Details for: SUPT6H

Gene ID: 6830

Symbol: SUPT6H

Ensembl ID: ENSG00000109111

Description: SPT6 homolog, histone chaperone and transcription elongation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 235.8157
    Cell Significance Index: -36.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.0318
    Cell Significance Index: -37.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.5678
    Cell Significance Index: -33.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.6899
    Cell Significance Index: -37.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.5047
    Cell Significance Index: -40.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.7269
    Cell Significance Index: -34.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.6678
    Cell Significance Index: -39.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0918
    Cell Significance Index: -37.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2492
    Cell Significance Index: -31.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.0911
    Cell Significance Index: -39.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8795
    Cell Significance Index: -17.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.0615
    Cell Significance Index: 41.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6053
    Cell Significance Index: 43.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4186
    Cell Significance Index: 37.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3894
    Cell Significance Index: 275.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2272
    Cell Significance Index: 246.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9123
    Cell Significance Index: 99.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8858
    Cell Significance Index: 87.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8700
    Cell Significance Index: 106.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8299
    Cell Significance Index: 49.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8126
    Cell Significance Index: 146.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7691
    Cell Significance Index: 22.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7098
    Cell Significance Index: 115.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5975
    Cell Significance Index: 31.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5684
    Cell Significance Index: 203.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5533
    Cell Significance Index: 5.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5471
    Cell Significance Index: 24.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5349
    Cell Significance Index: 14.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4853
    Cell Significance Index: 37.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4830
    Cell Significance Index: 66.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4472
    Cell Significance Index: 309.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4293
    Cell Significance Index: 29.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3804
    Cell Significance Index: 207.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3573
    Cell Significance Index: 157.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3505
    Cell Significance Index: 16.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3161
    Cell Significance Index: 20.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3106
    Cell Significance Index: 6.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1721
    Cell Significance Index: 8.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1531
    Cell Significance Index: 18.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1428
    Cell Significance Index: 9.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1396
    Cell Significance Index: 3.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1222
    Cell Significance Index: 3.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1203
    Cell Significance Index: 8.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1012
    Cell Significance Index: 190.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0842
    Cell Significance Index: 10.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0739
    Cell Significance Index: 4.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0726
    Cell Significance Index: 2.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0703
    Cell Significance Index: 1.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0587
    Cell Significance Index: 11.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0498
    Cell Significance Index: 76.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0445
    Cell Significance Index: 82.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0414
    Cell Significance Index: 1.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0384
    Cell Significance Index: 24.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0324
    Cell Significance Index: 1.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0253
    Cell Significance Index: 0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0218
    Cell Significance Index: 29.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0097
    Cell Significance Index: 4.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0093
    Cell Significance Index: 1.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0223
    Cell Significance Index: -3.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0256
    Cell Significance Index: -19.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0331
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0375
    Cell Significance Index: -27.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0443
    Cell Significance Index: -2.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0522
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0639
    Cell Significance Index: -36.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0715
    Cell Significance Index: -44.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0834
    Cell Significance Index: -2.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0845
    Cell Significance Index: -1.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0856
    Cell Significance Index: -8.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1095
    Cell Significance Index: -8.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1175
    Cell Significance Index: -33.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1677
    Cell Significance Index: -6.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1964
    Cell Significance Index: -22.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1967
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2006
    Cell Significance Index: -42.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2104
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2478
    Cell Significance Index: -28.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2907
    Cell Significance Index: -6.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3072
    Cell Significance Index: -9.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3103
    Cell Significance Index: -32.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3322
    Cell Significance Index: -17.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3480
    Cell Significance Index: -9.1500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3618
    Cell Significance Index: -5.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4179
    Cell Significance Index: -21.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4182
    Cell Significance Index: -33.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4508
    Cell Significance Index: -9.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5554
    Cell Significance Index: -34.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5719
    Cell Significance Index: -16.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5909
    Cell Significance Index: -9.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6180
    Cell Significance Index: -13.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6736
    Cell Significance Index: -4.0700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6864
    Cell Significance Index: -4.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7017
    Cell Significance Index: -11.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7043
    Cell Significance Index: -10.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7109
    Cell Significance Index: -17.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7185
    Cell Significance Index: -15.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7379
    Cell Significance Index: -25.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7661
    Cell Significance Index: -16.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Histone Chaperone Function**: Supt6h exhibits histone chaperone activity, facilitating the exchange of histones between nucleosomes, thereby regulating chromatin structure and accessibility to transcription factors. 2. **Transcription Elongation Factor**: Supt6h acts as a transcription elongation factor, interacting with RNA polymerase II (RNAPII) to enhance the efficiency of transcription elongation, thus regulating gene expression. 3. **Cellular Localization**: Supt6h is expressed in various cell types, including conjunctival epithelial cells, nasal mucosa goblet cells, and dopaminergic neurons, highlighting its diverse roles in different tissues and organs. 4. **Evolutionary Conservation**: The presence of Supt6h orthologs in various species underscores its conserved evolutionary significance, suggesting a fundamental role in maintaining genome stability and regulating gene expression. **Pathways and Functions:** 1. **Transcription Elongation**: Supt6h regulates transcription elongation by interacting with RNAPII, facilitating the progression of transcription and ensuring accurate gene expression. 2. **Histone Chaperone Activity**: Supt6h facilitates histone exchange between nucleosomes, regulating chromatin structure and accessibility to transcription factors. 3. **Gene Expression Regulation**: Supt6h modulates gene expression by regulating transcription elongation, histone chaperone activity, and chromatin organization. 4. **Chromatin Remodeling**: Supt6h is involved in chromatin remodeling, particularly during the transcription elongation process, which is essential for regulating gene expression and maintaining genome stability. **Clinical Significance:** 1. **Neurological Disorders**: Alterations in Supt6h expression have been linked to neurological disorders, such as autism spectrum disorder (ASD) and schizophrenia, highlighting its potential role in regulating gene expression and chromatin organization. 2. **Cancer**: Supt6h has been implicated in cancer development and progression, with studies suggesting its involvement in regulating transcription elongation and chromatin organization. 3. **Genetic Diseases**: Supt6h mutations have been associated with genetic diseases, such as intellectual disability and developmental delays, emphasizing its importance in regulating gene expression and chromatin organization. 4. **Epigenetic Regulation**: Supt6h plays a crucial role in epigenetic regulation, particularly in maintaining genome stability and regulating gene expression, making it an attractive target for therapeutic interventions. In conclusion, Supt6h is a multifunctional gene that plays a crucial role in regulating gene expression, particularly during transcription elongation. Its diverse cellular localization and conserved evolutionary significance underscore its fundamental importance in maintaining genome stability and regulating gene expression. Further research is necessary to fully elucidate the mechanisms of Supt6h and its clinical significance in various diseases.

