Details for: SNRPA1

Gene ID: 6627

Symbol: SNRPA1

Ensembl ID: ENSG00000131876

Description: small nuclear ribonucleoprotein polypeptide A'

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 215.7572
    Cell Significance Index: -33.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.1791
    Cell Significance Index: -33.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 103.1199
    Cell Significance Index: -42.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.7982
    Cell Significance Index: -43.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.0226
    Cell Significance Index: -43.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.8116
    Cell Significance Index: -43.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.2267
    Cell Significance Index: -42.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3015
    Cell Significance Index: -30.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1909
    Cell Significance Index: -44.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2660
    Cell Significance Index: -28.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9595
    Cell Significance Index: -17.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.1645
    Cell Significance Index: 485.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7897
    Cell Significance Index: 291.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3288
    Cell Significance Index: 18.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2841
    Cell Significance Index: 13.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2619
    Cell Significance Index: 59.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1681
    Cell Significance Index: 137.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1651
    Cell Significance Index: 31.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0988
    Cell Significance Index: 600.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0008
    Cell Significance Index: 27.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9850
    Cell Significance Index: 51.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8886
    Cell Significance Index: 41.4300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.8382
    Cell Significance Index: 12.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8365
    Cell Significance Index: 150.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8308
    Cell Significance Index: 17.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7855
    Cell Significance Index: 50.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7799
    Cell Significance Index: 27.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7684
    Cell Significance Index: 154.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7556
    Cell Significance Index: 22.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6906
    Cell Significance Index: 84.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6817
    Cell Significance Index: 19.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6779
    Cell Significance Index: 93.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6530
    Cell Significance Index: 45.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6375
    Cell Significance Index: 575.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6334
    Cell Significance Index: 125.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6120
    Cell Significance Index: 270.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5994
    Cell Significance Index: 16.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4790
    Cell Significance Index: 61.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4183
    Cell Significance Index: 150.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3880
    Cell Significance Index: 28.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3644
    Cell Significance Index: 25.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2872
    Cell Significance Index: 2.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2668
    Cell Significance Index: 5.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2477
    Cell Significance Index: 31.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2086
    Cell Significance Index: 10.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1686
    Cell Significance Index: 9.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1341
    Cell Significance Index: 25.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1323
    Cell Significance Index: 3.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1201
    Cell Significance Index: 7.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0960
    Cell Significance Index: 4.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0950
    Cell Significance Index: 16.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0815
    Cell Significance Index: 5.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0613
    Cell Significance Index: 115.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0364
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0350
    Cell Significance Index: 64.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0334
    Cell Significance Index: 51.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0248
    Cell Significance Index: 2.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0248
    Cell Significance Index: 0.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0138
    Cell Significance Index: 0.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0073
    Cell Significance Index: 4.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0067
    Cell Significance Index: 5.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0057
    Cell Significance Index: 7.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0191
    Cell Significance Index: -1.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0287
    Cell Significance Index: -0.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0313
    Cell Significance Index: -22.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0380
    Cell Significance Index: -5.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0446
    Cell Significance Index: -25.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0470
    Cell Significance Index: -4.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0568
    Cell Significance Index: -1.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0615
    Cell Significance Index: -6.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0680
    Cell Significance Index: -1.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0974
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0977
    Cell Significance Index: -20.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1010
    Cell Significance Index: -11.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1248
    Cell Significance Index: -35.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1657
    Cell Significance Index: -11.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1853
    Cell Significance Index: -4.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2113
    Cell Significance Index: -4.5000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2184
    Cell Significance Index: -1.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3196
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3257
    Cell Significance Index: -37.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3350
    Cell Significance Index: -5.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3372
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3408
    Cell Significance Index: -35.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3884
    Cell Significance Index: -17.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4577
    Cell Significance Index: -5.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4705
    Cell Significance Index: -37.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4801
    Cell Significance Index: -18.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5563
    Cell Significance Index: -14.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6208
    Cell Significance Index: -38.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6466
    Cell Significance Index: -16.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6790
    Cell Significance Index: -20.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7902
    Cell Significance Index: -8.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7926
    Cell Significance Index: -14.6500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.8463
    Cell Significance Index: -3.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8567
    Cell Significance Index: -16.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8905
    Cell Significance Index: -28.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SNRPA1 gene exhibits a range of characteristics that highlight its importance in RNA splicing and immune system function. These include: * **Expression in various cell types:** SNRPA1 is significantly expressed in erythroid progenitor cells, neural progenitor cells, placental villous trophoblasts, GABAergic neurons, and other cell types, suggesting its widespread role in cellular processes. * **Component of the U2 snRNP:** The SNRPA1 protein is a key component of the U2 snRNP, which is involved in the catalytic step 2 of the spliceosome, a complex responsible for the splicing of pre-mRNA. * **Implication in cytokine signaling:** The SNRPA1 gene is involved in cytokine signaling pathways, particularly in the context of IL-12 stimulation, which is crucial for immune system regulation and response. **Pathways and Functions:** The SNRPA1 gene is involved in several key pathways and functions, including: * **RNA splicing:** The SNRPA1 protein is essential for the catalytic step 2 of the spliceosome, a complex involved in the splicing of pre-mRNA. * **Cytokine signaling:** The SNRPA1 gene is implicated in cytokine signaling pathways, particularly in the context of IL-12 stimulation, which is crucial for immune system regulation and response. * **Immune system regulation:** The SNRPA1 gene plays a role in regulating the immune system, particularly in the context of cytokine signaling and RNA splicing. * **Metabolism of RNA:** The SNRPA1 gene is involved in the metabolism of RNA, particularly in the context of RNA splicing. **Clinical Significance:** The SNRPA1 gene has significant clinical implications, particularly in the context of immune system disorders and RNA splicing-related diseases. Altered expression or function of the SNRPA1 gene has been implicated in various diseases, including: * **Immune system disorders:** Altered expression or function of the SNRPA1 gene has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. * **RNA splicing-related diseases:** Altered expression or function of the SNRPA1 gene has been implicated in RNA splicing-related diseases, such as splicing factor deficiencies and RNA splicing disorders. * **Cancer:** Altered expression or function of the SNRPA1 gene has been implicated in cancer, particularly in the context of immune system regulation and RNA splicing. In conclusion, the SNRPA1 gene plays a critical role in RNA splicing and immune system regulation, and its dysregulation has significant clinical implications. Further research is needed to fully understand the complexities of the SNRPA1 gene and its role in human disease.

