Details for: STAT2

Gene ID: 6773

Symbol: STAT2

Ensembl ID: ENSG00000170581

Description: signal transducer and activator of transcription 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.7139
    Cell Significance Index: -32.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.6489
    Cell Significance Index: -31.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.2873
    Cell Significance Index: -32.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.4131
    Cell Significance Index: -31.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8136
    Cell Significance Index: -33.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6430
    Cell Significance Index: -31.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2297
    Cell Significance Index: -31.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0613
    Cell Significance Index: -22.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3780
    Cell Significance Index: -33.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6534
    Cell Significance Index: 30.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3955
    Cell Significance Index: 19.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2939
    Cell Significance Index: 36.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1545
    Cell Significance Index: 229.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8736
    Cell Significance Index: 95.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8367
    Cell Significance Index: 167.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7426
    Cell Significance Index: 120.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7159
    Cell Significance Index: 15.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5626
    Cell Significance Index: 10.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5413
    Cell Significance Index: 74.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4788
    Cell Significance Index: 171.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3998
    Cell Significance Index: 49.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3934
    Cell Significance Index: 70.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3708
    Cell Significance Index: 19.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3297
    Cell Significance Index: 9.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3294
    Cell Significance Index: 14.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3169
    Cell Significance Index: 19.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3113
    Cell Significance Index: 39.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2490
    Cell Significance Index: 110.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2413
    Cell Significance Index: 15.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2250
    Cell Significance Index: 10.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2085
    Cell Significance Index: 188.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2064
    Cell Significance Index: 5.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2009
    Cell Significance Index: 13.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1734
    Cell Significance Index: 94.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1491
    Cell Significance Index: 28.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1336
    Cell Significance Index: 10.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1219
    Cell Significance Index: 14.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1130
    Cell Significance Index: 7.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0972
    Cell Significance Index: 183.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0825
    Cell Significance Index: 5.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0604
    Cell Significance Index: 38.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0433
    Cell Significance Index: 1.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0379
    Cell Significance Index: 1.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0370
    Cell Significance Index: 3.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0355
    Cell Significance Index: 54.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0325
    Cell Significance Index: 59.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0220
    Cell Significance Index: 29.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0215
    Cell Significance Index: 3.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0111
    Cell Significance Index: 0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0080
    Cell Significance Index: -3.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0187
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0240
    Cell Significance Index: -18.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0269
    Cell Significance Index: -19.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0315
    Cell Significance Index: -19.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0369
    Cell Significance Index: -20.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0529
    Cell Significance Index: -5.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0609
    Cell Significance Index: -2.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0971
    Cell Significance Index: -27.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0980
    Cell Significance Index: -20.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1053
    Cell Significance Index: -15.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1072
    Cell Significance Index: -12.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1382
    Cell Significance Index: -17.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1434
    Cell Significance Index: -3.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1588
    Cell Significance Index: -8.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1763
    Cell Significance Index: -4.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1776
    Cell Significance Index: -13.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1797
    Cell Significance Index: -7.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1808
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1895
    Cell Significance Index: -21.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2046
    Cell Significance Index: -14.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2265
    Cell Significance Index: -25.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2268
    Cell Significance Index: -3.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2482
    Cell Significance Index: -9.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2637
    Cell Significance Index: -27.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3015
    Cell Significance Index: -7.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3341
    Cell Significance Index: -4.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3573
    Cell Significance Index: -18.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3682
    Cell Significance Index: -5.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3718
    Cell Significance Index: -29.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3746
    Cell Significance Index: -10.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4175
    Cell Significance Index: -9.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4371
    Cell Significance Index: -26.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4541
    Cell Significance Index: -23.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4967
    Cell Significance Index: -13.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5088
    Cell Significance Index: -17.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5316
    Cell Significance Index: -4.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5466
    Cell Significance Index: -9.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5570
    Cell Significance Index: -6.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5660
    Cell Significance Index: -8.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5805
    Cell Significance Index: -12.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5862
    Cell Significance Index: -18.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6474
    Cell Significance Index: -20.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6542
    Cell Significance Index: -21.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6777
    Cell Significance Index: -19.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6807
    Cell Significance Index: -19.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6912
    Cell Significance Index: -14.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7262
    Cell Significance Index: -25.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7502
    Cell Significance Index: -27.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7881
    Cell Significance Index: -21.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STAT2 is a cytoplasmic protein that, upon activation by phosphorylation, translocates to the nucleus where it regulates the expression of target genes. It is a member of the STAT family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and modulate gene expression in response to extracellular signals. STAT2 is primarily expressed in cells of the immune system, including monocytes, macrophages, and dendritic cells, as well as in neural and epithelial cells. **Pathways and Functions:** STAT2 is involved in multiple signaling pathways, including: 1. **Interferon alpha/beta signaling pathway:** STAT2 is a key component of this pathway, which is crucial for the induction of interferon-stimulated genes (ISGs) that combat viral infections. 2. **Cytokine signaling pathway:** STAT2 mediates the transcriptional activation of genes involved in the production of cytokines, chemokines, and other immune molecules. 3. **JAK-STAT pathway:** STAT2 is activated by JAK kinases, which phosphorylate and activate STAT2, leading to its nuclear translocation and transcriptional regulation of target genes. STAT2's functions include: 1. **Viral defense:** STAT2 regulates the expression of ISGs that are essential for the defense against viral infections, including influenza, respiratory syncytial virus (RSV), and SARS-CoV-2. 2. **Immune cell activation:** STAT2 mediates the activation of immune cells, including monocytes, macrophages, and dendritic cells, which are critical for the initiation of immune responses. 3. **Tumor suppression:** STAT2 has been implicated in the regulation of cell proliferation and apoptosis, suggesting its potential role in cancer prevention. **Clinical Significance:** Dysregulation of STAT2 has been implicated in various diseases, including: 1. **Viral infections:** Mutations in STAT2 have been associated with severe respiratory syncytial virus (RSV) infection and SARS-CoV-2 pneumonia. 2. **Autoimmune disorders:** STAT2 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, which are characterized by dysregulated immune responses. 3. **Cancer:** STAT2's role in tumor suppression and cell proliferation has led to its investigation as a potential therapeutic target in cancer treatment. In conclusion, STAT2 is a crucial transcription factor that plays a pivotal role in the regulation of immune responses, particularly in the context of viral infections and the innate immune system. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and pathogenesis. Further research is needed to elucidate the mechanisms by which STAT2 regulates immune responses and to develop therapeutic strategies targeting this transcription factor.

