Details for: SLC2A4

Gene ID: 6517

Symbol: SLC2A4

Ensembl ID: ENSG00000181856

Description: solute carrier family 2 member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 25.4588
    Cell Significance Index: -3.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.0031
    Cell Significance Index: -4.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.2891
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.5738
    Cell Significance Index: -4.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.4620
    Cell Significance Index: 84.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3091
    Cell Significance Index: -4.0800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.5869
    Cell Significance Index: 41.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6619
    Cell Significance Index: 13.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6312
    Cell Significance Index: -3.5700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.3510
    Cell Significance Index: 15.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2593
    Cell Significance Index: 32.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7065
    Cell Significance Index: 10.4300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6518
    Cell Significance Index: 5.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5926
    Cell Significance Index: 15.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4982
    Cell Significance Index: 38.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4524
    Cell Significance Index: 9.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4435
    Cell Significance Index: 7.4600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3348
    Cell Significance Index: 4.8800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.3306
    Cell Significance Index: 1.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3073
    Cell Significance Index: 18.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1728
    Cell Significance Index: 32.8900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.1508
    Cell Significance Index: 1.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1486
    Cell Significance Index: 16.1700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1415
    Cell Significance Index: 1.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1253
    Cell Significance Index: 12.4000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1047
    Cell Significance Index: 1.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0671
    Cell Significance Index: 10.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0632
    Cell Significance Index: 1.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0595
    Cell Significance Index: 3.6500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0562
    Cell Significance Index: 0.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0491
    Cell Significance Index: 9.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0438
    Cell Significance Index: 19.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0411
    Cell Significance Index: 5.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0297
    Cell Significance Index: 26.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0234
    Cell Significance Index: 1.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0226
    Cell Significance Index: 42.5700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0207
    Cell Significance Index: 0.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0184
    Cell Significance Index: 1.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0068
    Cell Significance Index: 0.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0062
    Cell Significance Index: 0.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -4.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0032
    Cell Significance Index: -1.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0036
    Cell Significance Index: -0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0054
    Cell Significance Index: -2.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0069
    Cell Significance Index: -5.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0087
    Cell Significance Index: -1.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0101
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0130
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0148
    Cell Significance Index: -4.2600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0160
    Cell Significance Index: -0.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0178
    Cell Significance Index: -3.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0189
    Cell Significance Index: -2.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0246
    Cell Significance Index: -4.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0254
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0281
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0290
    Cell Significance Index: -3.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0312
    Cell Significance Index: -1.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0325
    Cell Significance Index: -1.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0515
    Cell Significance Index: -1.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0550
    Cell Significance Index: -0.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0551
    Cell Significance Index: -4.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0576
    Cell Significance Index: -2.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0582
    Cell Significance Index: -4.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0599
    Cell Significance Index: -2.1000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0689
    Cell Significance Index: -1.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0705
    Cell Significance Index: -3.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0718
    Cell Significance Index: -3.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0735
    Cell Significance Index: -3.8300
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0780
    Cell Significance Index: -0.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0807
    Cell Significance Index: -1.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0852
    Cell Significance Index: -4.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0870
    Cell Significance Index: -2.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0952
    Cell Significance Index: -5.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0975
    Cell Significance Index: -1.4700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1007
    Cell Significance Index: -1.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1087
    Cell Significance Index: -1.9200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1097
    Cell Significance Index: -1.7600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1099
    Cell Significance Index: -1.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1152
    Cell Significance Index: -1.6500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1170
    Cell Significance Index: -0.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1230
    Cell Significance Index: -5.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1253
    Cell Significance Index: -3.6900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1270
    Cell Significance Index: -1.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1317
    Cell Significance Index: -2.2700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1322
    Cell Significance Index: -1.2700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1327
    Cell Significance Index: -1.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Glucose Transporter:** GLUT4 is a type of glucose transporter that spans the plasma membrane, allowing glucose to enter cells. 2. **Insulin-Stimulated Uptake:** GLUT4 is primarily activated in response to insulin, facilitating the uptake of glucose into cells. 3. **Glucose Homeostasis:** The SLC2A4 gene plays a critical role in maintaining glucose homeostasis by regulating glucose uptake in various tissues. 4. **Cellular Regulation:** GLUT4 is involved in regulating various cellular processes, including energy metabolism, cell growth, and differentiation. **Pathways and Functions:** 1. **Amylopectin Biosynthetic Process:** GLUT4 plays a role in the biosynthesis of amylopectin, a key component of starch. 2. **Brown Fat Cell Differentiation:** The SLC2A4 gene is involved in the differentiation of brown adipose tissue (BAT) cells, which are critical for thermogenesis and energy expenditure. 3. **Carbohydrate Metabolic Process:** GLUT4 facilitates the uptake of glucose, which is essential for carbohydrate metabolism. 4. **Cellular Response to Hypoxia:** The SLC2A4 gene is involved in the cellular response to hypoxia, a condition characterized by reduced oxygen availability. 5. **Cellular Response to Tumor Necrosis Factor:** GLUT4 regulates the cellular response to tumor necrosis factor (TNF), a cytokine involved in inflammation and immune responses. **Clinical Significance:** 1. **Diabetes Mellitus:** Impaired GLUT4 function has been implicated in the pathogenesis of type 2 diabetes mellitus, a metabolic disorder characterized by insulin resistance and impaired glucose regulation. 2. **Cardiovascular Disease:** The SLC2A4 gene has been associated with cardiovascular disease, particularly in the context of hypertension and atherosclerosis. 3. **Cancer:** GLUT4 has been shown to be overexpressed in various cancers, including breast, lung, and colon cancer, suggesting its potential role in cancer progression and metastasis. 4. **Neurological Disorders:** The SLC2A4 gene has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke. In conclusion, the SLC2A4 gene plays a critical role in glucose metabolism and cellular regulation, and its dysregulation has been implicated in various diseases, including diabetes mellitus, cardiovascular disease, and cancer. Further research is needed to fully understand the functions and clinical significance of the SLC2A4 gene.

