQIQRLLEAQ SLMPCSPKTT AVEDTVQAGR 
QMELVSVEAQ SSPGLHMRKG VSIAVSTGAS LFWNAAGEDQ EPDSQMKQDD TKISSEDMNF 
SVDINNEVTS LPGSASSLKA VDIPSFEESN IAVEEEFNQP LSVSNSSSLV VRKEPDVPVF 
FPSGQLAESV SMCLQTGPTG GASNNSETSE EPKIEHVMQP LLHQPSDNQK IYQDLLGQVN 
HLLNSSSKET EQPSTKAVII SHECTRTQNV YHTKKKTHHS RLVDKDCVLN ATLKQLRSLG 
VKIDSPTKVK KNAHNVDHAS VLACISPEAV ISGLNCMSFA NVGMSGLSPN GVDLSMEANA 
IALKYLNENQ LSQLSVTRSN QNNCDPFSLL HINTDRSTVG LSLISPNNMS FATKKYMKRY 
GLLQSSDNSE DEEEPPDNAD SKSEYLLNQN LRSIPEQLGG QKEPSKNDHE IINCSNCESV 
GTNADTPVLR NITNEVLQTK AKQQLTEKPA FLVKNLKPSP AVNLRTGKAE FTQHPEKENE 
GDITIFPESL QPSETLKQMN SMNSVGTFLD VKRLRQLPKL F

Genular Protein ID: 297162404

Symbol: E9PSF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PSF2

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1270
  • Mass: 141069
  • Checksum: 5DC00F8F75409A72
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNGQLAESVS MCLQTGPTGG ASNNSETSEE 
PKIEHVMQPL LHQPSDNQKI YQDLLGQVNH LLNSSSKETE QPSTKAVIIS HECTRTQNVY 
HTKKKTHHSR LVDKDCVLNA TLKQLRSLGV KIDSPTKVKK NAHNVDHASV LACISPEAVI 
SGLNCMSFAN VGMSGLSPNG VDLSMEANAI ALKYLNENQL SQLSVTRSNQ NNCDPFSLLH 
INTDRSTVGL SLISPNNMSF ATKKYMKRYG LLQSSDNSED EEEPPDNADS KSEYLLNQNL 
RSIPEQLGGQ KEPSKNDHEI INCSNCESVG TNADTPVLRN ITNEVLQTKA KQQLTEKPAF 
LVKNLKPSPA VNLRTGKAEF TQHPEKENEG DITIFPESLQ PSETLKQMNS MNSVGTFLDV 
KRLRQLPKLF

Genular Protein ID: 2324414953

Symbol: Q7Z626_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z626

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 919
  • Mass: 102385
  • Checksum: E5ACBEEE134B1F35
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTVDEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCALARN LSSNLNISQV 
QGTYKYGYLT MDETRKLLLL LESDPKVYSL PLVGIWLSGI THIYSPQVWA CCLRYIFNSS 
VQERVFSESG NFIIVLYSMT HKEPEFYECF PCDGKIPDFR FQLLTSKETL HLFKNVEPPD 
KNPIRCELSA ESQNAETEFF SKASKNFSIK RSSQKLSSGK MPIHDHDSGV EDEDFSPRPI 
PSPHPVSQKI SKIQPSVPEL SLVLDGNFIE SNPLPTPLEM VNNENPPLIN HLEHLKPLQP 
QLYDEKHSPE VEAGEPSLRG IPNQLNQDKP ALLRHCKVRQ PPAYKKGNPH TRNSIKPSSH 
NGPSHDIFEK LQTVSAGNVQ NEEYPIRPST LNSRQSSLAP QSQPHDFVFS PHNSGRPMEL 
QIPTPPLPSY CSTNVCRCCQ HHSHIQYSPL NSWQGANTVG SIQDVQSEAL QKHSLFHPSG 
CPALYCNAFC SSSSPIALRP QGDMGSCSPH SNIEPSPVAR PPSHMDLCNP QPCTVCMHTP 
KTESDNGMMG LSPDAYRFLT EQDRQLRLLQ AQIQRLLEAQ SLMPCSPKTT AVEDTVQAGR 
QMELVSVEAQ SSPGLHMRKG VSIAVSTGAS LFWNAAGEDQ EPDSQMKQDD TKISSEDMNF 
SVDINNEVTS LPGSASSLKA VDIPSFEESN IAVEEEFNQP LSVSNGQLAE SVSMCLQTGP 
TGGASNNSET SEEPKIEHVM QPLLHQPSDN QKIYQDLLGQ VNHLLNSSSK ETEQPSTKAV 
IISHECTRTQ NVYHTKKKK

Genular Protein ID: 3019953756

Symbol: B7ZLW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLW5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMR 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1270
  • Mass: 141116
  • Checksum: 7CD09826D50D9441
  • Sequence:
    • MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 
TIRLAYRHAK QNKKNSSCFL LGSLTVDEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNGQLAESVS MCLQTGPTGG ASNNSETSEE 
PKIEHVMQPL LHQPSDNQKI YQDLLGQVNH LLNSSSKETE QPSTKAVIIS HECTRTQNVY 
HTKKKTRHSR LVDKDCVLNA TLKQLRSLGV KIDSPTKVKK NAHNVDHASV LACISPEAVI 
SGLNCMSFAN VGMSGLSPNG VDLSMEANAI ALKYLNENQL SQLSVTRSNQ NNCDPFSLLH 
INTDRSTVGL SLISPNNMSF ATKKYMKRYG LLQSSDNSED EEEPPDNADS KSEYLLNQNL 
RSIPEQLGGQ KEPSKNDHEI INCSNCESVG TNADTPVLRN ITNEVLQTKA KQQLTEKPAF 
LVKNLKPSPA VNLRTGKAEF TQHPEKENEG DITIFPESLQ PSETLKQMNS MNSVGTFLDV 
KRLRQLPKLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.