Details for: SRPK2

Gene ID: 6733

Symbol: SRPK2

Ensembl ID: ENSG00000135250

Description: SRSF protein kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 616.0266
    Cell Significance Index: -95.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 355.9722
    Cell Significance Index: -90.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 204.6714
    Cell Significance Index: -96.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 189.5721
    Cell Significance Index: -77.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 173.9163
    Cell Significance Index: -89.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 144.1085
    Cell Significance Index: -96.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.4041
    Cell Significance Index: -77.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.2104
    Cell Significance Index: -96.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 32.6258
    Cell Significance Index: -87.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 28.3677
    Cell Significance Index: -87.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.5258
    Cell Significance Index: -96.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.0501
    Cell Significance Index: -46.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.2496
    Cell Significance Index: 1165.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.0984
    Cell Significance Index: 237.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0559
    Cell Significance Index: 613.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.9875
    Cell Significance Index: 83.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.7538
    Cell Significance Index: 169.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6819
    Cell Significance Index: 532.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6191
    Cell Significance Index: 146.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4599
    Cell Significance Index: 59.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.3659
    Cell Significance Index: 275.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.2915
    Cell Significance Index: 154.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2913
    Cell Significance Index: 120.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1799
    Cell Significance Index: 1507.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5324
    Cell Significance Index: 67.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5315
    Cell Significance Index: 29.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4939
    Cell Significance Index: 56.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4339
    Cell Significance Index: 40.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1485
    Cell Significance Index: 141.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9377
    Cell Significance Index: 169.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8407
    Cell Significance Index: 759.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7866
    Cell Significance Index: 20.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7488
    Cell Significance Index: 408.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7325
    Cell Significance Index: 93.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5282
    Cell Significance Index: 233.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5176
    Cell Significance Index: 12.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5075
    Cell Significance Index: 55.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4590
    Cell Significance Index: 63.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4269
    Cell Significance Index: 803.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4126
    Cell Significance Index: 262.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3894
    Cell Significance Index: 63.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3542
    Cell Significance Index: 6.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3221
    Cell Significance Index: 495.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2610
    Cell Significance Index: 118.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2573
    Cell Significance Index: 13.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2329
    Cell Significance Index: 6.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2208
    Cell Significance Index: 407.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2051
    Cell Significance Index: 278.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1374
    Cell Significance Index: 13.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0740
    Cell Significance Index: 14.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0283
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0581
    Cell Significance Index: -43.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0711
    Cell Significance Index: -52.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0778
    Cell Significance Index: -0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0798
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0813
    Cell Significance Index: -50.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1044
    Cell Significance Index: -79.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1049
    Cell Significance Index: -1.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1134
    Cell Significance Index: -7.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1317
    Cell Significance Index: -17.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1334
    Cell Significance Index: -75.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1544
    Cell Significance Index: -26.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1811
    Cell Significance Index: -13.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1975
    Cell Significance Index: -9.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2242
    Cell Significance Index: -22.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2531
    Cell Significance Index: -11.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2696
    Cell Significance Index: -12.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2856
    Cell Significance Index: -41.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2875
    Cell Significance Index: -60.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2927
    Cell Significance Index: -84.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4149
    Cell Significance Index: -48.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4487
    Cell Significance Index: -7.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4879
    Cell Significance Index: -10.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5037
    Cell Significance Index: -32.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5161
    Cell Significance Index: -11.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5234
    Cell Significance Index: -14.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5308
    Cell Significance Index: -55.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5622
    Cell Significance Index: -39.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5805
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6020
    Cell Significance Index: -68.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6143
    Cell Significance Index: -38.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6356
    Cell Significance Index: -33.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6676
    Cell Significance Index: -23.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7333
    Cell Significance Index: -83.7000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7718
    Cell Significance Index: -11.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8131
    Cell Significance Index: -23.8800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.9193
    Cell Significance Index: -8.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0072
    Cell Significance Index: -79.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0516
    Cell Significance Index: -28.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1787
    Cell Significance Index: -24.4500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1833
    Cell Significance Index: -14.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2102
    Cell Significance Index: -38.7600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.2442
    Cell Significance Index: -8.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.2559
    Cell Significance Index: -18.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2929
    Cell Significance Index: -17.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3561
    Cell Significance Index: -26.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3709
    Cell Significance Index: -84.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3930
    Cell Significance Index: -36.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4053
    Cell Significance Index: -46.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4489
    Cell Significance Index: -46.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SRPK2 is a member of the SRSF family of proteins, which are known for their involvement in splicing regulation and mRNA processing. This gene encodes a serine/threonine kinase enzyme that phosphorylates specific serine and threonine residues on target proteins. SRPK2's kinase activity is essential for its function, and it is activated by various signaling pathways, including those involved in cell differentiation, apoptosis, and viral infections. **Pathways and Functions** SRPK2's involvement in various cellular processes can be attributed to its participation in multiple signaling pathways, including: 1. **Spliceosome regulation**: SRPK2 phosphorylates and regulates the activity of spliceosomal proteins, which are essential for proper mRNA splicing. 2. **Cell differentiation**: SRPK2 is involved in the regulation of cell differentiation, particularly in neurons and other cells of the vertebrate nervous system. 3. **Apoptosis**: SRPK2's kinase activity is required for the regulation of apoptosis, particularly in neurons. 4. **Viral infections**: SRPK2 is involved in the regulation of viral genome replication and the modulation of the innate immune response during SARS-CoV-2 infections. 5. **Intracellular signaling**: SRPK2 is activated by various signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance** SRPK2's involvement in viral infections, particularly SARS-CoV-2, has significant clinical implications. Research has shown that SRPK2 is essential for the regulation of viral genome replication and the modulation of the innate immune response. Therefore, targeting SRPK2 could provide a novel therapeutic strategy for the treatment of viral diseases, including SARS-CoV-2 infections. Additionally, SRPK2's involvement in cell differentiation and apoptosis suggests its potential as a therapeutic target for the treatment of neurological disorders, including neurodegenerative diseases. In summary, SRPK2 is a serine/threonine kinase enzyme that plays a crucial role in various cellular processes, including cell differentiation, apoptosis, and mRNA processing. Its involvement in viral infections, particularly SARS-CoV-2, has significant clinical implications, and further research is needed to fully understand its role in human disease and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 381213144

