Details for: SOS2

Gene ID: 6655

Symbol: SOS2

Ensembl ID: ENSG00000100485

Description: SOS Ras/Rho guanine nucleotide exchange factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 333.0864
    Cell Significance Index: -51.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.6324
    Cell Significance Index: -51.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.1017
    Cell Significance Index: -53.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.7396
    Cell Significance Index: -43.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.5339
    Cell Significance Index: -50.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.1904
    Cell Significance Index: -44.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.4346
    Cell Significance Index: -52.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.1425
    Cell Significance Index: -51.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.9960
    Cell Significance Index: -32.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0829
    Cell Significance Index: -43.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3805
    Cell Significance Index: -52.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.7647
    Cell Significance Index: 53.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5129
    Cell Significance Index: 141.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2348
    Cell Significance Index: 171.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1793
    Cell Significance Index: 354.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.0755
    Cell Significance Index: 53.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9191
    Cell Significance Index: 384.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5416
    Cell Significance Index: 68.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5311
    Cell Significance Index: 57.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4575
    Cell Significance Index: 522.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4378
    Cell Significance Index: 35.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3752
    Cell Significance Index: 30.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2770
    Cell Significance Index: 253.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2206
    Cell Significance Index: 132.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2049
    Cell Significance Index: 62.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1738
    Cell Significance Index: 811.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8148
    Cell Significance Index: 22.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7598
    Cell Significance Index: 21.8900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.6726
    Cell Significance Index: 8.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6287
    Cell Significance Index: 15.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6156
    Cell Significance Index: 42.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5668
    Cell Significance Index: 38.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5523
    Cell Significance Index: 99.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5296
    Cell Significance Index: 65.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4787
    Cell Significance Index: 10.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3298
    Cell Significance Index: 14.9500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2702
    Cell Significance Index: 3.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2534
    Cell Significance Index: 228.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2416
    Cell Significance Index: 454.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2174
    Cell Significance Index: 98.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2023
    Cell Significance Index: 2.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1766
    Cell Significance Index: 24.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1762
    Cell Significance Index: 111.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1552
    Cell Significance Index: 29.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1519
    Cell Significance Index: 7.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1418
    Cell Significance Index: 2.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1394
    Cell Significance Index: 4.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1365
    Cell Significance Index: 60.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1282
    Cell Significance Index: 197.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1144
    Cell Significance Index: 62.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1005
    Cell Significance Index: 185.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0996
    Cell Significance Index: 2.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0739
    Cell Significance Index: 100.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0173
    Cell Significance Index: 2.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0064
    Cell Significance Index: -0.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0095
    Cell Significance Index: -0.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0124
    Cell Significance Index: -0.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0164
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0501
    Cell Significance Index: -31.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0595
    Cell Significance Index: -1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0675
    Cell Significance Index: -51.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0702
    Cell Significance Index: -39.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1114
    Cell Significance Index: -1.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1159
    Cell Significance Index: -7.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1293
    Cell Significance Index: -16.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1514
    Cell Significance Index: -31.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1580
    Cell Significance Index: -45.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1790
    Cell Significance Index: -20.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2169
    Cell Significance Index: -22.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2420
    Cell Significance Index: -1.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2477
    Cell Significance Index: -7.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2483
    Cell Significance Index: -31.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2689
    Cell Significance Index: -30.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2802
    Cell Significance Index: -33.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3119
    Cell Significance Index: -35.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3328
    Cell Significance Index: -4.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3528
    Cell Significance Index: -36.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3755
    Cell Significance Index: -10.2200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.4033
    Cell Significance Index: -3.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4240
    Cell Significance Index: -31.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4530
    Cell Significance Index: -32.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4770
    Cell Significance Index: -9.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4960
    Cell Significance Index: -31.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5132
    Cell Significance Index: -14.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5134
    Cell Significance Index: -40.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5330
    Cell Significance Index: -3.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5781
    Cell Significance Index: -35.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5952
    Cell Significance Index: -36.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6297
    Cell Significance Index: -7.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6489
    Cell Significance Index: -13.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6626
    Cell Significance Index: -9.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7178
    Cell Significance Index: -6.6100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.7326
    Cell Significance Index: -11.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8201
    Cell Significance Index: -26.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8251
    Cell Significance Index: -43.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8325
    Cell Significance Index: -17.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8697
    Cell Significance Index: -14.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ras/Rho GEF activity**: SOS2 possesses GEF activity, which enables it to activate small GTPases, such as Rac1 and RhoA, by facilitating their guanine nucleotide exchange. 2. **Cellular localization**: SOS2 is expressed in various cell types, including neurons, muscle cells, and immune cells, suggesting its involvement in multiple cellular processes. 3. **Signal transduction regulation**: SOS2 regulates signal transduction pathways, including those mediated by small GTPases, guanine nucleotide exchange factors, and protein heterodimerization. 4. **Developmental biology**: SOS2 has been implicated in developmental processes, such as axon guidance, nervous system development, and cell death signaling. 5. **Immune system regulation**: SOS2 plays a role in regulating immune responses, including B cell homeostasis, cytokine signaling, and T cell differentiation. **Pathways and Functions** 1. **Rac1 activation**: SOS2 activates Rac1 by facilitating its guanine nucleotide exchange, leading to the regulation of various cellular processes, including cell migration, cytoskeleton reorganization, and cell death signaling. 2. **Axon guidance**: SOS2 regulates axon guidance by modulating the activity of small GTPases, such as Rac1 and RhoA, which are involved in the regulation of neuronal migration and axon outgrowth. 3. **B cell homeostasis**: SOS2 regulates B cell homeostasis by modulating the activity of small GTPases, such as Rac1 and RhoA, which are involved in the regulation of B cell proliferation, differentiation, and survival. 4. **Cytokine signaling**: SOS2 regulates cytokine signaling by modulating the activity of small GTPases, such as Rac1 and RhoA, which are involved in the regulation of immune responses, including inflammation and immune cell activation. 5. **Cell death signaling**: SOS2 regulates cell death signaling by modulating the activity of small GTPases, such as Rac1 and RhoA, which are involved in the regulation of apoptosis and necrosis. **Clinical Significance** 1. **Cancer**: SOS2 has been implicated in various types of cancer, including breast cancer, lung cancer, and colon cancer, where it is often overexpressed and associated with poor prognosis. 2. **Neurological disorders**: SOS2 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it is often dysregulated and associated with disease progression. 3. **Immune system disorders**: SOS2 has been implicated in immune system disorders, such as autoimmune diseases, such as rheumatoid arthritis and lupus, where it is often dysregulated and associated with disease progression. 4. **Cardiovascular disease**: SOS2 has been implicated in cardiovascular disease, including atherosclerosis and heart failure, where it is often dysregulated and associated with disease progression. In conclusion, SOS2 is a multifunctional protein that plays a critical role in various cellular processes, including cell signaling, development, and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, immune system disorders, and cardiovascular disease. Further research is needed to fully elucidate the mechanisms by which SOS2 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 3769287058

