Details for: UAP1

Gene ID: 6675

Symbol: UAP1

Ensembl ID: ENSG00000117143

Description: UDP-N-acetylglucosamine pyrophosphorylase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 247.5164
    Cell Significance Index: -38.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.0712
    Cell Significance Index: -37.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.0148
    Cell Significance Index: -39.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.3017
    Cell Significance Index: -40.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.6170
    Cell Significance Index: -33.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.6835
    Cell Significance Index: -40.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.6431
    Cell Significance Index: -34.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.0125
    Cell Significance Index: -39.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1296
    Cell Significance Index: -40.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0835
    Cell Significance Index: -39.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1660
    Cell Significance Index: -22.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6481
    Cell Significance Index: -14.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.2525
    Cell Significance Index: 121.9000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.7703
    Cell Significance Index: 18.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8030
    Cell Significance Index: 84.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7699
    Cell Significance Index: 192.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6047
    Cell Significance Index: 74.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2194
    Cell Significance Index: 33.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1490
    Cell Significance Index: 19.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9662
    Cell Significance Index: 191.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9080
    Cell Significance Index: 117.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9074
    Cell Significance Index: 17.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6809
    Cell Significance Index: 93.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6374
    Cell Significance Index: 28.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6120
    Cell Significance Index: 42.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6055
    Cell Significance Index: 45.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5594
    Cell Significance Index: 28.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4879
    Cell Significance Index: 97.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3666
    Cell Significance Index: 9.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3551
    Cell Significance Index: 5.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3462
    Cell Significance Index: 9.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3148
    Cell Significance Index: 53.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3127
    Cell Significance Index: 282.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3064
    Cell Significance Index: 37.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2928
    Cell Significance Index: 47.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2825
    Cell Significance Index: 101.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2587
    Cell Significance Index: 141.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2573
    Cell Significance Index: 484.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2420
    Cell Significance Index: 153.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2372
    Cell Significance Index: 30.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2008
    Cell Significance Index: 14.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1997
    Cell Significance Index: 88.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1523
    Cell Significance Index: 105.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1518
    Cell Significance Index: 28.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1405
    Cell Significance Index: 2.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1075
    Cell Significance Index: 19.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0937
    Cell Significance Index: 9.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0096
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0161
    Cell Significance Index: -10.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0171
    Cell Significance Index: -26.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0177
    Cell Significance Index: -32.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0191
    Cell Significance Index: -14.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0263
    Cell Significance Index: -14.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0312
    Cell Significance Index: -42.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0315
    Cell Significance Index: -23.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0434
    Cell Significance Index: -19.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0483
    Cell Significance Index: -4.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0643
    Cell Significance Index: -3.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0846
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0922
    Cell Significance Index: -19.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0997
    Cell Significance Index: -1.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1043
    Cell Significance Index: -12.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1104
    Cell Significance Index: -31.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1289
    Cell Significance Index: -4.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1324
    Cell Significance Index: -2.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1410
    Cell Significance Index: -2.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1565
    Cell Significance Index: -2.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2016
    Cell Significance Index: -23.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2149
    Cell Significance Index: -24.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2294
    Cell Significance Index: -4.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2444
    Cell Significance Index: -12.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2558
    Cell Significance Index: -16.1200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2667
    Cell Significance Index: -4.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2679
    Cell Significance Index: -20.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2683
    Cell Significance Index: -7.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2734
    Cell Significance Index: -7.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3073
    Cell Significance Index: -35.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3267
    Cell Significance Index: -18.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3731
    Cell Significance Index: -38.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4155
    Cell Significance Index: -25.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4158
    Cell Significance Index: -27.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4196
    Cell Significance Index: -33.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4426
    Cell Significance Index: -28.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4498
    Cell Significance Index: -6.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4593
    Cell Significance Index: -15.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5235
    Cell Significance Index: -27.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5320
    Cell Significance Index: -14.2600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5520
    Cell Significance Index: -7.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5689
    Cell Significance Index: -34.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6140
    Cell Significance Index: -22.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6145
    Cell Significance Index: -6.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6300
    Cell Significance Index: -7.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6314
    Cell Significance Index: -16.2300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.6372
    Cell Significance Index: -2.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7272
    Cell Significance Index: -21.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7333
    Cell Significance Index: -32.4400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.7998
    Cell Significance Index: -8.7300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8125
    Cell Significance Index: -12.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8601
    Cell Significance Index: -32.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UAP1 is a pyrophosphorylase enzyme that catalyzes the conversion of UDP-N-acetylglucosamine 6-phosphate to UDP-N-acetylglucosamine, a critical step in the biosynthesis of UAG. This enzyme exhibits high specificity for its substrate, with a low Km value indicating efficient substrate binding. UAP1 is also capable of transferring a pyrophosphate group to UAG, facilitating its incorporation into nascent proteins. The enzyme's activity is positively regulated by type I interferon, suggesting that UAP1 may play a role in antiviral immune responses. **Pathways and Functions** UAP1 is involved in several cellular pathways, including: 1. **Antiviral innate immune response**: UAP1's positive regulation by type I interferon suggests that it may contribute to the host's defense against viral infections by promoting the production of antiviral cytokines. 2. **Asparagine n-linked glycosylation**: UAP1 is essential for the biosynthesis of UAG, which is a critical component of N-glycans. These glycoconjugates play important roles in protein folding, cell signaling, and immune responses. 3. **Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo)**: UAP1 is involved in the synthesis of UAG, which is necessary for the formation of llo, a precursor to N-glycans. 4. **Post-translational protein modification**: UAP1's ability to transfer a pyrophosphate group to UAG suggests that it may be involved in the modification of proteins, potentially influencing their stability, activity, or interactions. **Clinical Significance** The identification of UAP1 in various cell types and its involvement in antiviral immune responses suggest that it may play a role in the pathogenesis of viral infections. Dysregulation of UAP1 expression or activity could contribute to the development of viral diseases, such as influenza or HIV. Additionally, UAP1's involvement in N-glycan biosynthesis may have implications for the diagnosis and treatment of diseases related to glycosylation, such as cancer or neurodegenerative disorders. Further research is needed to fully elucidate the functional significance of UAP1 and its potential applications in human disease. In conclusion, UAP1 is a critical enzyme involved in the biosynthesis of UDP-N-acetylglucosamine, a key component of glycoproteins and glycolipids. Its expression and function in various cell types suggest that it plays a pivotal role in maintaining cellular homeostasis and responding to environmental stimuli. Further research is needed to fully understand the clinical significance of UAP1 and its potential applications in human disease.