Symbol: SRPK2_HUMAN

Name: SRSF protein kinase 2

UniProtKB Accession Codes:

P78362 A8MVX2 O75220 O75221 Q6NUL0 Q6V1X2 Q8IYQ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 2 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 10 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9472028

Title: SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.

PubMed ID: 9472028

DOI: 10.1083/jcb.140.4.737

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12134018

Title: Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein.

PubMed ID: 12134018

DOI: 10.1128/jvi.76.16.8124-8137.2002

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16122776

Title: Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein.

PubMed ID: 16122776

DOI: 10.1016/j.virol.2005.07.030

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18559500

Title: Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1.

PubMed ID: 18559500

DOI: 10.1158/0008-5472.can-08-0021

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18425142

Title: Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.

PubMed ID: 18425142

DOI: 10.1038/nsmb.1415

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21157427

Title: Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin.

PubMed ID: 21157427

DOI: 10.1038/emboj.2010.333

PubMed ID: 21205200

Title: Serine-arginine protein kinases: a small protein kinase family with a large cellular presence.

PubMed ID: 21205200

DOI: 10.1111/j.1742-4658.2010.07987.x

PubMed ID: 21056976

Title: The N-terminal fragment from caspase-cleaved serine/arginine protein-specific kinase2 (SRPK2) translocates into the nucleus and promotes apoptosis.

PubMed ID: 21056976

DOI: 10.1074/jbc.m110.193441

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28076779

Title: Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.

PubMed ID: 28076779

DOI: 10.1016/j.celrep.2016.12.050

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 688
  • Mass: 77527
  • Checksum: ACCAF2A887444EC2
  • Sequence:
    • MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPPPLPDP TPPEPEEEIL GSDDEEQEDP 
ADYCKGGYHP VKIGDLFNGR YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE 
TALDEIKLLK CVRESDPSDP NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS 
NYQGLPVRCV KSIIRQVLQG LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ 
KAGAPPPSGS AVSTAPQQKP IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK 
IIEENITSAA PSNDQDGEYC PEVKLKTTGL EEAAEAETAK DNGEAEDQEE KEDAEKENIE 
KDEDDVDQEL ANIDPTWIES PKTNGHIENG PFSLEQQLDD EDDDEEDCPN PEEYNLDEPN 
AESDYTYSSS YEQFNGELPN GRHKIPESQF PEFSTSLFSG SLEPVACGSV LSEGSPLTEQ 
EESSPSHDRS RTVSASSTGD LPKAKTRAAD LLVNPLDPRN ADKIRVKIAD LGNACWVHKH 
FTEDIQTRQY RSIEVLIGAG YSTPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA 
HIIELLGSIP RHFALSGKYS REFFNRRGEL RHITKLKPWS LFDVLVEKYG WPHEDAAQFT 
DFLIPMLEMV PEKRASAGEC LRHPWLNS

Genular Protein ID: 777301257

Symbol: C9J2M4_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J2M4

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChEBI 11 ChiTaRS 1 EC 2 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 4 Rhea 6 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 719
  • Mass: 81175
  • Checksum: 35143A5E7CCF1304
  • Sequence:
    • MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPPPLPDP TPPEPEEEIL GSDDEEQEDP 
ADYCKGGYHP VKIGDLFNGR YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE 
TALDEIKLLK CVRESDPSDP NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS 
NYQGLPVRCV KSIIRQVLQG LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ 
KAGAPPPSGS AVSTAPQQKP IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK 
IIEENITSAA PSNDQDGEYC PEVKLKTTGL EEAAEAETAK DNGEAEDQEE KEDAEKENIE 
KDEDDVDQEL ANIDPTWIES PKTNGHIENG PFSLEQQLDD EDDDEEDCPN PEEYNLDEPN 
AESDYTYSSS YEQFNGELPN GRHKIPESQF PEFSTSLFSG SLEPVACGSV LSEGSPLTEQ 
EESSPSHDRS RTVSASSTGD LPKAKTRAAD LLVNPLDPRN ADKIRVKIAD LGNACWVHKH 
FTEDIQTRQY RSIEVLIGAG YSTPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA 
HIIELLGSIP RHFALSGKYS REFFNRRDHI ALIIELLGKV PRKYAMLGKY SKEFFTRKGE 
LRHITKLKPW SLFDVLVEKY GWPHEDAAQF TDFLIPMLEM VPEKRASAGE CLRHPWLNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.