Details for: SMARCD3

Gene ID: 6604

Symbol: SMARCD3

Ensembl ID: ENSG00000082014

Description: SWI/SNF related BAF chromatin remodeling complex subunit D3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.1675
    Cell Significance Index: -32.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.8209
    Cell Significance Index: -31.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.8002
    Cell Significance Index: -32.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.5496
    Cell Significance Index: -26.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.7242
    Cell Significance Index: -31.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.4162
    Cell Significance Index: -32.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1582
    Cell Significance Index: -32.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2589
    Cell Significance Index: -32.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.5561
    Cell Significance Index: 46.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5917
    Cell Significance Index: 50.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1408
    Cell Significance Index: 14.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0486
    Cell Significance Index: 11.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8277
    Cell Significance Index: 296.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7720
    Cell Significance Index: 16.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7448
    Cell Significance Index: 149.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6575
    Cell Significance Index: 17.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6488
    Cell Significance Index: 17.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5735
    Cell Significance Index: 12.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5653
    Cell Significance Index: 77.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5289
    Cell Significance Index: 27.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4405
    Cell Significance Index: 33.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3867
    Cell Significance Index: 267.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3815
    Cell Significance Index: 23.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3328
    Cell Significance Index: 8.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3300
    Cell Significance Index: 62.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3070
    Cell Significance Index: 8.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2964
    Cell Significance Index: 7.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2899
    Cell Significance Index: 20.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2623
    Cell Significance Index: 33.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2028
    Cell Significance Index: 26.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1895
    Cell Significance Index: 83.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1650
    Cell Significance Index: 4.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1220
    Cell Significance Index: 4.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0921
    Cell Significance Index: 83.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0750
    Cell Significance Index: 47.6400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0734
    Cell Significance Index: 1.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0573
    Cell Significance Index: 2.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0558
    Cell Significance Index: 11.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0457
    Cell Significance Index: 2.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0363
    Cell Significance Index: 68.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0112
    Cell Significance Index: 17.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0098
    Cell Significance Index: 18.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0041
    Cell Significance Index: 0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0032
    Cell Significance Index: 2.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0015
    Cell Significance Index: 0.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0096
    Cell Significance Index: -0.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -5.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0215
    Cell Significance Index: -29.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0223
    Cell Significance Index: -4.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0292
    Cell Significance Index: -21.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0350
    Cell Significance Index: -1.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0415
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0439
    Cell Significance Index: -32.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0571
    Cell Significance Index: -1.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0588
    Cell Significance Index: -33.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0604
    Cell Significance Index: -37.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0764
    Cell Significance Index: -8.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0926
    Cell Significance Index: -26.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0930
    Cell Significance Index: -2.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0940
    Cell Significance Index: -4.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1104
    Cell Significance Index: -16.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1115
    Cell Significance Index: -1.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1117
    Cell Significance Index: -13.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1158
    Cell Significance Index: -13.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1231
    Cell Significance Index: -5.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1323
    Cell Significance Index: -2.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1412
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1648
    Cell Significance Index: -28.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1673
    Cell Significance Index: -17.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1798
    Cell Significance Index: -37.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1874
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1878
    Cell Significance Index: -21.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1951
    Cell Significance Index: -11.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2045
    Cell Significance Index: -13.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2224
    Cell Significance Index: -4.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2442
    Cell Significance Index: -16.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2544
    Cell Significance Index: -15.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2729
    Cell Significance Index: -28.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2778
    Cell Significance Index: -32.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2801
    Cell Significance Index: -15.7200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.3043
    Cell Significance Index: -1.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3062
    Cell Significance Index: -4.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3144
    Cell Significance Index: -16.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3244
    Cell Significance Index: -6.7300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3281
    Cell Significance Index: -4.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3416
    Cell Significance Index: -25.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3654
    Cell Significance Index: -28.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4095
    Cell Significance Index: -25.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4297
    Cell Significance Index: -9.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4399
    Cell Significance Index: -6.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4619
    Cell Significance Index: -13.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4807
    Cell Significance Index: -31.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4897
    Cell Significance Index: -25.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.5349
    Cell Significance Index: -8.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5353
    Cell Significance Index: -17.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5564
    Cell Significance Index: -11.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5578
    Cell Significance Index: -10.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5601
    Cell Significance Index: -11.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5601
    Cell Significance Index: -14.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5773
    Cell Significance Index: -18.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SMARCD3 is a 3.5-kilobase gene that encodes a protein belonging to the SWI/SNF family of chromatin remodeling complexes. The protein is characterized by its ability to interact with other proteins and DNA-binding factors to regulate chromatin structure and gene expression. SMARCD3 has been shown to be involved in various cellular processes, including cell differentiation, proliferation, and survival. Its expression is regulated by several transcription factors, including SREBP, BMAL1, and PPARα. **Pathways and Functions** SMARCD3 is involved in several key pathways and processes, including: 1. **Chromatin remodeling**: SMARCD3 is a component of the SWI/SNF complex, which facilitates the removal of histone proteins and the exposure of DNA to transcription factors. 2. **Gene expression regulation**: SMARCD3 regulates gene expression by interacting with transcription factors and other proteins to control chromatin structure and accessibility. 3. **Cell differentiation**: SMARCD3 is involved in the regulation of cell differentiation, including the differentiation of neural progenitor cells and muscle cells. 4. **Metabolic regulation**: SMARCD3 has been implicated in the regulation of lipid metabolism and cholesterol biosynthesis. 5. **Circadian rhythm regulation**: SMARCD3 is involved in the regulation of circadian gene expression, with its expression being controlled by the BMAL1-CLOCK complex. **Clinical Significance** Dysregulation of SMARCD3 has been implicated in several diseases, including: 1. **Cancer**: SMARCD3 has been found to be overexpressed in several types of cancer, including breast cancer and lung cancer. 2. **Metabolic disorders**: SMARCD3 has been implicated in the regulation of lipid metabolism and cholesterol biosynthesis, and its dysregulation has been linked to metabolic disorders such as obesity and type 2 diabetes. 3. **Neurological disorders**: SMARCD3 has been implicated in the regulation of neural development and function, and its dysregulation has been linked to neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Cardiac disorders**: SMARCD3 has been implicated in the regulation of cardiac development and function, and its dysregulation has been linked to cardiac disorders such as hypertrophic cardiomyopathy. In conclusion, SMARCD3 is a critical regulator of gene expression and chromatin organization, and its dysregulation has been implicated in several diseases. Further research is needed to fully understand the mechanisms by which SMARCD3 regulates gene expression and chromatin structure, and to develop therapeutic strategies to target its dysregulation in disease.

