ADAM17 | ENSG00000151694 | NCBI 6868

Details for: ADAM17

Gene ID: 6868

Symbol: ADAM17

Ensembl ID: ENSG00000151694

Description: ADAM metallopeptidase domain 17

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Cd163 mediating an anti-inflammatory response
(R-HSA-9662834)
Collagen degradation
(R-HSA-1442490)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 hd domain mutants
(R-HSA-2691232)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Constitutive signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660826)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Degradation of the extracellular matrix
(R-HSA-1474228)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Extracellular matrix organization
(R-HSA-1474244)
Growth hormone receptor signaling
(R-HSA-982772)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Nuclear signaling by erbb4
(R-HSA-1251985)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Parasitic infection pathways
(R-HSA-9824443)
Regulated proteolysis of p75ntr
(R-HSA-193692)
Release of hh-np from the secreting cell
(R-HSA-5362798)
Signaling by egfr
(R-HSA-177929)
Signaling by erbb4
(R-HSA-1236394)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 hd domain mutants in cancer
(R-HSA-2691230)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660825)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Tnf signaling
(R-HSA-75893)
Amyloid precursor protein catabolic process
(GO:0042987)
B cell differentiation
(GO:0030183)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell motility
(GO:0048870)
Cellular response to high density lipoprotein particle stimulus
(GO:0071403)
Commissural neuron axon guidance
(GO:0071679)
Cytokine binding
(GO:0019955)
Cytoplasm
(GO:0005737)
Defense response to gram-positive bacterium
(GO:0050830)
Endopeptidase activity
(GO:0004175)
Germinal center formation
(GO:0002467)
Golgi membrane
(GO:0000139)
Integrin binding
(GO:0005178)
Interleukin-6 receptor binding
(GO:0005138)
Membrane protein ectodomain proteolysis
(GO:0006509)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Metalloendopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902945)
Metallopeptidase activity
(GO:0008237)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Neutrophil mediated immunity
(GO:0002446)
Notch binding
(GO:0005112)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Pdz domain binding
(GO:0030165)
Peptidase activity
(GO:0008233)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of epidermal growth factor-activated receptor activity
(GO:0045741)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of leukocyte chemotaxis
(GO:0002690)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of mast cell apoptotic process
(GO:0033025)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to xenobiotic stimulus
(GO:0009410)
Sh3 domain binding
(GO:0017124)
Signal release
(GO:0023061)
Spleen development
(GO:0048536)
T cell differentiation in thymus
(GO:0033077)
Tumor necrosis factor binding
(GO:0043120)
Wound healing, spreading of epidermal cells
(GO:0035313)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 312.7708
Cell Significance Index: -48.6500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 184.9447
Cell Significance Index: -46.9100
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 112.0531
Cell Significance Index: -46.1600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 106.4130
Cell Significance Index: -50.2400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 102.7674
Cell Significance Index: -41.7500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 92.5960
Cell Significance Index: -47.6300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 43.7919
Cell Significance Index: -41.8100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.3583
Cell Significance Index: -49.7600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.7277
Cell Significance Index: -47.4900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.1366
Cell Significance Index: -43.4200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.0730
Cell Significance Index: -30.8000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.7140
Cell Significance Index: -50.1700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9731
Cell Significance Index: 26.9200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8148
Cell Significance Index: 364.0400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.8036
Cell Significance Index: 51.7000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.6362
Cell Significance Index: 43.6900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4722
Cell Significance Index: 292.1600
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.0488
Cell Significance Index: 20.4700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9320
Cell Significance Index: 71.5200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8851
Cell Significance Index: 49.6700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6433
Cell Significance Index: 17.5100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6366
Cell Significance Index: 17.7900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.6098
Cell Significance Index: 78.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6041
Cell Significance Index: 216.6900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.6003
Cell Significance Index: 16.0900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5903
Cell Significance Index: 532.9600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5759
Cell Significance Index: 62.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5189
Cell Significance Index: 24.3900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5091
Cell Significance Index: 82.8100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5024
Cell Significance Index: 30.8800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4735
Cell Significance Index: 258.5800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4599
Cell Significance Index: 23.8900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4560
Cell Significance Index: 56.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4279
Cell Significance Index: 12.3300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3788
Cell Significance Index: 261.9800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3666
Cell Significance Index: 66.1000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3473
Cell Significance Index: 15.7400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3458
Cell Significance Index: 23.2500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3321
Cell Significance Index: 146.8300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3071
Cell Significance Index: 42.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2893
Cell Significance Index: 18.6700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2853
Cell Significance Index: 537.2100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2768
Cell Significance Index: 10.4800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2745
Cell Significance Index: 12.1400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2447
Cell Significance Index: 6.2900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2353
Cell Significance Index: 30.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2311
Cell Significance Index: 22.8600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2105
