Details for: SLC22A4

Gene ID: 6583

Symbol: SLC22A4

Ensembl ID: ENSG00000197208

Description: solute carrier family 22 member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.4722
    Cell Significance Index: -8.4900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.3150
    Cell Significance Index: -1.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.6725
    Cell Significance Index: -8.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3611
    Cell Significance Index: -6.6100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.0495
    Cell Significance Index: 29.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2080
    Cell Significance Index: 29.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8352
    Cell Significance Index: 64.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.7058
    Cell Significance Index: 15.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6634
    Cell Significance Index: 126.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5332
    Cell Significance Index: 368.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3597
    Cell Significance Index: 72.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3357
    Cell Significance Index: 7.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3347
    Cell Significance Index: 5.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3171
    Cell Significance Index: 19.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3077
    Cell Significance Index: 18.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2827
    Cell Significance Index: 6.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2437
    Cell Significance Index: 220.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2255
    Cell Significance Index: 8.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2252
    Cell Significance Index: 22.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2225
    Cell Significance Index: 44.1600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2156
    Cell Significance Index: 2.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2136
    Cell Significance Index: 393.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1992
    Cell Significance Index: 4.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1944
    Cell Significance Index: 21.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1843
    Cell Significance Index: 8.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1799
    Cell Significance Index: 64.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1429
    Cell Significance Index: 219.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1315
    Cell Significance Index: 3.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1177
    Cell Significance Index: 19.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0986
    Cell Significance Index: 1.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0887
    Cell Significance Index: 4.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0839
    Cell Significance Index: 5.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0807
    Cell Significance Index: 2.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0748
    Cell Significance Index: 2.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0690
    Cell Significance Index: 4.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0571
    Cell Significance Index: 1.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0483
    Cell Significance Index: 65.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0257
    Cell Significance Index: 48.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0251
    Cell Significance Index: 0.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0243
    Cell Significance Index: 1.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0212
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0151
    Cell Significance Index: 8.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0149
    Cell Significance Index: 9.4400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0065
    Cell Significance Index: 0.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0035
    Cell Significance Index: 0.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0009
    Cell Significance Index: -0.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0029
    Cell Significance Index: -1.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0084
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0112
    Cell Significance Index: -0.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0126
    Cell Significance Index: -0.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0138
    Cell Significance Index: -1.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0139
    Cell Significance Index: -7.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0144
    Cell Significance Index: -1.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0161
    Cell Significance Index: -10.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0174
    Cell Significance Index: -2.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0238
    Cell Significance Index: -6.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0255
    Cell Significance Index: -3.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0361
    Cell Significance Index: -3.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0400
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0438
    Cell Significance Index: -7.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0475
    Cell Significance Index: -5.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0492
    Cell Significance Index: -0.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0505
    Cell Significance Index: -2.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0527
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0539
    Cell Significance Index: -6.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0670
    Cell Significance Index: -6.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0745
    Cell Significance Index: -8.7900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0778
    Cell Significance Index: -0.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0804
    Cell Significance Index: -3.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0817
    Cell Significance Index: -1.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0830
    Cell Significance Index: -5.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0846
    Cell Significance Index: -2.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0887
    Cell Significance Index: -4.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0930
    Cell Significance Index: -2.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1000
    Cell Significance Index: -2.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1063
    Cell Significance Index: -1.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1073
    Cell Significance Index: -6.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1130
    Cell Significance Index: -8.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1141
    Cell Significance Index: -2.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1183
    Cell Significance Index: -2.5200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1207
    Cell Significance Index: -1.2600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1249
    Cell Significance Index: -1.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1276
    Cell Significance Index: -4.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1312
    Cell Significance Index: -4.1800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1331
    Cell Significance Index: -1.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1403
    Cell Significance Index: -2.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1435
    Cell Significance Index: -9.2600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1470
    Cell Significance Index: -1.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1510
    Cell Significance Index: -4.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1511
    Cell Significance Index: -5.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC22A4 is a type of secondary active organic cation transporter, characterized by its ability to transport a wide range of molecules, including organic cations, amino acids, and xenobiotics, across cellular membranes. Its structure consists of a PDZ domain binding region, which allows it to interact with other proteins and modulate its activity. The protein is also capable of forming homodimers and heterodimers with other SLC transporters, further expanding its functional repertoire. **Pathways and Functions:** SLC22A4 is involved in several key transport processes, including: 1. **Acetate ester transport:** SLC22A4 plays a crucial role in the transport of acetate esters across cellular membranes, which is essential for maintaining cellular homeostasis and regulating metabolic processes. 2. **Amino acid import:** The protein is responsible for importing amino acids into cells, which is critical for protein synthesis and cellular growth. 3. **Neurotransmitter transport:** SLC22A4 is involved in the transport of neurotransmitters, such as acetylcholine, across synaptic membranes, which regulates neurotransmission and neuronal function. 4. **Xenobiotic transport:** The protein is capable of transporting a wide range of xenobiotics, including drugs and toxins, across cellular membranes, which is essential for maintaining cellular homeostasis and preventing toxicity. **Clinical Significance:** SLC22A4 has been implicated in various diseases and disorders, including: 1. **Alzheimer's disease:** Alterations in SLC22A4 expression have been linked to the development of Alzheimer's disease, highlighting its potential role in regulating neurotransmitter transport and maintaining cognitive function. 2. **Cancer:** The protein's ability to transport xenobiotics has led to its investigation as a potential target for cancer therapy. 3. **Kidney disease:** SLC22A4's role in regulating amino acid import and xenobiotic transport has led to its investigation as a potential biomarker for kidney disease. In conclusion, SLC22A4 is a multifunctional transporter protein that plays a critical role in maintaining cellular homeostasis and regulating various cellular processes. Its widespread expression and involvement in multiple transport processes make it an attractive target for therapeutic intervention in various diseases and disorders. Further research is needed to fully elucidate the function and clinical significance of SLC22A4, but its potential as a therapeutic target is clear.

