Details for: SNTA1

Gene ID: 6640

Symbol: SNTA1

Ensembl ID: ENSG00000101400

Description: syntrophin alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.6226
    Cell Significance Index: -19.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.8402
    Cell Significance Index: -19.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.7566
    Cell Significance Index: -18.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8481
    Cell Significance Index: -19.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9992
    Cell Significance Index: -18.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9417
    Cell Significance Index: -19.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2814
    Cell Significance Index: -13.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.4298
    Cell Significance Index: 28.8100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.1926
    Cell Significance Index: 30.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5376
    Cell Significance Index: 117.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3468
    Cell Significance Index: 34.6200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9549
    Cell Significance Index: 23.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8035
    Cell Significance Index: 50.6400
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.7572
    Cell Significance Index: 2.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6641
    Cell Significance Index: 133.2100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.6252
    Cell Significance Index: 8.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5949
    Cell Significance Index: 171.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5640
    Cell Significance Index: 55.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5059
    Cell Significance Index: 100.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4863
    Cell Significance Index: 7.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4663
    Cell Significance Index: 54.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4496
    Cell Significance Index: 310.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4263
    Cell Significance Index: 49.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3776
    Cell Significance Index: 340.9500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.3649
    Cell Significance Index: 6.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2784
    Cell Significance Index: 12.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2755
    Cell Significance Index: 44.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2422
    Cell Significance Index: 26.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2176
    Cell Significance Index: 78.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.2157
    Cell Significance Index: 3.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2074
    Cell Significance Index: 12.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1887
    Cell Significance Index: 2.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1762
    Cell Significance Index: 33.5400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1420
    Cell Significance Index: 2.3400
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.1386
    Cell Significance Index: 1.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1374
    Cell Significance Index: 9.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1068
    Cell Significance Index: 47.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0857
    Cell Significance Index: 2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0853
    Cell Significance Index: 11.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0721
    Cell Significance Index: 4.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0666
    Cell Significance Index: 125.3600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0546
    Cell Significance Index: 0.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0457
    Cell Significance Index: 2.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0454
    Cell Significance Index: 2.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0445
    Cell Significance Index: 5.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0326
    Cell Significance Index: 60.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0262
    Cell Significance Index: 14.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0252
    Cell Significance Index: 34.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0245
    Cell Significance Index: 0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0229
    Cell Significance Index: 10.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0208
    Cell Significance Index: 0.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0204
    Cell Significance Index: 3.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0198
    Cell Significance Index: 0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0167
    Cell Significance Index: 25.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0143
    Cell Significance Index: 0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0078
    Cell Significance Index: 4.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0045
    Cell Significance Index: 3.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0043
    Cell Significance Index: 0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0035
    Cell Significance Index: 0.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0023
    Cell Significance Index: -0.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0037
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0154
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0220
    Cell Significance Index: -16.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0257
    Cell Significance Index: -19.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0297
    Cell Significance Index: -16.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0344
    Cell Significance Index: -21.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0387
    Cell Significance Index: -2.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0683
    Cell Significance Index: -8.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0713
    Cell Significance Index: -7.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0777
    Cell Significance Index: -8.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0973
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1004
    Cell Significance Index: -21.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1006
    Cell Significance Index: -7.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1009
    Cell Significance Index: -2.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1227
    Cell Significance Index: -8.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1250
    Cell Significance Index: -6.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1310
    Cell Significance Index: -8.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1382
    Cell Significance Index: -8.9200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1433
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1470
    Cell Significance Index: -11.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1606
    Cell Significance Index: -1.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1634
    Cell Significance Index: -17.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1709
    Cell Significance Index: -3.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1781
    Cell Significance Index: -3.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2008
    Cell Significance Index: -11.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2026
    Cell Significance Index: -4.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2029
    Cell Significance Index: -9.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2084
    Cell Significance Index: -5.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2171
    Cell Significance Index: -3.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2332
    Cell Significance Index: -7.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2423
    Cell Significance Index: -6.4900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2512
    Cell Significance Index: -3.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3004
    Cell Significance Index: -10.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3168
    Cell Significance Index: -9.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3475
    Cell Significance Index: -9.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3495
    Cell Significance Index: -11.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3694
    Cell Significance Index: -12.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3711
    Cell Significance Index: -12.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3745
    Cell Significance Index: -7.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3806
    Cell Significance Index: -4.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNTA1 is a protein-coding gene that encodes for the alpha-1 subunit of syntrophin, a multifunctional protein that interacts with various partners to regulate cellular signaling and cytoskeletal dynamics. The SNTA1 protein is primarily expressed in the nervous system, muscles, and cardiovascular tissues, where it is involved in the regulation of muscle contraction, neuronal function, and cardiovascular homeostasis. SNTA1 exhibits a high degree of structural similarity to dystrophin, suggesting its potential role in maintaining muscle integrity. **Pathways and Functions:** SNTA1 is involved in a wide range of cellular processes, including: 1. **Actin binding and cytoskeleton regulation**: SNTA1 interacts with actin-binding proteins to regulate cytoskeletal dynamics, which is essential for maintaining cellular shape, motility, and intracellular signaling. 2. **Anchoring junction formation**: SNTA1 contributes to the formation of anchoring junctions, which are critical for maintaining the structural integrity of cells, particularly in muscles and neurons. 3. **Neuromuscular junction development**: SNTA1 plays a key role in the development and maintenance of neuromuscular junctions, which are essential for muscle function and neuronal signaling. 4. **Regulation of muscle contraction**: SNTA1 interacts with dystrophin and other proteins to regulate muscle contraction, which is critical for maintaining muscle function and overall physical activity. 5. **Cardiovascular homeostasis**: SNTA1 is involved in regulating cardiovascular homeostasis, including heart rate, blood pressure, and cardiac muscle cell membrane repolarization. **Clinical Significance:** Dysregulation of SNTA1 has been implicated in various diseases, including: 1. **Muscular dystrophy**: Mutations in SNTA1 have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Neurological disorders**: SNTA1 has been implicated in neurological disorders, including epilepsy, autism, and schizophrenia, where it may contribute to the regulation of neuronal function and synaptic plasticity. 3. **Cardiovascular disease**: Abnormalities in SNTA1 expression have been linked to cardiovascular disease, including hypertension, heart failure, and arrhythmias. In conclusion, SNTA1 is a crucial gene that plays a vital role in maintaining cellular integrity and function, particularly in the nervous system and muscles. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying SNTA1 function and its clinical significance.