Genular Protein ID: 3193160468

Symbol: SPT6H_HUMAN

Name: Transcription elongation factor SPT6

UniProtKB Accession Codes:

Q7KZ85 A7E2B4 Q15737 Q6GMQ4 Q7KYW9 Q7LDK4 Q8N526 Q92775 Q96AH3 Q9BTH9 Q9BTI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 13 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786132

Title: Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h.

PubMed ID: 8786132

DOI: 10.1006/geno.1996.0294

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9514752

Title: Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation.

PubMed ID: 9514752

DOI: 10.1006/jmbi.1997.1601

PubMed ID: 10933715

Title: Functional interaction between pleiotropic transactivator pUL69 of human cytomegalovirus and the human homolog of yeast chromatin regulatory protein SPT6.

PubMed ID: 10933715

DOI: 10.1128/jvi.74.17.8053-8064.2000

PubMed ID: 15060154

Title: Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.

PubMed ID: 15060154

DOI: 10.1128/mcb.24.8.3324-3336.2004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17234882

Title: The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.

PubMed ID: 17234882

DOI: 10.1101/gad.1503107

PubMed ID: 19141475

Title: The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

PubMed ID: 19141475

DOI: 10.1101/gad.1720008

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22567361

Title: Histone chaperones Spt6 and FACT: Similarities and differences in modes of action at transcribed genes.

PubMed ID: 22567361

DOI: 10.4061/2011/625210

PubMed ID: 21518874

Title: Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

PubMed ID: 21518874

DOI: 10.1073/pnas.1104423108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22171252

Title: The cellular protein SPT6 is required for efficient replication of human cytomegalovirus.

PubMed ID: 22171252

DOI: 10.1128/jvi.06776-11

PubMed ID: 22316138

Title: Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR.

PubMed ID: 22316138

DOI: 10.1186/1742-4690-9-13

PubMed ID: 23503590

Title: The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.