Genular Protein ID: 1402862912

Symbol: STAT2_HUMAN

Name: Signal transducer and activator of transcription 2

UniProtKB Accession Codes:

P52630 B4DLC7 G3V2M6 Q16430 Q16431 Q9UDL4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 EMDB 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1502204

Title: The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

PubMed ID: 1502204

DOI: 10.1073/pnas.89.16.7840

PubMed ID: 7885841

Title: The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.

PubMed ID: 7885841

DOI: 10.1093/nar/23.3.459

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1638633

Title: A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s).

PubMed ID: 1638633

DOI: 10.1016/0092-8674(92)90106-m

PubMed ID: 7532278

Title: Role of STAT2 in the alpha interferon signaling pathway.

PubMed ID: 7532278

DOI: 10.1128/mcb.15.3.1312

PubMed ID: 8601453

Title: Identification of alternative splicing form of Stat2.

PubMed ID: 8601453

DOI: 10.1016/0014-5793(96)00121-4

PubMed ID: 9020188

Title: Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.

PubMed ID: 9020188

DOI: 10.1074/jbc.272.7.4600

PubMed ID: 9121453

Title: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.

PubMed ID: 9121453

DOI: 10.1128/mcb.17.4.2048

PubMed ID: 10702714

Title: Viral inhibition of interferon signal transduction.

PubMed ID: 10702714

DOI: 10.1159/000053968

PubMed ID: 11150296

Title: Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.

PubMed ID: 11150296

DOI: 10.1074/jbc.m008821200

PubMed ID: 12509459

Title: Role of metazoan mediator proteins in interferon-responsive transcription.

PubMed ID: 12509459

DOI: 10.1128/mcb.23.2.620-628.2003

PubMed ID: 16227264

Title: Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1.

PubMed ID: 16227264

DOI: 10.1128/jvi.79.21.13434-13441.2005

PubMed ID: 18701593

Title: Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO.

PubMed ID: 18701593

DOI: 10.1128/jvi.00833-08

PubMed ID: 19812155

Title: Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.

PubMed ID: 19812155

DOI: 10.1128/jvi.01164-09

PubMed ID: 19279106

Title: NS5 of dengue virus mediates STAT2 binding and degradation.

