Details for: SMARCA1

Gene ID: 6594

Symbol: SMARCA1

Ensembl ID: ENSG00000102038

Description: SNF2 related chromatin remodeling ATPase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 310.0384
    Cell Significance Index: -48.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.9070
    Cell Significance Index: -47.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 105.3858
    Cell Significance Index: -49.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.7869
    Cell Significance Index: -42.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1945
    Cell Significance Index: -48.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 6.3136
    Cell Significance Index: 202.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5539
    Cell Significance Index: 506.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.1518
    Cell Significance Index: 57.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7835
    Cell Significance Index: 80.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4338
    Cell Significance Index: 74.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3206
    Cell Significance Index: 264.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2945
    Cell Significance Index: 34.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2481
    Cell Significance Index: 171.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1115
    Cell Significance Index: 29.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0675
    Cell Significance Index: 192.4300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.8783
    Cell Significance Index: 12.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8729
    Cell Significance Index: 107.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8706
    Cell Significance Index: 312.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8185
    Cell Significance Index: 50.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7973
    Cell Significance Index: 102.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7594
    Cell Significance Index: 685.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7495
    Cell Significance Index: 20.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7340
    Cell Significance Index: 507.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7322
    Cell Significance Index: 14.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7319
    Cell Significance Index: 41.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6835
    Cell Significance Index: 373.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6110
    Cell Significance Index: 27.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5648
    Cell Significance Index: 37.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5170
    Cell Significance Index: 39.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4921
    Cell Significance Index: 10.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4563
    Cell Significance Index: 17.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4514
    Cell Significance Index: 73.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4341
    Cell Significance Index: 20.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4202
    Cell Significance Index: 45.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4022
    Cell Significance Index: 20.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2460
    Cell Significance Index: 14.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2305
    Cell Significance Index: 6.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2059
    Cell Significance Index: 387.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1630
    Cell Significance Index: 3.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1572
    Cell Significance Index: 15.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1568
    Cell Significance Index: 71.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1409
    Cell Significance Index: 89.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1328
    Cell Significance Index: 25.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1204
    Cell Significance Index: 185.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0790
    Cell Significance Index: 145.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0774
    Cell Significance Index: 34.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0529
    Cell Significance Index: 1.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0393
    Cell Significance Index: 2.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0332
    Cell Significance Index: 0.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0146
    Cell Significance Index: 19.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0316
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0462
    Cell Significance Index: -34.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0501
    Cell Significance Index: -8.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0518
    Cell Significance Index: -29.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0694
    Cell Significance Index: -2.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0747
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0991
    Cell Significance Index: -20.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1069
    Cell Significance Index: -13.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1243
    Cell Significance Index: -18.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1410
    Cell Significance Index: -40.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1696
    Cell Significance Index: -12.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1939
    Cell Significance Index: -5.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2216
    Cell Significance Index: -25.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2255
    Cell Significance Index: -23.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2275
    Cell Significance Index: -26.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2335
    Cell Significance Index: -23.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2468
    Cell Significance Index: -12.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2477
    Cell Significance Index: -15.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2528
    Cell Significance Index: -11.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3095
    Cell Significance Index: -1.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3432
    Cell Significance Index: -21.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3462
    Cell Significance Index: -39.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3536
    Cell Significance Index: -6.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3692
    Cell Significance Index: -26.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3844
    Cell Significance Index: -20.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4191
    Cell Significance Index: -3.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4331
    Cell Significance Index: -51.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4487
    Cell Significance Index: -7.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4927
    Cell Significance Index: -6.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5249
    Cell Significance Index: -41.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5306
    Cell Significance Index: -11.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6009
    Cell Significance Index: -12.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6164
    Cell Significance Index: -8.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6483
    Cell Significance Index: -14.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6762
    Cell Significance Index: -11.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7435
    Cell Significance Index: -15.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7818
    Cell Significance Index: -50.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8220
    Cell Significance Index: -21.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8372
    Cell Significance Index: -12.3600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.8477
    Cell Significance Index: -4.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8533
    Cell Significance Index: -21.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8591
    Cell Significance Index: -12.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9279
    Cell Significance Index: -30.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9501
    Cell Significance Index: -30.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9737
    Cell Significance Index: -21.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9842
    Cell Significance Index: -28.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9907
    Cell Significance Index: -19.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** SMARCA1 shares significant structural homology with other members of the SWI/SNF family, suggesting its functional conservation across species. 2. **ATP-Dependent Chromatin Remodeling:** SMARCA1 exhibits ATP-dependent chromatin remodeling activity, enabling the dynamic reorganization of chromatin structure in response to cellular signals. 3. **Broad Tissue Expression:** SMARCA1 is expressed in a wide range of tissues, including cortical cells of the adrenal gland, hepatoblasts, enterocytes of the colon, and Sertoli cells, highlighting its importance in various cellular contexts. 4. **Protein-Protein Interactions:** SMARCA1 interacts with numerous proteins, including transcription factors, histone modifications, and other chromatin remodeling complexes, underscoring its central role in regulating gene expression. **Pathways and Functions:** 1. **Chromatin Remodeling:** SMARCA1 participates in the SWI/SNF complex, which regulates chromatin structure by exchanging nucleosomes and modulating transcription factor accessibility to DNA. 2. **Transcriptional Regulation:** As an ATP-dependent chromatin remodeler, SMARCA1 facilitates the recruitment of transcription factors to specific genomic regions, thereby regulating gene expression in response to cellular signals. 3. **Brain Development and Neuron Differentiation:** SMARCA1 plays a critical role in regulating brain development and neuron differentiation, highlighting its importance in the development of the central nervous system. 4. **Transcriptional Activation:** SMARCA1 acts as a positive regulator of DNA-templated transcription, influencing the activity of RNA polymerase II and other transcriptional regulators. **Clinical Significance:** 1. **Cancer Association:** SMARCA1 has been identified as a tumor suppressor gene, with mutations in this gene linked to various types of cancer, including breast cancer, prostate cancer, and melanoma. 2. **Neurological Disorders:** SMARCA1 mutations have also been associated with neurological disorders, such as Charcot-Marie-Tooth disease and progressive supranuclear palsy. 3. **Developmental Disorders:** SMARCA1 plays a critical role in brain development, and mutations in this gene have been linked to developmental disorders, including autism spectrum disorder and intellectual disability. 4. **Therapeutic Implications:** Targeting SMARCA1 in cancer therapy may provide a novel approach to treating these diseases, highlighting the potential of this gene as a therapeutic target. In conclusion, SMARCA1 is a crucial component of the SWI/SNF chromatin remodeling complex, playing a pivotal role in regulating gene expression and cellular function. Its involvement in various diseases, including cancer and neurological disorders, underscores its importance as a therapeutic target and highlights the need for further research into the molecular mechanisms underlying its function.