Genular Protein ID: 3439666620

Symbol: SMRD3_HUMAN

Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8804307

Title: Diversity and specialization of mammalian SWI/SNF complexes.

PubMed ID: 8804307

DOI: 10.1101/gad.10.17.2117

PubMed ID: 14701856

Title: Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.

PubMed ID: 14701856

DOI: 10.1074/jbc.m312288200

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18765789

Title: Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.

PubMed ID: 18765789

DOI: 10.1101/gad.471408

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22952240

Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.

PubMed ID: 22952240

DOI: 10.1074/jbc.r111.309302

PubMed ID: 26601204

Title: Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.

PubMed ID: 26601204

DOI: 10.1126/sciadv.1500447

PubMed ID: 29374058

Title: Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

PubMed ID: 29374058

DOI: 10.1074/jbc.ra117.001065

PubMed ID: 32417234

Title: LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.

PubMed ID: 32417234

DOI: 10.1016/j.bbagrm.2020.194577

Sequence Information:

  • Length: 483
  • Mass: 55016
  • Checksum: B7B28DD11DCD0B5C
  • Sequence:
  • MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY MGSPAVRPGL 
    APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR RKMADKILPQ RIRELVPESQ 
    AYMDLLAFER KLDQTIMRKR VDIQEALKRP MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA 
    SWELRVEGKL LDDPSKQKRK FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV 
    KRPGDLSVRC TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH 
    DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS DQKKTACYDI 
    DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN QLKIQRDFML SFSRDPKGYV 
    QDLLRSQSRD LKVMTDVAGN PEEERRAEFY HQPWSQEAVS RYFYCKIQQR RQELEQSLVV 
    RNT

Genular Protein ID: 1159196963

Symbol: A0A090N8Z9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

Sequence Information:

  • Length: 470
  • Mass: 53687
  • Checksum: DD6C2454B7AC2B04
  • Sequence:
  • MTPGLQHPPT VVQRPGMPSG ARMPHQGAPM GPPGSPYMGS PAVRPGLAPA GMEPARKRAA 
    PPPGQSQAQS QGQPVPTAPA RSRSAKRRKM ADKILPQRIR ELVPESQAYM DLLAFERKLD 
    QTIMRKRVDI QEALKRPMKQ KRKLRLYISN TFNPAKPDAE DSDGSIASWE LRVEGKLLDD 
    PSKQKRKFSS FFKSLVIELD KDLYGPDNHL VEWHRTPTTQ ETDGFQVKRP GDLSVRCTLL 
    LMLDYQPPQF KLDPRLARLL GLHTQSRSAI VQALWQYVKT NRLQDSHDKE YINGDKYFQQ 
    IFDCPRLKFS EIPQRLTALL LPPDPIVINH VISVDPSDQK KTACYDIDVE VEEPLKGQMS 
    SFLLSTANQQ EISALDSKIH ETIESINQLK IQRDFMLSFS RDPKGYVQDL LRSQSRDLKV 
    MTDVAGNPEE ERRAEFYHQP WSQEAVSRYF YCKIQQRRQE LEQSLVVRNT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.