PubMed ID: 19279106

DOI: 10.1128/jvi.02188-08

PubMed ID: 19754307

Title: Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation.

PubMed ID: 19754307

DOI: 10.1086/605847

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21931555

Title: Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

PubMed ID: 21931555

DOI: 10.1371/journal.ppat.1002247

PubMed ID: 23139419

Title: Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses.

PubMed ID: 23139419

DOI: 10.1074/jbc.m112.402529

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23391734

Title: STAT2 deficiency and susceptibility to viral illness in humans.

PubMed ID: 23391734

DOI: 10.1073/pnas.1220098110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26122121

Title: Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.

PubMed ID: 26122121

DOI: 10.1093/brain/awv182

PubMed ID: 25631085

Title: Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies.

PubMed ID: 25631085

DOI: 10.1128/jvi.00154-15

PubMed ID: 27782195

Title: Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling.

PubMed ID: 27782195

DOI: 10.1038/srep36179

PubMed ID: 27797853

Title: Zika virus inhibits type-I interferon production and downstream signaling.

PubMed ID: 27797853

DOI: 10.15252/embr.201642627

PubMed ID: 27212660

Title: Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.

PubMed ID: 27212660

DOI: 10.1016/j.chom.2016.05.009

PubMed ID: 28165510

Title: STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.

PubMed ID: 28165510

DOI: 10.1038/nsmb.3378

PubMed ID: 29886262

Title: Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling.

PubMed ID: 29886262

DOI: 10.1016/j.micinf.2018.05.007

PubMed ID: 30814285

Title: Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs.

PubMed ID: 30814285

DOI: 10.1128/jvi.02226-18

PubMed ID: 31040183

Title: Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.

PubMed ID: 31040183

DOI: 10.1074/jbc.ra118.006563

PubMed ID: 32699158

Title: Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

PubMed ID: 32699158

DOI: 10.4049/jimmunol.2000418

PubMed ID: 34319780

Title: Suppression of JAK-STAT Signaling by Epstein-Barr Virus Tegument Protein BGLF2 through Recruitment of SHP1 Phosphatase and Promotion of STAT2 Degradation.

PubMed ID: 34319780

DOI: 10.1128/jvi.01027-21

PubMed ID: 31836668

Title: Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.

PubMed ID: 31836668

DOI: 10.1126/sciimmunol.aav7501

PubMed ID: 32092142

Title: Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy.

PubMed ID: 32092142

DOI: 10.1084/jem.20192319

Sequence Information:

  • Length: 851
  • Mass: 97916
  • Checksum: E4C74674CB7A3215
  • Sequence:
    • MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG SDDSKATMLF 
FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQPFSQD PTQLAEMIFN LLLEEKRILI 
QAQRAQLEQG EPVLETPVES QQHEIESRIL DLRAMMEKLV KSISQLKDQQ DVFCFRYKIQ 
AKGKTPSLDP HQTKEQKILQ ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKA 
QQQKACIRAP IDHGLEQLET WFTAGAKLLF HLRQLLKELK GLSCLVSYQD DPLTKGVDLR 
NAQVTELLQR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL QEGNESLTVE 
VSIDRNPPQL QGFRKFNILT SNQKTLTPEK GQSQGLIWDF GYLTLVEQRS GGSGKGSNKG 
PLGVTEELHI ISFTVKYTYQ GLKQELKTDT LPVVIISNMN QLSIAWASVL WFNLLSPNLQ 
NQQFFSNPPK APWSLLGPAL SWQFSSYVGR GLNSDQLSML RNKLFGQNCR TEDPLLSWAD 
FTKRESPPGK LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERRLL KKTMSGTFLL 
RFSESSEGGI TCSWVEHQDD DKVLIYSVQP YTKEVLQSLP LTEIIRHYQL LTEENIPENP 
LRFLYPRIPR DEAFGCYYQE KVNLQERRKY LKHRLIVVSN RQVDELQQPL ELKPEPELES 
LELELGLVPE PELSLDLEPL LKAGLDLGPE LESVLESTLE PVIEPTLCMV SQTVPEPDQG 
PVSQPVPEPD LPCDLRHLNT EPMEIFRNCV KIEEIMPNGD PLLAGQNTVD EVYVSRPSHF 
YTDGPLMPSD F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.