PubMed ID: 23503590

DOI: 10.1038/emboj.2013.54

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1726
  • Mass: 199073
  • Checksum: F7EB22FA669EB030
  • Sequence:
    • MSDFVESEAE ESEEEYNDEG EVVPRVTKKF VEEEDDDEEE EEENLDDQDE QGNLKGFIND 
DDDEDEGEED EGSDSGDSED DVGHKKRKRT SFDDRLEDDD FDLIEENLGV KVKRGQKYRR 
VKKMSDDEDD DEEEYGKEEH EKEAIAEEIF QDGEGEEGQE AMEAPMAPPE EEEEDDEESD 
IDDFIVDDDG QPLKKPKWRK KLPGYTDAAL QEAQEIFGVD FDYDEFEKYN EYDEELEEEY 
EYEDDEAEGE IRVRPKKTTK KRVSRRSIFE MYEPSELESS HLTDQDNEIR ATDLPERFQL 
RSIPVKGAED DELEEEADWI YRNAFATPTI SLQESCDYLD RGQPASSFSR KGPSTIQKIK 
EALGFMRNQH FEVPFIAFYR KEYVEPELHI NDLWRVWQWD EKWTQLRIRK ENLTRLFEKM 
QAYQYEQISA DPDKPLADGI RALDTTDMER LKDVQSMDEL KDVYNHFLLY YGRDIPKMQN 
AAKASRKKLK RVREEGDEEG EGDEAEDEEQ RGPELKQASR RDMYTICQSA GLDGLAKKFG 
LTPEQFGENL RDSYQRHETE QFPAEPLELA KDYVCSQFPT PEAVLEGARY MVALQIAREP 
LVRQVLRQTF QERAKLNITP TKKGRKDVDE AHYAYSFKYL KNKPVKELRD DQFLKICLAE 
DEGLLTTDIS IDLKGVEGYG NDQTYFEEIK QFYYRDEFSH QVQEWNRQRT MAIERALQQF 
LYVQMAKELK NKLLAEAKEY VIKACSRKLY NWLRVAPYRP DQQVEEDDDF MDENQGKGIR 
VLGIAFSSAR DHPVFCALVN GEGEVTDFLR LPHFTKRRTA WREEEREKKA QDIETLKKFL 
LNKKPHVVTV AGENRDAQML IEDVKRIVHE LDQGQQLSSI GVELVDNELA ILYMNSKKSE 
AEFRDYPPVL RQAVSLARRI QDPLIEFAQV CSSDEDILCL KFHPLQEHVV KEELLNALYC 
EFINRVNEVG VDVNRAIAHP YSQALIQYVC GLGPRKGTHL LKILKQNNTR LESRTQLVTM 
CHMGPKVFMN CAGFLKIDTA SLGDSTDSYI EVLDGSRVHP ETYEWARKMA VDALEYDESA 
EDANPAGALE EILENPERLK DLDLDAFAEE LERQGYGDKH ITLYDIRAEL SCRYKDLRTA 
YRSPNTEEIF NMLTKETPET FYIGKLIICN VTGIAHRRPQ GESYDQAIRN DETGLWQCPF 
CQQDNFPELS EVWNHFDSGS CPGQAIGVKT RLDNGVTGFI PTKFLSDKVV KRPEERVKVG 
MTVHCRIMKI DIEKFSADLT CRTSDLMDRN NEWKLPKDTY YDFDAEAADH KQEEDMKRKQ 
QRTTYIKRVI AHPSFHNINF KQAEKMMETM DQGDVIIRPS SKGENHLTVT WKVSDGIYQH 
VDVREEGKEN AFSLGATLWI NSEEFEDLDE IVARYVQPMA SFARDLLNHK YYQDCSGGDR 
KKLEELLIKT KKEKPTFIPY FICACKELPG KFLLGYQPRG KPRIEYVTVT PEGFRYRGQI 
FPTVNGLFRW FKDHYQDPVP GITPSSSSRT RTPASINATP ANINLADLTR AVNALPQNMT 
SQMFSAIAAV TGQGQNPNAT PAQWASSQYG YGGSGGGSSA YHVFPTPAQQ PVATPLMTPS 
YSYTTPSQPI TTPQYHQLQA STTPQSAQAQ PQPSSSSRQR QQQPKSNSHA AIDWGKMAEQ 
WLQEKEAERR KQKQRLTPRP SPSPMIESTP MSIAGDATPL LDEMDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.