Details for: SKIL

Gene ID: 6498

Symbol: SKIL

Ensembl ID: ENSG00000136603

Description: SKI like proto-oncogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 395.3834
    Cell Significance Index: -61.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 237.1046
    Cell Significance Index: -60.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 154.1701
    Cell Significance Index: -63.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 127.1492
    Cell Significance Index: -60.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.6225
    Cell Significance Index: -49.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.8836
    Cell Significance Index: -56.5200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 89.5798
    Cell Significance Index: -60.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.3387
    Cell Significance Index: -49.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.9045
    Cell Significance Index: -61.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.7630
    Cell Significance Index: -58.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.6562
    Cell Significance Index: -61.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3520
    Cell Significance Index: -41.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.2186
    Cell Significance Index: -28.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8565
    Cell Significance Index: 301.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8150
    Cell Significance Index: 101.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7765
    Cell Significance Index: 92.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6717
    Cell Significance Index: 47.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3810
    Cell Significance Index: 37.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3070
    Cell Significance Index: 68.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2540
    Cell Significance Index: 251.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1734
    Cell Significance Index: 150.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0276
    Cell Significance Index: 111.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9220
    Cell Significance Index: 23.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9091
    Cell Significance Index: 180.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7959
    Cell Significance Index: 47.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7162
    Cell Significance Index: 98.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6681
    Cell Significance Index: 66.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5039
    Cell Significance Index: 61.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4807
    Cell Significance Index: 21.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4284
    Cell Significance Index: 20.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4204
    Cell Significance Index: 185.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3268
    Cell Significance Index: 58.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3088
    Cell Significance Index: 168.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2767
    Cell Significance Index: 249.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2764
    Cell Significance Index: 6.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2712
    Cell Significance Index: 7.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2396
    Cell Significance Index: 11.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2167
    Cell Significance Index: 25.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1363
    Cell Significance Index: 25.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1337
    Cell Significance Index: 92.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0963
    Cell Significance Index: 12.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0820
    Cell Significance Index: 5.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0813
    Cell Significance Index: 29.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0763
    Cell Significance Index: 48.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0568
    Cell Significance Index: 106.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0521
    Cell Significance Index: 80.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0411
    Cell Significance Index: 0.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0346
    Cell Significance Index: 2.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0227
    Cell Significance Index: 3.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0134
    Cell Significance Index: 18.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0126
    Cell Significance Index: 23.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0184
    Cell Significance Index: -11.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0239
    Cell Significance Index: -17.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0384
    Cell Significance Index: -1.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0511
    Cell Significance Index: -37.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0522
    Cell Significance Index: -23.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0628
    Cell Significance Index: -47.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0711
    Cell Significance Index: -40.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0904
    Cell Significance Index: -6.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0925
    Cell Significance Index: -9.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1284
    Cell Significance Index: -9.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1369
    Cell Significance Index: -8.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1554
    Cell Significance Index: -2.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1670
    Cell Significance Index: -48.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1690
    Cell Significance Index: -35.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1732
    Cell Significance Index: -20.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1835
    Cell Significance Index: -26.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1855
    Cell Significance Index: -12.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1890
    Cell Significance Index: -13.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2453
    Cell Significance Index: -6.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2996
    Cell Significance Index: -15.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3051
    Cell Significance Index: -34.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3422
    Cell Significance Index: -39.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3459
    Cell Significance Index: -3.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3571
    Cell Significance Index: -12.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3990
    Cell Significance Index: -24.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4329
    Cell Significance Index: -8.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4429
    Cell Significance Index: -5.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4806
    Cell Significance Index: -5.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4883
    Cell Significance Index: -9.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4978
    Cell Significance Index: -9.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5468
    Cell Significance Index: -7.4600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5657
    Cell Significance Index: -6.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5666
    Cell Significance Index: -59.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5712
    Cell Significance Index: -15.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6532
    Cell Significance Index: -51.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6536
    Cell Significance Index: -28.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6849
    Cell Significance Index: -9.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7298
    Cell Significance Index: -36.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7434
    Cell Significance Index: -23.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7466
    Cell Significance Index: -16.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7518
    Cell Significance Index: -21.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7691
    Cell Significance Index: -16.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8111
    Cell Significance Index: -49.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8164
    Cell Significance Index: -30.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9096
    Cell Significance Index: -19.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9129
    Cell Significance Index: -24.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0525
    Cell Significance Index: -31.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1578
    Cell Significance Index: -33.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.1868
    Cell Significance Index: -18.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SKIL is a transcriptional regulator that belongs to the Ski family of proteins, which are known to interact with various transcription factors and signaling molecules. The gene's expression is highly dynamic, with significant fluctuations in different cell types and developmental stages. SKIL's ability to bind to RNA polymerase II and other transcription factors suggests its involvement in regulating gene expression and transcriptional activity. Its negative regulatory functions in various signaling pathways, including TGF-β and extrinsic apoptotic pathways, underscore its role in modulating cellular responses to external stimuli. **Pathways and Functions** SKIL's involvement in multiple signaling pathways highlights its versatility and importance in regulating various cellular processes: 1. **TGF-β signaling pathway**: SKIL negatively regulates the TGF-β signaling pathway, which is crucial for cell growth, differentiation, and apoptosis. This regulation is essential for maintaining tissue homeostasis and preventing excessive cell proliferation. 2. **Extrinsic apoptotic signaling pathway**: SKIL positively regulates the extrinsic apoptotic signaling pathway via death domain receptors, which is involved in cell death and immune responses. This regulation is essential for eliminating damaged or unwanted cells. 3. **Intrinsic apoptotic signaling pathway**: SKIL also positively regulates the intrinsic apoptotic signaling pathway in response to DNA damage, which is crucial for maintaining genome stability and preventing cancer. 4. **Gene expression regulation**: SKIL's interaction with RNA polymerase II and other transcription factors suggests its involvement in regulating gene expression and transcriptional activity. 5. **Cell cycle regulation**: SKIL's negative regulatory functions in the TGF-β signaling pathway and other pathways suggest its role in regulating cell cycle progression and preventing excessive cell proliferation. **Clinical Significance** SKIL's involvement in various signaling pathways and cellular processes makes it a potential target for therapeutic interventions: 1. **Cancer therapy**: SKIL's negative regulatory functions in the TGF-β signaling pathway and other pathways suggest its potential as a therapeutic target in cancer treatment. Inhibiting SKIL activity may prevent excessive cell proliferation and tumor progression. 2. **Immune regulation**: SKIL's positive regulation of the extrinsic apoptotic signaling pathway via death domain receptors suggests its potential role in regulating immune responses. Modulating SKIL activity may be beneficial in treating autoimmune diseases or preventing excessive immune responses. 3. **Neurological disorders**: SKIL's expression in central nervous system macrophages and microglial cells suggests its potential involvement in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Regenerative medicine**: SKIL's role in regulating cell cycle progression and differentiation suggests its potential as a therapeutic target in regenerative medicine, particularly in tissue engineering and stem cell therapy. In conclusion, SKIL is a complex transcriptional regulator that plays a crucial role in regulating various cellular processes, including transcription, cell cycle, and apoptosis. Its involvement in multiple signaling pathways and cellular processes makes it a potential target for therapeutic interventions in various diseases, including cancer, immune disorders, and neurological disorders.

