Details for: HLTF

Gene ID: 6596

Symbol: HLTF

Ensembl ID: ENSG00000071794

Description: helicase like transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.7174
    Cell Significance Index: -32.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.9620
    Cell Significance Index: -36.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.7175
    Cell Significance Index: -36.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.8463
    Cell Significance Index: -40.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.1679
    Cell Significance Index: -31.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.6090
    Cell Significance Index: -40.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.7627
    Cell Significance Index: -31.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.8422
    Cell Significance Index: -39.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4427
    Cell Significance Index: -38.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6106
    Cell Significance Index: -32.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2381
    Cell Significance Index: -40.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7806
    Cell Significance Index: -14.8400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.5885
    Cell Significance Index: 27.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.6190
    Cell Significance Index: 259.0800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.1862
    Cell Significance Index: 52.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.0394
    Cell Significance Index: 25.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0168
    Cell Significance Index: 123.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7571
    Cell Significance Index: 98.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6286
    Cell Significance Index: 326.6900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3833
    Cell Significance Index: 10.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0360
    Cell Significance Index: 12.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0292
    Cell Significance Index: 711.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0152
    Cell Significance Index: 118.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0118
    Cell Significance Index: 362.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9553
    Cell Significance Index: 155.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8836
    Cell Significance Index: 33.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8736
    Cell Significance Index: 95.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7617
    Cell Significance Index: 33.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7521
    Cell Significance Index: 149.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7516
    Cell Significance Index: 39.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7116
    Cell Significance Index: 44.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.7022
    Cell Significance Index: 9.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6640
    Cell Significance Index: 39.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5727
    Cell Significance Index: 103.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4838
    Cell Significance Index: 264.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4831
    Cell Significance Index: 12.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4612
    Cell Significance Index: 23.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4606
    Cell Significance Index: 63.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4086
    Cell Significance Index: 50.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3862
    Cell Significance Index: 25.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3695
    Cell Significance Index: 43.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3046
    Cell Significance Index: 6.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3004
    Cell Significance Index: 7.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2876
    Cell Significance Index: 19.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2370
    Cell Significance Index: 18.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2353
    Cell Significance Index: 10.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2206
    Cell Significance Index: 4.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1906
    Cell Significance Index: 5.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1836
    Cell Significance Index: 23.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1803
    Cell Significance Index: 3.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1525
    Cell Significance Index: 67.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1330
    Cell Significance Index: 250.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1176
    Cell Significance Index: 106.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0947
    Cell Significance Index: 60.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0620
    Cell Significance Index: 1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0602
    Cell Significance Index: 92.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0542
    Cell Significance Index: 99.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0322
    Cell Significance Index: 6.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0285
    Cell Significance Index: 38.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0271
    Cell Significance Index: 0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0226
    Cell Significance Index: 10.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0219
    Cell Significance Index: 16.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0222
    Cell Significance Index: -3.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0302
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0333
    Cell Significance Index: -24.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0460
    Cell Significance Index: -34.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0520
    Cell Significance Index: -2.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0593
    Cell Significance Index: -33.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0714
    Cell Significance Index: -44.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0996
    Cell Significance Index: -10.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1123
    Cell Significance Index: -1.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1189
    Cell Significance Index: -34.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1281
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1302
    Cell Significance Index: -22.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1467
    Cell Significance Index: -3.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1699
    Cell Significance Index: -5.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1871
    Cell Significance Index: -12.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1967
    Cell Significance Index: -41.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2115
    Cell Significance Index: -27.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2229
    Cell Significance Index: -6.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2238
    Cell Significance Index: -15.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2530
    Cell Significance Index: -28.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2733
    Cell Significance Index: -12.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3022
    Cell Significance Index: -14.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3176
    Cell Significance Index: -6.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3242
    Cell Significance Index: -24.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3365
    Cell Significance Index: -26.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3382
    Cell Significance Index: -7.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3388
    Cell Significance Index: -35.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3501
    Cell Significance Index: -7.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4996
    Cell Significance Index: -10.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5159
    Cell Significance Index: -31.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5220
    Cell Significance Index: -18.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5223
    Cell Significance Index: -17.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5335
    Cell Significance Index: -16.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5691
    Cell Significance Index: -12.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5694
    Cell Significance Index: -7.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6314
    Cell Significance Index: -16.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6810
    Cell Significance Index: -5.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6909
    Cell Significance Index: -10.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLTF is a helicase-like transcription factor, characterized by its ability to bind to DNA and regulate transcriptional activity. It is a member of the AT-helix/AT-turn (AT-HT) family of transcription factors, which are known for their role in DNA repair and replication. The HLTF gene is highly expressed in various cell types, including Sertoli cells, oogonial cells, rod bipolar cells, granulosa cells, and neurons. **Pathways and Functions:** HLTF is involved in several key pathways, including: 1. **DNA Repair:** HLTF plays a crucial role in maintaining genome stability by participating in the repair of DNA damage. It interacts with other proteins involved in the nucleotide excision repair (NER) pathway, ensuring the accurate repair of DNA lesions. 2. **Transcriptional Regulation:** HLTF regulates the expression of target genes by interacting with RNA polymerase II and other transcriptional regulators. It modulates the activity of transcription factors, influencing the expression of genes involved in various cellular processes. 3. **Chromatin Remodeling:** HLTF is involved in chromatin remodeling, a process that reorganizes chromatin structure to facilitate gene expression. It interacts with chromatin remodeling complexes, influencing the accessibility of DNA to transcriptional machinery. 4. **Neurogenesis:** HLTF is highly expressed in neurons and plays a role in regulating neurogenesis, the process of neuronal development and differentiation. **Clinical Significance:** Dysregulation of the HLTF gene has been implicated in various diseases, including: 1. **Cancer:** Mutations in the HLTF gene have been associated with an increased risk of cancer, particularly in the context of DNA damage and repair. 2. **Neurodegenerative Disorders:** Alterations in HLTF expression have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Genetic Disorders:** HLTF mutations have been identified in individuals with genetic disorders, including intellectual disability and autism spectrum disorder. In conclusion, the HLTF gene is a complex and multifunctional gene that plays a critical role in maintaining genome stability, regulating transcription, and influencing neurogenesis. Further research is needed to fully understand the mechanisms by which HLTF regulates cellular processes and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Further Research:** Investigate the specific mechanisms by which HLTF regulates transcriptional activity and chromatin remodeling. 2. **Cellular Models:** Establish cellular models to study the role of HLTF in DNA repair, neurogenesis, and transcriptional regulation. 3. **Clinical Studies:** Conduct clinical studies to explore the relationship between HLTF expression and disease outcomes in various diseases, including cancer and neurodegenerative disorders. By advancing our understanding of the HLTF gene, we can uncover new therapeutic strategies for various diseases and improve our ability to maintain genome stability and regulate cellular processes.