Cell Significance Index: 4.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1674
Cell Significance Index: 19.7400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1652
Cell Significance Index: 254.2700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1378
Cell Significance Index: 254.0800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1234
Cell Significance Index: 78.3600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1224
Cell Significance Index: 166.3800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0766
Cell Significance Index: 14.5700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0338
Cell Significance Index: 0.5800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0170
Cell Significance Index: 1.2700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0119
Cell Significance Index: 5.3800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0071
Cell Significance Index: -0.4500
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0150
Cell Significance Index: -0.2200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0319
Cell Significance Index: -4.6400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0481
Cell Significance Index: -36.4300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0505
Cell Significance Index: -37.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0523
Cell Significance Index: -38.7100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0783
Cell Significance Index: -44.1800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0908
Cell Significance Index: -56.7100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1029
Cell Significance Index: -1.4800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1114
Cell Significance Index: -11.3800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1188
Cell Significance Index: -20.2800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1346
Cell Significance Index: -9.5200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1454
Cell Significance Index: -41.8500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1488
Cell Significance Index: -5.2300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1602
Cell Significance Index: -11.0800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1991
Cell Significance Index: -3.6800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2562
Cell Significance Index: -53.9600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2797
Cell Significance Index: -1.6900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2822
Cell Significance Index: -32.8900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2887
Cell Significance Index: -15.0400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2931
Cell Significance Index: -33.5800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2956
Cell Significance Index: -7.0900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3332
Cell Significance Index: -15.5400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3486
Cell Significance Index: -36.3000
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3616
Cell Significance Index: -4.3100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3691
Cell Significance Index: -3.0100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3709
Cell Significance Index: -12.8900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3799
Cell Significance Index: -10.8400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4257
Cell Significance Index: -8.8300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4280
Cell Significance Index: -11.2600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4412
Cell Significance Index: -11.0300
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4877
Cell Significance Index: -11.9000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4881
Cell Significance Index: -10.4000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5198
Cell Significance Index: -16.6500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5558
Cell Significance Index: -29.1800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5751
Cell Significance Index: -45.5500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6184
Cell Significance Index: -9.1300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6736
Cell Significance Index: -41.3000
Cell Name: peg cell (CL4033014)
Fold Change: -0.6737
Cell Significance Index: -15.5700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7072
Cell Significance Index: -11.8400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.7845
Cell Significance Index: -16.6500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.8376
Cell Significance Index: -18.3400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.8556
Cell Significance Index: -12.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** ADAM17 is a type II transmembrane glycoprotein that belongs to the ADAM (A Disintegrin and Metalloproteinase) family. It is characterized by its unique structure, which includes a disintegrin domain, a metalloprotease domain, and a cysteine-rich domain. ADAM17 is primarily expressed on the surface of various cell types, including immune cells, epithelial cells, and fibroblasts. **Pathways and Functions** ADAM17 is a key enzyme involved in the processing and shedding of various proteins, including cytokines, growth factors, and receptors. Its primary function is to cleave the extracellular domain of these proteins, releasing them from the cell surface and activating their signaling pathways. Some of the key pathways and functions associated with ADAM17 include: 1. **Notch signaling**: ADAM17 is involved in the processing and release of the Notch ligands, which play a crucial role in cell differentiation, proliferation, and survival. 2. **TNF-alpha processing**: ADAM17 is responsible for cleaving the extracellular domain of TNF-alpha, releasing the mature cytokine and activating its signaling pathways. 3. **Amyloid precursor protein (APP) cleavage**: ADAM17 is involved in the processing and shedding of APP, which is involved in Alzheimer's disease. 4. **Leukocyte chemotaxis**: ADAM17 is involved in the processing and release of chemokines, which play a crucial role in leukocyte migration and immune response. **Clinical Significance** ADAM17 has been implicated in various diseases, including: 1. **Cancer**: ADAM17 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with tumor growth, invasion, and metastasis. 2. **Neurodegenerative diseases**: ADAM17 has been implicated in Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it plays a role in APP processing and neuroinflammation. 3. **Infectious diseases**: ADAM17 has been shown to play a role in the processing and release of cytokines involved in the immune response to infections, such as HIV and tuberculosis. 4. **Inflammatory diseases**: ADAM17 has been implicated in various inflammatory diseases, including rheumatoid arthritis, lupus, and psoriasis, where it plays a role in the processing and release of cytokines and chemokines. In conclusion, ADAM17 is a multifunctional enzyme that plays a critical role in various biological processes, including cell signaling, immune response, and tissue remodeling. Its dysregulation has been implicated in various diseases, highlighting the importance of ADAM17 in understanding human disease and developing novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Disintegrin and metalloproteinase domain-containing protein 17

