Details for: SNTA1

Gene ID: 6640

Symbol: SNTA1

Ensembl ID: ENSG00000101400

Description: syntrophin alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.29
    Marker Score: 48954
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.72
    Marker Score: 565
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.64
    Marker Score: 9719
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.63
    Marker Score: 1593.5
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.55
    Marker Score: 34555
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169230
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.44
    Marker Score: 947
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20026
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.15
    Marker Score: 1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.13
    Marker Score: 559
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.02
    Marker Score: 9622
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1574
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48020
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.96
    Marker Score: 3424
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.96
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.95
    Marker Score: 58291
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.94
    Marker Score: 8951
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5132
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.89
    Marker Score: 519
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.88
    Marker Score: 7564
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.86
    Marker Score: 3589.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.86
    Marker Score: 1497
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.81
    Marker Score: 1776
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8
    Marker Score: 1832
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.79
    Marker Score: 3047
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.78
    Marker Score: 10408
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.77
    Marker Score: 2280
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1421
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1754
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 662
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 2999
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.71
    Marker Score: 26275
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 544
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1415
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 330
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.69
    Marker Score: 2806
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.65
    Marker Score: 1376
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.65
    Marker Score: 194
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.64
    Marker Score: 860
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 378
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.62
    Marker Score: 6221
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.6
    Marker Score: 252
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.58
    Marker Score: 21999
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3474
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.58
    Marker Score: 2044.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.57
    Marker Score: 11369
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.56
    Marker Score: 599
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.55
    Marker Score: 444
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.54
    Marker Score: 2098
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 168
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.53
    Marker Score: 4067
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.53
    Marker Score: 608
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.53
    Marker Score: 503
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.53
    Marker Score: 1412
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.52
    Marker Score: 211
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.51
    Marker Score: 5310
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 327
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.5
    Marker Score: 493
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 220
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.49
    Marker Score: 2062
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.49
    Marker Score: 922
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 134
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.49
    Marker Score: 519
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.47
    Marker Score: 265
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.47
    Marker Score: 7038
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 307
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.46
    Marker Score: 106
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.46
    Marker Score: 1140
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.45
    Marker Score: 1852
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.44
    Marker Score: 207
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.44
    Marker Score: 635
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.44
    Marker Score: 547
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.43
    Marker Score: 308
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.43
    Marker Score: 518
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.42
    Marker Score: 254
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.42
    Marker Score: 1136
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.41
    Marker Score: 272
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4
    Marker Score: 176
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.4
    Marker Score: 195
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.39
    Marker Score: 913
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.39
    Marker Score: 642
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.38
    Marker Score: 116
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.37
    Marker Score: 108
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.37
    Marker Score: 5028

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** SNTA1 is a protein-coding gene that encodes for the alpha-1 subunit of syntrophin, a multifunctional protein that interacts with various partners to regulate cellular signaling and cytoskeletal dynamics. The SNTA1 protein is primarily expressed in the nervous system, muscles, and cardiovascular tissues, where it is involved in the regulation of muscle contraction, neuronal function, and cardiovascular homeostasis. SNTA1 exhibits a high degree of structural similarity to dystrophin, suggesting its potential role in maintaining muscle integrity. **Pathways and Functions:** SNTA1 is involved in a wide range of cellular processes, including: 1. **Actin binding and cytoskeleton regulation**: SNTA1 interacts with actin-binding proteins to regulate cytoskeletal dynamics, which is essential for maintaining cellular shape, motility, and intracellular signaling. 2. **Anchoring junction formation**: SNTA1 contributes to the formation of anchoring junctions, which are critical for maintaining the structural integrity of cells, particularly in muscles and neurons. 3. **Neuromuscular junction development**: SNTA1 plays a key role in the development and maintenance of neuromuscular junctions, which are essential for muscle function and neuronal signaling. 4. **Regulation of muscle contraction**: SNTA1 interacts with dystrophin and other proteins to regulate muscle contraction, which is critical for maintaining muscle function and overall physical activity. 5. **Cardiovascular homeostasis**: SNTA1 is involved in regulating cardiovascular homeostasis, including heart rate, blood pressure, and cardiac muscle cell membrane repolarization. **Clinical Significance:** Dysregulation of SNTA1 has been implicated in various diseases, including: 1. **Muscular dystrophy**: Mutations in SNTA1 have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Neurological disorders**: SNTA1 has been implicated in neurological disorders, including epilepsy, autism, and schizophrenia, where it may contribute to the regulation of neuronal function and synaptic plasticity. 3. **Cardiovascular disease**: Abnormalities in SNTA1 expression have been linked to cardiovascular disease, including hypertension, heart failure, and arrhythmias. In conclusion, SNTA1 is a crucial gene that plays a vital role in maintaining cellular integrity and function, particularly in the nervous system and muscles. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying SNTA1 function and its clinical significance.

Genular Protein ID: 4155399932

Symbol: SNTA1_HUMAN

Name: Alpha-1-syntrophin

UniProtKB Accession Codes:

Q13424 A8K7H9 B4DX40 E1P5N1 Q16438

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 GO 25 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8576247

Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PubMed ID: 8576247

DOI: 10.1074/jbc.271.5.2724

PubMed ID: 8612778

Title: Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast.

PubMed ID: 8612778

DOI: 10.1016/0014-5793(96)00214-1

PubMed ID: 10212242

Title: Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.

PubMed ID: 10212242

DOI: 10.1074/jbc.274.18.12626

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10230395

Title: A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

PubMed ID: 10230395

DOI: 10.1016/s1097-2765(00)80470-0

PubMed ID: 11163757

Title: The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins.

PubMed ID: 11163757

DOI: 10.1016/s0014-5793(00)02373-5

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19684871

Title: alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.

PubMed ID: 19684871

DOI: 10.1161/circep.108.769224

PubMed ID: 18591664

Title: Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.

PubMed ID: 18591664

DOI: 10.1073/pnas.0801294105

Sequence Information:

  • Length: 505
  • Mass: 53895
  • Checksum: C07DA5F21C775CF8
  • Sequence:
    • MASGRRAPRT GLLELRAGAG SGAGGERWQR VLLSLAEDVL TVSPADGDPG PEPGAPREQE 
PAQLNGAAEP GAGPPQLPEA LLLQRRRVTV RKADAGGLGI SIKGGRENKM PILISKIFKG 
LAADQTEALF VGDAILSVNG EDLSSATHDE AVQVLKKTGK EVVLEVKYMK DVSPYFKNST 
GGTSVGWDSP PASPLQRQPS SPGPTPRNFS EAKHMSLKMA YVSKRCTPND PEPRYLEICS 
ADGQDTLFLR AKDEASARSW ATAIQAQVNT LTPRVKDELQ ALLAATSTAG SQDIKQIGWL 
TEQLPSGGTA PTLALLTEKE LLLYLSLPET REALSRPART APLIATRLVH SGPSKGSVPY 
DAELSFALRT GTRHGVDTHL FSVESPQELA AWTRQLVDGC HRAAEGVQEV STACTWNGRP 
CSLSVHIDKG FTLWAAEPGA ARAVLLRQPF EKLQMSSDDG ASLLFLDFGG AEGEIQLDLH 
SCPKTIVFII HSFLSAKVTR LGLLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.