Genular Protein ID: 1904756388

Symbol: UAP1_HUMAN

Name: Sperm-associated antigen 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8025165

Title: Characterization of a human antigen with sera from infertile patients.

PubMed ID: 8025165

DOI: 10.1095/biolreprod50.5.1087

PubMed ID: 9603950

Title: The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases: gene cloning, protein expression, and catalytic mechanism.

PubMed ID: 9603950

DOI: 10.1074/jbc.273.23.14392

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9765219

Title: A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc.

PubMed ID: 9765219

DOI: 10.1074/jbc.273.42.27055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 36603579

Title: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.

PubMed ID: 36603579

DOI: 10.1016/j.molcel.2022.12.007

PubMed ID: 11707391

Title: Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture.

PubMed ID: 11707391

DOI: 10.1093/emboj/20.22.6191

Sequence Information:

  • Length: 522
  • Mass: 58769
  • Checksum: 8A69B36D852B9472
  • Sequence:
  • MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS 
    HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY 
    PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK 
    HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME 
    QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ 
    VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY 
    VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT 
    ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRSATNGKS ETITADVNHN LKDANDVPIQ 
    CEISPLISYA GEGLESYVAD KEFHAPLIID ENGVHELVKN GI

Genular Protein ID: 2240918255

Symbol: A0A140VKC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 505
  • Mass: 57028
  • Checksum: 6BDB4DA54D637317
  • Sequence:
  • MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS 
    HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY 
    PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK 
    HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME 
    QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ 
    VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY 
    VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT 
    ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRLKDANDV PIQCEISPLI SYAGEGLESY 
    VADKEFHAPL IIDENGVHEL VKNGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.