Genular Protein ID: 4279282409

Symbol: S22A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H015 O14546

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 35 EMBL 5 Ensembl 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 7 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9426230

Title: Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1.

PubMed ID: 9426230

DOI: 10.1016/s0014-5793(97)01441-5

PubMed ID: 15795384

Title: Discovery of the ergothioneine transporter.

PubMed ID: 15795384

DOI: 10.1073/pnas.0408624102

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10215651

Title: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.

PubMed ID: 10215651

PubMed ID: 14608356

Title: An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.

PubMed ID: 14608356

DOI: 10.1038/ng1267

PubMed ID: 15832501

Title: Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.

PubMed ID: 15832501

DOI: 10.1021/mp0340082

PubMed ID: 16729965

Title: Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria.

PubMed ID: 16729965

DOI: 10.1016/j.bbrc.2006.05.026

PubMed ID: 20601551

Title: Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.

PubMed ID: 20601551

DOI: 10.1124/dmd.110.032763

PubMed ID: 22569296

Title: Regulation by physiological cations of acetylcholine transport mediated by human OCTN1 (SLC22A4). Implications in the non-neuronal cholinergic system.

PubMed ID: 22569296

DOI: 10.1016/j.lfs.2012.04.027

PubMed ID: 28209616

Title: OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.

PubMed ID: 28209616

DOI: 10.1158/0008-5472.can-16-2548

PubMed ID: 29530864

Title: Substrate Selectivity Check of the Ergothioneine Transporter.

PubMed ID: 29530864

DOI: 10.1124/dmd.118.080440

PubMed ID: 33124720

Title: Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.

PubMed ID: 33124720

DOI: 10.1096/fj.202001497r

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 12436193

Title: Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population.

PubMed ID: 12436193

DOI: 10.1007/s100380200088

PubMed ID: 15459889

Title: Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population.

PubMed ID: 15459889

DOI: 10.1002/jps.20190

PubMed ID: 15107849

Title: Functional variants of OCTN cation transporter genes are associated with Crohn disease.

PubMed ID: 15107849

DOI: 10.1038/ng1339

PubMed ID: 22206629

Title: The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease.

PubMed ID: 22206629

DOI: 10.1016/j.bbamem.2011.12.014

Sequence Information:

  • Length: 551
  • Mass: 62155
  • Checksum: C827A99AA78C9443
  • Sequence:
    • MRDYDEVIAF LGEWGPFQRL IFFLLSASII PNGFNGMSVV FLAGTPEHRC RVPDAANLSS 
AWRNNSVPLR LRDGREVPHS CSRYRLATIA NFSALGLEPG RDVDLGQLEQ ESCLDGWEFS 
QDVYLSTVVT EWNLVCEDNW KVPLTTSLFF VGVLLGSFVS GQLSDRFGRK NVLFATMAVQ 
TGFSFLQIFS ISWEMFTVLF VIVGMGQISN YVVAFILGTE ILGKSVRIIF STLGVCTFFA 
VGYMLLPLFA YFIRDWRMLL LALTVPGVLC VPLWWFIPES PRWLISQRRF REAEDIIQKA 
AKMNNIAVPA VIFDSVEELN PLKQQKAFIL DLFRTRNIAI MTIMSLLLWM LTSVGYFALS 
LDAPNLHGDA YLNCFLSALI EIPAYITAWL LLRTLPRRYI IAAVLFWGGG VLLFIQLVPV 
DYYFLSIGLV MLGKFGITSA FSMLYVFTAE LYPTLVRNMA VGVTSTASRV GSIIAPYFVY 
LGAYNRMLPY IVMGSLTVLI GILTLFFPES LGMTLPETLE QMQKVKWFRS GKKTRDSMET 
EENPKVLITA F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.