Genular Protein ID: 1272998355

Symbol: HLTF_HUMAN

Name: Helicase-like transcription factor

UniProtKB Accession Codes:

Q14527 D3DNH3 Q14536 Q16051 Q7KYJ6 Q86YA5 Q92652 Q96KM9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7876228

Title: Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.

PubMed ID: 7876228

DOI: 10.1074/jbc.270.9.4575

PubMed ID: 8672239

Title: Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene.

PubMed ID: 8672239

DOI: 10.1089/dna.1996.15.429

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8342330

Title: On the regulation of the plasminogen activator inhibitor-1 gene expression.

PubMed ID: 8342330

PubMed ID: 9126292

Title: Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family.

PubMed ID: 9126292

DOI: 10.1006/dbio.1996.8486

PubMed ID: 10391891

Title: Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene.

PubMed ID: 10391891

DOI: 10.1074/jbc.274.28.19573

PubMed ID: 11904375

Title: HLTF gene silencing in human colon cancer.

PubMed ID: 11904375

DOI: 10.1073/pnas.062459899

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18316726

Title: Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.

PubMed ID: 18316726

DOI: 10.1073/pnas.0800563105

PubMed ID: 18719106

Title: Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

PubMed ID: 18719106

DOI: 10.1073/pnas.0805685105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21457752

Title: Prolactin induces Jak2 phosphorylation of RUSHY195.

PubMed ID: 21457752

DOI: 10.1016/j.mce.2011.03.009

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1009
  • Mass: 113929
  • Checksum: 0AB96F6C8484FD15
  • Sequence:
    • MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF 
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL 
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK 
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC 
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ 
SETKGRAKAG SSKVIEDVAF ACALTSSVPT TKKKMLKKGA CAVEGSKKTD VEERPRTTLI 
ICPLSVLSNW IDQFGQHIKS DVHLNFYVYY GPDRIREPAL LSKQDIVLTT YNILTHDYGT 
KGDSPLHSIR WLRVILDEGH AIRNPNAQQT KAVLDLESER RWVLTGTPIQ NSLKDLWSLL 
SFLKLKPFID REWWHRTIQR PVTMGDEGGL RRLQSLIKNI TLRRTKTSKI KGKPVLELPE 
RKVFIQHITL SDEERKIYQS VKNEGRATIG RYFNEGTVLA HYADVLGLLL RLRQICCHTY 
LLTNAVSSNG PSGNDTPEEL RKKLIRKMKL ILSSGSDEEC AICLDSLTVP VITHCAHVFC 
KPCICQVIQN EQPHAKCPLC RNDIHEDNLL ECPPEELARD SEKKSDMEWT SSSKINALMH 
ALTDLRKKNP NIKSLVVSQF TTFLSLIEIP LKASGFVFTR LDGSMAQKKR VESIQCFQNT 
EAGSPTIMLL SLKAGGVGLN LSAASRVFLM DPAWNPAAED QCFDRCHRLG QKQEVIITKF 
IVKDSVEENM LKIQNKKREL AAGAFGTKKP NADEMKQAKI NEIRTLIDL