Genular Protein ID: 1565995391

Symbol: RU2A_HUMAN

Name: U2 small nuclear ribonucleoprotein A'

UniProtKB Accession Codes:

P09661 B2R5I6 Q8TBD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 37 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 30 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2928112

Title: Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein.

PubMed ID: 2928112

DOI: 10.1093/nar/17.5.1893

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9531537

Title: A coactivator of pre-mRNA splicing.

PubMed ID: 9531537

DOI: 10.1101/gad.12.7.996

PubMed ID: 10339552

Title: The SRm160/300 splicing coactivator is required for exon-enhancer function.

PubMed ID: 10339552

DOI: 10.1073/pnas.96.11.6125

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9716128

Title: Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA.

PubMed ID: 9716128

DOI: 10.1038/29234

PubMed ID: 27035939

Title: Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans.

PubMed ID: 27035939

DOI: 10.1073/pnas.1513682113

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 32494006

Title: Molecular architecture of the human 17S U2 snRNP.

PubMed ID: 32494006

DOI: 10.1038/s41586-020-2344-3

PubMed ID: 36797247

Title: Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.

PubMed ID: 36797247

DOI: 10.1038/s41467-023-36489-x

Sequence Information:

  • Length: 255
  • Mass: 28416
  • Checksum: 25902F07992B7209
  • Sequence:
    • MVKLTAELIE QAAQYTNAVR DRELDLRGYK IPVIENLGAT LDQFDAIDFS DNEIRKLDGF 
PLLRRLKTLL VNNNRICRIG EGLDQALPCL TELILTNNSL VELGDLDPLA SLKSLTYLSI 
LRNPVTNKKH YRLYVIYKVP QVRVLDFQKV KLKERQEAEK MFKGKRGAQL AKDIARRSKT 
FNPGAGLPTD KKKGGPSPGD VEAIKNAIAN ASTLAEVERL KGLLQSGQIP GRERRSGPTD 
DGEEEMEEDT VTNGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.