Details for: SNRPA1

Gene ID: 6627

Symbol: SNRPA1

Ensembl ID: ENSG00000131876

Description: small nuclear ribonucleoprotein polypeptide A'

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.65
    Marker Score: 2767
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.15
    Marker Score: 8331
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.75
    Marker Score: 6878
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.72
    Marker Score: 7158
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.64
    Marker Score: 56702
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.61
    Marker Score: 1622
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.58
    Marker Score: 6484
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.57
    Marker Score: 4277.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.57
    Marker Score: 2308.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.56
    Marker Score: 1135
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.54
    Marker Score: 52263.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.53
    Marker Score: 1041
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.53
    Marker Score: 4538
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.5
    Marker Score: 857
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.49
    Marker Score: 1403
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.48
    Marker Score: 1970
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.48
    Marker Score: 934.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.48
    Marker Score: 3081
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.47
    Marker Score: 3085
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.46
    Marker Score: 1545
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.45
    Marker Score: 534
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.44
    Marker Score: 2559
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.44
    Marker Score: 1540
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.44
    Marker Score: 2070.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.44
    Marker Score: 76059
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.43
    Marker Score: 1413
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.41
    Marker Score: 2398
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.4
    Marker Score: 1980
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.4
    Marker Score: 5174
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.37
    Marker Score: 828
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.37
    Marker Score: 6748
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.35
    Marker Score: 1015
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.34
    Marker Score: 403
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.34
    Marker Score: 475
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.34
    Marker Score: 2394
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.33
    Marker Score: 15509
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.33
    Marker Score: 473
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.32
    Marker Score: 11415
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.32
    Marker Score: 8418
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.31
    Marker Score: 821
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3
    Marker Score: 3185
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.3
    Marker Score: 1523
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.28
    Marker Score: 1611
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.27
    Marker Score: 3021
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.27
    Marker Score: 12554.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.26
    Marker Score: 3539.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.26
    Marker Score: 1328
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.25
    Marker Score: 299
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.25
    Marker Score: 274
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.24
    Marker Score: 1164
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.24
    Marker Score: 723
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.23
    Marker Score: 973
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.23
    Marker Score: 16175
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.22
    Marker Score: 3840
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.21
    Marker Score: 602
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.2
    Marker Score: 1553
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2
    Marker Score: 12154.5
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.2
    Marker Score: 285
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.2
    Marker Score: 419
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.2
    Marker Score: 5126
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.19
    Marker Score: 566
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.18
    Marker Score: 1057
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.17
    Marker Score: 888
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.17
    Marker Score: 478
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.17
    Marker Score: 1264
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.17
    Marker Score: 781
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.17
    Marker Score: 3177
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.17
    Marker Score: 2032
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.16
    Marker Score: 1601
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.16
    Marker Score: 571
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.15
    Marker Score: 972
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.15
    Marker Score: 15434
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.15
    Marker Score: 9965.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.15
    Marker Score: 1234
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.14
    Marker Score: 1070
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.13
    Marker Score: 830
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.13
    Marker Score: 1321
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.13
    Marker Score: 1853
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.13
    Marker Score: 593
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.12
    Marker Score: 2192
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.12
    Marker Score: 1213
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.11
    Marker Score: 1118
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.11
    Marker Score: 548
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.11
    Marker Score: 236.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.11
    Marker Score: 976
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.11
    Marker Score: 1713
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.11
    Marker Score: 5316
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.1
    Marker Score: 539
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.1
    Marker Score: 753
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1
    Marker Score: 2510.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.1
    Marker Score: 446
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.1
    Marker Score: 749
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.1
    Marker Score: 1165.5
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.1
    Marker Score: 2671
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.09
    Marker Score: 381
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.09
    Marker Score: 1051
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.09
    Marker Score: 797
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.09
    Marker Score: 422
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.08
    Marker Score: 453

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Other Information

**Key Characteristics:** The SNRPA1 gene exhibits a range of characteristics that highlight its importance in RNA splicing and immune system function. These include: * **Expression in various cell types:** SNRPA1 is significantly expressed in erythroid progenitor cells, neural progenitor cells, placental villous trophoblasts, GABAergic neurons, and other cell types, suggesting its widespread role in cellular processes. * **Component of the U2 snRNP:** The SNRPA1 protein is a key component of the U2 snRNP, which is involved in the catalytic step 2 of the spliceosome, a complex responsible for the splicing of pre-mRNA. * **Implication in cytokine signaling:** The SNRPA1 gene is involved in cytokine signaling pathways, particularly in the context of IL-12 stimulation, which is crucial for immune system regulation and response. **Pathways and Functions:** The SNRPA1 gene is involved in several key pathways and functions, including: * **RNA splicing:** The SNRPA1 protein is essential for the catalytic step 2 of the spliceosome, a complex involved in the splicing of pre-mRNA. * **Cytokine signaling:** The SNRPA1 gene is implicated in cytokine signaling pathways, particularly in the context of IL-12 stimulation, which is crucial for immune system regulation and response. * **Immune system regulation:** The SNRPA1 gene plays a role in regulating the immune system, particularly in the context of cytokine signaling and RNA splicing. * **Metabolism of RNA:** The SNRPA1 gene is involved in the metabolism of RNA, particularly in the context of RNA splicing. **Clinical Significance:** The SNRPA1 gene has significant clinical implications, particularly in the context of immune system disorders and RNA splicing-related diseases. Altered expression or function of the SNRPA1 gene has been implicated in various diseases, including: * **Immune system disorders:** Altered expression or function of the SNRPA1 gene has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. * **RNA splicing-related diseases:** Altered expression or function of the SNRPA1 gene has been implicated in RNA splicing-related diseases, such as splicing factor deficiencies and RNA splicing disorders. * **Cancer:** Altered expression or function of the SNRPA1 gene has been implicated in cancer, particularly in the context of immune system regulation and RNA splicing. In conclusion, the SNRPA1 gene plays a critical role in RNA splicing and immune system regulation, and its dysregulation has significant clinical implications. Further research is needed to fully understand the complexities of the SNRPA1 gene and its role in human disease.

Genular Protein ID: 1565995391

Symbol: RU2A_HUMAN

Name: U2 small nuclear ribonucleoprotein A'

UniProtKB Accession Codes:

P09661 B2R5I6 Q8TBD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 25 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 29 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2928112

Title: Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein.

PubMed ID: 2928112

DOI: 10.1093/nar/17.5.1893

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9531537

Title: A coactivator of pre-mRNA splicing.

PubMed ID: 9531537

DOI: 10.1101/gad.12.7.996

PubMed ID: 10339552

Title: The SRm160/300 splicing coactivator is required for exon-enhancer function.

PubMed ID: 10339552

DOI: 10.1073/pnas.96.11.6125

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9716128

Title: Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA.

PubMed ID: 9716128

DOI: 10.1038/29234

PubMed ID: 27035939

Title: Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans.

PubMed ID: 27035939

DOI: 10.1073/pnas.1513682113

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 255
  • Mass: 28416
  • Checksum: 25902F07992B7209
  • Sequence:
    • MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS DNEIRKLDGF 
PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL VELGDLDPLA SLKSLTYLSI 
LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV KLKERQEAEK MFKGKRGAQL AKDIARRSKT 
FNPGAGLPTD KKKGGPSPGD VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD 
DGEEEMEEDT VTNGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.