Genular Protein ID: 3649211879

Symbol: SMCA1_HUMAN

Name: Probable global transcription activator SNF2L1

UniProtKB Accession Codes:

P28370 Q5JV41 Q5JV42

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1408766

Title: Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae.

PubMed ID: 1408766

DOI: 10.1093/nar/20.17.4649

PubMed ID: 15310751

Title: A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling.

PubMed ID: 15310751

DOI: 10.1074/jbc.m406212200

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12112843

Title: Identification of the phosphotyrosine proteome from thrombin activated platelets.

PubMed ID: 12112843

DOI: 10.1002/1615-9861(200206)2:6<642::aid-prot642>3.0.co;2-i

PubMed ID: 14609955

Title: Isolation of human NURF: a regulator of Engrailed gene expression.

PubMed ID: 14609955

DOI: 10.1093/emboj/cdg582

PubMed ID: 15640247

Title: CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.

PubMed ID: 15640247

DOI: 10.1093/hmg/ddi048

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16740656

Title: The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells.

PubMed ID: 16740656

DOI: 10.1210/me.2005-0213

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 28801535

Title: Expansion of the ISWI chromatin remodeler family with new active complexes.

PubMed ID: 28801535

DOI: 10.15252/embr.201744011

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 26740508

Title: Identification of novel genetic causes of Rett syndrome-like phenotypes.

