Details for: UAP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 247.5164
Cell Significance Index: -38.5000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 146.0712
Cell Significance Index: -37.0500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 97.0148
Cell Significance Index: -39.9700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 86.3017
Cell Significance Index: -40.7500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 83.6170
Cell Significance Index: -33.9700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 60.6835
Cell Significance Index: -40.7200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.6431
Cell Significance Index: -34.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.0125
Cell Significance Index: -39.4700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.1296
Cell Significance Index: -40.5300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.0835
Cell Significance Index: -39.7900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.1660
Cell Significance Index: -22.0100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.6481
Cell Significance Index: -14.5500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.2525
Cell Significance Index: 121.9000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.7703
Cell Significance Index: 18.7700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.8030
Cell Significance Index: 84.7400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.7699
Cell Significance Index: 192.5200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.6047
Cell Significance Index: 74.8200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2194
Cell Significance Index: 33.1900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.1490
Cell Significance Index: 19.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9662
Cell Significance Index: 191.7400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.9080
Cell Significance Index: 117.3100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.9074
Cell Significance Index: 17.7100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6809
Cell Significance Index: 93.5000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6374
Cell Significance Index: 28.8900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6120
Cell Significance Index: 42.3300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6055
Cell Significance Index: 45.1300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.5594
Cell Significance Index: 28.2700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4879
Cell Significance Index: 97.8700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3666
Cell Significance Index: 9.7900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.3551
Cell Significance Index: 5.1000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3462
Cell Significance Index: 9.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3148
Cell Significance Index: 53.7600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3127
Cell Significance Index: 282.3400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3064
Cell Significance Index: 37.6800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2928
Cell Significance Index: 47.6300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2825
Cell Significance Index: 101.3400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2587
Cell Significance Index: 141.2800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2573
Cell Significance Index: 484.5200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2420
Cell Significance Index: 153.6900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2372
Cell Significance Index: 30.4100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2008
Cell Significance Index: 14.2000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1997
Cell Significance Index: 88.2900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1523
Cell Significance Index: 105.3400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1518
Cell Significance Index: 28.8900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1405
Cell Significance Index: 2.9400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1075
Cell Significance Index: 19.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0937
Cell Significance Index: 9.2700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0096
Cell Significance Index: -1.4000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0096
Cell Significance Index: -7.1000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0161
Cell Significance Index: -10.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0171
Cell Significance Index: -26.2900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0177
Cell Significance Index: -32.6900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0191
Cell Significance Index: -14.4900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0263
Cell Significance Index: -14.8600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0312
Cell Significance Index: -42.4000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0315
Cell Significance Index: -23.0900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0434
Cell Significance Index: -19.7000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0483
Cell Significance Index: -4.9300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0643
Cell Significance Index: -3.3400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0846
Cell Significance Index: -1.5000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0922
Cell Significance Index: -19.4200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0997
Cell Significance Index: -1.3600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1043
Cell Significance Index: -12.1500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1104
Cell Significance Index: -31.7600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1289
Cell Significance Index: -4.1300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1324
Cell Significance Index: -2.8200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1410
Cell Significance Index: -2.3600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1565
Cell Significance Index: -2.3100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2016
Cell Significance Index: -23.7700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2149
Cell Significance Index: -24.6300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2294
Cell Significance Index: -4.9700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2444
Cell Significance Index: -12.8300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2558
Cell Significance Index: -16.1200 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.2667
Cell Significance Index: -4.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2679
Cell Significance Index: -20.5600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2683
Cell Significance Index: -7.0600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2734
Cell Significance Index: -7.6400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3073
Cell Significance Index: -35.0800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3267
Cell Significance Index: -18.3300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3731
Cell Significance Index: -38.8500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4155
Cell Significance Index: -25.5400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4158
Cell Significance Index: -27.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4196
Cell Significance Index: -33.2300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4426
Cell Significance Index: -28.5600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4498
Cell Significance Index: -6.7400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4593
Cell Significance Index: -15.9600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5235
Cell Significance Index: -27.2700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5320
Cell Significance Index: -14.2600 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.5520
Cell Significance Index: -7.9100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5689
Cell Significance Index: -34.8800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6140
Cell Significance Index: -22.5400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.6145
Cell Significance Index: -6.6800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6300
Cell Significance Index: -7.5100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6314
Cell Significance Index: -16.2300 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.6372
Cell Significance Index: -2.4400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7272
Cell Significance Index: -21.4200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7333
Cell Significance Index: -32.4400 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.7998
Cell Significance Index: -8.7300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.8125
Cell Significance Index: -12.8900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8601
Cell Significance Index: -32.5700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1904756388
Symbol: UAP1_HUMAN
Name: Sperm-associated antigen 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8025165
Title: Characterization of a human antigen with sera from infertile patients.
PubMed ID: 8025165
PubMed ID: 9603950
Title: The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases: gene cloning, protein expression, and catalytic mechanism.
PubMed ID: 9603950
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9765219
Title: A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc.
PubMed ID: 9765219
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 36603579
Title: Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.
PubMed ID: 36603579
PubMed ID: 11707391
Title: Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture.
PubMed ID: 11707391
Sequence Information:
- Length: 522
- Mass: 58769
- Checksum: 8A69B36D852B9472
- Sequence:
MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRSATNGKS ETITADVNHN LKDANDVPIQ CEISPLISYA GEGLESYVAD KEFHAPLIID ENGVHELVKN GI
Genular Protein ID: 2240918255
Symbol: A0A140VKC0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 505
- Mass: 57028
- Checksum: 6BDB4DA54D637317
- Sequence:
MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRLKDANDV PIQCEISPLI SYAGEGLESY VADKEFHAPL IIDENGVHEL VKNGI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.