Genular Protein ID: 1931135158

Symbol: SKIL_HUMAN

Name: Ski-like protein

UniProtKB Accession Codes:

P12757 A6NGT1 B4DT50 O00464 P12756 Q07501

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2762147

Title: Isolation of human cDNA clones of ski and the ski-related gene, sno.

PubMed ID: 2762147

DOI: 10.1093/nar/17.14.5489

PubMed ID: 9207045

Title: Proto-oncogene Sno expression, alternative isoforms and immediate early serum response.

PubMed ID: 9207045

DOI: 10.1093/nar/25.14.2930

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8233802

Title: SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno.

PubMed ID: 8233802

DOI: 10.1093/nar/21.19.4632

PubMed ID: 15221015

Title: Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

PubMed ID: 15221015

DOI: 10.1038/sj.onc.1207885

PubMed ID: 17591695

Title: Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

PubMed ID: 17591695

DOI: 10.1128/mcb.00664-07

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 684
  • Mass: 76976
  • Checksum: 6A04D4ECEC214CF1
  • Sequence:
    • MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA 
PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 
FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL 
QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP 
QNGSVLPAKS SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG 
KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS 
QSKELTKTEA SKSISRQSEK AHSSGKLQKT VSYPDVSLEE QEKMDLKTSR ELCSRLDASI 
SNNSTSKRKS ESATCNLVRD INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK 
QQEKLNLILQ KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL QDELRQEREA 
RQKLEMMIKE LKLQILKSSK TAKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.