PubMed ID: 26740508

DOI: 10.1136/jmedgenet-2015-103568

Sequence Information:

  • Length: 1054
  • Mass: 122605
  • Checksum: D3FBFCA177F7D3C0
  • Sequence:
    • MEQDTAAVAA TVAAADATAT IVVIEDEQPG PSTSQEEGAA AAATEATAAT EKGEKKKEKN 
VSSFQLKLAA KAPKSEKEMD PEYEEKMKAD RAKRFEFLLK QTELFAHFIQ PSAQKSPTSP 
LNMKLGRPRI KKDEKQSLIS AGDYRHRRTE QEEDEELLSE SRKTSNVCIR FEVSPSYVKG 
GPLRDYQIRG LNWLISLYEN GVNGILADEM GLGKTLQTIA LLGYLKHYRN IPGPHMVLVP 
KSTLHNWMNE FKRWVPSLRV ICFVGDKDAR AAFIRDEMMP GEWDVCVTSY EMVIKEKSVF 
KKFHWRYLVI DEAHRIKNEK SKLSEIVREF KSTNRLLLTG TPLQNNLHEL WALLNFLLPD 
VFNSADDFDS WFDTKNCLGD QKLVERLHAV LKPFLLRRIK TDVEKSLPPK KEIKIYLGLS 
KMQREWYTKI LMKDIDVLNS SGKMDKMRLL NILMQLRKCC NHPYLFDGAE PGPPYTTDEH 
IVSNSGKMVV LDKLLAKLKE QGSRVLIFSQ MTRLLDILED YCMWRGYEYC RLDGQTPHEE 
REDKFLEVEF LGQREAIEAF NAPNSSKFIF MLSTRAGGLG INLASADVVI LYDSDWNPQV 
DLQAMDRAHR IGQKKPVRVF RLITDNTVEE RIVERAEIKL RLDSIVIQQG RLIDQQSNKL 
AKEEMLQMIR HGATHVFASK ESELTDEDIT TILERGEKKT AEMNERLQKM GESSLRNFRM 
DIEQSLYKFE GEDYREKQKL GMVEWIEPPK RERKANYAVD AYFREALRVS EPKIPKAPRP 
PKQPNVQDFQ FFPPRLFELL EKEILYYRKT IGYKVPRNPD IPNPALAQRE EQKKIDGAEP 
LTPEETEEKE KLLTQGFTNW TKRDFNQFIK ANEKYGRDDI DNIAREVEGK SPEEVMEYSA 
VFWERCNELQ DIEKIMAQIE RGEARIQRRI SIKKALDAKI ARYKAPFHQL RIQYGTSKGK 
NYTEEEDRFL ICMLHKMGFD RENVYEELRQ CVRNAPQFRF DWFIKSRTAM EFQRRCNTLI 
SLIEKENMEI EERERAEKKK RATKTPMVKF SAFS

Genular Protein ID: 1045992044

Symbol: A0A0A0MRP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MRP6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 5 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 13 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1058
  • Mass: 122864
  • Checksum: 662CB8EC20284A23
  • Sequence:
    • MEQDTAAVAA TVAAADATAT IVVIEDEQPG PSTSQEEGAA AAATEATAAT EKGEKKKEKN 
VSSFQLKLAA KAPKSEKEMD PEYEEKMKAD RAKRFEFLLK QTELFAHFIQ PSAQKSPTSP 
LNMKLGRPRI KKDEKQSLIS AGDYRHRRTE QEEDEELLSE SRKTSNVCIR FEVSPSYVKG 
GPLRDYQIRG LNWLISLYEN GVNGILADEM GLGKTLQTIA LLGYLKHYRN IPGPHMVLVP 
KSTLHNWMNE FKRWVPSLRV ICFVGDKDAR AAFIRDEMMP GEWDVCVTSY EMVIKEKSVF 
KKFHWRYLVI DEAHRIKNEK SKLSEIVREF KSTNRLLLTG TPLQNNLHEL WALLNFLLPD 
VFNSADDFDS WFDTKNCLGD QKLVERLHAV LKPFLLRRIK TDVEKSLPPK KEIKIYLGLS 
KMQREWYTKI LMKDIDVLNS SGKMDKMRLL NILMQLRKCC NHPYLFDGAE PGPPYTTDEH 
IVSNSGKMVV LDKLLAKLKE QGSRVLIFSQ MTRLLDILED YCMWRGYEYC RLDGQTPHEE 
REEAIEAFNA PNSSKFIFML STRAGGLGIN LASADVVILY DSDWNPQVDL QAMDRAHRIG 
QKKPVRVFRL ITDNTVEERI VERAEIKLRL DSIVIQQGRL IDQQSNKLAK EEMLQMIRHG 
ATHVFASKES ELTDEDITTI LERGEKKTAE MNERLQKMGE SSLRNFRMDI EQSLYKFEGE 
DYREKQKLGM VEWIEPPKRE RKANYAVDAY FREALRVSEP KIPKAPRPPK QPNVQDFQFF 
PPRLFELLEK EILYYRKTIG YKVPRNPDIP NPALAQREEQ KKIDGAEPLT PEETEEKEKL 
LTQGFTNWTK RDFNQFIKAN EKYGRDDIDN IAREVEGKSP EEVMEYSAVF WERCNELQDI 
EKIMAQIERG EARIQRRISI KKALDAKIAR YKAPFHQLRI QYGTSKGKNY TEEEDRFLIC 
MLHKMGFDRE NVYEELRQCV RNAPQFRFDW FIKSRTAMEF QRRCNTLISL IEKENMEIEE 
RERAEKKKRA TKTPMSQKRK AESATESSGK KDVKKVKS