Symbol: SOS2_HUMAN

Name: Son of sevenless homolog 2

UniProtKB Accession Codes:

Q07890 B7ZKT6 D3DSB4 Q15503 Q17RN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 6 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8493579

Title: Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

PubMed ID: 8493579

DOI: 10.1126/science.8493579

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25795793

Title: Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.

PubMed ID: 25795793

DOI: 10.1136/jmedgenet-2015-103018

Sequence Information:

  • Length: 1332
  • Mass: 152979
  • Checksum: 0D1D4FAB8E37C371
  • Sequence:
    • MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC 
MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY 
KVDYHVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK VLMDMFDQDD 
IGLVSLCEDE PSSSGELNYY DLVRTEIAEE RQYLRELNMI IKVFREAFLS DRKLFKPSDI 
EKIFSNISDI HELTVKLLGL IEDTVEMTDE SSPHPLAGSC FEDLAEEQAF DPYETLSQDI 
LSPEFHEHFN KLMARPAVAL HFQSIADGFK EAVRYVLPRL MLVPVYHCWH YFELLKQLKA 
CSEEQEDREC LNQAITALMN LQGSMDRIYK QYSPRRRPGD PVCPFYSHQL RSKHLAIKKM 
NEIQKNIDGW EGKDIGQCCN EFIMEGPLTR IGAKHERHIF LFDGLMISCK PNHGQTRLPG 
YSSAEYRLKE KFVMRKIQIC DKEDTCEHKH AFELVSKDEN SIIFAAKSAE EKNNWMAALI 
SLHYRSTLDR MLDSVLLKEE NEQPLRLPSP EVYRFVVKDS EENIVFEDNL QSRSGIPIIK 
GGTVVKLIER LTYHMYADPN FVRTFLTTYR SFCKPQELLS LLIERFEIPE PEPTDADKLA 
IEKGEQPISA DLKRFRKEYV QPVQLRILNV FRHWVEHHFY DFERDLELLE RLESFISSVR 
GKAMKKWVES IAKIIRRKKQ AQANGVSHNI TFESPPPPIE WHISKPGQFE TFDLMTLHPI 
EIARQLTLLE SDLYRKVQPS ELVGSVWTKE DKEINSPNLL KMIRHTTNLT LWFEKCIVEA 
ENFEERVAVL SRIIEILQVF QDLNNFNGVL EIVSAVNSVS VYRLDHTFEA LQERKRKILD 
EAVELSQDHF KKYLVKLKSI NPPCVPFFGI YLTNILKTEE GNNDFLKKKG KDLINFSKRR 
KVAEITGEIQ QYQNQPYCLR IEPDMRRFFE NLNPMGSASE KEFTDYLFNK SLEIEPRNCK 
QPPRFPRKST FSLKSPGIRP NTGRHGSTSG TLRGHPTPLE REPCKISFSR IAETELESTV 
SAPTSPNTPS TPPVSASSDL SVFLDVDLNS SCGSNSIFAP VLLPHSKSFF SSCGSLHKLS 
EEPLIPPPLP PRKKFDHDAS NSKGNMKSDD DPPAIPPRQP PPPKVKPRVP VPTGAFDGPL 
HSPPPPPPRD PLPDTPPPVP LRPPEHFINC PFNLQPPPLG HLHRDSDWLR DISTCPNSPS 
TPPSTPSPRV PRRCYVLSSS QNNLAHPPAP PVPPRQNSSP HLPKLPPKTY KRELSHPPLY 
RLPLLENAET PQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.