Genular Protein ID: 4113420038

Symbol: GLUT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P14672 Q05BQ3 Q14CX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 9 EMDB 2 Ensembl 4 ExpressionAtlas 1 GO 43 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2656669

Title: Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.

PubMed ID: 2656669

DOI: 10.1016/s0021-9258(18)83106-4

PubMed ID: 1397719

Title: Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.

PubMed ID: 1397719

DOI: 10.2337/diab.41.11.1436

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7916714

Title: Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter.

PubMed ID: 7916714

DOI: 10.1016/0378-1119(93)90438-9

PubMed ID: 8300557

Title: A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.

PubMed ID: 8300557

DOI: 10.1016/s0021-9258(17)41949-1

PubMed ID: 11842083

Title: The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.

PubMed ID: 11842083

DOI: 10.1074/jbc.m110294200

PubMed ID: 16647043

Title: Identification and characterization of p49/STRAP as a novel GLUT4-binding protein.

PubMed ID: 16647043

DOI: 10.1016/j.bbrc.2006.04.017

PubMed ID: 17382906

Title: Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.

PubMed ID: 17382906

DOI: 10.1016/j.bbrc.2007.03.029

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 28057756

Title: DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation.

PubMed ID: 28057756

DOI: 10.1074/jbc.m116.747139

PubMed ID: 1918382

Title: Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.

PubMed ID: 1918382

DOI: 10.1172/jci115437

PubMed ID: 1756912

Title: Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.

PubMed ID: 1756912

DOI: 10.2337/diab.40.12.1712

PubMed ID: 1521731

Title: Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.

PubMed ID: 1521731

DOI: 10.1007/bf02342449

Sequence Information:

  • Length: 509
  • Mass: 54787
  • Checksum: 8E20CD97562C1EBF
  • Sequence:
    • MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK VIEQSYNETW 
LGRQGPEGPS SIPPGTLTTL WALSVAIFSV GGMISSFLIG IISQWLGRKR AMLVNNVLAV 
LGGSLMGLAN AAASYEMLIL GRFLIGAYSG LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI 
VIGILIAQVL GLESLLGTAS LWPLLLGLTV LPALLQLVLL PFCPESPRYL YIIQNLEGPA 
RKSLKRLTGW ADVSGVLAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL 
SGINAVFYYS TSIFETAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR TLHLLGLAGM 
CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG PIPWFIVAEL FSQGPRPAAM 
AVAGFSNWTS NFIIGMGFQY VAEAMGPYVF LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS 
AAFHRTPSLL EQEVKPSTEL EYLGPDEND

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.