Genular Protein ID: 3591830002

Symbol: B7ZLQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLQ5

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 11 Gene3D 5 GeneTree 1 HGNC 1 InterPro 13 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1070
  • Mass: 124327
  • Checksum: 4023C5E104DC7D9A
  • Sequence:
    • MEQDTAAVAA TVAAADATAT IVVIEDEQPG PSTSQEEGAA AAATEATAAT EKGEKKKEKN 
VSSFQLKLAA KAPKSEKEMD PEYEEKMKAD RAKRFEFLLK QTELFAHFIQ PSAQKSPTSP 
LNMKLGRPRI KKDEKQSLIS AGDYRHRRTE QEEDEELLSE SRKTSNVCIR FEVSPSYVKG 
GPLRDYQIRG LNWLISLYEN GVNGILADEM GLGKTLQTIA LLGYLKHYRN IPGPHMVLVP 
KSTLHNWMNE FKRWVPSLRV ICFVGDKDAR AAFIRDEMMP GEWDVCVTSY EMVIKEKSVF 
KKFHWRYLVI DEAHRIKNEK SKLSEIVREF KSTNRLLLTG TPLQNNLHEL WALLNFLLPD 
VFNSADDFDS WFDTKNCLGD QKLVERLHAV LKPFLLRRIK TDVEKSLPPK KEIKIYLGLS 
KMQREWYTKI LMKDIDVLNS SGKMDKMRLL NILMQLRKCC NHPYLFDGAE PGPPYTTDEH 
IVSNSGKMVV LDKLLAKLKE QGSRVLIFSQ MTRLLDILED YCMWRGYEYC RLDGQTPHEE 
REDKFLEVEF LGQREAIEAF NAPNSSKFIF MLSTRAGGLG INLASADVVI LYDSDWNPQV 
DLQAMDRAHR IGQKKPVRVF RLITDNTVEE RIVERAEIKL RLDSIVIQQG RLIDQQSNKL 
AKEEMLQMIR HGATHVFASK ESELTDEDIT TILERGEKKT AEMNERLQKM GESSLRNFRM 
DIEQSLYKFE GEDYREKQKL GMVEWIEPPK RERKANYAVD AYFREALRVS EPKIPKAPRP 
PKQPNVQDFQ FFPPRLFELL EKEILYYRKT IGYKVPRNPD IPNPALAQRE EQKKIDGAEP 
LTPEETEEKE KLLTQGFTNW TKRDFNQFIK ANEKYGRDDI DNIAREVEGK SPEEVMEYSA 
VFWERCNELQ DIEKIMAQIE RGEARIQRRI SIKKALDAKI ARYKAPFHQL RIQYGTSKGK 
NYTEEEDRFL ICMLHKMGFD RENVYEELRQ CVRNAPQFRF DWFIKSRTAM EFQRRCNTLI 
SLIEKENMEI EERERAEKKK RATKTPMSQK RKAESATESS GKKDVKKVKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.