Genular Protein ID: 4028310968

Symbol: ADA17_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 17

UniProtKB Accession Codes:

P78536 O60226

Database IDs:

Citations:

PubMed ID: 9034191

Title: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.

PubMed ID: 9034191

DOI: 10.1038/385733a0

PubMed ID: 9034190

Title: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.

PubMed ID: 9034190

DOI: 10.1038/385729a0

PubMed ID: 9574564

Title: TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha.

PubMed ID: 9574564

PubMed ID: 12058067

Title: Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

PubMed ID: 12058067

DOI: 10.1091/mbc.01-11-0561

PubMed ID: 12441351

Title: Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.

PubMed ID: 12441351

DOI: 10.1074/jbc.m208326200

PubMed ID: 12621058

Title: Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.

PubMed ID: 12621058

DOI: 10.1074/jbc.m300331200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20592283

Title: Junctional adhesion molecule-C is a soluble mediator of angiogenesis.

PubMed ID: 20592283

DOI: 10.4049/jimmunol.1000556

PubMed ID: 20188673

Title: Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.

PubMed ID: 20188673

DOI: 10.1016/j.molcel.2010.01.034

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22010916

Title: Inflammatory skin and bowel disease linked to ADAM17 deletion.

PubMed ID: 22010916

DOI: 10.1056/nejmoa1100721

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24226769

Title: The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality.

PubMed ID: 24226769

DOI: 10.1038/nature12723

PubMed ID: 24337742

Title: ADAM17-mediated shedding of FcgammaRIIIA on human NK cells: identification of the cleavage site and relationship with activation.

PubMed ID: 24337742

DOI: 10.4049/jimmunol.1301024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24227843

Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.

PubMed ID: 24227843

DOI: 10.1128/jvi.02202-13

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 28923481

Title: ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.

PubMed ID: 28923481

DOI: 10.1016/j.neulet.2017.09.034

PubMed ID: 28060820

Title: Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

PubMed ID: 28060820

DOI: 10.1371/journal.pbio.2000080

PubMed ID: 29897333

Title: iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

PubMed ID: 29897333

DOI: 10.7554/elife.35032

PubMed ID: 29897336

Title: FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

PubMed ID: 29897336

DOI: 10.7554/elife.35012

PubMed ID: 36078095

Title: Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17.

PubMed ID: 36078095

DOI: 10.3390/cells11172683

PubMed ID: 9520379

Title: Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.

PubMed ID: 9520379

DOI: 10.1073/pnas.95.7.3408

Sequence Information:

Length: 824
Mass: 93021
Checksum: 5B1032F6B88A837F
Sequence:

MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 
QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD GKNESEYTVK WQDFFTGHVV 
GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 
PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG 
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 
HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 
SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 
TCKGVSYCTG NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHP SNVEMLSSMD 
SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA APKLDHQRMD TIQEDPSTDS HMDEDGFEKD 
PFPNSSTAAK SFEDLTDHPV TRSEKAASFK LQRQNRVDSK ETEC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADAM17

Associated with

Cells (max top 100)

Other Information

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. PubMed ID: 9034191

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. PubMed ID: 9034190

TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha. PubMed ID: 9574564

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. PubMed ID: 12058067

Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding. PubMed ID: 12441351

Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. PubMed ID: 12621058

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Junctional adhesion molecule-C is a soluble mediator of angiogenesis. PubMed ID: 20592283

Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. PubMed ID: 20188673

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Inflammatory skin and bowel disease linked to ADAM17 deletion. PubMed ID: 22010916

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality. PubMed ID: 24226769

ADAM17-mediated shedding of FcgammaRIIIA on human NK cells: identification of the cleavage site and relationship with activation. PubMed ID: 24337742

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. PubMed ID: 24227843

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling. PubMed ID: 26876177

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. PubMed ID: 28923481

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation. PubMed ID: 28060820

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE. PubMed ID: 29897333

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex. PubMed ID: 29897336

Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17. PubMed ID: 36078095

Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme. PubMed ID: 9520379