Genular Protein ID: 2563696412

Symbol: A8K5B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K5B6

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 4 IntAct 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 1009
  • Mass: 113938
  • Checksum: D37CD99027BAE6B3
  • Sequence:
    • MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF 
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL 
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK 
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC 
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ 
SETKGRAKAG SSKVIEDVAF ACALTSSVPT TKKKMLKKGA CAVEGSKKTD VEERPRTTLI 
ICPLSVLSNW IDQFGQHIKS DVHLNFYVYY GPDRIREPAL LSKQDIVLTT YNILTHDYGT 
KGDSPLHSIR WLRVILDEGH AIRNPNAQQT KAVLDLESER RWVLTGTPIQ NSLKDLWSLL 
SFLKLKPFID REWWHRTIQR PVTMGDEGGL RRLQSLIKNI TLRRTKTSKI KGKPVLELPE 
RKVFIQHITL SDEERRIYQS VKNEGRATIG RYFNEGTVLA HYADVLGLLL RLRQICCHTY 
LLTNAVSSNG PSGNDTPEEL RKKLIRKMKL ILSSGSDEEC AICLDSLTVP VITHCAHVFC 
KPCICQVIQN EQPHAKCPLC RNDIHEDNLL ECPPEELAHD SEKKSDMEWT SSSKINALMH 
ALTDLRKKNP NIKSLVVSQF TTFLSLIEIP LKASGFVFTR LDGSMAQKKR VESIQCFQNT 
EAGSPTIMLL SLKAGGVGLN LSAASRVFLM DPAWNPAAED QCFDRCHRLG QKQEVIITKF 
IVKDSVEENM LKIQNKKREL AAGAFGTKKP NADEMKQAKI NEIRTLIDL

Genular Protein ID: 2906875335

Symbol: Q05BZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05BZ6

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 460
  • Mass: 51868
  • Checksum: 7D190D48A77D69F5
  • Sequence:
    • MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF 
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL 
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK 
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC 
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ 
SETKGRAKAG SSKVIEDVAF ACALTSSVPI KKKKKKKKKK

Genular Protein ID: 435918744

Symbol: A0A0C4DGA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGA6

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 7 Gene3D 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 4 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1008
  • Mass: 113858
  • Checksum: FA13E86686EE3586
  • Sequence:
    • MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF 
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL 
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK 
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC 
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ 
SETKGRAKGS SKVIEDVAFA CALTSSVPTT KKKMLKKGAC AVEGSKKTDV EERPRTTLII 
CPLSVLSNWI DQFGQHIKSD VHLNFYVYYG PDRIREPALL SKQDIVLTTY NILTHDYGTK 
GDSPLHSIRW LRVILDEGHA IRNPNAQQTK AVLDLESERR WVLTGTPIQN SLKDLWSLLS 
FLKLKPFIDR EWWHRTIQRP VTMGDEGGLR RLQSLIKNIT LRRTKTSKIK GKPVLELPER 
KVFIQHITLS DEERKIYQSV KNEGRATIGR YFNEGTVLAH YADVLGLLLR LRQICCHTYL 
LTNAVSSNGP SGNDTPEELR KKLIRKMKLI LSSGSDEECA ICLDSLTVPV ITHCAHVFCK 
PCICQVIQNE QPHAKCPLCR NDIHEDNLLE CPPEELARDS EKKSDMEWTS SSKINALMHA 
LTDLRKKNPN IKSLVVSQFT TFLSLIEIPL KASGFVFTRL DGSMAQKKRV ESIQCFQNTE 
AGSPTIMLLS LKAGGVGLNL SAASRVFLMD PAWNPAAEDQ CFDRCHRLGQ KQEVIITKFI 
VKDSVEENML KIQNKKRELA AGAFGTKKPN ADEMKQAKIN EIRTLIDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.