Genular Protein ID: 4155399932

Symbol: SNTA1_HUMAN

Name: Alpha-1-syntrophin

UniProtKB Accession Codes:

Q13424 A8K7H9 B4DX40 E1P5N1 Q16438

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8576247

Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PubMed ID: 8576247

DOI: 10.1074/jbc.271.5.2724

PubMed ID: 8612778

Title: Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast.

PubMed ID: 8612778

DOI: 10.1016/0014-5793(96)00214-1

PubMed ID: 10212242

Title: Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.

PubMed ID: 10212242

DOI: 10.1074/jbc.274.18.12626

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10230395

Title: A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

PubMed ID: 10230395

DOI: 10.1016/s1097-2765(00)80470-0

PubMed ID: 11163757

Title: The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.

PubMed ID: 11163757

DOI: 10.1016/s0014-5793(00)02373-5

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19684871

Title: alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.

PubMed ID: 19684871

DOI: 10.1161/circep.108.769224

PubMed ID: 18591664

Title: Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.

PubMed ID: 18591664

DOI: 10.1073/pnas.0801294105

Sequence Information:

  • Length: 505
  • Mass: 53895
  • Checksum: C07DA5F21C775CF8
  • Sequence:
    • MASGRRAPRT GLLELRAGAG SGAGGERWQR VLLSLAEDVL TVSPADGDPG PEPGAPREQE 
PAQLNGAAEP GAGPPQLPEA LLLQRRRVTV RKADAGGLGI SIKGGRENKM PILISKIFKG 
LAADQTEALF VGDAILSVNG EDLSSATHDE AVQVLKKTGK EVVLEVKYMK DVSPYFKNST 
GGTSVGWDSP PASPLQRQPS SPGPTPRNFS EAKHMSLKMA YVSKRCTPND PEPRYLEICS 
ADGQDTLFLR AKDEASARSW ATAIQAQVNT LTPRVKDELQ ALLAATSTAG SQDIKQIGWL 
TEQLPSGGTA PTLALLTEKE LLLYLSLPET REALSRPART APLIATRLVH SGPSKGSVPY 
DAELSFALRT GTRHGVDTHL FSVESPQELA AWTRQLVDGC HRAAEGVQEV STACTWNGRP 
CSLSVHIDKG FTLWAAEPGA ARAVLLRQPF EKLQMSSDDG ASLLFLDFGG AEGEIQLDLH 
SCPKTIVFII HSFLSAKVTR LGLLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.